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On May 3rd, TissueGnostics surpassed 1,500 scientific reference publications

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 Most of the 1500 research publications referencing TissueGnostics (over 50%) originated in the United States, Austria, Germany, Taiwan (China) and mainland China.

  

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Customer Publications (A total of 1522 papers published)

01
Tissues derived from reprogrammed Wharton's jelly stem cells of the umbilical cord as a platform to study gestational diabetes mellitus

CM Kong, A Subramanian, SU Gan, A Biswas, B Ariff, CY Fong

Stem Cell Research (Elsevier) Singapore, 26 June 2020

Stem Cell Research

Key words: Gestational diabetes mellitus, Induced pluripotent stem cells, Reprogramming, Wharton’s jelly stem cells, Pancreatic cells

Organism: Human

Cell Line: iPSCs

02
Comparison between paramagnetic and CD71 magnetic activated cell sorting of fetal nucleated red blood cells from the maternal blood

D Nemescu, D Constantinescu, V Gorduza, A Carauleanu, L Caba, DB Navolan

Journal of Clinical Laboratory Analysis (Wiley) Romania, 25 June 2020

Biological Methods

Key words: CD71, fluorescent in situ hybridization, magnetic‐activated cell sorting, nucleated red blood cells, prenatal diagnosis

Organism: Human

Cell Line: Blood

03
BMI1-KLF4 axis deficiency improves responses to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer

YC Hsu, CW Luo, WL Huang, CC Wu, CL Chou, CI Chen, SJ Chang, CY Chai, HC Wang, TY Chen, CF Li, MR Pan

Radiotherapy and Oncology (Elsevier) Taiwan, 24 June 2020

Radiotherapy, Oncology

Key words: BMI1, CCRT, Rectal cancers, Radioresistance

Organism: Human

Tissue: Colon

Pathological State: Cancer

04
The chemokine lymphotactin and its recombinant variants in oral cancer cell regulation

AZ Abdullah Zubir, SA Whawell, TS Wong, SA Khurram

Oral Diseases (Wiley) UK, 19 June 2020

Oncology

Key words: Cancer‐associated fibroblast, Lymphotactin, Oral squamous cell carcinoma, Tumour microenvironment, XCR1

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

05
p16 in highly malignant esophageal carcinomas: the correlation with clinicopathological factors and human papillomavirus infection

H Ishida, A Kasajima, F Fujishima, R Akaishi, S Ueki, Y Yamazaki, Y Onodera, X Gao, H Okamoto, Y Taniyama, T Kamei, H Sasano

Virchows Archiv (Springer) Japan, Australia, Germany, 16 June 2020

Oncology

Key words: Esophagus Small-cell carcinoma, Poorly differentiated squamous cell carcinoma, Basaloid squamous cell carcinoma, p16, Human papillomavirus

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

06
Reciprocal Regulation Between Indoleamine 2, 3-Dioxigenase 1 and Notch1 Involved in Radiation Response of Cervical Cancer Stem Cells

HY Low, YC Lee, YJ Lee, HL Wang, YI Chen, PJ Chien, ST Li, WW Chang

Cancers (MDPI) Taiwan, 12 June 2020

Oncology, Stem Cell Research

Key words: IDO1; notch1; radiation; cervical cancer; cancer stem cells

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

07
Tumor Microenvironment Targeting Nano–Bio Emulsion for Synergistic Combinational X‐Ray PDT with Oncolytic Bacteria Therapy

W Park, S Cho, D Kang, JH Han, JH Park, B Lee, J Lee, DH Kim

Advanced Healthcare Materials (Wiley) South Korea, USA, 11 June 2020

Oncology, Nanomedicine

Key words: Bacteriolytic therapy, Nano–bio emulsions, Scintillating nanoparticles, Tumor microenvironments, X‐ray photodynamic therapy (PDT)

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

08
Regulatory T cells promote adipocyte beiging in subcutaneous adipose tissue

W Fang, Z Deng, F Benadjaoud, D Yang C Yang, GP Shi

The FASEB journal (Wiley) USA, China, 08 June 2020

Immunology

Key words: epididymal white adipose tissue, gonadal white adipose tissue, macrophage polarization, regulatory T cell, subcutaneous adipose tissue, uncoupling protein‐1

09
Yttrium-90 Radioembolization and Tumor Hypoxia: Gas-challenge BOLD Imaging in the VX2 Rabbit Model of Hepatocellular Carcinoma

AC Gordon, SB White, VL Gates, D Procissi, KR Harris, Y Yang, Z Zhang, W Li, T Lyu, X Huang, RA Omary, R Salem, RJ Lewandowski, AC Larson

Academic Radiology (Elsevier) USA, 07 June 2020

Radiotherapy, Oncology

Key words: Oxygenation, Hepatic radioembolization, Magnetic resonance imaging, Yttrium-90

Organism: Rabbit

Tissue: Kidney

Pathological State: Cancer

10
A prominent environmental endocrine disruptor, 4-nonylphenol, promotes endometriosis development via plasmacytoid dendritic cells

P Sharma, HH Tzeng, JYL Lee, EM Tsai, JL Suen

Molecular Human Reproduction (Oxford Academic) Taiwan, 04 June 2020

Reproductive Medicine

Key words: CD36, endometriosis, environmental endocrine disruptor, estrous cycle, IL-10, 4-nonylphenol, plasmacytoid dendritic cell

Organism: Mouse

Tissue: Uterus

Pathological State: Endometriosis

11
A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure

H Shawer, E Aiyelaagbe, C Clowes, SC Lean, Y Lu, KE Kadler, A Kerby, MR Dilworth, KE Hentges, AEP Heazell

PLoS One (PLOS) UK, 03 June 2020

Reproductive Medicine

Key words: Mouse models, Stillbirths, Embryos, Placenta, Fetal death, Myocardium, Heart, Giant cells

Organism: Mouse

Tissue: Placenta

12
AB0154 MERTK AND THE RESOLUTION OF INFLAMMATION IN IGG4-RELATED DISEASE

E Della Torre, L Rovati, A Monno, T Maehara, N Kaneko, M Lanzillotta, F Pedica, C Doglioni, S Pillai, A Manfredi

Annals of the Rheumatic Diseases (BMJ Journals) Italy, Japan, USA, 02 June 2020

Immunology

Organism: Human

Tissue: Tonsil

13
Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer

CS Lu, AL Shiau, BH Su, TS Hsu, CT Wang, YC Su, MS Tsai, YH Feng, YL Tseng, YT Yen, CL Wu, GS Shieh

Journal of Hematology & Oncology (Springer) Taiwan, 01 June 2020

Oncology

Key words: Lung cancer, Oct4, M2 macrophage, Tumor-associated macrophage, M-CSF

Organism: Human, Mouse

Tissue: Lung

Pathological State: Cancer

14
CD68+ macrophages as crucial components of the foreign body reaction demonstrate an unconventional pattern of functional markers quantified by analysis with double fluorescence staining

U Klinge, A Dievernich, R Tolba, B Klosterhalfen, L Davies

Journal of Biomedical Materials Research: Part B (Wiley) Germany, UK, 30 May 2020

Biological Materials

Key words: Fluorescence microscopy, Foreign body reaction, Lymphocyte, Macrophage, Mesh

Organism: Human

Tissue: Stomach

Pathological State: Abdominal Wall Hernia

15
Caveolar communication with xenobiotic-stalled ribosomes compromises gut barrier integrity

SH Park, J Kim, Y Moon

Communications Biology (Nature) South Korea, 27 May 2020

Gastroenterology

Key words: Biomarkers, Cell Biology, Chemokines, Inflammation, Signal Transduction

Organism: Mouse

Tissue: Small Intestine

16
Interaction of different cell types with magnesium modified by plasma electrolytic oxidation

M Echeverry-Rendon, F Echeverria, MC Harmsen

Colloids and Surfaces B: Biointerfaces (Elsevier) Colombia, The Netherlands, 26 May 2020

Biological Materials

Key words: Magnesium, PEO, Adipose-derived stromal, ASC, Differentiation, Cytotoxicity

Organism: Human

Cell Line: HUVECs, ACSs

17
Absence of α-calcitonin gene-related peptide modulates bone remodeling properties of murine osteoblasts and osteoclasts in an age-dependent way

T Niedermair, S Schirner, RH Straub, S Grässel

Mechanisms of Ageing and  Development (Elsevier) Germany, 22 May 2020

Osteology

Key words: Bone, Osteoblast, Osteoclast, α-calcitonin gene-related peptide (α-CGRP), Osteopenia

Organism: Mouse

Tissue: Bone

18
KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGFβ1 Activation

RAF Gjaltema, D Goubert, C Huisman, C del Pilar Garcia Tobilla, M Koncz, PG Jellema, D Wu, U Brouwer; A Kiss, PJ Verschure, RA Bank, MG Rots

International Journal of Molecular Sciences (MDPI) The Netherlands, Hungary, 21 May 2020

Oncology

Key words: Pigenetic editing; KRAB; Gene repression; PLOD2; Fibrosis; Cancer

Organism: Human

Cell Line: Human skin fibroblasts

19
Synergistic effect of cell-derived extracellular matrix and topography on osteogenesis of mesenchymal stem cells

L Yang, L Ge, P van Rijn

ACS Applied Materials & Interfaces (ACS Publications) The Netherlands, 18 May 2020

Tissue Engineering

Key words: Extracellular matrix, Topography, Mesenchymal stem cells, Osteogenic differentiation, Mechanotransduction

Organism: Human

Cell Line: hBM-MSCs

20
Biomimetic Multiscale Hierarchical Topography Enhances Osteogenic Differentiation of Human Mesenchymal Stem Cells

L Yang, L Ge, Q Zhou, T Mokabber, Y Pei, R Bron, P van Rijn

Advanced Materials Interfaces (Wiley) The Netherlands, China, 13 May 2020

Stem Cell Research

Key words: collagen, extracellular matrix, hierarchical topography, human mesenchymal stem cells, mechanotransduction, osteogenic differentiation

Organism: Human

Cell Line:  hBM‐MSCs

21
Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome

Kim L. Brunekreeft, Sterre T. Paijens, Maartje C.A. Wouters, Fenne L. Komdeur, Florine A. Eggink, Joyce M. Lubbers, Hagma H. Workel, Elisabeth C. Van Der Slikke, Noor E.J. Pröpper, Ninke Leffers, Julien Adam, Harry Pijper, Annechien Plat, Arjan Kol, Hans W. Nijman, Marco De Bruyn

OncoImmunology (Taylor & Francis) The Netherlands, France, Canada, 13 May 2020

Oncology, Immunology

Key words: Epithelial ovarian cancer, chemotherapy, tumor microenvironment, cancer immunology, MHC-I

Organism: Human

Tissue: Ovaries, Lymphoid Tissue

Pathological State: Cancer

22
Progesteron receptor expression in insulin producing cells of neuroendocrine neoplasms

T Tachibana, A Kasajima, T Aoki, T Tabata, K McNamara, S Yazdani, S Satoko, F Fujishima, F Motoi, M Unno, H Sasano

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Japan, Germany, 11 May 2020

Endocrinology

Key words: Neuroendocrine neoplasm, Insulinoma, Progesteron receptor

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

23
Decoupling the Amplitude and Wavelength of Anisotropic Topography and the Influence on Osteogenic Differentiation of Mesenchymal Stem Cells Using a High-Throughput Screening Approach

L Yang, L Ge, Q Zhou, K Jurczak, P van Rijn

ACS Applied Bio Materials (ACS Publications) The Netherlands, China, 06 May 2020

Stem Cell Research

Organism: Human

Cell Line: hBM-MSCs

24
Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program

Massimo Granai, Lucia Mundo, Ayse U. Akarca, Maria Chiara Siciliano, Hasan Rizvi, Virginia Mancini, Noel Onyango, Joshua Nyagol, Nicholas Othieno Abinya, Ibrahim Maha, Sandra Margielewska, Wenbin Wi, Michele Bibas, Pier Paolo Piccaluga, Leticia Quintanilla-Martinez, Falko Fend, Stefano Lazzi, Lorenzo Leoncini, Teresa Marafioti

Infectious Agents and Cancer (BMC) Italy, Germany, UK, Kenya, Egypt,, 06 May 2020

Oncology, Virology

Key words: Burkitt lymphoma, Tumour microenvironment, EBV, PD-L1, Immunotherapy, Immune checkpoint

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

25
High‐Throughput Screening and Hierarchical Topography‐Mediated Neural Differentiation of Mesenchymal Stem Cells

L Yang, KM Jurczak, L Ge, P van Rijn

Advanced Healthcare Materials (Wiley Online Library) The Netherlands, 04 May 2020

Stem Cell Research

Key words: anisotropic topography, hierarchical structures, high‐throughput screening, human mesenchymal stem cells, neural differentiation

Organism: Human

Cell Line: hMSCs

26
ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research

Talita Glaser, Hiromi Shimojo, Deidiane Elisa Ribeiro, Patrícia Pereira Lopes Martins, Renata Pereira Beco, Michal Kosinski, Vanessa Fernandes Arnaud Sampaio, Juliana Corrêa-Velloso, Ágatha Oliveira-Giacomelli, Claudiana Lameu, Ana Paula de Jesus Santos, Héllio Danny Nóbrega de Souza, Yang D. Teng, Ryoichiro Kageyama & Henning Ulrich

Molecular Psychiatry (Nature) Japan, Brazil, USA, Poland, 29 April 2020

Cell Biology, Neuroscience

Key words: Cell biology, Diseases, Molecular biology, Neuroscience

Organism: Mouse

Cell Line: E14Tg2A cells

27
The Prognostic and Predictive Value of SOX2+ Cell Densities in Patients Treated for Colorectal Cancer

TJ Miller, MJ McCoy, TF Lee-Pullen, CC Anyaegbu, C Hemmings, MK Bulsara, CF Platell

Cancers (MDPI) Australia, 29 April 2020

Oncology

Key words: SOX2; colorectal cancer; chemotherapy; prognosis; oxaliplatin; 5-fluorouracil; cancer stem cell

Organism: Human

Tissue: Colon

Pathological State: Cancer

28
A characteristic expression pattern of core circadian genes in the diurnal tree shrew

PH Luo, YM Shu, RJ Ni, YJ Liu, JN Zhou

Neuroscience (Elsevier) China, 25 April 2020

Neuroscience

Key words: tree shrew, diurnal animal, circadian gene, brain rhythm, peripheral rhythm

Organism: Tree Shrew

Tissue: Brain

29
In vitro and in vivo biocompatibility study of surface modified TiN deposited on Ti6Al4V using high-power impulse magnetron sputtering technique

SC Liao, CY Chen, YH Hsu, CT Li, CC Hsieh, MS Tsai, MY Chan, CH Lee, SH Wang, SK NG, HK Tsou, WY Wu

Surface and Coatings Technology (Elsevier) Taiwan, 21 April 2020

Biological Materials

Key words: HiPIMS, TiN, Acrylamide crosslinking, BMP2 attachment, in vitro and in vivo studies

Organism: Mouse

Tissue: Skin

30
The Effect of the Chorion on Size-Dependent Acute Toxicity and Underlying Mechanisms of Amine-Modified Silver Nanoparticles in Zebrafish Embryos

ZY Chen, NJ Li, FY Cheng, JF Hsueh, CC Huang, FI Lu, TF Fu, SJ, Yan, YH Lee, YJ Wang

International Journal of Molecular Sciences (MDPI) Taiwan, 20 April 2020

Nanomedicine

Key words: zebrafish embryos; acute toxicity; silver nanoparticles; chorion pore size; lysosomal activity; apoptosis

Organism: Zebrafish

Tissue: Whole Organism

31
Characterization of CD103+ CD8+ tissue‑resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti‑PD‑1 blockade

L Han, QL Gao, XM Zhou, C Shi, GY Chen, YP Song, YJ Yao, YM Zhao, XY Wen, SL Liu, YM Qi, YF Gao

Cancer Immunology, Immunotherpay (Springer) China, 20 April 2020

Oncology, Immunology

Key words: CD103, Tissue-resident T cells,Tumor-infiltrating lymphocytes, Esophageal squamous cell carcinoma

Organism: Mouse

Tissue: Tumor

Pathological State: Cancer

32
Macrophages and Fibroblasts Differentially Contribute to Tattoo Stability

H Strandt, O Voluzan, T Niedermair, U Ritter, J Thalhamer, B Malissen, A Stoeklinger, S Henri

Dermatology (Karger) France, Germany, 19 April 2020

Dermatology

Key words: Tattoo, Macrophage, Fibroblast, Tattoo maintenance

Organism: Human

Tissue: Skin

33
Dynamic Malignant Wave of Ribosome-insulted Gut Niche via the Wnt-CTGF/CCN2 Circuit

KH Kim, SJ Lee, J Kim, Y Moon

iScience (Cell Press) South Korea, 18 April 2020

Cell Biology

Key words: CTGF/CCN2, Wnt, Ribosomal insult, Colorectal cancer, Tumor niche

Organism: Human

Cell Line: HCT8 and HCT116 cells

34
Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma

JR Podojil, AP Glaser, D Baker, ET Courtois, D Fantini, Y Yu, V Eaton, S Sivajothi, M Chiang, A Das, KA McLauglin, P Robson, SD Miller, JJ Meeks

OncoImmunology (Taylor & Francis) USA, 16 April 2020

Oncology, Immunology

Key words: Immunotherapy, bladder cancer, macrophage, T cell, checkpoint inhibitor

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

35
Functional diversity between HSP70 paralogs due to variable interactions with specific co-chaperones.

D Serlidaki, MAWH van Waarde, L Rohland, AS Wentink, SL Dekker, MJ Kamphuis, JM Boertien, JF Brunsting, NB Nillegoda, B Bukau, MP Mayer, HH Kampinga, S Bergink

Journal of Biological Chemistry (ASBMB) The Netherlands, Germany, 13 April 2020

Cell Biology

Key words: Hsp110 ,HSPA4, HSPH2, protein folding, superoxide dismutase (SOD), 70 kilodalton heat shock protein (Hsp70), proteostasis amyotrophic lateral sclerosis (ALS) (Lou Gehrig disease), heat shock protein (HSP)

Organism: Human

Cell Line: HEK293 Cells

36
IFN-κ suppresses the replication of influenza A viruses through the IFNAR-MAPK-Fos-CHD6 axis

Y He, W Fu, K Cao, Q He, X Ding, J Chen, L Zhu, T Chen, L Ding, Y Yang, C Zhu, S Yuan, Z Li, C Zhao, X Zhang, J Xu

Science Signaling (AAAS) China, 07 April 2020

Immunology

Organism: Mouse

Tissue: Lung

37
EMI2 expression as a poor prognostic factor in patients with breast cancer

A Vadhan, YY Wang, SSF Yuan, YC Lee, SCS Hu, JY Huang, T Ishikawa, MF Hou

Kaohsiung Journal of Medical Sciences (Wiley) Taiwan, Japan, 06 April 2020

Oncology

Key words: breast cancer, EMI2 (FBXO43), metastasis

38
Topography induced stiffness alteration of stem cells influences osteogenic differentiation

L Yang, Q Gao, L Ge, Q Zhou, EM Warszawik, R Bron, KW Lai, P van Rijn

Biomaterials Science (Royal Society of Chemistry) The Netherlands, China, 05 April 2020

Stem Cell Research

Organism: Human

Cell Line: hBM-MSCs

39
Loss of S6K1 But Not S6K2 in the Tumor Microenvironment Suppresses Tumor Growth by Attenuating Tumor Angiogenesis

S Lee, HS Roh, SS Song, J Shin, J Lee, DH Bhang,BG Kim, SH Um, HS Jeong, KH Baek

Translational Oncology (Elsevier) South Korea, 03 April 2020

Oncology

Organism: Human

Cell Line: Endothelial Cells

40
Anti-apoptotic molecule BCL2 is a therapeutic target in steroid-refractory graft-versus-host disease

J Strobl, RV Pandey, T Kausgruber, L Kleißl, B Reininger, M Herac, N Bayer, C Krall, P Wohlfarth, M Mitterbauer, P Kalhs, W Rabitsch, C Bock, G Hopfinger, G Stary

Journal of Investigative  Dermatology (Elsevier) Austria, 02 April 2020

Dermatology

Organism: Human

Tissue: Skin

41
Thyrotropin receptor signaling deficiency impairs spatial learning and memory in mice

S Luan, W Bi, S Shi, L Peng, Z Li, J Jiang, L Gao, Y Du, X Hou, Z He, J Zhao

Journal of Endocrinology (Society for Endocrinology) China, 01 April 2020

Endocrinology

42
Distinct galectin profile in inflammation-mediated cartilage damage

S Hayer, B Niederreiter, R Windhager, D Aletaha, HJ Gabius, S Toegel

Osteoarthritis and Cartilage (OARSI Journal) Austria, 01 April 2020

Osteology

Organism: Mouse

Tissue: Joint

Pathological State: Arthritis

43
Anti-VEGF Treatment Enhances CD8+ T-Cell Antitumor Activity by Amplifying Hypoxia

Patricia E de Almeida, Judy Mak, Genevive Hernandez, Rajiv Jesudason, Aurelie Herault, Vincent Javinal, Jovencio Borneo, Jeong M Kim and Kevin Barry Walsh

Cancer Immunology Research (AACR) USA, 27 March 2020

Oncology

Key words: VEGF, CD8+ T cells, hypoxia, angiogenesis, hypoxia-inducible factor-1

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

44
Functionalized graphene oxide thin films for anti-tumor drug delivery to melanoma cells

LE Sima, G Chiritoiu, I Negut, V Grumezescu, S Orobeti, CVA Munteanu, F Sima, E Axente

Frontiers in Chemistry (Frontiers Media S.A.) Romania, 25 March 2020

Nanomedicine

Organism: Human

Cell Line: HDF cells, NHEM cells

45
Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR‐AKT‐mTOR signaling

KY Lee, PW Shueng, CM Chou, BX Lin, MH Lin, DY Kuo, IL Tsai, SM Wu, CW Lin

Cancer Science (Japanese Cancer Association) Taiwan, 25 March 2020

Oncology

Key words: CD109, EGFR, lung cancer, metastasis, mTOR

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

46
Advancements in developing an effective and preventive dengue vaccine

K Zahid, S Shakoor, HA Sajid, S Afzal, L Ali, I Amin, M Shahid, M Idrees

Future Virology (Future Medicine) Pakistan, 24 March 2020

Virology

Key words: aedes mosquito, chimeric vaccine, dengue fever, dengue virus, endemic, pandemic, public health, subtropical, tropical, vaccines

47
Iron and advanced glycation end products: Emerging role of iron in androgen deficiency in obesity

SH Chen, KC Yuan, YC Lee, CK Shih, SH Tseng, AA Tinkov, AV Skalny, JS Chang

Antioxidants (MDPI) Taiwan, 22 March 2020

Endocrinology

Key words: obesity; iron; fat; advanced glycation end products; testis; testosterone

Organism: Rat

Tissue: Liver, Testis

Pathological State: Obesity

48
Soluble Alpha-Klotho Alleviates Cardiac Fibrosis without Altering Cardiomyocytes Renewal

WY Chen

International Journal of Molecular Sciences (MDPI) Taiwan, 22 March 2020

Cardiology

Key words: klotho; FGF-23; cardiac fibrosis; genetic fate mapping

Organism: Mouse

Tissue: Heart

49
Upregulation of protein synthesis and proteasome degradation confers sensitivity to proteasome inhibitor bortezomib in myc-atypical teratoid/rhabdoid tumors

HM Tran, KS Wu, SY Sung, CA Changou, TH Hsieh, YR Liu, YL Liu, ML Tsai, HL Lee, KL Hsieh, WC Huang, ML Liang, HH Chen, YY Lee, SC Lin, DM Ho, FC Chang, ME Chao, W Chen, SS Chu, AL Yu, Y Yen, CC Chang, TT Wong

Cancers (MDPI) Taiwan, Vietnam, 22 March 2020

Oncology

Key words: Myc-ATRTs; protein synthesis; proteasome degradation; bortezomib; p53

Organism: Human, Mouse

Tissue: Brain, Xenograft Tumor

50
Role of HMGB1 in an Animal Model of Vascular Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion

AN Vidyanti, JY Hsieh, KJ Lin, YC Fang, I Setyopranoto, CJ Hu

International Journal of Molecular Sciences (MDPI) Taiwan, 21 March 2020

Neuroscience

Key words: vascular cognitive impairment; chronic cerebral hypoperfusion; modified bilateral common carotid artery occlusion; HMGB1

Organism: Mouse

Tissue: Brain

51
Analysis of sensitivity and specificity: precise recognition of neutrophils during regeneration of contused skeletal muscle in rats

J Niu, G An, Z Gu, P Li, Q Liu, R Bai, J Sun, Q Du

Forensic Sciences Research (Taylor & Francis) China, 19 March 2020

Neuroscience

Key words: Forensic sciences, forensic pathology, immunohistochemistry, TissueFAXS 200 digital pathological analysis system, parameter optimization, cut-off value of staining area, neutrophil staining area

Organism: Rat

Tissue: Muscle

52
Autophagy attenuates high glucose-induced oxidative injury to lens epithelial cells

X Liu, X Zhao, R Cheng, Y Huang

Bioscience Reports (Portland Press) China, 18 March 2020

Endocrinology

Key words: diabetic cataract, high glucose, autophagy, oxidative stress, lens

Organism: Mouse

Tissue: Eye

53
MeCP2 mediates transgenerational transmission of chronic pain

W Tao, C Chen, Y Wang, W Zhou, Y Jin, Y Mao, H Wang, L Wang, W Xie, X Zhang, J Li, J Li, X Li, ZQ Tang, C Zhou, ZZ Pan, Z Zhang

Progress in Neurobiology (Elsevier) China, USA, 18 March 2020

Neuroscience

Key words: Chronic pain, MeCP2, Primary somatosensory cortex, Glutamatergic neuron, Transgenerational transmission

Organism: Mouse

Tissue: Brain

54
Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation

Chia-Chen Ku, Kenly Wuputra, Kohsuke Kato, Wen-Hsin Lin, Jia-Bin Pan, Shih-Chieh Tsai, Che-Jung Kuo, Kan-Hung Lee, Yan-Liang Lee, Ying-Chu Lin, Shigeo Saito, Michiya Noguchi, Yukio Nakamura, Hiroyuki Miyoshi, Richard Eckner, Kyosuke Nagata, Deng-Chyang Wu, Chang-Shen Lin & Kazunari K. Yokoyama

Scientific Reports (Nature) Taiwan, Japan, 18 March 2020

Neuroscience

Key words: Apoptosis, Molecular neuroscience

Organism: Mouse

Tissue: Brain

55
Regulatory T cells specifically suppress conventional CD8αβ T cells in intestinal tumors of APC Min/+ mice

L Szeponik, P Akeus, W Rodin, S Raghavan, M Quiding-Järbrink

Cancer Immunology, Immunotherpay (Springer) Sweden, 17 March 2020

Immunology

Key words: Regulatory T cells, APCmin/+, Colon cancer, Tumor-infiltrating lymphocytes, Anti-tumor immunity

Organism: Mouse

Tissue: Small Intestine

Pathological State: Cancer

56
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis

Shi-Ting Li, De Huang, Shengqi Shen, Yongping Cai, Songge Xing, Gongwei Wu, Zetan Jiang, Yijie Hao, Mengqiu Yuan, Nana Wang, Lianbang Zhu, Ronghui Yan, Dongdong Yang, Lin Wang, Zhaoji Liu, Xin Hu, Rongbin Zhou, Kun Qu, Ailing Li, Xiaotao Duan, Huafeng Zhang & Ping Gao

Nature Metabolism (Nature) China, 16 March 2020

Oncology

Key words: Cancer, Cancer metabolism, Cell growth

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

57
Long-Term Deleterious Effects of Short-term Hyperoxia on Cancer Progression—Is Brain-Derived Neurotrophic Factor an Important Mediator? An Experimental Study

A Tiron, I Ristescu, PA Postu, CE Tiron, F Zugun-Eloae, I Grigoras

Cancers (MDPI) Romania, 14 March 2020

Oncology

Key words: cancer progression; breast cancer; hyperoxia; perioperative; metastasis; BDNF; Vimentin; E-Cadherin; epithelial mesenchymal transition; angiogenesis

Cell Line: human MDA-MB-231 and murine 4T1 TNBC cell lines

58
Proteomic profiling of hepatic stellate cells in alcohol liver fibrosis reveals proteins involved in collagen production

L Yin, Y Zhang, H Shi, Y Feng, L Zhang

Alcohol (Elsevier) China, 12 March 2020

Hepathology

Key words: Ethanol, Liver, HSC, Proteomics, collagen, Ndufv2

Organism: Rat

Tissue: Liver

Pathological State: Liver Fibrosis

59
Commercial 4-dimensional echocardiography for murine heart volumetric evaluation after myocardial infarction

Cody Rutledge, George Cater, Brenda McMahon, Lanping Guo, Seyed Mehdi Nouraie, Yijen Wu, Flordeliza Villanueva & Brett A. Kaufman

Cardiovascular Ultrasound (BMC) USA, 12 March 2020

Cardiology

Organism: Mouse

Tissue: Heart

Pathological State: Myocardial Infarction

60
Placental Morphology and Cellular Characteristics in Stillbirths in Women With Diabetes and Unexplained Stillbirths

A Kerby, D Shingleton, G Batra, MC Sharps, BC Baker, AEP Heazell

Archives of Pathology & Laboratory Medicine (College of American Pathologists) UK, 09 March 2020

Reproductive Medicine

Organism: Human

Tissue: Placenta

61
PTH hypersecretion triggered by a GABA B1 and Ca 2+-sensing receptor heterocomplex in hyperparathyroidism

Wenhan Chang, Chia-Ling Tu, Frederic G. Jean-Alphonse, Amanda Herberger, Zhiqiang Cheng, Jenna Hwong, Hanson Ho, Alfred Li, Dawei Wang, Hongda Liu, Alex D. White, Insoo Suh, Wen Shen, Quan-Yang Duh, Elham Khanafshar, Dolores M. Shoback, Kunhong Xiao & Jean-Pierre Vilardaga

Nature Metabolism (Nature) USA, 09 March 2020

Endocrinology

Key words: Calcium and vitamin D, Homeostasis, Mechanisms of disease, Parathyroid diseases

Organism: Mouse

Tissue: Thyroid

62
Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement

AH Liao, KH Lin, HC Chuang, CH Tsai, YC Lin, CH Wang, CP Shih, HL Liu

Scientific Reports (Nature) Taiwan, 09 March 2020

Tissue Engineering

Key words: Biophysics, Medical research

Organism: Mouse

Tissue: Skin

63
Surface functionalization of pegylated gold nanoparticles with antioxidants suppresses nanoparticle-induced oxidative stress and neurotoxicity

X Zhang, XL Guo, X Kang, H Yang, W Guo, L Guan, H Wu, L Du

Chemical Research in Toxicology (ACS Publications) China, 05 March 2020

Toxicology

Key words: pegylation; gold nanoparticle; neurotoxicity; drug delivery

Organism: Mouse

Tissue: Brain

64
Topography Mediated Fibroblast Cell Migration is Influenced by Direction, Wavelength, and Amplitude

L Ge, L Yang, R Bron, JK Burgess, P van Rijn

ACS Applied Bio Materials (ACS Publications) , 04 March 2020

Biological Materials

Key words: topography, gradient, cell migration, biointerface, wound healing

Organism: Human

Cell Line: Fibroblasts

65
A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure

Michelle L. Cook Sangar, Emily J. Girard, Gene Hopping, Chunfeng Yin, Fiona Pakiam, Mi-Youn Brusniak, Elizabeth Nguyen, Raymond Ruff, Mesfin M. Gewe, Kelly Byrnes-Blake, Natalie W. Nairn, Dennis M. Miller, Christopher Mehlin, Andrew D. Strand, Andrew J. Mhyre, Colin E. Correnti, Roland K. Strong, Julian A. Simon, James M. Olson

Science Translational Medicine (AAAS) USA, 04 March 2020

Endocrinology

Organism: Human

Tissue: Cartilage

66
Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR-AKT-mTOR signaling

KY Lee, PW Shueng, CM Chou, BX Lin, MH Lin, DY Kuo, IL Tsai, SM Wu, CW Lin

Cancer Science (Wiley) Taiwan, 04 March 2020

Oncology

Key words: CD109, EGFR, lung cancer, metastasis, mTOR

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

67
Targeting alveolar macrophages shows better treatment response than deletion of interstitial macrophages in EGFR mutant lung adenocarcinoma

K Alikhanyan, Y Chen, S Kraut, R Sotillo

Immunity, Inflammation and Disease (Wiley) Germany, 03 March 2020

Immunology, Oncology

Key words: alveolar macrophages, clodronate liposomes, EGFR mutation, interstitial macrophages, lung cancer

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

68
Artificial intelligence as the next step towards precision pathology

B Acs, M Rantalainen, J Hartman

Journal of Internal Medicine (Wiley) Sweden, 03 March 2020

Medical Imaging

Key words: artificial intelligence, deep learning, digital image analysis, digital pathology, machine learning, pathology

69
Discoidin domain receptor 1 regulates endochondral ossification through terminal differentiation of chondrocytes

LY Chou, CH Chen, YH Lin, SC Chuang, HC Chou, SY Lin, YC Fu, JK Chang, ML Ho, CZ Wang

The FASEB Journal (FASEB) Taiwan, 03 March 2020

Osteology

Key words: chondrocytes, DDR1, discoidin domain receptor 1, endochondral ossification, skeletal development

Organism: Mouse

Tissue: Bone

70
Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Carmen Rapp, Steffen Dettling, Fang Liu, Anna Theresa Ull, Rolf Warta, Christine Jungk, Saskia Roesch, Andreas Mock, Felix Sahm, Melissa Schmidt, Gerhard Jungwirth, Klaus Zweckberger, Katrin Lamszus, Konstaninos Gousias, Almuth F. Kessler, Niels Grabe, Mario Loehr, Ralf Ketter, Steffi Urbschat, Christian Senft, Manfred Westphal, Amir Abdollahi, Juergen Debus, Andreas von Deimling, Andreas Unterberg, Matthias Simon and Christel C. Herold-Mende

Clinical Cancer Research (AACR) Germany, 02 March 2020

Oncology

Key words: Clinically aggressive meningioma, T-cell infiltration, primary and recurrent tumors TILs, PD-1

Organism: Human

Tissue: Brain

Pathological State: Cancer

71
The Determination of Immunomodulation and Its Impact on Survival of Rectal Cancer Patients Depends on the Area Comprising a Tissue Microarray

ES Gruber, G Oberhuber, D Pils, T Stork, K Sinn, S Gruber, R Nica, D Kolmer, SD Turner, M Schlederer, J Widder, W Doerr, B Teleky, L Kenner

Cancers (MDPI) Austria, 29 February 2020

Oncology

Key words: Irradiated rectal cancer; Immunoscore; virtual microscopy; digital pathology; tissue microarray (TMA)

Organism: Human

Tissue: Colon

Pathological State: Cancer

72
Transcranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats

YJ Wu, ME Chien, CH Huang, CC Chiang, CC Lin, CW Huang, DM Durand, KS Hsu

Experimental Neurology (Elsevier) Taiwan, USA, 29 February 2020

Neuroscience

Key words: Status epilepticus, Seizure, Electroencephalography, Mossy fiber sproutin, gBrain-derived neurotrophic factor, Transcranial direct current stimulation

Organism: Rat

Tissue: Brain

Pathological State: Seizures

73
Dermal fillers do not induce upregulation of NLRP3 inflammasomes or expression of inflammatory cytokines in granulomas

Markus Reinholz, Benjamin M. Clanner‐Engelshofen, Markus V. Heppt, Enklajd Marsela, Yoshio Kawakami, Luitgard G. Wiest, Lars E. French, Wilhelm Stolz, Gerd G. Gauglitz

Journal of Cosmetic Dermatology (Wiley) Germany, Japan, 28 February 2020

Dermatology

Key words: Caspase, Fillers, Granulomas, Inflammasome, Interleukins

Organism: Human

Tissue: Skin

74
A transcriptionally distinct CXCL13+ CD103+ CD8+ T-cell population is associated with B-cell recruitment and neoantigen load in human cancer

Hagma H Workel, Joyce M Lubbers, Roland Arnold, Thalina M Prins, Pieter van der Vlies, Kim de Lange, Tjalling Bosse, Inge C Van Gool, Florine A Eggink, Maartje CA Wouters, Fenne L Komdeur, Elisabeth C van der Slikke, Carien L Creutzberg, Arjan Kol, Annechien Plat, Mark Glaire, David N Church, Hans W Nijman and Marco de Bruyn

Cancer immunology Research (AACR) The Netherlands, UK, Canada, 27 February 2020

Oncology

Key words: CXCL13, TGFβ1, tertiary lymphoid structures, CD103+ T cell, immune checkpoint inhibitors

Organism: Human

Pathological State: Cancer

75
Ultrasound-responsive neurotrophic factor-loaded microbubble-liposome complex: Preclinical investigation for Parkinson's disease treatment

CY Lin, YC Lin, CY Huang, SR Wu, CM Chen, HL Liu

Journal of Controlled Release (Elsevier) Taiwan, 27 February 2020

Neuroscience

Key words: Ultrasound (US)-targeted microbubble destruction (UTMD), Gene therapy, Blood-brain barrier opening, GDNF, BDNF

Organism: Mouse

Tissue: Brain

Pathological State: Parkinson's disease

76
cPLA2α reversibly regulates different subsets of cancer stem cells transformation in cervical cancer

Y He, M Xiao, H Fu, L Chen, L Qi, D Liu, P Guo, L Chen, Y Luo, H Xiao, N Zhang, H Guo

STEM CELLS (Wiley) China, 26 February 2020

Oncology

Key words: cancer stem cells, CD133, CD24, CD44, cPLA2α, epithelial‐mesenchymal transition

Organism: Human

Tissue: Uterus

Pathological State: Cancer

77
Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway

H Kim, SC Cho, HJ Jeong, HY Lee, MH Jeong, JH Pyun, D Ryu, MS Kim, YS Lee, MS Kim, SC Park, YI Lee, JS Kang

Journal of Cachexia , Sarcopenia and Muscle (Wiley) South Korea, 25 February 2020

Neuroscience

Key words: Exercise mimetic, Hypertrophic response, Indoprofen, Muscle wasting, Muscle weakness, PDK1

Organism: Mouse

Tissue: Muscle

78
Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations

P Chen, S Lou, ZH Huang, Z Wang, QH Shan, Y Wang, Y Yang, X Li, H Gong, Y Jin, Z Zhang, JN Zhou

Neuron (Cell Press) China, 25 February 2020

Neuroscience

Key words: corticotropin-releasing factor neurons, prefrontal cortex, behavioral style selection, social defeat stress

Organism: Mouse

Tissue: Brain

79
Sox2 induces tumorigenesis and angiogenesis of early stage esophagealsquamous cell carcinoma through secretion of Suprabasin

K Takahashi, N Asano, A Imatani, Y Kondo, M Saito, A Takeuchi, X Jin, M Saito, W Hatta, K Asanuma, K Uno, T Koike, A Masamune

Carcinogenesis (Oxford University Press) Japan, 14 February 2020

Oncology

Key words: angiogenesis, signal transduction, cell proliferation, endothelial cells, bodily secretions, carcinogenesis, squamous cell carcinoma, esophageal, protein overexpression, proto-oncogene proteins c-akt, tumorigenesis, microvessels, squamous epithelial cell

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

80
Sox2 induces tumorigenesis and angiogenesis of early-stage esophageal squamous cell carcinoma through secretion of Suprabasin

Kiichi Takahashi, Naoki Asano, Akira Imatani, Yutaka Kondo, Masashi Saito, Akio Takeuchi, Xiaoyi Jin, Masahiro Saito, Waku Hatta, Kiyotaka Asanuma, Kaname Uno, Tomoyuki Koike, Atsushi Masamune

Carcinogenesis (Oxford University Press) Japan, 14 February 2020

Oncology

Key words: Sox2, esophageal cancer, Suprabasin, carcinogenesis, angiogenesis

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

81
The Accumulation and Effects of Liposomal Doxorubicin in Tissues Treated by Radiofrequency Ablation and Irreversible Electroporation in Liver: In Vivo Experimental Study on Porcine Models

Tomáš Andrašina, Josef Jaroš, Tomáš Jůza, Tomáš Rohan, Dalibor Červinka, Michal Crha, Vlastimil Válek & Nahum S. Goldberg

Cardiovascular and Interventional Radiology (Springer) Czech Republic, Israel, 13 February 2020

Cardiology

Key words: Liposomal doxorubicin, Radiofrequency ablation, Irreversible electroporation

Organism: Pig

Tissue: Liver

82
The Impact of Cand1 in Prostate Cancer

Andrea Eigentler, Piotr Tymoszuk, Johanna Zwick, Arndt A. Schmitz, Andreas Pircher, Florian Kocher, Andreas Schlicker, Ralf Lesche, Georg Schäfer, Igor Theurl, Helmut Klocker, Isabel Heidegger

Cancers (MDPI) Austria, Germany, 12 February 2020

Oncology

Key words: Prostate cancer; Cand1; cancer aggressiveness; survival; tumor recurrence; mutation; enzalutamide resistance

Organism: Human

Tissue: Prostate

Pathological State: Cancer

83
Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance

J Dudas, A Ladanyi, J Ingruber, TB Steinbichler, H Riechelmann

Cells (MDPI) Austria, Hungary, 12 February 2020

Oncology

Key words: silibinin; MRX34; PD-L1; NRF2; Krüppel-like factors (KLFs); neurotrophin

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

84
MRI radiomics for early prediction of response to vaccine therapy in a transgenic mouse model of pancreatic ductal adenocarcinoma

A Eresen, J Yang, J Shangguan, Y Li, S Hu, C Sun, Y Velichko, V Yaghmai, AB Benson, Z Zhang

Journal of Translational Medicine (BMC) USA, China, 10 February 2020

Gastroenterology

Key words: Dendritic cell vaccine, Machine learning, Magnetic resonance imaging, Pancreatic ductal adenocarcinoma, Radiomics

Organism: Mouse

Tissue: Xenograft Tumor, Pancreas

Pathological State: Cancer

85
Single cell approaches to address adipose tissue stromal cell heterogeneity

EA Rondini, JG Granneman

Biochemical Journal (Portland Press) USA, 06 February 2020

Endocrinology

Key words: plasticity, single cell RNA-seq, stromal cells, white adipose tissue

86
Acquisition of chromosome instability is a mechanism to evade oncogene addiction

L Salgueiro, C Buccitelli, K Rowald, K Somogyi, S Kandala, JO Korbel, R Sotillo

EMBO Molecular Medicine (EMBO press) Germany, 06 February 2020

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

87
Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability

WC Liao, CK Liao, TJ Tseng, YJ Ho, YR Chen, KH Lin, TJ Lai, CT Lan, KC Wie, CH Liu

Oncogenesis (Nature) Taiwan, 04 February 2020

Oncology

Key words: CNS cancer, Growth factor signalling

Organism: Human

Tissue: Brain

Pathological State: Cancer

88
Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy

Y Luo, S Lu, Y Gao, K Yang, D Wu, X Xu, G Sun, X Sun

Aging (Albany NY) (Impact Journals) China, 31 January 2020

Cardiology

Key words: atherosclerosis, macrophage polarization, autophagy, Sirt1, Araloside C

Organism: Mouse

Tissue: Heart

Pathological State: Atherosclerosis

89
The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I

F Bufalieri, M Caimano, L Lospinoso Severini, I Basili, F Paglia, L Sampirisi, E loricchio, M Petroni, G Canettieri, A Santoro, L D'Angelo, P Infante, L Di Marcotullio

Cancers (MDPI) Italy, 30 January 2020

Oncology

Key words: glioblastoma multiforme (GB); ubiquitylation; E3-ligase; MEX3A; RIG-I

Organism: Human

Pathological State: Cancer

Cell Line: glioblastoma A-172 cells

90
Unidirectional rotating molecular motors dynamically interact with adsorbed proteins to direct the fate of mesenchymal stem cells

Q Zhou, J Chen, Y Luan, PA Vainikka, S Thallmair, SJ Marrink, BL Fering, P van Rijn

Science Advances (AAAS) China, The Netherlands, 29 January 2020

Biological Materials

Organism: Human

Cell Line: hBM-MSCs Cells

91
Cytotoxic CD4+ T lymphocytes may induce epithelial cell apoptosis in systemic sclerosis

Takashi Maehara, Naoki Kaneko, Cory Adam Perugino, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S. Mahajan, Hang Liu, Samuel J.H. Murphy, Musie Ghebremichael, David A. Fox, Aimee S. Payne, Robert Lafyatis, John H. Stone, Dinesh Khanna, and Shiv Pillai

Journal of Clinical Investigation (American Society of Clinical Investigation) USA, Japan, The Netherlands, Canada, China, 28 January 2020

Immunology

Organism: Human

Tissue: Skin

92
Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis

Takashi Maehara, Naoki Kaneko, Cory Adam Perugino, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S. Mahajan, Hang Liu, Samuel J.H. Murphy, Musie Ghebremichael, David A. Fox, Aimee S. Payne, Robert Lafyatis, John H. Stone, Dinesh Khanna, and Shiv Pillai

Journal of Clinical Investigation (American Society of Clinical Investigation) USA, Japan, The Netherlands, Canada, China, 28 January 2020

Immunology

Organism: Human

Tissue: Skin

93
Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas

J He, Z Huang, M He, J Liao, Q Zhang, S Wang, L Xie, L Ouyang, HP Koeffler, D Yin, A Liu

Molecular Cancer (BMC) China, USA, 28 January 2020

Oncology

Key words: Circ-MAPK4, P38/MAPK signaling pathway, MiR-125a-3p, Gliomas, Apoptosis

Organism: Mouse

Tissue: Xenograft Tumor, Brain

Pathological State: Cancer

94
Effects of exosome-mediated delivery of myostatin propeptide on functional recovery of mdx mice

N Ran, X Gao, X Dong, J Li, C Lin, M Geng, HF Yin

Biomaterials (Elsevier) China, 25 January 2020

Biological Materials

Key words: Exosome, Duchenne muscular dystrophy, Myostatin, Propeptide

Organism: Rat

Tissue: Muscle, Liver, Kidney

95
The Establishment of Esophageal Precancerous Lesion Model by Using p53 Conditional Knockout Mouse in Esophageal Epithelium

L Zhu, Y Xu, X Chen, J Qin, T Niu, Y Zhu, Y Jiang, S Zhao, K Liu, J Lu, G Jin, J Ma

BioMed Research International (Hindawi Publishing Corporation) China, 25 January 2020

Oncology

Organism: Mouse

Tissue: Esophagus

96
Surfactant expression defines an inflamed subtype of lung adenocarcinoma brain metastases that correlates with prolonged survival

Kolja Pocha, Andreas Mock, Carmen Rapp, Steffen Dettling, Rolf Warta, Christoph Geisenberger, Christine Jungk, Leila R Martins, Niels Grabe, David Reuss, Jürgen Debus, Andreas von Deimling, Amir Abdollahi, Andreas Unterberg and Christel C Herold-Mende

Clinical Cancer Research (AACR) Germany, 17 January 2020

Oncology

Organism: Human

Tissue: Lung

Pathological State: Cancer

97
Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-α/TNFR1-mediated inhibition of NF-κB phosphorylation

E Jo, HJ Jang, KE Yang MS Jang, YH Huh, HS Yoo, JS Park, IK Jang, SJ Park

BMC Complementary Medicine and Therapies (BMC) South Korea, 13 January 2020

Oncology

Key words: Apoptosis, TNF-α, TNFR1, NF-κB, C. militaris

Organism: Human

Cell Line: SKOV-3 Cells

98
High Extra-tumoral Mast Cell Counts are Associated with a Higher Risk of Adverse Prostate Cancer Outcomes

HH Sullivan, CM Heaphy, I Kulac, N Cuka, J Lu, JR Barber, AM De Marzo, TL Lotan, CE Joshu, KS Sfanos

Cancer Epidemiology, Biomarkers & Prevention (AACR) USA, 13 January 2020

Oncology

99
Novel titanium-apatite hybrid scaffolds with spongy bone-like micro architecture intended for spinal application: In vitro and in vivo study

MD Vlad, EF Aguado, SG González, IC Ivanov, EV Sindilar, I Poeata, AS Iencean, M Butnaru, ER Avadanei, J Lopez Lopez

Materials Science and Engineering: C (Elsevier) Romania, Spain, 11 January 2020

Biological Materials

Key words: Titanium-apatite hybrid scaffolds, Osteogenic biomimetic porous scaffolds, Hydroxyapatite bioactive matrix, Bone restoration, Spinal fusion, Additive manufacturing

Organism: Human

Cell Line: Osteoblasts

100
Sensory neuropeptides are required for bone and cartilage homeostasis in a murine destabilization-induced osteoarthritis model

D Muschter, L Fleischhauer, S Taheri, AF Schilling, H Clausen-Schaumann, S Grässel

Bone (Elsevier) Germany, 08 January 2020

Osteology

Key words: Osteoarthritis, Destabilization of the medial meniscus, Substance P, alpha- Calcitonin gene-related peptide, Bone, Cartilage

Organism: Mouse

Tissue: Bone

101
Racial difference in prostate cancer cell telomere lengths in men with higher-grade prostate cancer: a clue to the racial disparity in prostate cancer outcomes

CM Heaphy, CE Joshu, JR Barber, C Davis, R Zarinshenas, AM De Marzo, TL Lotan, KS Sfanos, AK Meeker, EA Platz

Cancer Epidemiology, Biomarkers & Prevention (AACR) USA, 08 January 2020

Oncology

102
Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer

CW Chang, HC Lee, LH Li, JS Chiang Chiau, TE Wang, WH Chuang, MJ Chen, HY Wang, SC Shih, CY Liu, TH Tsai, YJ Chen

International Journal of Molecular Sciences (MDPI) Taiwan, 08 January 2020

Oncology, Microbiology

Key words: FOLFOX; fecal microbiota transplant; intestinal mucositis; apoptosis; gut microbiota

Organism: Mouse

Tissue: Small Intestine

Pathological State: Cancer

103
Impact of the Sensory and Sympathetic Nervous System on Fracture Healing in Ovariectomized Mice

T Niedermair, RH Straub, C Brochhausen, S Grässel

International Journal of Molecular Sciences (MDPI) Germany, 08 January 2020

Neuroscience

Key words: fracture; substance P; alpha-CGRP; sympathectomy; sympathetic nerve fibers; ovariectomy; sensory nervous system; bone repair; bone remodeling

Organism: Mouse

Tissue: Bone

104
Efficient Labeling Of Mesenchymal Stem Cells For High Sensitivity Long-Term MRI Monitoring In Live Mice Brains

AAA Ali, RA Shahror, KY Chen

International Journal of Nanomedicine (Dove Press) Taiwan, 08 January 2020

Nanomedicine

Key words: iron oxide nanoparticles, FGF21, regenerative medicine, tracking of cells, non-invasive imaging modality

Organism: Human

Cell Line: Mesenchymal Stem Cells

105
Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway

D Liu, H Wang, Y Zhang, Z Zhang

Drug Design, Development and Therapy (Dove Press) China, 07 January 2020

Neuroscience

Key words: cerebral ischemia/reperfusion injury, chlorogenic acid, oxidative stress, neuroprotection, NF-E2-related factor 2 pathway

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

106
The MyoD family inhibitor domain-containing protein enhances the chemoresistance of cancer stem cells in the epithelial state by increasing β-catenin activity

CJ Chen, CJ Yang, SF Yang, MS Huang, YP Liu

Oncogene (Nature) Taiwan, 07 January 2020

Oncology

Key words: Non-small lung cancer, Prognostic

Organism: Human

Tissue: Lung

Pathological State: Cancer

107
TIAM2S as a novel regulator for serotonin level enhances brain plasticity and locomotion behavior

CH Chu, JS Chen, PC Chuang, CH Su, ZL Chan, ZJ Zang, ZT Chiang, PW Gean, HS Sun

The FASEB Journal (Wiley) Taiwan, 07 January 2020

Neuroscience

Key words: guanine nucleotide exchange factor (GEF), hyperlocomotion, neuroplasticity, serotonergic fiber, serotonin (5‐HT), TIAM2

Organism: Mouse

Tissue: Brain

108
Microvascular Disease in Chronic Thromboembolic Pulmonary Hypertension: Hemodynamic Phenotyping and Histomorphometric Assessment

Christian Gerges, Mario Gerges, Richard Friewald, Pierre Fesler, Peter Dorfmüller, Smriti Sharma, Kristof Karlocai, Nika Skoro-Sajer, Johannes Jakowitsch, Bernhard Moser, Shahrokh Taghavi, Walter Klepetko, Irene M. Lang

Circulation (American Heart Association) Austria, Germany, France, Hungary, 03 January 2020

Cardiology

Key words: chronic thromboembolic pulmonary hypertension; upstream resistance; pulmonary vascular resistance; pulmonary arterial compliance; microvascular disease

Organism: Human

Tissue: Lung

109
Anti-BAFF treatment interferes with humoral responses in a model of renal transplantation in rats

L Steines, H Poth, A Schuster, EK Geissler, K Amann, B Banas, T Bergler

Transplantation (Wolters Kluwer) Germany, 01 January 2020

Transplantation Medicine

Organism: Rat

Tissue: Kidney

110
Effects of neoadjuvant FOLFIRONOX and gemcitabine-based chemotherapy on cancer cell survival and death in patients with pancreatic ductal adenocarcinoma

L Xie, L Xia, U Klaiber, M Sachsenmaier, U Hinz, F Bergmann, O Strobel, MW Büchler, JP Neoptolemos, F Fortunato, T Hackert

Oncotarget (Impact Journals) Germany, 31 December 2019

Oncology

Key words: autophagy, cell death, stroma, neoadjuvant therapy, prognosis

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

111
Protein Kinase B Inactivation Is Associated with Magnolol-Enhanced Therapeutic Efficacy of Sorafenib in Hepatocellular Carcinoma In Vitro and In Vivo

JH Chen, I Chiang, FT Hsu

Cancers (MDPI) Taiwan, 30 December 2019

Oncology

Key words: Magnolol, Sorafenib, AKT, Hepatocellular carcinoma

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

112
High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra

YC Kao, WY Wei, KJ Tsai, LC Wang

International Journal of Molecular Sciences (MDPI) Taiwan, 27 December 2019

Neuroscience

Key words: high-fat diet (HFD); dopamine (DA); Parkinson disease (PD); peroxisome proliferator-activated receptor (PPAR)

Organism: Mouse

Tissue: Brain

113
Nanoplatforms with Remarkably Enhanced Absorption in the Second Biological Window for Effective Tumor Thermo-Radiotherapy

C Zhang, D Men, T Zhang, Y Yu, J Xiang, G Jiang, and L Han

ACS Applied Materials & Interfaces (ACS Publications) China, 25 December 2019

Nanomedicine

Key words: Copper sulfide, Gold, Second near-infrared window, Thermo-radiotherapy, Synergistic effect

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

114
Heat-killed Mycobacterium paragordonae therapy exerts an anti-cancer immune response via enhanced immune cell mediated oncolytic activity in xenograft mice model

SY Lee, SB Yang, YM Choi, SJ Oh, BJ Kim, YH Kook, BJ Kim

Cancer Letters (Elsevier) South Korea, 23 December 2019

Oncology

Key words: Cancer immnotherapy, Natural killer cells, Dendritic cells, Interleukin-12

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

115
Dendritic cells treated with a prostaglandin I2 analog, iloprost, promote antigen-specific regulatory T cell differentiation in mice

TH Wong, RJ Gau, YF Chen, HH Shen, CTY Lin, SL Chen, JL Suen

International Immunopharmacology (Elsevier) Taiwan, 23 December 2019

Immunology

Key words: Allergic inflammation, Prostaglandin I2, mPEG-PLGA hydrogel, Regulatory T-cell, Tolerogenic dendritic cell, PD-L1

Organism: Mouse

Tissue: Lung

116
Switching to a Healthy Diet Prevents the Detrimental Effects of Western Diet in a Colitis-Associated Colorectal Cancer Model

C Gröschel, M Prinz-Wohlgenannt, I Mesteri, S Karuthedom George, L Trawnicek, D Heiden, A Aggarwal, S Tennakoon, M Baumgartner, C Gasche, M Lang, R Marculescu, T Manhardt, M Schepelmann, E Kallay

Nutrients (MDPI) Austria, Germany, 23 December 2019

Gastroenterology, Oncology

Key words: inflammatory bowel disease; colitis-associated cancer; microbiome; western diet; vitamin D; non-alcoholic fatty liver disease; CYP24A1; Wnt pathway; aberrant crypt foci; mucosal regeneration

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

117
Visfatin Mediates Malignant Behaviors through Adipose-Derived Stem Cells Intermediary in Breast Cancer

JY Huang, YY Wang, S Lo, LM Tseng, DR Chen, YC Wu, MF Hou, SSF Yuan

Cancers (MDPI) Taiwan, 20 December 2019

Oncology

Key words: Breast cancer, Visfatin, Adipose-derived stem cells (ADSCs), GDF15

Organism: Human

Tissue: Breast

Pathological State: Cancer

118
Modulating Macrophage Phenotype by Sustained MicroRNA Delivery Improves Host‐Implant Integration

J Lin, I Mohamed, PH Lin, H Shirahama, U Milbreta, JL Sieow, Y Peng, M Bugiani, SC Wong, H Levinson, SY Chew

Advanced Healthcare Materials (Wiley) Singapore, USA, The Netherlands, 18 December 2019

Tissue Engineering

Key words: Electrospinning, Fibrous capsule formation, Gene silencing, RNA interference, Tissue engineering

Organism: Mouse

119
Rhubarb-evoke Mucus Secretion through Aggregation and Degranulation of Mast cell in the colon of Rat: in vivo and ex vivo studies

D Wu, X Xue, C Gao, Y Liu, T Wang, L Li, X Tong, F Li, J Xu

Scientific Reports (Nature) China, 18 December 2019

Gastroenterology

Key words: Gastroenterology, Physiology

120
Assembly of vascular smooth muscle cells in 3D aggregates provokes cellular quiescence

M Jäger, C De la Torre, C Arnold, J Kohlhaas, L Kappert, M Hecker, A Feldner, T Korff

Experimental Cell Research (Elsevier) Germany, 16 December 2019

Tissue Engineering

Key words: TGF, Vascular smooth muscle cells, Differentiation, 3D culture

Organism: Human

Cell Line: HUASMCs

121
Effects of Circadian Rhythm Disorder on the Hippocampus of SHR and WKY Rats

YL Wang, YG Zhang, WZ Wang, X Liu, YF Chi, JF Lei, BG Zhang, T Zhang

Neurobiology of Learning and Memory (Elsevier) China, 16 December 2019

Neuroscience

Key words: Circadian rhythm disorder, Hypertension, Cognition, Hippocampus

Organism: Rat

Tissue: Brain

Pathological State: Circadian Rhythm Disorder

122
Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice

T Elajnaf, L Iamartino, I Mesteri, C Müller, M Bassetto, T Manhardt, S Baumgartner-Parzer, E Kallay, M Schepelmann

Nutrients (MDPI) Austria, Germany, UK, 16 December 2019

Gastroenterology

Key words: IBD, Colitis, Inflammation, Calcium, Mucin

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

123
Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations

Daniel Y. Zhang, Crismita Dmello, Li Chen, Victor A. Arrieta, Edgar Gonzalez-Buendia, J. Robert Kane, Lisa P. Magnusson, Aneta Baran, C. David James, Craig Horbinski, Alexandre Carpentier, Carole Desseaux, Michael Canney, Miguel Muzzio, Roger Stupp and Adam M. Sonabend

Clinical Cancer Research (AACR) USA, Mexico, France, 12 December 2019

Oncology

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

124
Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice

Katherine C. Wood , Brittany G. Durgin , Heidi M. Schmidt , Scott A. Hahn , Jeffrey J. Baust , Tim Bachman , Dario A. Vitturi , Samit Ghosh , Solomon F. Ofori-Acquah , Ana L. Mora , Mark T. Gladwin , Adam C. Straub

Blood Advances (ASH Publications) USA, 10 December 2019

Cardiology

Organism: Mouse

Tissue: Heart

125
Targeting FOXA1-mediated repression of TGF-b signaling suppresses castration-resistant prostate cancer progression

Song B, Park SH, Zhao JC, Fong KW, Li S, Lee Y, Yang YA, Sridhar S, Lu X, Abdulkadir SA, Vessella RL, Morrissey C, Kuzel TM, Catalona W, Yang X, Yu J

JCI insight (American Society of Clinical Investigation) USA, 04 December 2019

Oncology

Key words: Genetics, Oncology, Prostate Cancer

Organism: Human

Tissue: Prostate

Pathological State: Cancer

126
Molecular Pattern and Density of Axons in the Long Head of the Biceps Tendon and the Superior Labrum

S Boesmueller, R Blumer, B Gesslbauer, L Hirtler, C Fialka, R Mittermayr

Journal of Clinical Medicine (MDPI) Austria, 03 December 2019

Physiology

Key words: axons; pain; long head of the biceps tendon; superior labrum; SLAP

Organism: Human

Tissue: Connective Tissue

127
Early appearance of key transcription factors influence the spatiotemporal development of the human inner ear

LJ Chacko, C Sergi, T Eberharter, J Dudas, H Rask-Anderson, R Hoermann, H Fritsch, N Fischer, R Glueckert, A Schrott-Fischer

Cell and Tissue Research (Springer) Austria, Canada, Sweden, 02 December 2019

Developmental Biology

Key words: Inner ear, Human, Transcription factors, Immunohistochemistry, SOX2, TAK1, GATA3, Electron microscopy

Organism: Human

Tissue: Bone

128
PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes

MH Jeong, HJ Jeong, BY Ahn, JH Pyun, I Kwon, H Cho, JS Kang

Cell Death & Disease (Nature) South Korea, 02 December 2019

Cardiology

Key words: Cell death, Heart failure

Organism: Mouse

Tissue: Heart

129
Tissue-infiltrating immune cells contribute to understanding the pathogenesis of Kimura disease: A case report

T Maehara, R Munemura, M Shimizu, N Kakizoe, N Kaneko, Y Murakami, M Masafumi, T Kiyoshima, S Kawano, S Nakamura

Medicine (Wolters Kluwer) Japan, USA, 01 December 2019

Immunology

Key words: CD4+ T cell; CD4+ GATA3+ T cell; IgE; Kimura disease; mast cell

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Kimura Disease

130
Histologic Analysis of Sensory and Motor Axons in Branches of the Human Brachial Plexus

LM Mioton, GA Dumanian, A Gregory, M de la Garza, JH Ko

Plastic and Reconstructive Surgery (American Society of Plastic Surgeons) USA, 01 December 2019

Regenerative Medicine

Organism: Human

Tissue: Nerves

131
Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI

T Chiba, KD Peasley, KR Cargill, KV Maringer, SS Bharathi, E Mukherjee, Y Zhang, A Holtz, N Basisty, SD Yagobian, B Schilling, ES Goetzman, S Sims-Lucas

Journal of The American Society of Nephrology (American Society of Nephrology) USA, 29 November 2019

Nephrology

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

132
Development of Kaempferol-Loaded Gelatin Nanoparticles for the Treatment of Corneal Neovascularization in Mice

YL Chuang, HW Fang, A Ajitsaria, KH Chen, CY Su, GS Liu, CL Tseng

Pharmaceutics (MDPI) Taiwan, Australia, 28 November 2019

Nanomedicine

Key words: gelatin nanoparticles; kaempferol; corneal neovascularization; anti-angiogenesis; human umbilical vascular endothelial cells (HUVECs)

Organism: Mouse

Tissue: Eye

133
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function

Lercher A, Bhattacharya A, Popa AM, Caldera M, Schlapansky MF, Baazim H, Agerer B, Gürtl B, Kosack L, Májek P, Brunner JS, Vitko D, Pinter T, Genger JW, Orlova A, Pikor N, Reil D, Ozsvár-Kozma M, Kalinke U, Ludewig B, Moriggl R, Bennett KL, Menche J, Cheng PN, Schabbauer G, Trauner M, Klavins K, Bergthaler A

Immunity (Elsevier) Austria, USA, Switzerland, Germany, China, 26 November 2019

Immunology

Key words: CD8 T cells; hepatitis; hepatocyte; immunometabolism; infection; inflammation; interferons; liver; urea cycle; virus

Organism: Mouse

Tissue: Liver

134
DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation

SC Lai, YT Su, CC Chi, YC Kuo, KF Lee, YC Wu, PC Lan, MH Yang, TS Chang, YH Huang

Jornal of Experimental & Clinical Cancer Research (BMC) Taiwan, 26 November 2019

Oncology

Key words: , Interleukin-6, Phospho-STAT3, OCT4, DNMT3b, Drug resistance, Hepatocellular carcinoma

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

135
Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice

CM Smith, MK Proulx, R Lai, MC Kiritsy, TA Bell, P hock, FP de Villena, MT Ferris, RE Baker, SM Behar, CM Sassetti

mBio (American Society for Microbiology) USA, 26 November 2019

Microbiology

Key words: Mycobacterium tuberculosis, adaptive immunity, Collaborative Cross mice, host genetics, host response, host-pathogen interactions

Organism: Mouse

Tissue: Lung

Pathological State: M. Tuberculosis Infection

136
Promising Therapeutic Efficacy of GC1118, an Anti-EGFR Antibody, against KRAS Mutation-Driven Colorectal Cancer Patient-Derived Xenografts

HW Lee, E Son, K Lee, Y Lee, Y Kim, JC Lee, Y Lim, M Hur, D Kim, DH Nam

International Journal of Molecular Sciences (MDPI) South Korea, 24 November 2019

Oncology

Key words: colorectal cancer; patient-derived xenograft; EGFR-targeting therapeutic antibody; KRAS mutation; PI3K/mTOR/AKT inhibitor

Organism: Mouse

Tissue: Colon, Xenograft Tumor

Pathological State: Cancer

137
Translational interest of immune profiling

PN Pushparaj

Precision Medicine for Investigators, Practitioners and Providers (Elsevier) Saudi Arabia, 22 November 2019

Immunology

Key words: Biomarkers, Immunoprofiling, Multiplex Immunohistochemistry, Novel Therapies, Next Generation Sequencing, Protein Arrays, Translational Research, xMAP Assays

138
Cordycepin inhibits human ovarian cancer by inducing autophagy and apoptosis through Dickkopf-related protein 1/β-catenin signaling

HJ Jang, KE Yang, IH Hwang, YH Huh, DJ Kim, KS Yoo, SJ Park, IS Jang

American Journal of Translational Regulation (NCBI) South Korea, 15 November 2019

Oncology

Key words: Apoptosis, Dickkopf-related protein 1, β-catenin, autophagy, cordycepin

Organism: Human

Pathological State: Cancer

Cell Line: SKOV-3, OVCAR-3

139
Influence of Platelet Lysate on 2D and 3D Amniotic Mesenchymal Stem Cell Cultures

M Pasztorek, E Rossmanith, C Mayr, F Hauser, J Jacak, A Ebner, V Weber, MB Fischer

Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) Austria, 15 November 2019

Regenerative Medicine

Key words: mesenchymal stem cells, stress fibers, mitochondrial dynamics, platelet lysate, membrane elasticity

Organism: Human

Cell Line: hMSCs

140
Endoplasmic reticulum stress-mediated basolateral amygdala GABAergic neuron injury is associated with stress-induced mental disorders in rats

S Wang, W Shi, G Zhang, X Zhang, C Ma, K Zhao, B Cong, Y Li

Frontiers in cellular Neuroscience (NCBI) China, Usa, Mexico, 14 November 2019

Neuroscience

Key words: stress, amygdala, GABAergic neurons, mental disorder, endoplasmic reticulum stress

Organism: Rat

Tissue: Brain

141
Large‐scale Production of LGR5‐positive Bipotential Human Liver Stem Cells

Kerstin Schneeberger, Natalia Sánchez‐Romero, Shicheng Ye, Frank G. van Steenbeek, Loes A. Oosterhoff, Iris Pla Palacin,Chen Chen, Monique E. van Wolferen, Gilles van Tienderen, Ruby Lieshout, Haaike Colemonts‐Vroninks, Imre Schene, Ruurdtje Hoekstra, Monique M.A. Verstegen, Luc J.W. van der Laan, Louis C. Penning, Sabine A. Fuchs, Hans Clevers, Joery De Kock, Pedro M. Baptista, Bart Spee

Hepatology (AASLD) The Netherlands, Spain, Belgium, 12 November 2019

Hepathology

Key words: Liver organoids, suspension culture, spinner flask, hepatocyte differentation, tissue engineering

Organism: Human

Tissue: Liver

142
Linear ubiquitin assembly complex regulates lung epithelial driven responses during influenza infection

PL Brazee, L Morales-Nebreda, ND Magani, JGN Garcia, AV Misharin, KM Ridge, GRS Budinger, K Iwai, LA Dada, JI Sznajder

Journal of Clinical Investigation (American Society of Clinical Investigation) USA, Japan, 12 November 2019

Immunology

Organism: Mouse

Tissue: Lung

Pathological State: Infulenza Infection

143
P2Y6 and P2X7 receptor antagonism exerts neuroprotective/neuroregenerative effects in an animal model of Parkinson's disease

Á Oliveira-Giacomelli, CM Albino, HD Nobrega de Souza, J Correa-Velloso, AP de Jesus Santos, J Baranova, H Ulrich

Frontiers in cellular Neuroscience (Frontiers Media S.A.) Brazil, 08 November 2019

Neuroscience

Key words: purinergic receptors, Brilliant Blue G, P2X7 receptor, MRS2578, P2Y6 receptor, Parkinson’s disease, microglia

Organism: Rat

Tissue: Brain

Pathological State: Prakinson's Disease

144
A self-assembled RNA-triple helix hydrogel drug delivery system targeting triple-negative breast cancer

L Ding, J Li, C Wu, F Yan, X Li, S Zhang

Journal of Materials Chemistry B (Royal Society of Chemistry) China, 08 November 2019

Nanomedicine, Oncology

Organism: Human

Pathological State: Cancer

Cell Line: MDA-MB-231 cells, MCF-7 cells and HeLa cells

145
Gastroprotective effects of Kangfuxin against water-immersion and restraint stress-induced gastric ulcer in rats: roles of antioxidation, anti-inflammation, and pro-survival

S Lu, D Wu, G Sun, F Geng, Y Shen, J Tan, X Sun, Y Luo

Pharmaceutical Biology (Taylor & Francis) China, 07 November 2019

Gastroenterology

Key words: Periplaneta americana L., gastric diseases, IGF-1/PTEN/Akt signalling, KFX

Organism: Rat

Tissue: Stomach

Pathological State: Gastric Ulcer

146
Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis

CM Mazur, JJ Woo, CS Yee, AJ Fields, C Acevedo, KN Bailey, S Kaya, TW Fowler, JC Lotz, A Dang, AC Kuo, TP Vail, T Alliston

Bone research (Nature) USA, 05 November 2019

Osteology

Key words: Bone, Bone quality and biomechanics, Pathogenesis

Organism: Human

Tissue: Bone

147
Well Plate Integrated Topography Gradient Screening Technology for Studying Cell‐Surface Topography Interactions

TAB van der Boon, L Yang, L Li, DE Cordova, Galvan, Q Zhou, J e Boer, P van Rijn

Advanced Biosystems (Wiley) The Netherlands, China, 04 November 2019

Biological Materials

Key words: Biointerfaces, gradients, high-throughput screening, stem cells surface topography

Organism: Human

Cell Line: hBM-MSCs

148
Mapping of c-Fos expression in male tree shrew forebrain

RJ Ni, J Wang, YM Shu, L Xu, JN Zhou

Neuroscience letters (Elsevier) China, 03 November 2019

Neuroscience

Key words: Aversive stimulus, Prefrontal cortex, Lateral septal nucleus, Bed nucleus of the stria terminalis, Hypothalamus, Amygdala

Organism: Tree Shrew

Tissue: Brain

149
Dendritic cell immunotherapy induces anti-tumor effect in a transgenic mouse model of pancreatic ductal adenocarcinoma

J Yang, S Hu, J Shangguan, A Eresen, Y Li, L Pan, Q Ma, Y Velichko, J Wang, C Hu, V Yagmai, Z Zhang

American Journal of Cancer Research (NCBI) USA, China, 01 November 2019

Oncology

Key words: Pancreatic ductal adenocarcinoma, DC-based immunotherapy, magnetic resonance imaging

Organism: Mouse

Tissue: Spleen

Pathological State: Cancer

150
Phospholipase D2 in prostate cancer: protein expression changes with Gleason score

AR Noble, K Hogg, R Suman, DM Berney, S Bourgoin, NJ Maitland, MG Rumsby

British journal of Cancer (Nature) UK, Canada, 01 November 2019

Oncology

Key words: Cell growth, Prostate cancer, Time-lapse imaging

Organism: Human

Tissue: Prostate

Pathological State: Cancer

151
A New Histone Deacetylase Inhibitor Enhances Radiation Sensitivity through the Induction of Misfolded Protein Aggregation and Autophagy in Triple-Negative Breast Cancer

HW Chiu, YL Yeh, SY Ho, YH Wu, B Wang Jr, WJ Huang, YS Ho, YJ Wang, LC Chen, SH Tu

Cancers (MDPI) Taiwan, 01 November 2019

Oncology

Key words: histone deacetylase inhibitor; aggresome; radiation; autophagy; triple-negative breast cancer

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

152
Directional topography gradients drive optimum alignment and differentiation of human myoblasts

AMA Suarez, Q Zhou, P van Rijn, MC Harmsen

Journal of Tissue Engineering and Regenerative Medicine (Wiley) The Netherlands, 01 November 2019

Regenerative Medicine

Key words: Myoblasts, Myotubes, Polydimethylsiloxane (PDMS), Tissue Engineering, Topography Gradient

Organism: Human

Cell Line: Myoblasts

153
Responsive exosome nano‐bioconjugates for synergistic cancer therapy

W Nie, G Wu, J Zhang, LL Huang, J Ding, A Jiang, Y Zhang, Y Liu, J Li, K Pu, HY Xie

Angewandte Chemie (Wiley) China, Singapore, 31 October 2019

Nanomedicine

Key words: Exosome, immunotherapy, antibodies, cancer, nanoconjugate

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

154
Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

KQ Fan, YY Li, HL Wang, XT Mao, JX Guo, F Wang, LJ Huang, YN Li, XY Ma, ZJ Gao, W Chen, DD Qian, WJ Xue, Q Cao, L Zhang, L Shen, L Zhang, C Tong, JY Zhong, W Lu, L Lu, KM Ren, G Zhong, Y Wang, M Tang, XH Feng, RJ Chai, J Jin

CELL (Cell Press) China, 31 October 2019

Neuroscience

Key words: T cell, stress, leukotriene B4, anxiety, purine metabolism, amygdala, AdorA1, IRF-1, xanthine

Organism: Mouse

Cell Line: CD4 T Cells

155
Distribution of Tyrosine‐Hydroxylase‐Immunoreactive Neurons in the Hypothalamus of Tree Shrews

ZH Huang, RJ Ni, PH Luo, JN Zhou

Journal of Comparative Neurology (Wily) China, 31 October 2019

Neuroscience

Key words: Tyrosine hydroxylase, Hypothalamus, Immunohistochemistry, RRID: AB_2201526, Vasopressin, Aromatic L-amino acid decarboxylase

Organism: Tree Shrew

Tissue: Brain

156
Histological evidence of chitosan-encapsulated curcumin suppresses heart and kidney damages on streptozotocin-induced type-1 diabetes in mice model

S Sudirman, CS Lai, YL Yan, HI Yeh, ZL Kong

Scientific Reports (Nature) Taiwan, 23 October 2019

Endocrinology

Key words: Experimental models of disease, Immunology

Organism: Mouse

Tissue: Heart, Kidney

Pathological State: Diabetes Type 2

157
Nasal Pneumococcal Density is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens

Elena Mitsi , Beatriz Carniel , Jesús Reiné , Jamie Rylance , Seher Zaidi , Alessandra Soares-Schanoski , Victoria Connor , Andrea M Collins , Andreas Schlitzer , Elissavet Nikolaou , Carla Solórzano , Sherin Pojar , Helen Hill , Angela D Hyder-Wright , Kondwani C Jambo ; Marco R Oggioni , Megan De Ste Croix , Stephen B Gordon ; Simon P Jochems , and Daniela M Ferreira

American Journal of Respiratory and Critical Care Medicine (ATS Journals) UK, Brazil, Germany, Malawi, The Netherlands, 18 October 2019

Immunology

Key words: Nasopharygeal colonization; Microaspiration; Alveolar macrophages; Controlled Human Infection model; CD4+ T cells

Organism: Human

Cell Line: BAL Cells

158
Human Mesenchymal Stem Cell Response to Lactoferrin-based Composite Coatings

M Icriverzi, A Bonciu, L Rusen, LE Sima, S Brajnicov, A Cimpean, RW Evans, V Dinca, A Roseanu

Materials (MDPI) Romania, UK, 18 October 2019

Biological Materials

Key words: mesenchymal stem cells; osteogenic differentiation; lactoferrin; polymer composite

Organism: Human

Cell Line: hMSCs

159
Facile and efficient encapsulation of antimicrobial peptides via crosslinked DNA nanostructures and their application in wound therapy

S Obuobi, HKL Tay, NDT Tram, V Selvarajan, J Singh Khara, Y Wang, PLR Ee

Journal of Controlled Release (Elsevier) Singapore, 16 October 2019

Nanomedicine

Key words: DNA hydrogel, S. aureus infection, Wound healing, Antimicrobial peptides, Controlled release, Electrostatic interactions

Organism: Mouse

Tissue: Skin

Pathological State: Wound

160
Functional loss of ATRX and TERC activates Alternative Lengthening of Telomeres (ALT) in LAPC4 prostate cancer cells

MK Graham, J Kim, J Da, JA Brosnan-Cashman, A Rizzo, JA Baena Del Valle, L Chia, M Rubenstein, C Davis, Q Zheng, L Cope, M Considine, MC Haffner, AM De Marzo, AK Meeker, CM Heaphy

Molecular Cancer  Research (AACR) USA, 14 October 2019

Oncology

Key words: ATRX, TERC, Telomeres, Alternative lengthening of telomeres, Cancer, Prostate cancer, telomerase, gene knockout, CRISPR/Cas

Organism: Human

Pathological State: Cancer

Cell Line: LAPC-4 Cells

161
Comparing the Osteogenic Potentials and Bone Regeneration Capacities of Bone Marrow and Dental Pulp Mesenchymal Stem Cells in a Rabbit Calvarial Bone Defect Model

YC Lee, YH Chan, SC Hsieh, WZ Lew, SW Feng

International Journal of Molecular Sciences (MDPI) Taiwan, 10 October 2019

Regenerative Medicine

Key words: mesenchymal stem cells; dental pulp stem cells; bone marrow stem cells; bone regeneration; calvarial defect

Organism: Rabbit

Tissue: Bone

162
Nanoparticulated Honokiol Mitigates Cisplatin-Induced Chronic Kidney Injury by Maintaining Mitochondria Antioxidant Capacity and Reducing Caspase 3-Associated Cellular Apoptosis

HT Liu, TE Wang, YT Hsu, CC Chou, KH Huang, CC Hsu, HJ Liang, HW Chang, TH Lee, PS Tsai

Antioxidants (MDPI) Taiwan, 09 October 2019

Biological Materials

Key words: honokiol; cisplatin; kidney injury; oxidative stress; apoptosis; nanotechnology

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

163
Loss of smooth muscle CYB5R3 amplifies angiotensin II–induced hypertension by increasing sGC heme oxidation

BG Durgin, SA Hahn, HM Schmidt, MP Miller, N Hafeez, I Mathar, D Freitag, P Sandner, AC Straub

JCI insight (American Society of Clinical Investigation) Germany, USA, 03 October 2019

Cardiology

Key words: Vascular Biology, Guanylate cyclase, Hypertension, Nitric oxide

Organism: Mouse

Tissue: Heart, Blood Vessels

Pathological State: Hypertension

164
Cajaninstilbene Acid Ameliorates Cognitive Impairment Induced by Intrahippocampal Injection of Amyloid-β1-42 Oligomers

LS Wang, X Tao, XM Liu, YF Zhou, MD Zhang, YH Liao, RL Pan, Q Chang

Frontiers in Pharmacology (Frontiers Media S.A.) China, 24 September 2019

Pharmacology

Organism: Mouse

Tissue: Brain

165
Pancreatic stellate cells activated by mutant KRAS-mediated PAI-1 upregulation foster pancreatic cancer progression via IL-8

HC Wang, YL Lin, CC Hsu, YJ Chao, YC Hou, TJ Chiu, PH Huang, MJ Tang, LT Chen, YS Shan

Theranostics (NCBI) Taiwan, 23 September 2019

Oncology

Key words: pancreatic cancer, PSC, stiffness, organotypic coculture, PAI-1

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

166
A Method for Predicting the Success of Pulsinell's Four-Vessel Occlusion Rat Model by LDF Monitoring of Cerebral Blood Flow Decline

W Wang, X Liu, H Lu, L Liu, Y Wang, Y Yu, T Zhang

Journal of Neuroscience Methods (Elsevier) China, 20 September 2019

Neuroscience

Key words: Global cerebral ischemia-reperfusion injury, Laser Doppler flowmetry, Pulsinelli's four-vessel occlusion method, cerebral blood flow decline

Organism: Rat

Tissue: Brain

167
Magnesium Sulfate Mitigates the Progression of Monocrotaline Pulmonary Hypertension in Rats

CY Chang, HJ Shih, IT Huang, PS Tsai, KY Chen, CJ Huang

International Journal of Molecular Sciences (MDPI) Taiwan, 18 September 2019

Cardiology

Key words: Right heart failure, oxidation, mitochondria, inflammation, inflammasomes, apoptosis

Organism: Rat

Tissue: Lung

Pathological State: Hypertension

168
Diffusion-Weighted MR Imaging to Evaluate Immediate Response to Irreversible Electroporation in a Rabbit VX2 Liver Tumor Model

S Hu, C Sun, B Wang, K Zhou, L Pan, J Shangguan, V Yaghmai, M Figini, Z Zhang

Journal of Vascular and Interventional Radiology (Elsevier) China, 18 September 2019

Oncology

Organism: Rabbit

Tissue: Liver

Pathological State: Cancer

169
Disruption of mitochondrial homeostasis with artemisinin unravels anti-angiogenesis effects via auto-paracrine mechanisms

KH Tsui, MY Wu, LT Lin, ZH Wen, YH Li, PY Chu, CJ Li

Theranostics (NCBI) Taiwan, USA, 17 September 2019

Endocrinology

Key words: artemisinin, mitochondria, VEGF, angiogenesis, auto-paracrine

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

170
Murine iPSC-derived microglia and macrophage cell culture models recapitulate distinct phenotypical and functional properties of classical and alternative neuro-immune polarisation

A Quarta, D Le Blon, T D'aes, Z Pieters, SH Taj, F Miro-Mur, E Luyckx, E Van Breedam, J Daans, H Goossens, S Dewilde, N Hens, V Pasque, AM Planas, M Hoehn, Z Berneman, P Ponsaerts

Brain, Behavior, and Immunity (Elsevier) Belgium, Germany, Spain, The Netherlands, 13 September 2019

Immunology, Neuroscience

Key words: iPSC, Microglia, Macrophages, Stroke, Neuroinflammation, Interleukin (IL) 13, Polarisation, Classical activation, Alternative activation

Organism: Mouse

Tissue: Brain

171
The Effect of Wharton Jelly-Derived Mesenchymal Stromal Cells and Their Conditioned Media in the Treatment of a Rat Spinal Cord Injury

Milada Chudickova ,Irena Vackova ,Lucia Machova Urdzikova ,Pavlina Jancova ,Kristyna Kekulova ,Monika Rehorova ,Karolina Turnovcova ,Pavla Jendelova and Sarka Kubinova

International Journal of Molecular Sciences (MDPI) Czech Republic, 12 September 2019

Neuroscience

Key words: spinal cord injury; mesenchymal stem cells; Wharton’s jelly; conditioned medium; cell secretome; cell therapy

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

172
Next-generation computational tools for interrogating cancer immunity

F Finotello, D Rieder, H Hackl, Z Trajanoski

Nature Reviews Genetics (Nature) Austria, 12 September 2019

Oncology

Key words: Antigen presentation, Cancer genetics, Cancer genomics, Cancer immunotherapy, Computational biology and bioinformatics, Tumor immunology

173
Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

X Wu, C Lei, T Xia, X Zhong, Q Yang, HB Shu

Nature communications (Nature) China, 11 September 2019

Immunology

Key words: Bacterial Infection, Innate immune cells, Pattern recognition receptors, Ubiquitylation

Organism: Mouse

Tissue: Lung

174
Region-specific parasympathetic nerve remodeling in the left atrium contributes to creation of a vulnerable substrate for atrial fibrillation

G Gussak, A Pfenniger, L Wren, M Gilani, W Zhang, S Yoo, DA Johnson, A Burrell, B Benefield, G Knight, BP Knight, R Passman, JJ Goldberger, G Aistrup, JA Wasserstrom, Y Shiferaw, R Arora

JCI Insight (American Society of Clinical Investigation) USA, 10 September 2019

Neuroscience

Organism: Dog

Tissue: Heart

175
Region specific parasympathetic nerve remodeling in the left atrium contributes to creation of a vulnerable substrate for atrial fibrillation

Georg Gussak, Anna Pfenniger, Lisa M. Wren, Mehul Gilani, Wenwei Zhang, Shin Yoo, David A. Johnson, Amy Burrell, Brandon Benefield, Gabriel M. Knight, Bradley P. Knight, Rod Passman, Jeffrey J. Goldberger, Gary Aistrup, J. Andrew Wasserstrom, Yohannes Shiferaw, and Rishi Arora

The Journal of Clinical Investigation (Am Soc Clin Investig) USA, 10 September 2019

Cardiology

Organism: Mouse

Tissue: Heart

176
Calcium‐sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice

Cheng Z, Li A, Tu CL, Santa Maria C, Szeto N, Herberger A, Chen TH, Song F, Wang J, Liu X, Shoback DM, Chang W

Journal of Bone and Mineral Research (Wiley) USA, 09 September 2019

Osteology

Key words: chondrogenesis, osteogenesis, endochondral bone formation, cartilage, chondrocyte, osteoblast, CaSR knockout, unfixed fracture, fracture healing

177
Worm-Based Alternate Assessment of Probiotic Intervention against Gut Barrier Infection

J Kim, Y Moon

Nutrients (MDPI) South Korea, 08 September 2019

Immunology

Key words: Gut health, Probiotics, Caenorhabditis elegans, Epithelial barrier infection

Organism: Mouse

Tissue: Colon

Pathological State: Worm Infestation

178
Loss of smooth muscle CYB5R3 amplifies angiotensin-II induced hypertension by increasing sGC heme oxidation

BG Durgin, SA Hahn, HM Schmidt, MP Miller, N Hafeez, I Mathar, D Freitag, P Sandner, AC Straub

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, Germany, 05 September 2019

Cardiology

Organism: Mouse

Tissue: Heart

179
ATMIN is a tumor suppressor gene in lung adenocarcinoma

Hanna Foster, E. Josue Ruiz, Christopher Moore, Gordon W H Stamp, Emma L Nye, Ningning Li, Yihang Pan, Yulong He, Julian Downward, Axel Behrens

Cancer Research (AACR) UK, 03 September 2019

Oncology

180
Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer

TT Wei, YT Lin, SP Tang, CK Luo, CT Tsai, CT Shun, CC Chen

Oncogene (Nature) Taiwan, 02 September 2019

Oncology

Key words: Cancer therapeutic resistance, Tumor angiogenesis

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Cancer

181
Novel Semi-Replicative Retroviral Vector Mediated Double Suicide Gene Transfer Enhances Antitumor Effects in Patient-Derived Glioblastoma Models

M Lee, YS Kim, K Lee, M Kang, H Shin, JW Oh, H Koo, D Kim, Y Kim, DS Kong, DH Nam, H Won Lee

Cancers (MDPI) South Korea, 31 August 2019

Oncology

Key words: glioblastoma; patient-derived glioblastoma stem-like cells; semi- and pseudotyped-retroviral replicating vector; dual suicide gene therapy; bystander effect

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

182
The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain

E Nasyrov, KA Nolan, RH Wenger, HH Marti, R Kunze

The FASEB Journal (FASEB) Germany, Switzerland, 30 August 2019

Neuroscience

Key words: PHD, HIF, VEGF, Adrenomedullin, Cerebral angiogenesis

Organism: Mouse

Tissue: Brain

183
Insights into Early Recovery from Influenza Pneumonia by Spatial and Temporal Quantification of Putative Lung Regenerating Cells and by Lung Proteomics

JWJ Ong, KS Tan, SG Ler, J Gunaratne, H Choi, JE Seet, VTK Chow

Cells (MDPI) Singapore, 26 August 2019

Pulmonology

Key words: influenza; pneumonia; lung regeneration; stem cells; comparative quantification; P63; KRT5; proliferating alveolar type II cells; proteomics

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia

184
Macrophage HIF‐2α regulates tumor‐suppressive Spint1 in the tumor microenvironment

Rosa M. Susen, Rebekka Bauer, Catherine Olesch, Dominik C. Fuhrmann, Annika F. Fink, Nathalie Dehne, Arpit Jain, Ingo Ebersberger, Tobias Schmid, Bernhard Brüne

Molecular Carcinogenesis (Wiley) Germany, 22 August 2019

Oncology

Key words: HAI‐1, HGF, hypoxia, proliferation, tumor‐associated macrophages

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

185
Nononcogenic restoration of the intestinal barrier by E. coli–delivered human EGF

M Yu, J Kim, JH Ahn, Y Moon

The Journal of Clinical Investigation (Am Soc Clin Investig) South Korea, 22 August 2019

Microbiology

Organism: Mouse

Tissue: Small Intestine

Pathological State: Colitis

186
Microstimulation of primate neocortex targeting striosomes induces negative decision-making

S Amemori, K Amemori, T Yoshida, GK Papageorgiou, R Xu, H Shimazu, R Desimone, AM Graybiel

European Journal of Neuroscience (Wiley) USA, 20 August 2019

Neuroscience

Key words: anterior cingulate cortex; approach-avoidance; microstimulation; orbitofrontal cortex; striatum

Organism: Monkey

Tissue: Brain

187
Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity

Z Tang, S Cheng, Y Sun, Y Zhang, X Xiang, Z Ouyang, X Zhu, B Wang, M Hei

Experimental Neurology (Elsevier) China, 20 August 2019

Neuroscience

Key words: Hypoxia-ischemia(HI), Neuroprotection, Brain injuries, Hippocampus, Toll-like receptor 4, Rat model

Organism: Rat

Tissue: Brain

Pathological State: Hypoxic-Ischemic Brain Damage

188
IL‐10 from plasmacytoid dendritic cells promotes angiogenesis in the early stage of endometriosis

JL Suen, Y Chang, YS Shiu, CY Hsu, P Sharma, CC Chiu, YJ Chen, TC Hour, EM Tsai

The Journal of Pathology (Wiley) Taiwan, 16 August 2019

Reproductive Medicine

Key words: Angiogenesis, Endometriosis, IL-10, Plasmacytoid dendritic cell, Zebrafish

Organism: Human, Mouse

Tissue: Endometrium

Pathological State: Endometriosis

189
Targeting the IL-17 receptor using liposomal spherical nucleic acids as topical therapy for psoriasis

H Liu, RS Kang, K Bagnowski, JM Yu, S Radecki, WL Daniel, BR Anderson, S Nallagatla, A Schook, R Agarwal, DA Giljohann, AS Paller

Journal of Investigative Dermatology (Elsevier) USA, 15 August 2019

Dermatology

Pathological State: Psoriasis

190
JAK‐STAT inhibition impairs K‐RAS‐driven lung adenocarcinoma progression

Julian Mohrherr, Marcel Haber, Kristina Breitenecker, Petra Aigner, Stefan Moritsch, Viktor Voronin, Robert Eferl, Richard Moriggl, Dagmar Stoiber, Balázs Győrffy, Luka Brcic, Viktória László, Balázs Döme, Judit Moldvay, Katalin Dezső, Martin Bilban, Helmut Popper, Herwig P. Moll, Emilio Casanova

International Journal of Cancer (Wiley) Austria, Hungary, 12 August 2019

Oncology

Key words: non-small cell lung cancer, lung adenocarcinoma (AC), Kirsten rat sarcoma viral proto-oncogene (K-RAS), Janus kinase (JAK),ruxolitinib, cell-line derived xenografts, genetically engineered mouse models, tumor microenvironment (TME), tumor promotinginflammation

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

191
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway

P Guan, ZM Sun, N Wang, J Zhou, LF Luo, YS Zhao, ES Ji

Life Science (Elsevier) China, 11 August 2019

Cardiology

Key words: Resveratrol, Chronic intermittent hypoxia, Cardiac hypertrophy, mTOR

Organism: Rat

Tissue: Heart

Pathological State: Cardiac hypertrophy

192
Antibiotics drive microbial imbalance and vitiligo development in mice

Emilia R. Dellacecca, Cormac Cosgrove, Zhussipbek Mukhatayev, Suhail Akhtar, Victor H. Engelhard, Alfred W. Rademaker, Katherine Knight, I. Caroline Le Poole

Journal of Investigative Dermatology (Elsevier) USA, Kazakhstan, 09 August 2019

Dermatology

Key words: Vitiligo, Microbiome, Pseudomonas, T cells

Organism: Mouse

Tissue: Small Intestine, Colon

Pathological State: Vitiligo

193
Phosphatidylethanolamine binding protein-4 (PEBP4) is increased in IgA nephropathy and is associated with IgA-positive B-cells in affected kidneys

S Taylor, K Pieri, P Nanni, J Tica, J Barratt, A Didangelos

Journal of Autoimmunity (Elsevier) UK, 09 August 2019

Immunology

Key words: IgA nephropathy (IgAN), PEBP4, Urine, Proteomics, Biomarker, B-Cells

Organism: Human

Tissue: Kidney

Pathological State: IgA nephropathy

194
Overexpression of Histone H3 Lysine 27 Trimethylation Is Associated with Aggressiveness and Dedifferentiation of Thyroid Cancer

CC Tsai, MN Chien, YC Chang, JJ Lee, SH Dai, SP Cheng

Endocrine Pathology (Springer) Taiwan, 08 August 2019

Oncology

Key words: H3K27me3, EZH2, Thyroid cancer, Immunohistochemistry

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

195
Senescence‐associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15

Y Guo, JL Ayers, KT Carter, T Wang, SK Maden, D Edmonds, PP Newcomb, C Li, C Ulrich, M Yu, WM Grady

Aging cell (Wiley) USA, 06 August 2019

Cell Biology

Key words: Colon organoids, Colorectal cancer, GDF15, microenivronment, senescence

Organism: Human

Tissue: Colon

Pathological State: Cancer

196
Cancer-Derived VEGF-C Increases Chemokine Production in Lymphatic Endothelial Cells to Promote CXCR2-Dependent Cancer Invasion and MDSC Recruitment

JY Chen, YS Lai, PY Chu, SH Chan, LH Wang, WC Hung

Cancers (MDPI) Taiwan, 06 August 2019

Oncology

Key words: vascular endothelial growth factor-C; CXC chemokine receptor 2; lymphovascular niche; myeloid-derived suppressor cells

Organism: Human

Tissue: Breast

Pathological State: Cancer

197
Analysis of Telomere Lengths in p53 Signatures and Incidental Serous Tubal Intraepithelial Carcinomas Without Concurrent Ovarian Cancer

S Asaka, C Davis, SF Lin, TL Wang, CM Heaphy, IM Shih

The American journal Surgical Pathology (Wolters Kluwer) USA, 01 August 2019

Oncology

Key words: ovarian cancer precursor, fallopian tube, p53 signature, serous tubal intraepithelial carcinoma, telomere

198
Increased ILC3s associated with higher levels of IL-1 aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase

Tzu‐Yi Chan, Chia‐Liang Yen, Ya‐Fang Huang, Pei‐Chi Lo, Peter A. Nigrovic, Chia‐Ying Cheng, Wei‐Zhi Wang, Szu‐Yu Wu, Chi‐Chang Shieh

European Journal of Immunology (Wiley) Taiwan, Japan, USA, 26 July 2019

Rheumatology

Key words: Innate lymphoid cells; Chronic granulomatous disease; NADPH oxidase; Reactive oxygen species; Serum-induced arthritis

Organism: Mouse

Tissue: Bone, Connective Tissue

Pathological State: Arthritis

199
Phthalate exposure alters gut microbiota composition and IgM vaccine response in human newborns

Yung-Ning Yang, Yu-Chen S.H. Yang, I-Hsuan Lin, Ying-Yu Chen, Hung-Yun Lin, Chien-Yi Wu, Yu-Tsun Su, Yao-Jong Yang, San-Nan Yang, Jau-Ling Suen

Food and Chemical Toxicology (Elsevier) Taiwan, USA, 26 July 2019

Toxicology

Key words: Di-(2-ethylhexyl) phthalate, Intravenous infusion, Microbiota, Anti-HBsAg-IgM, Newborn

200
An Amyloid-β Targeting Chemical Exchange Saturation Transfer Probe for In Vivo Detection of Alzheimer's Disease

R Wang, C Wang, Z Dai, Y Chen, Z Shen, G Xiao, Y Chen, JN Zhou, Z Zhuang, R Wu

ACS Chemical Neuroscience (ACS Publications) China, 25 July 2019

Neuroscience

Key words: Alzheimer’s disease; Amyloid-β; Magnetic resonance imaging; Chemical exchange saturation transfer; Angiopep-2

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s disease

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