Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 3351 - 3360 of 3476
3351
Somatic Mutations throughout the Entire Mitochondrial Genome Are Associated with Elevated PSA Levels in Prostate Cancer Patients

Anita Kloss-Brandstätter, Georg Schäfer, Gertraud Erhart, Alexander Hüttenhofer, Stefan Coassin, Christof Seifarth, Monika Summerer, Jasmin Bektic, Helmut Klocker, Florian Kronenberg

American Journal of Human Genetics (Elsevier) Austria , 02 December 2010

Oncology

Key words: Somatic mitochondrial DNA (mtDNA) mutations, mitochondrial genes MT-CO2, MT-CO3, MT-ATP6, and MT-ND6, human mitochondrial genome

3352
Neuronal hyperexcitability and seizures are associated with changes in glial–neuronal interactions in the hippocampus of a mouse model of epilepsy with mental retardation

Torun Melø, Paolo Bigini, Ursula Sonnewald, Silvia Balosso, Alfredo Cagnotto, Sara Barbera, Sarah Uboldi, Annamaria Vezzani, Tiziana Mennini

Journal of Neurochemistry (Wiley) Norway, Italy , 19 November 2010

Neuroscience

Key words: 13C nuclear magnetic resonance spectroscopy, astrocytes and microglia, glutamate and GABA, hippocampus, neuronal ceroid lipofuscinosis, seizures

3353
Semi-automatic identification of punching areas for tissue microarray building: the tubular breast cancer pilot study

Federica Viti, Ivan Merelli, Mieke Timmermans, Michael den Bakker, Francesco Beltrame, Peter Riegman, Luciano Milanesi

BMC Bioinformatics (Springer) Italy, The Netherlands , 18 November 2010

Medical Image Analysis

Key words: Pixel Intensity, Pathological Region, Virtual Microscope, Donor Block, Unaffected Area

3354
Nuclear localization of Nm23-H1 in head and neck squamous cell carcinoma is associated with radiation resistance

Haeng Ran Park, Se-Heon Kim, Sei Young Lee, Ji Min Sung, Ae Ran Park, Suki Kang, Baek Gil Kim, Yoon Pyo Choi, Yong-Bae Kim, Nam Hoon Cho

Cancer (Wiley) South Korea , 18 November 2010

Oncology

Key words: Nm23-H1, nuclear localization, radiation resistance, head and neck squamous cell carcinoma, predictor

3355
Standards and impact of hematopathology in myelodysplastic syndromes (MDS)

Peter Valent, Attilio Orazi, Guntram Büsche, Annette Schmitt-Gräff, Tracy I George, Karl Sotlar, Berthold Streubel, Christine Beham-Schmid, Sabine Cerny-Reiterer, Otto Krieger, Arjan van de Loosdrecht, Wolfgang Kern, Kiyoyuki Ogata, Friedrich Wimazal, Judit Csomor, Judit Varkonyi, Wolfgang R Sperr, Martin Werner, Hans Kreipe, Horny Hans-Peter

Oncotarget (Impact Journals) Austria, Germany, Hungary, USA, Japan, The Netherlands , 16 November 2010

Oncology

Key words: MDS, hematopathology, diagnostic criteria, prognostication

3356
p53 activation mediates polyglutamine-expanded ataxin-3 upregulation of Bax expression in cerebellar and pontine nuclei neurons

An-Hsun Chou, An-Chi Lin, Kue-Yi Hong, Su-Huei Hu, Ying-Ling Chen, Ju-Yu Chen, Hung-Li Wang

Neurochemistry International (Elsevier) Taiwan , 16 November 2010

Neuroscience

Key words: Spinocerebellar ataxia type 3, Polyglutamine-expanded ataxin-3, Cerebellum, Pontine nuclei, Bax,

3357
The role of collagen receptors Endo180 and DDR-2 in the foreign body reaction against non-crosslinked collagen and gelatin

Qingsong Ye, Martin C Harmsen, Yijin Ren, Ruud A Bank

Biomaterials (Elsevier) The Netherlands, China, Australia , 10 November 2010

Biomaterials

Key words: Collagen, Gelatin, Endo180, DDR-2, Foreign body reaction, Giant cells

3358
Highly malignant intra-hepatic metastatic hepatocellular carcinoma in rats

Y Guo, R Klein, RA Omary, GY Yang, AC Larson

American Journal of Translational Research (e-Century Publishing Corporation) USA , 01 November 2010

Hepathology

Key words: Hepatocellular carcinoma (HCC), rodent model, orthotopic implantation, N1-S1 rat HCC cell line, McARH7777 rat HCC cell line, MRI, histopathology

3359
Spatiotemporal expression of the serine protease inhibitor, SERPINE2, in the mouse placenta and uterus during the estrous cycle, pregnancy, and lactation

Schu-Rern Chern, Sheng-Hsiang Li, Chung-Hao Lu, Edmund I Tsuen Chen

Reproductive Biology and Endocrinology (Springer) Taiwan , 27 October 2010

Reproductive Medicine

Key words: Estrous Cycle, Mouse Uterus, Trophoblast Giant Cell, Pregnant Uterus, Ectoplacental Cone

3360
The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection

Huajie Bu, Stefanie Bormann, Georg Schäfer, Wolfgang Horninger, Petra Massoner, Antje Neeb, Vinoth-Kumar Lakshmanan, Danilo Maddalo, Andrea Nestl, Holger Sültmann, Andrew CB Cato, Helmut Klocker

The Prostate (Wiley) Austria, Germany , 13 October 2010

Oncology

Key words: Urine prostate cancer marker, cell migration, cell-cycle progression, invasion, metastasis

Results 3351 - 3360 of 3476

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