Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3293 papers published)

Results 3001 - 3010 of 3293
3001
Tracing Conidial Fate and Measuring Host Cell Antifungal Activity Using a Reporter of Microbial Viability in the Lung

Anupam Jhingran, Katrina B Mar, Debra K Kumasaka, Sue E Knoblaugh, Lisa Y Ngo, Brahm H Segal, Yoichiro Iwakura, Clifford A Lowell, Jessica A Hamerman, Xin Lin, Tobias M Hohl

Cell Reports (Cell Press) USA, Japan , 27 December 2012

Virology

Key words: FLARE conidia, C-type lectin receptor, leukocyte-fungal cell

Organism: Mouse

Tissue: Lung

Pathological State: Fungal Infection

3002
Comprehensive morphometric analysis of mononuclear cell infiltration during experimental renal allograft rejection

Ute Hoffmann, Tobias Bergler, Bettina Jung, Andreas Steege, Claudia Pace, Petra Rümmele, Stephan Reinhold, Bernd Krüger, Bernhard K Krämer, Bernhard Banas

Transplant Immunology (Elsevier) Germany , 23 December 2012

Transplantation Medicine

Key words: B-cells, different analysis methods, experimental renal allograft rejection, macrophages, T-cells

Organism: Rat

Tissue: Kidney

Pathological State: Allogeneic Transplantation

3003
Ectopic Pregnancy-Derived Human Trophoblastic Stem Cells Regenerate Dopaminergic Nigrostriatal Pathway to Treat Parkinsonian Rats

Tony Tung-Yin Lee, Cheng-Fang Tsai, Tsung-Hsun Hsieh, Jia-Jin Jason Chen, Yu-Chih Wang, Mi-Chun Kao, Ruey-Meei Wu, Sher Singh, Eing-Mei Tsai, Jau-Nan Lee

PLoS One (PLOS) Taiwan , 21 December 2012

Stem Cell Research

Key words: Neurons, pluripotency, flow cytometry, pregnancy, dopamine, dopaminergics, rats, cell differentiation

Organism: Rat

Tissue: Brain

Pathological State: Parkinson's Disease

3004
Enhancement of the Immunogenicity and Protective Efficacy of a Mucosal Influenza Subunit Vaccine by the Saponin Adjuvant GPI-0100

Heng Liu, Harshad P Patil, Jacqueline de Vries-Idema, Jan Wilschut, Anke Huckriede

PLoS One (PLOS) The Netherlands , 17 December 2012

Immunology

Key words: Vaccines, immunologic adjuvants, influenza, immune response, antibodies, antibody response, influenza viruses, viral vaccines

Organism: Mouse

Tissue: Lung

Pathological State: Influenza Infection

3005
Spatiotemporal evolution of early innate immune responses triggered by neural stem cell grafting

Kristien Reekmans, Nathalie De Vocht, Jelle Praet, Erik Fransen, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Herman Goossens, Annemie Van der Linden, Zwi Berneman, Peter Ponsaerts

Stem Cell Research & Therapy (BMC) Belgium , 14 December 2012

Stem Cell Research

Key words: Anti-APC (Adenomatous polyposis coli protein) antibody, central nervous system, enhanced green fluorescent protein, neuronal nuclei

Organism: Mouse

Tissue: Brain

3006
CHC promotes tumor growth and angiogenesis through regulation of HIF-1α and VEGF signaling

Kuo-Hua Tung, Cheng-Wei Lin, Chun-Chen Kuo, Li-Tzu Li, Ya-Hsun Kuo, Chung-Wu Lin, Han-Chung Wu

Cancer Letters (Elsevier) Taiwan , 07 December 2012

Oncology

Key words: Pancreatic cancer, monoclonal antibody, clathrin heavy chain, HIF-1a, angiogenesis

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

3007
Depletion of tristetraprolin in breast cancer cells increases interleukin-16 expression and promotes tumor infiltration with monocytes/macrophages

Larissa Milke, Kathrin Schulz, Andreas Weigert, Weixiao Sha, Tobias Schmid, Bernhard Brüne

Carcinogenesis (Oxford University Press) Germany , 04 December 2012

Oncology

Key words: RNA-binding protein tristetraprolin, macrophages, interleukin-16, granulocyte macrophage-colony

3008
Stem Cell-Like Differentiation Potentials of Endometrial Side Population Cells as Revealed by a Newly Developed In Vivo Endometrial Stem Cell Assay

Kaoru Miyazaki, Tetsuo Maruyama, Hirotaka Masuda, Akiko Yamasaki, Sayaka Uchida, Hideyuki Oda, Hiroshi Uchida, Yasunori Yoshimura

PLoS One (PLOS) Japan , 04 December 2012

Stem Cell Research

Key words: Stem cells, cell differentiation, kidneys, stem cell transplantation, endometrium, flow cytometry, stem cell niche, renal transplantation

Organism: Mouse

Tissue: Kidney

3009
Towards the Automated Detection and Characterization of Osteoclasts in Microscopic Images

Andreas Heindl, Martin Schepelmann, Rupert Ecker, Peter Pietschmann, Isabella Ellinger, Alexander K Seewald, Theresia Thalhammer

Principles of Osteoimmunology (Springer) Austria , 01 December 2012

Medical Image Analysis

Key words: Giant Cell Tumor, Joint Photographic Expert Group, Portable Network Graphic, Biological Expert, Osteoclast Culture

Organism: Human

Cell Line: Osteoclasts

3010
Crypts detection in microscopic images using hierarchical structures

Cristian Smochina, Vasile Manta, Walter Kropatsch

Pattern Recognition Letters (Elsevier) Romania, Austria , 29 November 2012

Pathology

Key words: Crypt segmentation, morphological hierarchy, morphological pyramid, biomedical imaging, pathology, microscopy

Organism: Human

Tissue: Colon

Results 3001 - 3010 of 3293
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