Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 1211 - 1220 of 3476
1211
Mitigation of Cellular and Bacterial Adhesion on Laser Modified Poly (2-Methacryloyloxyethyl Phosphorylcholine)/Polydimethylsiloxane Surface

S Nistorescu, M Icriverzi, P Florian, A Bonciu, V Marascu, N Dumitrescu, G Gradisteanu Pircalabioru, L Rusen, A Mocanu, A Roseanu, A Cimpean, F Grama 6, V Dinca, DA Cristian

Nanomaterials (MDPI) Romania , 23 December 2022

Tissue Engineering

Key words: MAPLE, zwitterionic coating, cellular response

Cell Line: Fibroblasts cultured on PDMS scaffolds

1212
Biomimetic Prussian blue nanozymes with enhanced bone marrow-targeting for treatment of radiation-induced hematopoietic injury

B Zhang, G Chen, X Wu, Y Li, Y Xiao, J Li, L He, Y Li, S Wang, J Zhao, C Liu, H Zhou, Y Li, X Pei

Biomaterials (Elsevier) China , 21 December 2022

Nanomedicine

Key words: Prussian blue nanozymes, Mesenchymal stem cell membrane, Reactive oxygen species, Radiation-induced hematopoietic injury, Targeting therapy

Organism: Mouse

Tissue: Bone

Pathological State: Radiation-induced hematopoietic injury

1213
Avicularin Alleviates Osteoporosis in Ovariectomized Mice by Inhibiting Osteoclastogenesis through NF-κB Pathway Inhibition

Q Zhuang, S Chen, W Zhang, M Gu, L Xiao, Y Li, Y Yang, C Feng, H Li, D Geng, Z Wang

Journal of Agricultural and Food Chemistry (ACS Publications) China , 20 December 2022

Osteology

Key words: osteoclast avicularin bone loss NF-κB

Organism: Mouse

Tissue: Bone

1214
R158Q and G212S, novel pathogenic compound heterozygous variants in SLC12A3 of Gitelman syndrome

Z Li, H Wu, S Wei, M Liu, Y Shi, M Li, N Wang, L Fang, B Xiang, L Gao, C XU, J Zhao

Frontiers of Medicine (Frontiers Media S.A.) China , 19 December 2022

Endocrinology

Key words: Gitelman syndrome, mouse model, compound heterozygous, hypokalemia, Slc12a3

Organism: Mouse

Tissue: Kidney

Pathological State: Gitelman syndrome

1215
A hepatocyte-targeting nanoparticle for enhanced hepatobiliary magnetic resonance imaging

H Zhang, Y Guo, J Jiao, Y Qiu, Y Miao, Y He, Z Li, C Xa, L Li, J Cai, K Xu, X Liu, C Zhang, BH Bay, S Song, Y Yang, M Peng, Y Wang, H Fan

Nature Biomedical Engineering (Nature) China , 19 December 2022

Biological Methods

Key words: Biomedical engineering, Magnetic resonance imaging

Organism: Pig

Tissue: Liver

1216
Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies

PA Goldsteen, AM Sabogal Guaqueta, PPM Mulder, IST Bos, M Eggens, L Van der Koog, JT Soeiro, AJ Halayko, K Mathwig, LEM Kistemaker, EMJ Verpoorte, AM Dolga, R Gosens

Frontiers in Pharmacology (Frontiers Media S.A.) The Netherlands , 18 December 2022

Neuroscience

Key words: asthma, cholinergic, neuron, organ-on-chip, stem cell

Cell Line: Airway cholinergic neurons

1217
Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice

STJ Ang, EM Crombie, H Dong, KT Tan, A Hernando, D Yu, S Adamson, S Kim, DJ Withers, H Huang, SY Tsai

Nature Communications (Nature) Singapore, USA, UK , 17 December 2022

Aging

Key words: Ageing, Muscle stem cells, Skeletal muscle

Organism: Mouse

Tissue: Muscle

1218
Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10

J Yang, C Hou, H Wang, EA Perez, HC Do-Umehara, H Dong, V Arunagiri, F Tong, M Van Scoyk, M Cho, X Liu, X Ge, RA Winn, KM Ridge, X Wang, NS Chandel, J Liu

Cancer Letters (Elsevier) USA , 17 December 2022

Oncology

Key words: KRAS, Non-small cell lung cancer, Pcdh10, Gene regulation, Miz1

Organism: Mouse

Tissue: Lung

1219
FOXM1 increases hTERT protein stability and indicates poor prognosis in gastric cancer

Q Tang, C Liu, S Zhang, L He, Y Liu, J Wang, X Zhao, X Li

Neoplasia (Elsevier) China , 16 December 2022

Oncology

Key words: Gastric cancer, FOXM1, hTERT, ubiquitination, Wnt/β-catenin

Organism: Human

Tissue: Stomach

Pathological State: Cancer

1220
Distribution and Toxicity of Submicron Plastic Particles in Mice

TY Tsou, SH Lee, TH Kuo, CC Chien, HC Chen, TJ Cheng

Environmental Toxicology and Pharmacology (Elsevier) Taiwan , 15 December 2022

Toxicology

Key words: Submicron microplastics, Oral gavage, Number concentration, Flow cytometry, Oxidative stress, Inflammation

Organism: Mouse

Tissue: Lung

Results 1211 - 1220 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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