Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 1681 - 1690 of 3476
1681
Conifer essential oils reversed amyloid beta1-42 action by modulating BDNF and ARC expression in the rat hippocampus

PA Postu, A Tiron, CE Tiron, DL Gorgan, M Mihasan, L Hritcu

CNS & Neurological Disorders (ingentaconnect) Romania , 30 July 2021

Neuroscience

Key words: Alzheimer's disease, Pinus halepensis, Tetraclinis articulata, amyloid-beta peptide, memory, neuroprotection

Pathological State: Alzheimer's Disease

1682
Causal evidence for induction of pessimistic decision-making in primates by the network of frontal cortex and striosomes

S Amemori, AM Graybiel, K Amemori

Frontiers in Neuroscience (Frontiers Media S.A.) Japan, USA , 30 July 2021

Neuroscience

Key words: Anxiety, Caudal Orbitofrontal Cortex, Pregenual Anterior Cingulate Cortex, Approach-Avoidance Conflict, Monkey, Microstimulation, Striosome Compartment, Caudate Nucleus

Organism: Monkey

Tissue: Brain

1683
S-nitroso human serum albumin as a nitric oxide donor in drug-eluting vascular grafts: biofunctionality and preclinical evaluation

M Enayati, KH Schneider, C Almeria, C Grasl, C Kaun, B Messner, S Rohringer, I Walter, J Wojta, L Budinsky, BH Walpoth, H Schima, G Kager, S Hallström, BK Podesser, H Bergmeister

Acta Biomaterialia (Elsevier) Austria, Slovakia, Switzerland , 28 July 2021

Cardiology

Key words: Nitric Oxide Donor, Drug Eluting Vascular Graft, Poly-Caprolactone, Electrospinning

Organism: Rat

Tissue: Blood Vessels

Pathological State: Vascular Graft

1684
Myeloid cells are enriched in tonsillar crypts providing insight into the host tropism of HPV

AK Mattox, J Roelands, TM Saal, Y Cheng, D Rinchai, W Hendrickx, GD Young, TJ Diefenbach, AE Berger, WH Westra, JA Bishop, WC Faquin, FM Marincola, MJ Pittet, D Bedognetti, SI Pai

The American Journal of Pathology (Elsevier) USA, Qatar, The Netherlands , 23 July 2021

Virology

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: HPV Infection

1685
Liposomal IR-780 as a Highly Stable Nanotheranostic Agent for Improved Photothermal/Photodynamic Therapy of Brain Tumors by Convection-Enhanced Delivery

YJ Lu, TS Anikumar, CC Chuang, JP Chen

Cancers (MDPI) Taiwan , 22 July 2021

Oncology

Key words: Nanomedicine, Cancer Therapy, Brain Tumor, Photothermal Therapy, Photodynamic Therapy, Liposome, IR-780, Convection Enhanced Delivery

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

1686
Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning

WH Yang, JS Westman, DM Heithoff, M Sperandio, JW Cho, MJ Mahan, JD Marth

PNAS (United States National Academy of Sciences) USA, South Korea, Germany , 20 July 2021

Gastroenterology

Key words: Colitis, Neuraminidase, Inflammation

Organism: Mouse

Tissue: Intestine

Pathological State: Colitis

1687
Electromagnetic Field‐Programmed Magnetic Vortex Nanodelivery System for Efficacious Cancer Therapy

X Liu, Y Zhang, Y Guo, W Jiao, X Gao, WSV Lee, Y Wang, X Deng, Y He, J Jiao, C Zhang, G Hu, XJ Liang, H Fan

Advanced Science (Wiley) China, Singapore , 18 July 2021

Nanomedicine, Oncology

Organism: Mouse

Tissue: Breast, Xenograft Tumor

Pathological State: Cancer

1688
Effect of high fat diet on the severity and repair of lung fibrosis in mice

AE Hegab, M Ozaki, S Kagawa, K Fukunaga

Stem Cells and Development (Mary Ann Liebert Inc.) Japan , 16 July 2021

Endocrinology, Pulmonology

Key words: High Fat Diet, Fibrosis, Alveolar Type-2 Cells, Bronchioalveolar Stem Cells, Fatty Acid Oxidation

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Fibrosis

1689
HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells

R Fardoos, OE Asowata, N Herbert, SK Nyquist, Y Zungu, A Singh, A Ngoepe, IM Mbano, N Mthabela, D Ramjit, F Karim, W Kuhn, FG Madela, VT Manzini, F Anderson, B Berger, TH Pers, AK Shalek, A Leslie, H Kløverpris

JCI Insight (The American Society for Clinical Investigation) Denmark, South Africa, USA , 12 July 2021

Virology

Key words: AIDS/HIV, Covid-19

Organism: Human

Tissue: Colon

Pathological State: HIV Infection

1690
Down-regulation of A20 promotes immune escape of lung adenocarcinomas

K Breitenecker, M Homolya, AC Luca, V Lang, C Trenk, G Petroczi, J Mohrherr, J Horvath, S Moritsch, L Haas, M Kurnaeva, R Eferl, D Stoiber, R Moriggl, M Bilban, AC Obenauf, C Ferran, B Dome, V Laszlo, B Györffy, K Dezso, J Moldvay, E Casanova, HP Moll

Science Translational Medicine (AAAS) Austria, USA, Hungary , 07 July 2021

Oncology, Pulmonology

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

Results 1681 - 1690 of 3476

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