Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 2881 - 2890 of 3476
2881
Molecular characterization of whole mount prostate specimens using 5-color fluorescence labeling, virtual slide technology and automated image analysis

Georg E Steiner, Gwenaelle Gaillard, Karina Pfeil, Claudia Strele, Christine Linder, Vincent Laurain, Radu Rogojanu, Rupert C Ecker, Katja Oesterreicher, Lukas Kenner, Johannes Schmid, Helmut Klocker

Cancer Research (AACR Publications) Austria , 01 April 2015

Medical Image Analysis

Key words: Prostate tissue samples, tubular epithelial ducts, epithelial and non-epithelial cells

2882
Chondroitin sulfate-polyethylenimine copolymer-coated superparamagnetic iron oxide nanoparticles as an efficient magneto-gene carrier for microRNA-encoding plasmid DNA delivery

YL Lo, HL Chou, ZX Liao, SJ Huang, JH Ke, YS Liu, CC Chiu, LF Wang

Nanoscale (Royal Society of Chemistry) Taiwan , 01 April 2015

Nanomedicine

Key words: Magnetofection, MicroRNA, Glioblastoma, Gene delivery

Organism: Human

Pathological State: Cancer

Cell Line: U87 cells

2883
nk4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis

Ryo Seishima, Takeyuki Wada, Kenji Tsuchihashi, Shogo Okazaki, Momoko Yoshikawa, Hiroko Oshima, Masanobu Oshima, Toshiro Sato, Hirotoshi Hasegawa, Yuko Kitagawa, James R Goldenring, Hideyuki Saya, Osamu Nagano

Cancer Prevention Research (AACR Publications) Japan, USA , 26 March 2015

Oncology

Key words: Spasmolytic polypeptide–expressing metaplasia, reactive oxygen species, parietal cells

Organism: Mouse

Tissue: Stomach

2884
Trained immunity in newborn infants of HBV-infected mothers

Michelle Hong, Elena Sandalova, Diana Low, Adam J Gehring, Stefania Fieni, Barbara Amadei, Simonetta Urbani, Yap-Seng Chong, Ernesto Guccione, Antonio Bertoletti

Nature Communications (Nature) Singapore, Italy, UK , 25 March 2015

Immunology, Virology

Key words: Calcium-sensing receptor, colon cancer, calcium, vitamin D, chemoprevention, calcimimetic

Organism: Human

Pathological State: Cancer

Cell Line: CD2- cells (non-T non-NK cells)

2885
Low-dose irradiation affects expression of inflammatory markers in the heart of ApoE-/-mice

Daniel Mathias, Ronald E J Mitchel, Mirela Barclay, Heather Wyatt, Michelle Bugden, Nicholas D Priest, Stewart C Whitman †, Markus Scholz, Guido Hildebrandt, Manja Kamprad, Annegret Glasow

PLoS One (PLOS) Germany, Canada , 23 March 2015

Cardiology

Key words: Collagens, Dosimetry, Inflammation, Fibrinogen, Blood plasma, Heart, White blood cells, Endothelial cells

Organism: Mouse

Tissue: Heart

2886
Reproductive Sciences

Reproductive Sciences (SAGE Journals) , 22 March 2015

Reproductive Medicine

2887
Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra

Jelle Praet, Jasmien Orije, Firat Kara, Caroline Guglielmetti, Eva Santermans, Jasmijn Daans, Niel Hens, Marleen Verhoye, Zwi Berneman, Peter Ponsaerts, Annemie Van der Linden

NMR in Biomedicine (Wiley) Belgium , 19 March 2015

Oncology

Key words: GDF10/BMP3b, TGFBR3, oral cancer, prognostic marker, EMT, chemotherapy resistance

Organism: Mouse

Tissue: Brain

Pathological State: Demyelination

2888
Tissue Microarrays for Translational Research

Ronald Simon, Martina Mirlacher

Microarrays in Diagnostics and Biomarker Development (Springer) Germany , 19 March 2015

Biological Methods

Key words: Tissue microarray,

2889
CD20+ T cells have a predominantly Tc1 effector memory phenotype and are expanded in the ascites of patients with ovarian cancer

Marco de Bruyn, Valerie R Wiersma, Maartje C A Wouters, Douwe F Samplonius, Harry G Klip, Wijnand Helfrich, Hans W Nijman, Paul Eggletonc, Edwin Bremer

OncoImmunology (Taylor and Francis) The Netherlands, UK, Canada , 19 March 2015

Immunology

Key words: Ascites, cancer immunology, CD20, ovarian cancer, trogocytosis, APC, Antigen-Presenting Cell, CTL, Cytotoxic T Lymphocyte, FSC, Forward Scatter, OC, Ovarian Cancer, PBMC, Peripheral Blood Mononuclear Cell, SCC, Side Scatter, TC, Cytotoxic T cell, TCM, Central Memory T cell, TEM, Effector Memory T cell, TH, Helper T cell, TIL, Tumor Infiltrating T cell, TNaïve, Naïve T cell, Treg, Regulatory T cell, TTD, Terminally Differentiated T cell

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

2890
The calcium-sensing receptor suppresses epithelial-to-mesenchymal transition and stem cell- like phenotype in the colon

Abhishek Aggarwal, Maximilian Prinz-Wohlgenannt, Charlotte Gröschel, Samawansha Tennakoon, Anastasia Meshcheryakova, Wenhan Chang, Edward M Brown, Diana Mechtcheriakova, Enikö Kállay

Molecular Cancer (Springer) Austria, USA , 18 March 2015

Oncology

Key words: EVI1, MS4A3, transcriptional repression, myeloid leukemia, tumor growth

Organism: Mouse, Human

Tissue: Colon

Pathological State: Cancer

Cell Line: HT29 cells (colon cancer cell line)

Results 2881 - 2890 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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