Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 61 - 70 of 3476
61
Tissue Cytometry Assay with Nuclear Segmentation for Quantifying NETotic Cells in Neutrophils Stimulated by Spermatozoa in Veterinary Species

R Rivera-Concha, M León, NRPonce-Rojas, AS Prado-Sanhueza, P Uribe, A Taubert, C Hermosilla, R Sánchez, F Zambrano

Animals (MDPI) Chile , 19 September 2025

Medical Image Analysis

Key words: neutrophil extracellular traps, spermatozoa, bovine, canine, image cytometry

Organism: Dog

Tissue: Semen

62
Trefoil factor 2 interacts with A4GNT to regulate inflammation to protect against pneumonia during influenza virus infection

W Fu, J Fan, T Peng, P Sun, S Yuan, C Zhu, L Ding, L Zhang, C Zhao, S Zhang, X Zhang, J Xu

iScience (Cell) China , 19 September 2025

Virology

Key words: Cell biology, Microbiology, Viral microbiology

Organism: Mouse

Tissue: Lung

Pathological State: Viral Infection

63
Low Indoleamine 2, 3-Dioxygenase 1 Expression Enhances Dendritic Cells Response to Tumor Cells Against Hepatocellular Carcinoma

C Mo, M Hong, Y Li, D Huang, Q Ji, Y Liu

Journal of Hepatocellular Carcinoma (Taylor & Francis) China , 19 September 2025

Oncology

Key words: hepatocellular carcinoma, indoleamine 2,3 dioxygenase 1, dendritic cells, T cells

Organism: Human

Tissue: Liver

Pathological State: Cancer

64
Mesenchymal progenitor–derived proteoglycan 4 regulates the transdifferentiation of chondrocytes into osteoblasts during fracture healing

N Ninkovic, JM Corpuz, A Stahl, A Olsen, CM Unger, AA Ardebili, H Sun, J Cha, D Kaketsis, SL Manske, IT Haider, RS Marcucio, TA Schmidt, GD Jay, TM Underhill, WB Edwards, DE Rancourt, J Biernaskie, RJ Krawetz

Stem Cells Translational Medicine (Oxford Academic) Canada , 19 September 2025

Osteology

Key words: fracture healing, mesenchymal progenitor cells, Prg4, transdifferentiation

Organism: Mouse

Tissue: Bone

Pathological State: Fracture

65
Drug screening in 3D microtumors reveals DDR1/2-MAPK12-GLI1 as a vulnerability in cancer-associated fibroblasts

N Nishida-Aoki, S Zhu, M Chan, Y Kang, M Fujita, X Jiang, M McCabe, JM Vaz, NE Davidson, CM Ghajar, K Hansen, AL Welm, VG Pillarisetty, TS Gujral

Cell Reports Medicine (Cell) USA, Japan , 19 September 2025

Oncology

Key words: microtumor, tumor microenvironment, functional screening, CAF, hedgehog pathway, kinase signaling, precision oncology

Organism: Mouse

Pathological State: Cancer

Cell Line: CMC-38

66
CD163/CD63+ Monocyte-Derived DC Profiled in Tissue by Multi-Antigen Analysis (MAA) Discriminate Chronic Eczema and Psoriasis

S Windorfer, M Kirr, W Fröhlich, B Plosnita, C Ostalecki, C Berking, M Sticherling, AS Baur

International Journal of Molecular Sciences (MDPI) Germany, Austria , 18 September 2025

Dermatology

Key words: psoriasis; eczema; atopic dermatitis; inflammatory dendritic cells; DC; multiplex imaging; multi-antigen analysis; DC3 cells; Langerhans cells

Organism: Human

Tissue: Skin

Pathological State: Psoriasis

67
High MRPL12 expression drives esophageal cancer proliferation, invasion and migration

G Wang, X Sun, Q Liu, Z Pang, Y Huang, L Lv, H Zhang, H Liu, L Zhu

Bulletin du Cancer (Elsevier) China , 17 September 2025

Oncology

Key words: Esophageal squamous cell carcinoma, MRPL12, ZNF460, ZNF135, Mitochondrial metabolism

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

68
Entamoeba histolytica–binding of the lipopeptidophosphoglycan-specific monoclonal antibody EH5 to dextrans

A Nagode, J Vanbeselaere, S Rauscher, J Tobias, IBH Wilson, M Duchene

Carbohydrate Research (Elsevier) Austria , 16 September 2025

Nutritional Science

Key words: Entamoeba histolytica, Lipopeptidophosphoglycan, Dextran, Monoclonal antibody, Epitope

Organism: Entamoeba histolytica

Tissue: Whole Organism

69
Maintenance DNA methylation is required for induced Treg reparative function following viral pneumonia in mice

AM Joudi, JK Gurkan, Q Liu, EM Steinert, MAT Acosta, KA Helmin, L Morales-Nebreda, N Mambetsariev, CPR Flores, H Abdala-Valencia, SE Weinberg, BD Singer

Journal of Clinical Investigation (JCI) USA , 16 September 2025

Pulmonology

Organism: Mouse

Tissue: Lung

Pathological State: Viral Infection

70
Single-cell analysis identifies PI3+ S100A7+ keratinocytes in early cervical squamous cell carcinoma with HPV infection

P Fan, D Dong, Y Feng, X Zhu, R Wang

Chinese Medical Journal (Wolters Luwer) China , 15 September 2025

Oncology

Key words: Cervical squamous cell carcinoma; Single-cell RNA sequencing; human papillomavirus; HPV; Keratinocytes

Organism: Human

Tissue: Cervix

Pathological State: Cancer

Results 61 - 70 of 3476

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