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Exploring Immune Checkpoint Markers in Glioma Mechanisms
In a recent study, Wang et al. investigated RNA and protein expression of various immune checkpoint molecules, highlighting their prognostic value. To scan multiple markers simultaneously on TMAs the multispectral tissue cytometer TissueFAXS SPECTRA was used, as well as StrataQuest for in-depth phenotyping.
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TissueFAXS SPECTRA – From Whole-Slide Imaging to Multispectral Tissue Cytometry
TissueFAXS SPECTRA provides multispectral whole-slide imaging and spectral unmixing. This technology allows for a higher number of markers by eliminating autofluorescence and bleed-through between channels. Combined with TGs contextual tissue cytometry it is the perfect solution for in-depth spatial phenotyping.
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EMT-Transcription Factors as the Drivers for Recurrence in HNSCC
In a recent study, Ingruber et al. investigated the role of partial epithelial to mesenchymal transition (pEMT)-related proteins in modulating Cisplatin resistance in head and neck squamous cell carcinoma (HNSCC). To perform an in-depth quantitative analysis, the power of TissueFAXS platform and StrataQuest software was utilized.
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Quantification of the Tumor Microenvironment
TissueGnostics’ StrataQuest Apps provide solutions for the comprehensive analysis of the tumor microenvironment, such as the assessment of immune cells, tumor detection, and blood vessel identification. If you cannot find the perfect solution for your research question among our cytometry solutions, please contact us. TissueGnostics offers the development of customized Apps for your specific analysis needs.
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In-Situ Analysis of NETotic Cell Reaction Upon Infectious Vaginitis
Zambrano et al. investigated a rarely addressed issue in public health – infectious vaginitis – by characterizing NETotic cells and neutrophil extracellular traps (NETs) in vaginal discharges of women with vaginitis. Identification of extracellular DNA, neutrophil elastase, and citrullinated histones was performed with TissueFAXS i Plus system.
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Case Study: High-content Phenotyping with Imaging Mass Cytometry
TissueGnostics contextual image analysis software, StrataQuest, is able to process high-content images (multiple channels/markers) of virtual tissue sections acquired via Imaging Mass Cytometry (IMC). The following case study (including single cell and proximity measurements) was performed as a comprehensive analysis of 30 markers within one tissue section.
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