Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 2931 - 2940 of 3476
2931
TLR4-mediated inflammation promotes foam cell formation of vascular smooth muscle cell by upregulating ACAT1 expression

Y-W Yin, S-Q Liao, M-J Zhang, Y Liu, B-H Li, Y Zhou, L Chen, C-Y Gao, J-C Li and L-L Zhang

Cell Death & Disease (Nature) China , 18 December 2014

Cardiology

Key words: Atherosclerosis, Cell signalling, Foam cells, Inflammation

Organism: Mouse

Tissue: Blood Vessels

2932
Epidermal Elafin Expression Is an Indicator of Poor Prognosis in Cutaneous Graft-versus-Host Disease

Marie-Charlotte Brüggen, Peter Petzelbauer, Hildegard Greinix, Emmanuel Contassot, Dragana Jankovic, Lars French, Gérard Socié, Werner Rabitsch, Zoya Kuzmina, Peter Kalhs, Robert Knobler, Georg Stingl, Georg Stary

Journal of Investigative Dermatology (Elsevier) Austria, Switzerland, France , 18 December 2014

Dermatology

Key words: Epidermal elafin, cutaneous graft, host disease

Organism: Human

Tissue: Skin

Pathological State: Graft-versus-host disease

2933
The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation

Stefan J Kempf, Arianna Casciati, Sonja Buratovic, Dirk Janik, Christine von Toerne, Marius Ueffing, Frauke Neff, Simone Moertl, Bo Stenerlöw, Anna Saran, Michael J Atkinson, Per Eriksson, Simonetta Pazzaglia, Soile Tapio

Molecular Neurodegeneration (BioMed Central) Germany, Italy, Sweden , 16 December 2014

Neuroscience

Key words: Dendritic spines, hippocampus, cortex, CREB, miR-132, ionising radiation, proteomics, Rac1, cofilin, alzheimer

Organism: Mouse

Tissue: Brain

2934
Quantitative measurement of cancer tissue biomarkers in the lab and in the clinic

Daniel E Carvajal-Hausdorf, Kurt A Schalper, Veronique M Neumeister and David L Rimm

Laboratory Investigation (Nature) USA , 15 December 2014

Oncology

Key words: Breast cancer

2935
Carboxylated Short Single-Walled Carbon Nanotubes But Not Plain and Multi-Walled Short Carbon Nanotubes Show in vitro Genotoxicity

Maria Mrakovcic, Claudia Meindl, Gerd Leitinger, Eva Roblegg, Eleonore Fröhlich

Toxicological Sciences (Oxford University Press) Austria , 10 December 2014

Toxicology

Key words: Carbon nanotubes, cytotoxicity, genotoxicity, oxidative stress, HPRT mutation, assay micronucleus

Cell Line: V79 cells

2936
Pharmacodynamic and Therapeutic Investigation of Focused Ultrasound-Induced Blood-Brain Barrier Opening for Enhanced Temozolomide Delivery in Glioma Treatment

Hao-Li Liu, Chiung-Yin Huang, Ju-Yu Chen, Hay-Yan Jack Wang, Pin-Yuan Chen, Kuo-Chen Wei

PLoS One (PLOS) Taiwan , 09 December 2014

Oncology

Key words: Cancer treatment, magnetic resonance imaging, glioma, drug therapy, pharmacodynamics, blood plasma, liquid chromatography-mass spectrometry, glioma cells

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

2937
Clec4n Is Essentially Involved in Innate Immune Response of Experimental Arthritis

V Stögner, T Shvets, B Niederreiter, M Koenders, W van den Berg,J Smolen, K Redlich, S Hayer

Rehabilitation () The Netherlands , 04 December 2014

Rheumatology

2938
Effects of azithromycin and tanomastat on experimental bronchiolitis obliterans

Katharina Krenn, Matthias Gmeiner, Patrick Paulus, Nezir Sela, Linda Torres, Karin Zins, Gerhard Dekan, Seyedhossein Aharinejad

The Journal of thoracic and cardiovascular surgery (Elsevier) Austria, Germany , 04 December 2014

Pulmonology

Key words: Azithromycin, tanomastat

Organism: Rat

Tissue: Lung

Pathological State: Bronchiolitis

2939
TonEBP/NFAT5 regulates ACTBL2 expression in biomechanically activated vascular smooth muscle cells

M Hödebeck, C Scherer, AH Wagner, M Hecker, T Korff

Frontiers in Physiology (Frontiers Media S.A.) Germany , 03 December 2014

Physiology

Organism: Human

Cell Line: HUASMCs

2940
Selective delivery of IFN-γ to renal interstitial myofibroblasts: a novel strategy for the treatment of renal fibrosis

Fariba Poosti, Ruchi Bansal, Saleh Yazdani, Jai Prakash, Eduard Post, Pieter Klok, Jacob van den Born, Martin H de Borst, Harry van Goor, Klaas Poelstra, Jan-Luuk Hillebrands

The FASEB Journal (FASEB) The Netherlands , 02 December 2014

Nephrology

Key words: Drug targeting, PDGFRβ, kidney, unilateral ureteral obstruction

Organism: Mouse

Pathological State: Renal Fibrosis

Cell Line: NIH3T3 Fibroblasts

Results 2931 - 2940 of 3476

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