Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 2891 - 2900 of 3476
2891
MAP4K4 regulates integrin-FERM binding to control endothelial cell motility

Philip Vitorino, Stacey Yeung, Ailey Crow, Jesse Bakke, Tanya Smyczek, Kristina West, Erin McNamara, Jeffrey Eastham-Anderson, Stephen Gould, Seth F Harris, Chudi Ndubaku and Weilan Ye

Nature (Nature) USA , 18 March 2015

Cell Biology

Key words: Focal adhesion

Organism: Mouse

Pathological State: Cancer

2892
CARDIAC MAGNETIC RESONANCE T1 MAPPING FOR QUANTIFICATION OF EXTRACELLULAR MATRIX - VALIDATION BY MYOCARDIAL BIOPSY

Andreas Anselm Kammerlander, Caroline Tufaro, Alina Bachmann, Beatrice Marzluf, Stefan Aschauer, Andreas Greiser, Diana Bonderman, Julia Mascherbauer

Journal of the American College of Cardiology (Elsevier) Austria , 16 March 2015

Cardiology

Key words: Diffuse myocardial fibrosis, extracellular matrix expansion, cardiac magnetic resonance

Organism: Human

Tissue: Heart

Pathological State: Heart Failure

2893
The Upregulation of LAG-3 on T Cells Defines a Subpopulation with Functional Exhaustion and Correlates with Disease Progression in HIV-Infected Subjects

The Journal of Immunology (American Association of Immunologists) China , 16 March 2015

Immunology, Virology

Key words: Plasmodium infection, virus–specific CD8+ T cells, human embryonic kidney cells

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Plasmodium Infection

2894
Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells

Charlotte Gröschel, Abhishek Aggarwal, Samawansha Tennakoon, Julia Höbaus, Maximilian Prinz-Wohlgenannt, Brigitte Marian, Petra Heffeter, Walter Berger, Eniko Kállay

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Austria , 14 March 2015

Oncology

Key words: 1, 25-Dihydroxyvitamin D3, colorectal cancer, chemoprevention, wnt pathway, LGR5

Organism: Human

Tissue: Colon

Pathological State: Cancer

2895
Vimentin regulates activation of the NLRP3 inflammasome

Gimena dos Santos, Micah R Rogel, Margaret A Baker, James R Troken, Daniela Urich, Luisa Morales-Nebreda, Joseph A Sennello, Mikhail A Kutuzov, Albert Sitikov, Jennifer M Davis, Anna P Lam, Paul Cheresh, David Kamp, Dale K Shumaker, G R Scott Budinger and Karen M Ridge

Nature Communications (Nature) USA , 12 March 2015

Cell Biology

Key words: Cytoskeletal proteins, Inflammasome, NOD-like receptors, Respiratory tract diseases

Organism: Mouse

Tissue: Heart, Lung

2896
Nitric Oxide Prevents Alveolar Senescence and Emphysema in a Mouse Model

Amanda E Boe, Mesut Eren, Luisa Morales-Nebreda, Sheila B Murphy, G R Scott Budinger, Gökhan M Mutlu, Toshio Miyata, Douglas E Vaughan

PLoS One (PLOS) USA, Japan , 10 March 2015

Pulmonology

Key words: Nω-nitro-L-arginine methyl ester, alveolar tissue destruction, plasminogen activator inhibitor-1

Organism: Mouse

Tissue: Lung

Pathological State: Chronic Obstructive Pulmonary Disease

2897
Clinical improvement in psoriasis with specific targeting of interleukin-23

Tamara Kopp, Elisabeth Riedl, Christine Bangert, Edward P Bowman, Elli Greisenegger, Ann Horowitz, Harald Kittler, Wendy M Blumenschein, Terrill K McClanahan, Thomas Marbury, Claus Zachariae, Danlin Xu, Xiaoli Shirley Hou, Anish Mehta, Anthe S Zandvliet, Diana Montgomery, Frank van Aarle and Sauzanne Khalilieh

Nature (Nature) Austria, USA, Denmark , 09 March 2015

Dermatology

Key words: Psoriasis, interleukin-23

Pathological State: Psoriasis

2898
Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer

TT Wei, YC Lin, PH Lin, JY Shih, CW Chou, WJ Huang, YC Yang, PW Hsiao, CC Chen

Oncotarget (Impact Journals) Taiwan , 08 March 2015

Oncology

Key words: c-Cbl, EGFR, HDAC inhibitors, lung cancer

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

2899
Active vitamin D potentiates the anti-neoplastic effects of calcium in the colon: A cross talk through the calcium-sensing receptor

Abhishek Aggarwal, Julia Höbaus, Samawansha Tennakoon, Maximilian Prinz-Wohlgenannt, João Graça, Sally A Price, Petra Heffeter, Walter Berger, Sabina Baumgartner-Parzer, Enikö Kállay

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Austria, UK , 07 March 2015

Oncology

Key words: Calcium-sensing receptor, Colon cancer, Calcium, Vitamin D, Chemoprevention, Calcimimetic

Organism: Mouse

Tissue: Colon

2900
Zileuton, 5-Lipoxygenase Inhibitor, Acts as a Chemopreventive Agent in Intestinal Polyposis, by Modulating Polyp and Systemic Inflammation

Elias Gounaris, Michael J Heiferman, Jeffrey R Heiferman, Manisha Shrivastav, Dominic Vitello, Nichole R Blatner, Lawrence M Knab, Joseph D Phillips, Eric C Cheon, Paul J Grippo, Khashayarsha Khazaie, Hidayatullah G Munshi, David J Bentrem

PLoS One (PLOS) USA , 06 March 2015

Oncology

Key words: Calcium-sensing receptor, tumor suppressor, colorectal cancer, colon, calcium, calcimimetic, calcilytic

Organism: Mouse

Tissue: Intestine

Pathological State: Cancer

Results 2891 - 2900 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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