Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 2601 - 2610 of 3476
2601
Involvement of Pancreatic Stellate Cells in Regeneration of Remnant Pancreas after Partial Pancreatectomy

Shigenori Ota, Miyuki Nishimura, Yuya Murakami, Naoko Kubo Birukawa, Akihiro Yoneda, Hiroki Nishita, Ryosuke Fujita, Yasushi Sato, Kenjiro Minomi, Keiko Kajiwara, Miyono Miyazaki, Maki Uchiumi, Shintaro Mikuni, Yasuaki Tamura, Toru Mizuguchi, Masafumi Imamura, Makoto Meguro, Yasutoshi Kimura, Koichi Hirata, Yoshiro Niit

PLoS One (PLOS) Japan , 09 December 2016

Regenerative Medicine

Key words: Pancreatectomy, siRNA, activated pancreas stellate cells (aPSCs), apoptosis

Organism: Rat

Tissue: Pancreas

2602
Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative

Jun Wei,Hongyan Zhu, Gabriel Lord, Mitra Bhattachayya, Brielle M Jones, Graham Allaway, Shyam S Biswal, Benjamin Korman, Roberta G Marangoni, Warren G Tourtellotte, John Varga

Translational Research (Elsevier) USA , 09 December 2016

Neuroscience

Key words: Nrf2-nuclear factor erythroid 2–related factor 2, systemic sclerosis, TGF-β, CDDO, TMC

Organism: Human

Tissue: Skin

Pathological State: Systemic Sclerosis

2603
Lead-Free Piezoelectric (Ba,Ca)(Zr,Ti)O3 Thin Films for Biocompatible and Flexible Devices

N D Scarisoreanu, F Craciun, V Ion, R Birjega, A Bercea V Dinc, M Dinescu, L E Sima, M Icriverzi, A Roseanu, L Gruionu, and G Gruionu

Applied Materials and Interfaces (ACS Publications) Romania , 08 December 2016

Biomaterials

Key words: Biocompatible materials, laser processing, lead-free thin films, mesenchymal stem cells, osteogenic differentiation

Organism: Human

Pathological State: Cancer

Cell Line: HEK 293T and A375 cells (Human epithelial embryonic kidney and human malignant melanoma cells)

2604
Silica-Coated Metal Chelating-Melanin Nanoparticles as a Dual-Modal Contrast Enhancement Imaging and Therapeutic Agent

Soojeong Cho, Wooram Park and Dong-Hyun Kim

Applied Materials and Interfaces (ACS Publications) USA , 08 December 2016

Nanomedicine

Key words: Fluorescence imaging, melanin, metal-chelation, MRI, multimodal image-guidance, silica coating

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2605
Nodal metastasis signatures in breast cancer

Kyeongmee ParK, Joo Hyun Lee, Hyun Ho Han, Seong Gyeong Mun, Suki Kang, Youn Jin Cha, Ja-Seung Koo, Min Ju Kim, Hye Sun Lee, Jieun Moon, Nam Hoon Cho

Pathology-Research and Practice (Elsevier) South Korea , 05 December 2016

Oncology

Key words: Breast cancer, node positive ratio, node positive number, ERK, WDR1, c-MET

Organism: Human

Tissue: Breast

Pathological State: Cancer

2606
Solid stress and elastic energy as measures of tumour mechanopathology

Hadi T Nia, Hao Liu, Giorgio Seano, Meenal Datta, Dennis Jones, Nuh Rahbari, Joao Incio, Vikash P Chauhan, Keehoon Jung, John D Martin, Vasileios Askoxylakis, Timothy P Padera, Dai Fukumura, Yves Boucher, Francis J Hornicek, Alan J Grodzinsky, James W Baish, Lance L Munn and Rakesh K Jain

Nature Biomedical Engineering (Nature) USA , 28 November 2016

Neuroscience

Key words: Solid stress, tissue stiffness, tumour

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2607
Mast Cells Are Abundant in Primary Cutaneous T-Cell Lymphomas: Results from a Computer-Aided Quantitative Immunohistological Study

Johanna Eder, Radu Rogojanu, Waltraud Jerney, Friedrich Erhart, Alexander Dohnal, Melitta Kitzwögerer, Georg Steiner, Julia Moser, Franz Trautinger

PLoS One (PLOS) Austria , 28 November 2016

Oncology

Key words: Mast cells, cutaneous T-cell lymphomas (CTCL), haematopoetic cells

Organism: Human

Tissue: Skin

Pathological State: Cancer

2608
Cardiac extracellular matrix is associated with adverse outcome in patients with chronic heart failure

Franz Duca,Caroline Zotter-Tufaro,Andreas A Kammerlander,Adelheid Panzenböck,Stefan Aschauer,Daniel Dalos,Benedikt Köll,Benedikt Börries,Hermine Agis,Renate Kain,Klaus Aumayr,Florian Klinglmüller,Julia Mascherbauer,Diana Bonderman

European Journal of Heart Failure (Wiley) Austria , 27 November 2016

Cardiology

Key words: Extracellular matrix (ECM), heart failure (HF), endomyocardial biopsy

Organism: Human

Tissue: Heart

Pathological State: Heart Failure

2609
Antimicrobial polycaprolactone/ polyethylene glycol embedded lysozyme coatings of Ti implants for osteoblast functional properties in tissue engineering

A Visan, R Cristescu, N Stefan, M Miroiu, C Nita, M Socol, C Florica, O Rasoga, I Zgura, LE Sima, M Chiritoiu, MC Chifiriuc, AM Holban, IN Mihailescu, G SocoL

Applied Surface Science (Elsevier) Romania , 19 November 2016

Immunology

Key words: MAPLE, Dip coating, Lysozyme, Blends, Antimicrobial, Biocompatible

Organism: Human

Cell Line: Primary osteogenic sarcoma cells (SAOS2), Human mesenchymal stem cells (hMSCs)

2610
Rhinophototherapy in persistent allergic rhinitis

Zsolt Bella, Ágnes Kiricsi, Éva Dósa-Rácz Viharosné, Attila Dallos, Ádám Perényi, Mária Kiss, Andrea Koreck, Lajos KeményJózsef JóriLászló Rovó, Edit Kadocsa

European Archives of Oto-Rhino-Laryngology (Springer) Hungary , 18 November 2016

Allergy Research

Key words: Intercellular adhesion molecule-1 expression, Intranasal phototherapy, Mucociliary clearance, Nasal inspiratory peak flow, Persistent allergic rhinitis, Rhinolight

Organism: Human

Tissue: Mucosa

Pathological State: Allergy

Results 2601 - 2610 of 3476

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