Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 1221 - 1230 of 3476
1221
Synergistic cytotoxicity of perifosine and ABT‐737 to colon cancer cells

B Adamová, K Říhová, J Pokludová, P Beneš, J Šmarda, J Navrátilová

Journal of Cellular and Molecular Medicine (Wiley) Czech Republic , 15 December 2022

Oncology

Tissue: Spheroid

Cell Line: HT-29 and HCT-116 human adenocarcinoma cells

1222
Staphylococcus aureus extracellular adherence protein (Eap) reduces immune cell phenotype in developing but not in established atherosclerotic lesions

M Salzmann, H Platzer, M Mussbacher, M Derler, M Lenz, P Haider, M Brekalo, JB Kral-Pointner, S Kastl, WS Speidl, KT Preissner, U Schubert, M Bischoff, J Wojta, PJ Hohensinner

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) Austria, Germany , 10 December 2022

Immunology, Microbiology

Key words: Atherosclerosis, ICAM-1, Extracellular adherence protein, Neutrophils, NET

Organism: Mouse

Tissue: Heart

Pathological State: Staphylococcus aureus Infection

1223
Nonmuscle myosin IIA promotes the internalization of influenza A virus and regulates viral polymerase activity through interacting with nucleoprotein in human pulmonary cells

J Chen, J Liu, Z Chen, D Feng, C Zhu, J Fan, S Zhang, X Zhang, J Xu

Virologica Sinica (Elsevier) China , 10 December 2022

Virology

Key words: Myosin IIA (MYH9), Influenza A virus (IAV), vRNP activity, Virus-host interactions, Virus entry

Cell Line: MDCK cells

1224
A Proof-of-Concept Preclinical Study Using a Novel Thermal Insulation Device in a Porcine Kidney Auto-Transplantation Model

L Ernst, Z Czigany, P Paschenda, M Schulz, L Breuer, J Kunczik, M Czapli, W Liu, D Jiang, U Klinge, S Djudjaj, P Boor, G Lurje, E Kobayashi, RH Tolba

International Journal of Molecular Sciences (MDPI) Germany, Japan , 09 December 2022

Transplantation Medicine

Key words: kidney transplantation, organ insulation, ischemic reperfusion injury

Organism: Pig

Tissue: Kidney

1225
The hibernation-derived compound SUL-138 shifts the mitochondrial proteome towards fatty acid metabolism and prevents cognitive decline and amyloid plaque formation in an Alzheimer's disease mouse model

CF de Veij Mestdagh, F Koopmans, JC Breiter, JA Timmerman, PC Vogelaar, G Krenning, HD Mansvelder, AB Smit, RH Henning, RE van Kesteren

Alzheimer's Research & Therapy (Springer) The Netherlands , 09 December 2022

Neuroscience

Key words: Alzheimer's disease, APP/PS1 mice, Hibernation-derived compound, SUL-138, Chromanols, Long-term potentiation, Hippocampus-dependent contextual fear memory, Amyloid-beta plaques, Mass-spectrometry, Mitochondria, Fatty acid metabolism

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

1226
Angiotensin-converting enzyme 2 in human plasma and lung tissue

J Xie, QF Huang, Z Zhang, Y Dong, H Xu, Y Cao, X Wang, JG Wang

Blood Pressure (Taylor & Francis) China , 09 December 2022

Cardiology

Key words: ACE2, plasma, lung, tissue, hypertension

1227
Fumarate hydratase inhibits non‑small cell lung cancer metastasis via inactivation of AMPK and upregulation of DAB2

A Vadhan, YF Yang, YM Wang, PY Chen, SC Tzou, KH Cheng, SCS Hu, TL Cheng, YY Wang, SSF Yuan

Oncology Letters (Spandidos Publications) Taiwan , 09 December 2022

Oncology

Organism: Human

Tissue: Lung

Pathological State: Cancer

1228
Clinical Implications and Molecular Characterization of Drebrin-Positive, Tumor-Infiltrating Exhausted T Cells in Lung Cancer

K Imamura, Y Tomita, R Sato, T Ikeda, S Iyama, T Jodai, M Takahashi, A Takaki, K Akaike, S Hamada, S Sakata, K Saruwatari, S Saeki, K Ikeda, M Suzuki, T Sakagami

International Journal of Molecular Sciences (MDPI) Japan, USA , 08 December 2022

Oncology

Key words: drebrins, lymphocytes, tumor-infiltrating, lung neoplasms, tumor microenvironment, prognosis

Organism: Human

Tissue: Lung

Pathological State: Cancer

1229
Effects of a Phytogenic Supplement Containing Olive By-Product and Green Tea Extracts on Growth Performance, Lipid Metabolism, and Hepatic Antioxidant Capacity in Largemouth Bass (Micropterus salmoides) Fed a High Soybean Meal Diet

J Liu, M Xue, S Morais, M He, H Wang, J Wang, JJ Pastor, RA Gonçalves, X Liang

Antioxidants (MDPI) China, Spain , 07 December 2022

Zoology

Key words: largemouth bass, soybean meal, phytogenic feed additive, antioxidant capacity, lipid metabolism

Organism: Fish

Tissue: Liver

1230
Hybrid Transcytosis Nanopomegranates for Sensitizing Breast Cancer Radiotherapy in Deep Tumor Tissue

L Wang, L Xiao, Z Zhao, K Zhong, W Zhu, H Liu, X Li

Nano Research (Scipen) China , 07 December 2022

Oncology

Key words: Breast cancer, transcytosis, hybrid nanopomegranate, hypoxia alleviation, radiosensitization

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

Results 1221 - 1230 of 3476

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