Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 1481 - 1490 of 3476
1481
EMT-related transcription factors and protein stabilization mechanisms involvement in cadherin switch of head and neck squamous cell carcinoma

J Ingruber, J Dudás, D Savic, G Schweigl, TB Steinbichler, M do Carmo Greier, M Santer, S Carollo, Z Trajanoski, H Riechelmann

Experimental Cell Research (Elsevier) Austria , 25 February 2022

Oncology

Key words: Mesenchymal-to-epithelial transition, Cell-transfection, TissueFax, UPCI-SCC090, SCC25, FaDu

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

1482
Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus

JH Lee, C Ostalecki, T Oberstein, S Schierer, E Zinser, M Eberhardt, K Blume, B Plosnita, L Stich, H Bruns, R Coras, J Vera-Gonzales, M Maler, AS Baur

EBioMedicine (Elsevier) Germany, Austria , 25 February 2022

Neuroscience

Key words: Alzheimer's disease, Plasma extracellular vesicles, Choroid plexus, Hippocampus, Hyaluronan, Hyaluronic acid synthetase, Secretases, BACE, Aβ, APP

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

1483
Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms

X Guo, X Jin, K Han, S Kang, S Tian, X Lv, M Feng, H Zheng, Y Zuo, G Xu, M Hu, J Xu, P Lv, YZ Chang

Free Radical Biology and Medicine (Elsevier) China , 24 February 2022

Neuroscience

Key words: Iron, Ischemic stroke, Gliosis, Synaptic plasticity, Myelination, Nerve regeneration

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

1484
Tumor Necrosis Factor-α Mediates Lung Injury in the Early Phase of Endotoxemia

KY Chen, CY Chang, HJ Hsu, HJ Shih, IT Huang, HH Patel, CJ Huang

Pharmaceuticals (MDPI) Taiwan, Australia , 24 February 2022

Pulmonology

Key words: lung injury, endotoxin, cytokines, cytokine receptors, peptide, mice

Organism: Mouse

Tissue: Lung

Pathological State: Endotoxemia

1485
Neuropilin‐1‐Mediated SARS‐CoV‐2 Infection in Bone Marrow‐Derived Macrophages Inhibits Osteoclast Differentiation

J Gao, H Mei, J Sun, H Li, Y Huang, Y Tang, L Duan, D Liu, Y Pang, Q Wang, Y Gao, K Song, J Zhao, C Zhang, J Liu

Advanced Biology (Wiley) China, Australia , 23 February 2022

Virology, Osteology

Organism: Human

Pathological State: Covid-19

Cell Line: Bone marrow cells

1486
High farnesoid X receptor expression predicts favorable clinical outcomes in PD‑L1low/negative non‑small cell lung cancer patients receiving anti‑PD‑1‑based chemo‑immunotherapy

L Wang, X Xu, B Shang, J Sun, B Liang, X Wang, W You, S Jiang

International Journal of Oncology (Spandidos Publications) China , 23 February 2022

Oncology

Key words: Farnesoid X receptor, Predictor, anti‑PD‑1‑based, Chemo‑immunotherapy, Non‑small cell lung cancer, PD‑L1low/negative patients

Organism: Human

Tissue: Lung

Pathological State: Cancer

1487
Prompt Antiviral Action of Pulmonary CD8+ TRM Cells Is Mediated by Rapid IFN-γ Induction and Its Downstream ISGs in the Lung

L Jiang, L Liu, M Zhang, L Zhang, C Zhu, Q He, L Ye, C Zhao, Z Li, J Xu, X Zhang

Frontiers in Immunology (Frontiers Media S.A.) China , 22 February 2022

Immunology

Key words: influenza, lung-resident memory CD8 T cells, IFN-γ, interferon-induced genes, inflammatory cytokines

Organism: Mouse

Tissue: Lung

Pathological State: Influenza Infection

1488
Meloxicam Inhibits Hepatocellular Carcinoma Progression and Enhances the Sensitivity of Immunotherapy via the MicroRNA-200/PD-L1 Pathway

S Guangshun, S Guoqiang, C Xin, K Xiangyi, Z Wubin, L Zhitao, Z Zhiying, C Hongyong, L Chengyu, X Yongxiang, T Weiwei

Journal of Oncology (Hindawi Publishing Corporation) China , 21 February 2022

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1489
TSPAN6 is a suppressor of Ras-driven cancer

PO Humbert, TZ Pryjda, B Pranjic, A Farrell, K Fujikura, R de Matos Simoes, R Karim, I Kozieradzki, SJF Cronin, GG Neely, TF Meyer, A Hagelkruys, HE Richardson, JM Penninger

Oncogene (Nature) Australia, Austria, Germany, Canada , 19 February 2022

Oncology

Key words: Cancer genetic, Cell polarity, Growth factor signalling

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

1490
Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration in calvarial bone defects

YH Chan, KN Ho, YC Lee, MJ Chou, WZ Lew, HM Huang, PC Lai, SW Feng

Stem Cell Research & Therapy (Springer) Taiwan, USA , 19 February 2022

Osteology

Key words: Melatonin, Dental pulp mesenchymal stem cells, Osteogenesis, COX2/NF-κB, p38/ERK signaling pathwaym, Bone regeneration, Calvarial bone defect

Organism: Rabbit

Tissue: Bone

Results 1481 - 1490 of 3476

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