Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Read the Publication
Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

Read the Publication
AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Read the Publication
Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

Read the Publication
COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Read the Publication
Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Read the Publication
Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Read the Publication
Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Read the Publication
Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Read the Publication
Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Read the Publication
Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

Read the Publication
SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

Read the Publication
CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Read the Publication
previous arrow
next arrow

Filter publications

Customer Publications (A total of 3476 papers published)

Results 3361 - 3370 of 3476
3361
Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid

Mansour Mohamadzadeh, Erika A Pfeiler, Jeffrey B Brown, Mojgan Zadeh, Matthew Gramarossa, Elizabeth Managlia, Praveen Bere, Bara Sarraj, Mohammad W Khan, Krishna Chaitanya Pakanati, M Javeed Ansari, Sarah O'Flaherty, Terrence Barrett, Todd R Klaenhammer

PNAS (PNAS) USA , 12 October 2010

Immunology, Microbiology

Key words: Antiinflammatory lactobacilli Toll-like receptor 2 innate immunity

3362
ABSTRACTS OF THE NINTH INTERNATIONAL CONFERENCE OF ANTICANCER RESEARCH

Anticancer Research (Anticancer Research) Greece , 10 October 2010

Oncology

Key words: Antitumor lymphocytes, ES cells, bioluminiscence imaging

3363
Endo180 and MT1-MMP are involved in the phagocytosis of collagen scaffolds by macrophages and is regulated by interferon-gamma

Ye Q, Xing Q, Ren Y, Harmsen MC, Bank RA

European Cells and Materials (NCBI) The Netherlands , 07 October 2010

Regenerative Medicine

Key words: Hexamethylenediisocyanate, glutaraldehyde cross-linked sheep collagen,

3364
Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance

Tatsuaki Mizutani, Nina Neugebauer, Eva M Putz, Nadine Moritz, Olivia Simma, Eva Zebedin-Brandl, Dagmar Gotthardt, Wolfgang Warsch, Eva Eckelhart, Hans-Peter Kantner, Ulrich Kalinke, Stefan Lienenklaus, Siegfried Weiss, Birgit Strobl, Mathias Müller, Veronika Sexl, Dagmar Stoiber

OncoImmunology (Taylor and Francis) Austria, Germany , 01 October 2010

Oncology

Key words: IFNAR1, IFNß, NK cells, leukemia, tumor surveillance

3365
Transcriptional coactivators p300 and CBP stimulate estrogen receptor-beta signaling and regulate cellular events in prostate cancer

Jan Bouchal, Frédéric R Santer, Philipp PS Höschele, Eva Tomastikova, Hannes Neuwirt, Zoran Culig

The Prostate (Wiley) Austria, Czech Republic , 21 September 2010

Oncology

Key words: Transcriptional coactivators, prostate cancer, estrogen receptor-ß, migration, genistein

3366
Physicochemical characterization and in vivo bioluminescence imaging of nanostructured lipid carriers for targeting the brain: apomorphine as a model drug

Shu-Hui Hsu, Chih-Jen Wen, S A Al-Suwayeh, Hui-Wen Chang, Tzu-Chen Yen, Jia-You Fang

Nanotechnology (IOP Science) Taiwan , 08 September 2010

Nanomedicine

Key words: Drug administration, Fluorescence microscopy, Drug release, Nuclear magnetic resonance, Brain Aqueous solutions, Saline Particle size, Transmission electron microscopy, Fluorescence, Nanoparticles Water Bioluminescence

3367
Towards a versatile automated cell-detection system for science and diagnostics

Heindl, A, Dekan, S, Ellinger, I, Seewald, AK

Engineering in Medicine and Biology Society (IEEEXplore) Austria , 04 September 2010

Medical Image Analysis

Key words: Pixel, Proteins, Algorithm design and analysis, Histograms, Microscopy, Software tools

3368
Self-assembling peptide amphiphile promotes plasticity of serotonergic fibers following spinal cord injury

Vicki M Tysseling, Vibhu Sahni, Eugene T Pashuck, Derin Birch, Amy Hebert, Catherine Czeisler, Samuel I Stupp, John A Kessler

Journal of Neuroscience Research (Wiley) USA , 03 September 2010

Neuroscience

Key words: Spinal cord injury, nanotechnology, biomaterials, regeneration, serotonin

Pathological State: Spinal Cord Injury

3369
TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer

Zhan Yao, Silvia Fenoglio, Ding Cheng Gao, Matthew Camiolo, Brendon Stiles, Trine Lindsted, Michaela Schlederer, Chris Johns, Nasser Altorki, Vivek Mittal, Lukas Kenner, Raffaella Sordella

PNAS (PNAS) USA , 31 August 2010

Oncology

Key words: Epidermal growth-factor receptor nonsmall cell lung cancer

3370
Segmentation of cell nuclei within complex configurations in images with colon sections

Rogojanu, R, Bises, G, Smochina, C, Manta, V

Intelligent Computer Communication and Processing (IEEEXplore) Austria, Romania , 28 August 2010

Medical Image Analysis

Key words: Nuclei segmentation

Results 3361 - 3370 of 3476

LogoOrangewhite2025

TissueGnostics GmbH
Taborstraße 10/2/8
1020 Vienna, Austria
+43 1 216 11 90
This email address is being protected from spambots. You need JavaScript enabled to view it.

Contact us

About Us

TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

Keep in Touch

Be the first to hear about the latest scientific updates