Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 51 - 60 of 3476
51
Gut symbiont-derived ursodeoxycholic acid promotes fatty acid oxidation to protect against renal ischemia-reperfusion injury

M Xie, J Zheng, Y Yu, Q Yang, Z Zhou, J Xue, B Wang, Y Qiu, Z Zhu, Q Sun, X Shi, W Shangguan, L Li, Z Zou, J Zhao, P Wu

Cell Reports Medicine (Cell) China , 26 September 2025

Nephrology

Key words: renal ischemia-reperfusion injury, gut microbiome, ursodeoxycholic acid, lipid metabolism, fatty acid oxidation, peroxisome proliferator-activated receptor-gamma, acute kidney injury, bile acid, gut-kidney axis, Eubacterium limosum

Organism: Human

Tissue: Kidney

Pathological State: Ischemia

52
CD169+ macrophages identify and eliminate tumor cells in colorectal cancer through CD169/CD43 interaction and FasL-driven apoptosis

J Hu, F Guo, C Han, Q Zhao, H Yi, J Xu, H Jia, Y Wu, L Dong, X Kao, G Li, J Chen, J Zhang, Z Huang

Cell Reports (Cell) China , 26 September 2025

Oncology

Key words: CD169+ macrophages, colorectal cancer, CD43, FasL

Organism: Human

Tissue: Colon, Rectum

Pathological State: Cancer

53
A new investigation of nonalcoholic fatty liver disease: Effects of hypoxia on mitochondrial function and lipid droplet autophagy

M Tian, Y Zhang, Z Liu, N Zhao, D Huang, J Hou, L Sun, Y Jiang, G Zhang, Y Ma

PloS one (PLOS) China , 25 September 2025

Hepathology

Key words: Mitochondria, Lipids, Hepatocytes, Autophagic cell death, Medical hypoxia, Mouse models, Fatty liver, Hypoxia,

Organism: Mouse

Tissue: Liver

Pathological State: Fatty Liver Disease

54
Astroglia-Mediated Neuroinflammation as a Putative Mechanism of Neurological Outcomes in COVID-19? Insights from a Brazilian Cohort

E Segabinazi, FR Tocantins, T Glaser, T Maglio, NC Oliveira, AG Castanha, FB Russo, PEC Leite, A Brito, CV Molina, GP Paludo, RdO Souza, SRM Alves, MdP Cunha, H Ulrich, EL Durigon, PC Beltrão-Braga, P Minoprio

Brain Behavior and Immunity (Elsevier) Brazil, France , 25 September 2025

Virology

Key words: SARS-CoV-2, neuroCOVID-19, astrocytes, neuroinflammation, disease modeling

Organism: Human

Pathological State: Viral Infection

Cell Line: hiPSCs

55
Cryo-EM structure of the full-length LGR4-RSPOs complex and a targeting nanobody for anti-obesity therapy

L Wang, H Qiao, H Jiang, S Guo, Y Li, N Zhang, T Geng, Q Cui, Z Lan, J Hong, W Gu, R Liu, G Ning, J Li, J Wang, Y Geng

Nature Communications (Nature) China , 25 September 2025

Pharmacology

Key words: Antibody therapy, Cryoelectron microscopy, Obesity, Target validation, Thermodynamics

Organism: Mouse

Tissue: Liver

Pathological State: Adipose

56
Proteomic analysis of chronically inflamed intestine and disease-related strictures in Crohn's disease patients

J Alfredsson

(Gothenburg University Library) Sweden , 24 September 2025

Gastroenterology

Key words: Crohn’s Disease, Strictures, Fibrosis, Proteomics, Spatial analysis

Organism: Human

Pathological State: Crohn's Diesease

Cell Line: EpCAM⁺CD45⁻

57
Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

MC Rominger, S O'Brien, S Gupta, S Moorthi, M McSharry, S Kamlapurkar, AR Lowe, A Waldum, A Lo, F Duke, F Wu, MB Headley, E Cromwell, R Glabman, A Koehne, AH Berger

Cell Reports (Cell) USA , 24 September 2025

Oncology

Key words: lung cancer, GTPase, epithelial-to-mesenchymal transition, Hippo, YAP, RAS, RIT1, AP-1, EMT, GEMM

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

58
Developing a Functional Osteoarthritis Model Using Human Osteochondral–Synovial Explants

L Labusca, CM Zara-Danceanu, AE Minuti, C Stavila, A Petrovici, P Plamadeala, I Ivanov, F Zugun-Eloae, D Anita, A Anita, N Lupu

Tissue Engineering Part A (MARY ANN LIEBERT) Romania , 23 September 2025

Osteology

Key words: Arthroplasty, Medicine, Surgery, Diagnosis, Orthopedic surgery, Surgical and operative procedures

Organism: Human

Tissue: Mesenchymal Cells

Pathological State: Obesity

59
Spatiotemporal multi-omics analysis uncovers NAD-dependent immunosuppressive niche triggering early gastric cancer

p Gao, C Zuo, W Yuan, J Cai, X Chai, R Gong, J Yu, L Yao, W Su, Z Liu, S Lin, Y Wang, M Cai, L Ma, Q Li, P Zhou

Signal Transduction and Targeted Therapy (Nature) China , 22 September 2025

Oncology

Key words: Gastrointestinal cancer, Oncogenes

Organism: Mouse

Tissue: Stomache

Pathological State: Cancer

60
High mobility group box 1 attenuates aortic stenosis by modulating macrophages to reduce valvular calcification

D Zhao, Y Zhao, LN Luan

Polish Journal of Pathology (Vesalius Uiniv Medical Publ) China , 22 September 2025

Cardiology

Key words: HMGB1, valvular interstitial cells, calcific aortic valve disease, aortic stenosis, macrophage

Organism: Human

Tissue: Heart

Pathological State: calcific aortic valve disease

Results 51 - 60 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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