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On May 3rd, TissueGnostics surpassed 1,500 scientific reference publications

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 Most of the 1500 research publications referencing TissueGnostics (over 50%) originated in the United States, Austria, Germany, Taiwan (China) and mainland China.

  

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Customer Publications (A total of 1522 papers published)

801
Towards personalised treatment in primary Sjögren's syndrome: baseline parotid histopathology predicts responsiveness to rituximab treatment

Konstantina Delli, Erlin A Haacke, Frans G M Kroese, Rodney P Pollard, Stephan Ihrler, Bert van der Vegt, Arjan Vissink, Hendrika Bootsma, Frederik K L Spijkervet

Annals of the Rheumatic Diseases (High Wire) The Netherlands, Germany, 15 January 2016

Rheumatology

Key words: Sjögren's syndrome, parotid histopathology, responsiveness to rituximab treatment

Organism: Human

Pathological State: Sjögren's Syndrome

802
Low birth weight associates with hippocampal gene expression

J.P. Buschdorf, M.L. Ong, S.X. Ong, J.L. MacIsaac, K. Chng, M.S. Kobor, M.J. Meaney, J.D. Holbrook

Neuroscience (Elsevier) Singapore, Canada, 12 January 2016

Neuroscience

Key words: Low birth weight, hippocampus, DNA methylation, mental disorders, microarray

Organism: Monkey

Tissue: Brain

803
Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease

Meliana Riwanto, Sarika Kapoor, Daniel Rodriguez, Ilka Edenhofer, Stephan Segerer, Rudolf P. Wüthrich

PLoS One (PLOS) Switzerland, 11 January 2016

Nephrology

Key words: Kidneys, glycolysis, renal system, epithelial cells, glucose metabolism, apoptosis, ERK signaling cascade, polycystic kidney disease

Organism: Rat

Tissue: Kidney

Pathological State: Polycystic Kidney Disease

804
Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer

Leila Akkari, Vasilena Gocheva, Marsha L. Quick, Jemila C. Kester, Alison K. Spencer, Alfred L. Garfall, Robert L. Bowman, Johanna A. Joyce

Genes and Development (CHS Press) USA, Switzerland, 10 January 2016

Oncology

Key words: Cathepsin protease, compensatory mechanism, cancer

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

805
Toll-Like Receptor 4 Is Essential in the Development of Abdominal Aortic Aneurysm

Chao-Han Lai, Kuan-Chieh Wang, Fang-Tzu Lee, Hung-Wen Tsai, Chih-Yuan Ma, Tsung-Lin Cheng, Bi-Ing Chang, Yu-Jen Yang, Guey-Yueh Shi, Hua-Lin Wu

PLoS One (PLOS) Taiwan, 07 January 2016

Immunology

Key words: Macrophages, immune receptor signaling, aneurysms, inflammation, toll-like receptors, aorta, small interfering RNAs, cytokines

Organism: Mouse

Tissue: Kidney

806
The single-chain anti-TNF-a antibody DLX105 induces clinical and biomarker responses upon local administration in patients with chronic plaque-type psoriasis

Athanasios Tsianakas, Patrick M. Brunner, Kamran Ghoreschi, Claudia Berger, Karin Loser, Martin Röcken, Georg Stingl, Thomas Luger, Thomas Jung

Experimental Dermatology (Wiley) Germany, Austria, Switzerland, 06 January 2016

Dermatology

Key words: Psoriasis, TNF-alpha, TNF-alpha-blocker

Organism: Human

Tissue: Skin

Pathological State: Psoriasis

807
3, 4-Dihydroxy-L-phenylalanine as a novel covalent linker of extracellular matrix proteins to polyacrylamide hydrogels with a tunable stiffness

Olaf Y. Wouters, Diana T.A. Ploeger, Sander M. van Putten, and Ruud A. Bank

Tissue Engineering Part C (Mary Ann Liebert Inc.) The Netherlands, 05 January 2016

Regenerative Medicine

Key words: Tissue Enigneering, 3,4-Dihydroxy-L-Phenylalanine, Linker, Extracellular Matrix, Hydrogel, Stiffness

Organism: Human

Cell Line: Human dermal fetal fibroblasts

808
T1 Mapping by CMR Imaging : From Histological Validation to Clinical Implication

Andreas A. Kammerlander, Beatrice A. Marzluf, Caroline Zotter-Tufaro, Stefan Aschaue, Franz Duca, Alina Bachman, Klaus Knechtelsdorfer, Matthias Wiesinger, Stefan Pfaffenberge, Andreas Greiser Irene M. Lang, Diana Bonderman, Julia Mascherbauer

JACC: Cardiovascular Imaging (Elsevier) Austria, Germany, 01 January 2016

Cardiology

Key words: CMR imaging, histological validation

Organism: Human

Tissue: Heart

809
N-octanoyl dopamine attenuates the development of transplant vasculopathy in rat aortic allografts via smooth muscle cell protective mechanisms

J Wedel, MC Hottenrott, M Bulthuis, S Huitema, BA Yard, JK Hillebrands

Transplantation (Wolters Kluwer) The Netherlands, Germany, 01 January 2016

Transplantation Medicine

Key words: N-octanoyl Dopamine, Transplant Vasculopathy, Aortic Allografts, Smooth Muscle Cells, Protective Mechanisms

Organism: Rat

Tissue: Blood Vessels

810
The anti-inflammatory compound curcumin enhances locomotor and sensory recovery after spinal cord injury in rats by immunomodulation

Lucia Machova Urdzikova , Kristyna Karova , Jiri Ruzicka , Anna Kloudova , Craig Shannon , Jana Dubisova , Raj Murali , Sarka Kubinova , Eva Sykova , Meena Jhanwar-Uniyal and Pavla Jendelova

International Journal of Molecular Sciences (MDPI) Czech Republic, USA, 31 December 2015

Neuroscience

Key words: spinal cord injury; curcumin; inflammation; cytokines; secondary processes; NF-κB

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

811
Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters

Elisabeth Strak, Isabella Ellinger, Christina Balthasar, Matthias Scheinast, Jasmin Schatz, Tamara Szattler, Sonja Bleichert, Leila Saleh, Martin Knöfler, Harald Zeisler, Markus Hengstschläger, Margit Rosner, Hans Salzer, Claudia Gundacker

Toxicology (Elsevier) Austria, 29 December 2015

Toxicology

Key words: Mercury, placenta, amino acid transporters

Organism: Human

Tissue: Placenta

812
Long-term in vitro expansion of salivary gland stem cells driven by Wnt signals

Martti Maimets, Cecilia Rocchi, Reinier Bron, Sarah Pringle, Jeroen Kuipers, Ben N.G. Giepmans, Robert G.J. Vries, Hans Clevers, Gerald de Haan, Ronald van Os, Robert P. Coppes

Stem Cell Reports (Elsevier) The Netherlands, 24 December 2015

Stem Cell Research

Key words: In Vitro Expansion, Salivary Gland, Stem Cells, Wnt

Organism: Mouse

Tissue: Salivary Gland

813
Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals

Martti Maimets, Cecilia Rocchi, Reinier Bron, Sarah Pringle, Jeroen Kuipers, Ben N.G. Giepmans, Robert G.J. Vries, Hans Clevers, Gerald de Haan, Ronald van Os, Robert P. Coppes

Stem Cell Reports (Elsevier) The Netherlands, 24 December 2015

Stem Cell Research

Key words: Stem cells, in vitro expansion, wnt signals

Organism: Human

Tissue: Salivary Gland

814
Co-culture of placental explants with isolated CD4 and CD8 T cells: a functional model to define the consequences of placental inflammation

Hayley Derricott, Rebecca L. Jones, Alexander E.P. Heazell, Susan L. Greenwood

Journal of Biological Methods (Springer) UK, 22 December 2015

Reproductive Medicine

Key words: inflammation, placenta, T lymphocytes, villitis, VUE

Organism: Human

Cell Line: Placental T-cells

815
Mycolic acid-specific T cells protect against Mycobacterium tuberculosis infection in a humanized transgenic mouse model

J Zhao, S Siddiqui, S Shang, Y Bian, S Bagchi, Y He, CR Wang

eLife (eLife Sciences Publications) USA, 10 December 2015

Microbiology

Key words: Mycolic acid-specific T cells, Mycobacterium tuberculosis, humanized transgenic mouse model

Organism: Mouse

Tissue: Lung

Pathological State: Bacterial Infection

816
Reproductive periodicity, spawning induction, and larval metamorphosis of the hemichordate acorn worm Ptychodera flava

Ching-Yi Lin, Che-Huang Tung, Jr-Kai Yu, Yi-Hsien Su

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution (Wiley) Taiwan, 10 December 2015

Zoology

Key words: Reproductive periodicity, larval metamorphosis, hemichordate

Organism: Acorn worm

Tissue: Penis

817
Low Hodgkin/Reed-Sternberg Cell Density Assessed with Automated Image Analysis Is a Poor Prognostic Factor in Classic Hodgkin Lymphoma Patients

Vit Prochazka, Tereza Dyskova, Zuzana Prouzova, Tomas Papajik, Jiri Minarik, Juraj Duras, Jozef Michalka, Alice Sykorova, Peter Mikula, Ludek Raida and Eva Kriegova

Blood (American Society of Hematology) Czech Republic, 03 December 2015

Oncology

Key words: Cell Density, Automated Image Analysis, Prognostic Factor, Hodgkin Lymphoma

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

818
Quantitative Analysis of Tissue Inflammation and Responses to Treatment in Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked (IPEX) Syndrome and Review of Literature

Chih-An Chen, Wan-Chen Chung, Yuan-Yow Chiou, Yao-Jong Yang, Yung-Chieh Lin, Hans D. Ochs, Dr. Chi-Chang Shieh

Journal of Microbiology, Immunology and Infection (Elsevier) Taiwan, USA, 01 December 2015

Immunology, Microbiology

Key words: Immune dysregulation, polyendocrinopathy, enteropathy, X-Linked (IPEX) syndrome, regulatory T cells, T helper 2 cells

Organism: Human

Tissue: Small Intestine

Pathological State: Endocrinopathy, Enteropathy, X-linked syndrome

819
Hirsutella sinensis mycelium attenuates bleomycin-induced pulmonary inflammation and fibrosis in vivo

TT Huang, HC Lai, YF Ko, DM Ojcius, YW Lan, J Martel, JD Young,

J Cancer Treat Diagnosis (Nature) Taiwan, USA, 26 November 2015

Microbiology

Key words: Drug development, Inflammasome

Organism: Human

Tissue: Lung

Pathological State: Inflammation, Fibrosis

820
Dynamic Trk and G Protein Signalings Regulate Dopaminergic Neurodifferentiation in Human Trophoblast Stem Cells

Eing-Mei Tsai, Yu-Chih Wang, Tony Tung-Yin Lee, Cheng-Fang Tsai, Hung-Sheng Chen, Feng-Jie Lai, Kazunari K. Yokoyama, Tsung-Hsun Hsieh, Ruey-Meei Wu, Jau-nan Lee

PLoS One (PLOS) Taiwan, USA, 25 November 2015

Neuroscience

Key words: Neurons, DNA transcription, G-protein signaling, stem cells, genomic signal processing, retinoic acid signaling cascade, retinoid signaling, neuronal differentiation

Organism: Human

Cell Line: hTS cells

821
Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma

Cheng-Fang Tsai, Tsung-Hua Hsieh, Jau-Nan Lee, Chia-Yi Hsu, Yu-Chih Wang, Kung-Kai Kuo, Hua-Lin Wu, Chien-Chih Chiu, Eing-Mei Tsa, and Po-Lin Kuo

Journal of Agricultural Food Chemistry (ACS Publications) Taiwan, 20 November 2015

Oncology

Key words: Phthalate, curcumin, hepatocellular carcinoma, metastasis, side population, cancer stem cells

Organism: Mouse

Tissue: Liver, Lung

822
Alpha-Actinin 4 Is Associated with Cancer Cell Motility and Is a Potential Biomarker in Non–Small Cell Lung Cancer

MC Wang, YH Chang, CC Wu, YC Tyan, HC Chang, YG Goan, WW Lai, PN Cheng, PC Liao

Journal of Thoracic Oncology (Elsevier) Taiwan, 20 November 2015

Oncology

Key words: ACTN4, non–small-cell lung cancers, CL1-0 and CL1-5 cell lines, siRNA

Organism: Human

Tissue: Lung

Pathological State: Cancer

823
MiR-125b is critical for fibroblast-to-myofibroblast transition and cardiac fibrosis

Varun Nagpal , Rahul Rai , Aaron T. Place , Sheila B. Murphy , Suresh K. Verma , Asish K. Ghosh , and Douglas E. Vaughan

Circulation (AHA Journals) USA, 19 November 2015

Cardiology

Key words: RNA sequence, fibrosis, angiotensin II, transforming growth factor, miR-125b

Organism: Mouse

Tissue: Heart

Pathological State: Fibrosis

824
CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow

A Nakamura-Ishizu, K Takubo, H Kobayashi, K Suzuki-Inoue, T Suda

Journal of Experimental Medicine (Rockefeller University Press) Japan, 09 November 2015

Stem Cell Research

Key words: CLEC-2, megakaryocyte, hematopoietic stem cells, bone marrow

Organism: Mouse

Tissue: Bone Marrow

825
IMPS-11 Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma

Seunggu Han, Gerald Reis, Gary Kohanbash, Shruti Srivastav, Stephen Magill, Annette Molinaro, Michael McDermott, Philip Theodosopoulos, Manish Aghi, Mitchel Berger, Igor Barani, Joanna Phillips, Arie Perry, Hideho Okada

Neuro-Oncology (Oxford University Press) USA, 09 November 2015

Oncology

Key words: meningioma, patient prognosis, impact, molecule, programmed cell death 1 ligand 1

Organism: Human

Tissue: Brain

Pathological State: Cancer

826
Transdermal drug targeting and functional imaging of tumor blood vessels in the mouse auricle

H Schröder, D Komljenovic, M Hecker, T Korff

The FASEB Journal (FASEB) Germany, 06 November 2015

Oncology

Key words: angiogenesis • blood vessel growth • bortezomib • mouse model • perfusion

Organism: Mouse

Pathological State: Cancer

827
Melanin pigmentation in rat eyes: in vivo imaging by polarization-sensitive optical coherence tomography and comparison to histology

Bernhard Baumann; Johannes Schirmer; Sabine Rauscher; Stanislava Fialová; Martin Glösmann; Marco Augustin; Michael Pircher; Marion Gröger; Christoph K. Hitzenberger

Investigative Ophthalmology and Visual Science (ARVO Journals) Austria, 01 November 2015

Ophthalmology

Key words: Melanin Pigmentation, Eyes, In Vivo Imaging, Polarization-Sensitive Optical Coherence Tomography

Organism: Rat

Tissue: Eye

828
Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-a Production in Women

Morgane Griesbeck, Susanne Ziegler, Sophie Laffont, Nikaïa Smith, Lise Chauveau, Phillip Tomezsko, Armon Sharei, Georgio Kourjian, Filippos Porichis, Meghan Hart, Christine D. Palmer, Michael Sirignano, Claudia Beisel, Heike Hildebrandt, Claire Cénac, Alexandra-Chloé Villani, Thomas J. Diefenbach, Sylvie Le Gall, Olivier Schwartz, Jean-Philippe Herbeuval, Brigitte Autran, Jean-Charles Guéry, J. Judy Chang, and Marcus Altfeld

Journal of Immunology (American Association of Immunologists) France, Germany, UK, Australia, 30 October 2015

Immunology

Key words: Plasmacytoid dendridic cell levels, IRF5

Organism: Human, Mouse

Cell Line: PBMCs (Peripheral blood mononuclear cells )

829
Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury

Shao-Ming Wang, Jung-Yu C. Hsu, Chiung-Yuan Ko, Nai-En Chiu, Wai-Ming Kan, Ming-Derg Lai, Ju-Ming Wang

Molecular Neurobiology (Springer) Taiwan, 28 October 2015

Neuroscience

Key words: Astrogliosis C/EBPd, MMP-3 RhoA, astrocyte migration

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

830
Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy

Nastasia Wilfinger, Shane Austin, Barbara Scheiber-Mojdehkar, Walter Berger, Siegfried Reipert, Monika Praschberger, Jakob Paur, Robert Trondl, Bernhard K. Keppler, Christoph C. Zielinski, and Karin Nowikovsky

Oncotarget (Impact Journals) Austria, 26 October 2015

Oncology

Key words: cancer, p53, BNIP3L, mitophagy, gallium complex

Organism: Human

Pathological State: Cancer

Cell Line: Human colon carcinoma cells

831
Quantitative Image Analysis of Epithelial and Stromal Area in Histological Sections of Colorectal Cancer: An Emerging Diagnostic Tool.

R. Rogojanu, T. Thalhammer, U. Thiem, A. Heindl, I. Mesteri, A. Seewald, W. Jäger, C. Smochina, I. Ellinger, G. Bises

Biomed Research International (Hindawi Publishing Corporation) Austria, Romania, 22 October 2015

Oncology

Key words: Image analysis, histology, colorectal cancer, diagnosis tool

Organism: Human

Tissue: Colon

Pathological State: Cancer

832
Glucose-regulated protein 94 mediates cancer progression via AKT and eNOS in hepatocellular carcinoma

Chien-Yu Huang, Uyanga Batzorig, Wan-Li Cheng, Ming-Te Huang, Wei- Yu Chen, Po-Li Wei, Yu-Jia Chang

Tumor Biology (Springer) Taiwan, Mongolia, 22 October 2015

Oncology

Key words: GRP94 HCC eNOS AKT Proliferation

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

833
Redox Regulation of Pro-IL-1β Processing May Contribute to the Increased Severity of Serum-Induced Arthritis in NOX2-Deficient Mice

Ya-Fang Huang, Pei-Chi Lo, Chia-Liang Yen, Peter Andrija Nigrovic, Wen-Chen Chao, Wei-Zhi Wang, George Chengkang Hsu, Yau-Sheng Tsai, and Chi-Chang Shieh

Antioxidants and Redox Signaling (Mary Ann Liebert Inc.) Taiwan, USA, 21 October 2015

Rheumatology

Key words: Redox Regulation,Pro-IL-1β,Serum-Induced Arthritis, NOX2

Organism: Mouse

Tissue: Bone, Connective Tissue

Pathological State: Rheumatoid Arthritis

834
An Emerging Approach for Parallel Quantification of Intracellular Protozoan Parasites and Host Cell Characterization Using TissueFAXS Cytometry

Maximilian Schmid, Bianca Dufner, Julius Dürk, Konstanze Bedal, Kristina Stricker, Lukas Ali Prokoph, Christoph Koch, Anja K. Wege, Henner Zirpel, Ger van Zandbergen, Rupert Ecker, Bogdan Boghiu, Uwe Ritter

PLoS One (PLOS) Germany, Austria, 21 October 2015

Parasitology

Key words: Macrophages, parasitic diseases, host cells, leishmania major, DAPI staining, cell staining, host-pathogen interactions, intracellular pathogens

Organism: Mouse

Pathological State: Parasitic Infection

Cell Line: Makrophages

835
The Role of Lysophosphatidic Acid on Airway Epithelial Cell Denudation in a Murine Heterotopic Tracheal Transplant Model

Yukiko Tando, Chiharu Ota, Mitsuhiro Yamada, Satoshi Kamata, Mutsuo Yamaya, Kuniyuki Kano, Shinichi Okudaira, Junken Aoki, and Hiroshi Kubo,

Transplantation (Wolters Kluwer) Japan, 19 October 2015

Transplantation Medicine

Key words: Lysophosphatidic Acid, Airway Epithelial Cells, Denudation, Murine Heterotopic Tracheal Transplant Model

Organism: Mouse

Cell Line: BEAS-2B cells

836
Development of recombinant collagen-peptide-based vehicles for delivery of adipose-derived stromal cells (ADSC)

M. Parvizi, J.A. Plantinga, C. van Spreuwel-Goossens, S. van Dongen, S. G. Kluijtmans, M.C. Harmsen

Journal of Biomedical Materials Research (Wiley) The Netherlands, 14 October 2015

Biological Materials

Key words: Recombinant-Collagen Microspheres, integrin binding motives, crosslinked, ADSC, delivery

Organism: Human

Cell Line: Adipose tissue derived stromal cells (ADSC)

837
Cardioprotective Actions of TGFßRI Inhibition Through Stimulating Autocrine/Paracrine of Survivin and Inhibiting Wnt in Cardiac Progenitors

Yu-Sian Ho, Wan-Hsuan Tsai, Fen-Chiung Lin, Wei-Pang Huang, Lung-Chun Lin, Sean M. Wu, Yu-Ru Liu, Wen-Pin Chen

Stem Cells (Wiley) Taiwan, USA, 10 October 2015

Stem Cell Research

Key words: Nkx2.5, sca1, Birc5, survivin, MEK/ERK, Wnt3a

Organism: Mouse

Tissue: Heart

Pathological State: Fibrosis

838
YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased Fibroblasts

Bram Piersma, Saskia de Rond, Paul M.N. Werker, Stellar Boo, Boris Hinz, Marike M. van Beuge, Ruud A. Bank

The American Journal of Pathology (Elsevier) The Netherlands, Canada, 10 October 2015

Pathology

Key words: Myofibroblast, fibroblasts, YAP 1

Organism: Human

Pathological State: Dupuytren's Disease

Cell Line: Dermal fibroblasts

839
The pro-fibrotic properties of transforming growth factor on human fibroblasts are counteracted by caffeic acid by inhibiting myofibroblast formation and collagen synthesis

Masum M. Mia, Ruud A. Bank

Cell and Tissue Research (Springer) The Netherlands, 09 October 2015

Cell Biology

Key words: Fibrosis, collagen, myofibroblasts, caffeic acid, lysyl hydroxylase

Organism: Human

Cell Line: HDFa and HLFa Fibroblasts

840
Characterization of sulfur mustard resistant keratinocyte cell line HaCaT/SM

Wolf Markus, Siegert Markus, Rothmiller Simone, Scheithauer Nina, Strobelt Romano, Steinritz Dirk, Thiermann Horst, Schmidt Annette

Toxicology Letters (Elsevier) Germany, 09 October 2015

Toxicology

Key words: Sulfur mustard, resistance, keratinocytes

Organism: Human

Cell Line: HaCaTs (human keratinocyte cell line )

841
YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model

Tsion Zewdu Minas, Jenny Han, Tahereh Javaheri, Sung-Hyeok Hong, Michaela Schlederer, Yasemin Saygideğer-Kont, Haydar Çelik, Kristina M. Mueller, Idil Temel, Metin Özdemirli, Heinrich Kovar, Hayriye Verda Erkizan, Jeffrey Toretsky, Lukas Kenner, Richard Moriggl,and Aykut Üren

Oncotarget (Impact Journals) USA, Austria, 08 October 2015

Oncology

Key words: EWS-FLI1, ETS fusion proteins, YK-4-279, ewing sarcoma, erythoid leukemia

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

842
Synergy of endothelial and neural progenitor cells from adipose-derived stem cells to preserve neurovascular structures in rat hypoxic-ischemic brain injury

Yuan-Yu Hsueh, Ya-Ju Chang, Chia-Wei Huang, Fitri Handayani, Yi-Lun Chiang, Shih-Chen Fan, Chien-Jung Ho, Yu-Min Kuo, Shang-Hsun Yang, Yuh-Ling Chen, Sheng-Che Lin, Chao-Ching Huang and Chia-Ching Wu

Scientific Reports (Nature) Taiwan, 08 October 2015

Neuroscience

Key words: Neural progenitors, stem cells, brain injury

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

843
Sympathetic Neurotransmitters Modulate Osteoclastogenesis and Osteoclast Activity in the Context of Collagen-Induced Arthritis

Dominique Muschter, Nicole Schäfer, Hubert Stangl, Rainer H. Straub, Susanne Grässel

PLoS One (PLOS) Germany, 02 October 2015

Rheumatology

Key words: Osteoclasts, neurotransmitters, arthritis, macrophages, apoptosis, gene expression, adenylyl cyclase, immune receptors

Organism: Human

Pathological State: Cancer

Cell Line: SAOS2 cells (primary osteogenic sarcoma cells)

844
Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis

Eva Hainzl, Silvia Stockinger, Isabella Rauch, Susanne Heider, David Berry, Caroline Lassni, Clarissa Schwab, Felix Rosebrock, Gabriel Milinovich, Michaela Schlederer, Michael Wagner, Christa Schleper, Alexander Loy, Tim Urich, Lukas Kenner, Xiaonan Han, Thomas Decker, Birgit Strobl, Mathias Müller

The Journal of Immunology (American Association of Immunologists) Austria, USA, 02 October 2015

Gastroenterology

Key words: Intestinal epithelial cell, acute colitis

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

845
The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence

Monika Maleszewska, Byambasuren Vanchin, Martin C. Harmsen, Guido Krenning

Angiogenesis (Springer) The Netherlands, Germany, 28 September 2015

Cell Biology

Key words: Endothelial cell, enhancer of zeste homolog-2 (EZH2), fluid shear stress (FSS), mechanotransduction, chromatin

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

846
Putative Prostate Cancer Risk SNP in an AR Binding Site of the Melanophilin Gene Illustrates Enrichment of Risk SNPs in AR Target Sites

Huajie Bu, Narisu Narisu, Bettina Schlick, Johannes Rainer, Thomas Manke, Georg Schäfer, Lorenza Pasqualini, Peter Chines, Michal R. Schweiger, Christian Fuchsberger, Helmut Klocker

Human Mutation (Wiley) Austria, Germany, Italy, USA, 28 September 2015

Oncology

Key words: Prostate cancer, risk SNPs, androgen receptor, melanophilin, MLPH;androgen regulation, AR

Organism: Human

Tissue: Prostate

Pathological State: Cancer

847
A sunblock based on bioadhesive nanoparticles

Y Deng, A Ediriwickrema, F Yang, J Lewis, M Girardi, WM Saltzman

Nature Materials (Nature) USA, 28 September 2015

Nanomedicine

Key words: Biomedical engineering, Drug delivery

Organism: Mouse

Tissue: Skin

848
Amelioration of Chemotherapy-Induced Intestinal Mucositis by Orally Administered Probiotics in a Mouse Model

Chun-Yan Yeung , Wai-Tao Chan , Chun-Bin Jiang, Mei-Lien Cheng, Chia-Yuan Liu, Szu-Wen Chang, Jen-Shiu Chiang Chiau, Hung-Chang Lee

PLoS One (PLOS) Taiwan, 25 September 2015

Oncology

Key words: Probiotics, gastrointestinal tract, diarrhea, mouse models, cytokines, jejunum, lactobacillus, cancer treatment

Organism: Mouse

Tissue: Small Intestine

Pathological State: Mucositis

849
The great escape: Pseudomonas breaks out of the lung

A Zhang, SM Rangel, AR Hauser

Microbial Cell (NCBI) USA, 23 September 2015

Microbiology

Key words: Pseudomonas aeruginosa, ExoS, pneumonia, dissemination

Organism: Mouse

Tissue: Lung

Pathological State: Bacterial Infection

850
Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage

Patricia Aparicio-Domingo, Monica Romera-Hernandez, Julien J. Karrich, Ferry Cornelissen, Natalie Papazian, Dicky J. Lindenbergh-Kortleve, James A. Butler, Louis Boon, Mark C. Coles, Janneke N. Samsom, Tom Cupedo

Journal of Experimental Medicine (Rockefeller University Press) The Netherlands, UK, 21 September 2015

Stem Cell Research

Key words: Type 3 innate lymphoid cells, intestinal epithelial stem cells, tissue damage

Organism: Mouse

Tissue: Small Intestine, Colon

851
Bone marrow micro-environmental CD4+ and CD8+ lymphocyte infiltration patterns define overall- and progression free survival in standard risk Multiple Myeloma – an analysis from the Austrian Myeloma Registry

Wolfgang Willenbacher, Ella Willenbacher, Claudia Zelle-Rieser, Rainer Biedermann, Roman Weger, Karin Jöhrer, Andrea Brunner

Leukemia and Lymphoma (Taylor and Francis) Austria, 19 September 2015

Oncology

Key words: Bone marrow, lymphocite infiltration, myeloma

Organism: Human

Tissue: Bone

Pathological State: Cancer

852
Quantitative functional MRI in a clinical orthotopic model of pancreatic cancer in immunocompetent Lewis rats

Zhuoli Zhang, Linfeng Zheng, Weiguo Li, Andrew C Gordon, Yi Huan, Junjie Shangguan, Daniel Procissi, David J Bentrem, Andrew C Larson

American Journal of Translational Research (e-Century Publishing Corporation) USA, China, 15 September 2015

Oncology

Key words: Magnetic resonance imaging, imaging biomarker, pancreatic cancer, immunocompetent Lewis rats

Organism: Rat

Tissue: Pancreas

Pathological State: Cancer

853
Nuclear HDAC6 inhibits invasion by suppressing NF-κB/MMP2 and is inversely correlated with metastasis of non-small cell lung cancer

CJ Yang, YP Liu, HY Dai, YL Shiue, CJ Tsai, MS Huang, YT Yeh

Oncotarget (Impact Journals) Taiwan, 15 September 2015

Oncology

Key words: HDAC6, NF-κB, MMP2, metastasis, lung cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

854
Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences

Aswin Mangerich, Malgorzata Debiak, Matthias Birtel, Viviane Ponath, Frank Balszuweit, Kirsten Lex, Rita Martello, Waltraud Burckhardt-Boer, Romano Strobelt, Markus Siegert, Horst Thiermanb, Dirk Steinritz, Annette Schmidt, Alexander Bürkle

Toxicology Letters (Elsevier) Germany, 14 September 2015

Toxicology

Key words: Poly(ADP-ribose), PARP inhibitors, sulfur mustard, nitrogen mustard, genotoxicity, HaCaT, mass spectrometry, micronucleus

Organism: Human

Cell Line: HaCaTs (human keratinocyte cell line )

855
Efficient therapy of ischaemic lesions with VEGF121-fibrin in an animal model of systemic sclerosis.

Allipour Birgani S, Mailänder M, Wasle I, Dietrich H, Gruber J, Distler O, Sgonc R

Annals of the Rheumatic Diseases (BMJ Journals) Austria, Switzerland, 11 September 2015

Rheumatology

Key words: Outcomes research, systemic sclerosis, treatment

Organism: Chicken

Tissue: Skin

Pathological State: Systemic Sclerosis

856
The ß-catenin signaling pathway induces aggressive potential in breast cancer by up-regulating the chemokine CCL5

Rika Yasuhara, Tarou Irié, Kenya Suzuki, Terumasa Sawada, Noriko Miwa, Akiko Sasaki, Yuko Tsunoda, Seigo Nakamura, Kenji Mishima

Experimental Cell Research (Elsevier) Japan, 10 September 2015

Oncology

Key words: ß-Catenin, metastasis, breast cancer, cytokines, CCL5

Organism: Human

Tissue: Breast

Pathological State: Cancer

857
Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling

S Kaduwal, WJ Jeong, JC Park, KH Lee, YM Lee, SH Jeon, YB Lim, DS Min, KY Choi

Oncotarget (Impact Journals) South Korea, 05 September 2015

Oncology

Key words: Sur8, Ras, PI3K, cell migration, metastasis

Organism: Human

Tissue: Skin

Pathological State: Cancer

858
The IκB kinase inhibitor ACHP strongly attenuates TGF β1‐induced myofibroblast formation and collagen synthesis

Masum M. Mia, Ruud A. Bank

Journal of Cellular and Molecular Medicine (Wiley) The Netherlands, 04 September 2015

Cell Biology

Key words: Fibrosis, collagen, myofibroblasts, fibronectin, lysyl hydroxylase

Organism: Human

Cell Line: HDFa and HLFa Fibroblasts

859
Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain

Christoph Geisenberger, Andreas Mock, Rolf Warta,Carmen Rapp, Christian Schwager, Andrey Korshunov, Ann-Katrin Nied, David Capper, Benedikt Brors, Christine Jungk, David Jones, V. Peter Collins, Koichi Ichimura, L. Magnus Bäcklund, Elena Schnabel, Michel Mittelbron, Bernd Lahrmann, Siyuan Zheng, Roel G. W. Verhaak, Niels Grabe, Stefan M. Pfister, Christian Hartmann, Andreas von Deimling, Jürgen Debus, Andreas Unterberg, Amir Abdollahi, Christel Herold-Mende

Acta Neuropathologica (Springer) Germany, UK, Japan, Sweden, USA, 01 September 2015

Pathology

Key words: Glioblastoma, molecular profiling, microglia, long-term survival, short-term survival

Organism: Human

Tissue: Brain

Pathological State: Cancer

860
Increased complexity in carcinomas: analyzing and modeling the interaction of human cancer cells with their microenvironment

Mira Stadler, Stefanie Walter, Angelika Walzl, Nina Kramer, Christine Unger, Martin Scherze, Daniela Unterleuthner, Markus Hengstschläger, Georg Krupitza, Helmut Dolznig

Seminars in Cancer Biology (Elsevier) Austria, 28 August 2015

Oncology

Key words: Carcinoma, human cancer cells, microenvironment

861
SPIO-labeled yttrium microspheres for MR imaging quantification of transcatheter intrahepatic delivery in a rodent model

W Li, Z Zhang, AC Gordon, J Chen, J Nicolai, RJ Lewandowski, RA Omary, AC Larson

Radiology (Radiological Society of North America) USA, 27 August 2015

Medical Imaging

Organism: Rat

Tissue: Liver

862
Vascular Proteomics Reveal Novel Proteins Involved in SMC Phenotypic Change: OLR1 as a SMC Receptor Regulating Proliferation and Inflammatory Response

Dong Hoon Kang, Mina Choi, Soyoung Chang, Min Young Lee, Doo Jae Lee, Kyungsun Choi, Junseong Park, Eun Chun Han, Daehee Hwang, Kihwan Kwon, Hanjoong Jo, Chulhee Choi, Sang Won Kang

PLoS One (PLOS) South Korea, 25 August 2015

Cell Biology

Key words: Carotid arteries, small interfering RNAs, transfection, proteomics, membrane proteins, immunohistochemistry techniques, protein interaction networks, network analysis

Organism: Human

Tissue: Blood Vessels

863
Acceleration of atherogenesis in ApoE−/− mice exposed to acute or low-dose-rate ionizing radiation

Mariateresa Mancuso, Emanuela Pasquali, Ignacia Braga-Tanaka, Satoshi Tanaka, Alessandro Pannicelli, Paola Giardullo, Simonetta Pazzaglia, Soile Tapio, Michael J. Atkinson, Anna Saran

Oncotarget (Impact Journals) Italy, Japan, Germany, 22 August 2015

Oncology

Key words: Atherosclerosis, ApoE mice, radiation, aorta

Organism: Mouse

Tissue: Heart, Blood Vessels

864
Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model

M Butinar, M T Prebanda, J Rajkovic, B Jeric, V Stoka, C Peters, T Reinheckel, A Krüger, V Turk, B Turk and O Vasiljeva

Oncogene (Nature) Slovenia, Germany, USA, 19 August 2015

Oncology

Key words: Tumor cells, oxidative stress, breast cancer

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

865
Differential Utilization of Dietary Fatty Acids in Benign and Malignant Cells of the Prostate

Andrea Dueregger, Bernd Schöpf, Theresa Eder, Julia Höfer, Erich Gnaiger, Astrid Aufinger, Lukas Kenner, Bernhard Perktold, Reinhold Ramoner, Helmut Klocker, Iris E. Eder

PLoS One (PLOS) Austria, 18 August 2015

Oncology

Key words: Prostate gland, mitochondria, glucose, glucose metabolism, mitochondrial DNA, fatty acids, cell metabolism, prostate cancer

Organism: Human

Pathological State: Cancer

Cell Line: Prostate Cancer cells

866
Impact of CYP24A1 overexpression on growth of colorectal tumour xenografts in mice fed with vitamin D and soy

Julia Höbaus, Samawansha Tennakoon, Petra Heffeter, Charlotte Groesche, Abhishek Aggarwal, Doris M. Hummel, Ursula Thiem, Rodrig Marculescu, Walter Berger, Enikö Kállay

International Journal of Cancer (Wiley) Austria, 17 August 2015

Oncology

Key words: Colon cancer, vitamin D, CYP24A1, soy, xenograft

Organism: Human

Pathological State: Cancer

Cell Line: HT29 cells (colon cancer cell line)

867
Interleukin 2 Topical Cream for Treatment of Diabetic Foot Ulcer: Experiment Protocol

SWS Chan

JMIR Research Protocols (JMIR Publications) USA, 14 August 2015

Dermatology

Key words: type 1 diabetes, topical cream, chronic wound healing, immunotherapy, IL-2

Organism: Mouse

Tissue: Skin

868
An Echinococcus multilocularis antigen B3 proteoform that shows specific antibody responses against active stage alveolar echinococcosis

CS Ahn, H Cai, JG Kim, X Han, X Ma, YA Bae, HJ Yang, I Kang, H Wang, Y Kong

Journal of Clinical Microbiology (American Society for Microbiology) China, South Korea, 12 August 2015

Microbiology

Key words: Echinococcus multilocularis, Antigen B3, Antibody Response, Alveolar Echinococcosis

Organism: Human, Mouse

Pathological State: Bacterial Infection

869
Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol alleviates elastase-induced emphysema in a mouse model

Young-Bin Chen, Ying-Wei Lan, Lih-Geeng Chen, Tsung-Teng Huang, Kong-Bung Choo, Winston T. K. Cheng, Hsuan-Shu Lee , Kowit-Yu Chong

Cell Stress and Chaperones (Springer) China, 05 August 2015

Cell Biology

Key words: Stem cell-based gene therapy, resveratrol Hsp70 promoter VEGFA, mouse model, emphysema

Organism: Mouse

Tissue: Lung

870
Abstract 1091: A new image processing approach for functional context-based analysis of tryptase positive mast cells in cutaneous T-cell lymphomas

Radu Rogojanu, Johanna Eder, Waltraud Jerey, Gabriele Klosner, Verene Paulitschke, Isabella Ellinger, Theresia Thalhammer, Dan Kolmer, Franz Trautinger

Cancer Research (AACR Publications) Austria, 01 August 2015

Oncology

Key words: Image processing, tryptase positive mast cells, cutaneous, T-cell lymphoma

Organism: Human

Tissue: Skin

Pathological State: Cancer

871
Abstract 1292: Validation study on quantitative analysis method of interrelationships between immune cells and prostate epithelial and cancer cells

Gero Kramer, Lukas Kenner, Thomas Szekeres, Shahrokh Shariat, Sarah Schwarz

Cancer Research (AACR Publications) Austria, 01 August 2015

Oncology

Key words: Quantitative analysis, immune cells, prostate epithelial, cancer cells

Organism: Human

Tissue: Prostate

Pathological State: Cancer

872
Early inflammatory responses following cell grafting in the CNS trigger activation of the subventricular zone: a proposed model of sequential cellular events

Praet J, Santermans E, Daans J, Le Blon D, Hoornaert C, Goossens H, Hens N, Van der Linden A, Berneman Z, Ponsaerts P.

Cell Transplantation (SAGE Journals) Belgium, 01 August 2015

Neuroscience

Key words: Cell transplantation, Graft apoptosis, Immune response, Angiogenesis, Cell proliferation

Organism: Mouse

Tissue: Brain

873
Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B

Pablo Muñoz-Llancao, Daniel R. Henríquez, Carlos Wilson, Felipe Bodaleo, Erik W. Boddeke, Frank Lezoualc'h, Martina Schmidt, Christian González-Billault

Journal of Neuroscience (Society for Neuroscience) The Netherlands, Chile, France, 01 August 2015

Neuroscience

Key words: Exchange protein, cAMP, neuronal polarization, Rap1B

Organism: Rat

Cell Line: Hippocampal neurons 

874
Significant Therapeutic Efficacy with Combined Radioimmunotherapy and Cetuximab in Preclinical Models of Colorectal Cancer

Vessela Vassileva, Vineeth Rajkumar, Mario Mazzantini, Mathew Robson, Adam Badar, Surinder Sharma, Erik Årstad, Daniel Hochhauser, Mark F. Lythgoe, Geoffrey M. Boxer, Rosmund Barbara Pedley

The Journal of Nuclear Medicine (SNMMI) UK, 01 August 2015

Oncology

Key words: Radioimmunotherapy, cetuximab, colorectal cancer

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

875
Outcome in Heart Failure with Preserved Ejection Fraction: The Role of Myocardial Structure and Right Ventricular Performance

Georg Goliasch, Caroline Zotter-Tufaro, Stefan Aschauer, Franz Duca, Benedikt Koell, Andreas A. Kammerlander, Robin Ristl, Irene M. Lang, Gerald Maurer, Julia Mascherbauer, Diana Bonderman

PLoS One (PLOS) Austria, 30 July 2015

Cardiology

Key words: Extracellular matrix, biopsy, blood pressure, heart failure, hemodynamics, echocardiography, pulmonary arteries, ejection fraction

Organism: Human

Tissue: Heart

Pathological State: Heart Failure

876
Elevated S100A9 expression in tumor stroma functions as an early recurrence marker for early-stage oral cancer patients through increased tumor cell invasion, angiogenesis, macrophage recruitment and interleukin-6 production

WY Fang, YW Chen, JR Hsiao, CS Liu, YZ Kuo, YC Wang, KC Chang, ST Tsai, MZ Chang, SH Lin, LW Wu

Oncotarget (Impact Journals) Taiwan, 22 July 2015

Oncology

Key words: S100A9, oral cancer, recurrence, IL-6, macrophages

Organism: Human

Tissue: Skin

Pathological State: Cancer

877
Development of Blood and Lymphatic Endothelial Cells in Embryonic and Fetal Human Skin

Schuster C, Mildner M, Botta A, Nemec L, Rogojanu R, Beer L, Fiala C, Eppel W, Bauer W, Petzelbauer P, Elbe-Bürger A

American Journal of Pathology (Elsevier) Austria, 16 July 2015

Pathology

Key words: Blood, lymphatic endothelial cells, embryonic, fetal human skin

Organism: Human

Tissue: Skin

878
POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Inge C. van Gool, Florine A. Eggink, Luke Freeman-Mills, Ellen Stelloo, Emanuele Marchi, Marco de Bruyn, Claire Palles, Remi A. Nout, Cor D. de Kroon, Elisabeth M. Osse, Paul Klenerman, Carien L. Creutzberg, Ian P.M. Tomlinson, Vincent T.H.B.M. Smit, Hans W. Nijman, Tjalling Bosse, David N. Church

Clinical Cancer Research (AACR Publications) The Netherlands, UK, 15 July 2015

Oncology

Key words: Pole proofreading mutation, antitumor, immune response, endometrial cancer

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

879
Langerhans Cells Maintain Local Tissue Tolerance in a Model of Systemic Autoimmune Disease

Jennifer K. King, Rachael L. Philips, Anna U. Eriksson, Peter J. Kim, Ramesh C. Halder, Delphine J. Lee, Ram Raj Singh

The Journal of Immunology (American Association of Immunologists) USA, 15 July 2015

Immunology

Key words: Lupus, langerhans cells

Organism: Mouse

Tissue: Skin

880
mi R‐135b‐and mi R‐146b‐dependent silencing of calcium‐sensing receptor expression in colorectal tumors

Irfete S. Fetahu, Samawansha Tennakoon, Kate E. Lines, Charlotte Gröschel, Abhishek Aggarwal, Ildiko Mesteri, Sabina Baumgartner‐Parzer, Robert M. Mader, Rajesh V. Thakker , Enikő Kállay

International Journal of Cancer (Wiley) Austria, UK, 14 July 2015

Oncology

Key words: calcium‐sensing receptor, microRNAs, colorectal cancer, miR‐135b, miR‐146b

Organism: Human

Pathological State: Cancer

Cell Line: Caco2 cells, HT29 cells

881
miR-135b- and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors

Irfete S. Fetahu, Samawansha Tennakoon, Kate E. Lines, Charlotte Gröschel, Abhishek Aggarwal, Ildiko Mesteri, Sabina Baumgartner-Parzer, Robert M. Mader, Rajesh V. Thakker, Eniko Kállay

International Journal of Cancer (Wiley) Austria, UK, 14 July 2015

Oncology

Key words: Calcium-sensing receptor, microRNAs, colorectal cancer, miR-135b, miR-146b

Organism: Human

Pathological State: Cancer

Cell Line: Caco2 cells

882
Tumor dosimetry for I-131 trastuzumab therapy in a Her2+ NCI N87 xenograft mouse model using the Siemens SYMBIA E gamma camera with a pinhole collimator

Young Sub Lee, Jin Su Kim, Kyung Deuk Cho, Joo Hyun Kang, Sang Moo Lim

Journal of Instrumentation (IOP Science) South Korea, 06 July 2015

Oncology

Key words: Tumor dosimetry, xenograft mouse model, gamma camera, Siemens

Organism: Mouse

Pathological State: Cancer

Cell Line: Her2 Cells

883
Male-Specific Alleviation of Iron-Induced Striatal Injury by Inhibition of Autophagy

Li-Fang Wang, Kazunari K. Yokoyama, Tzu-Yin Chen, Hsiu-Wen Hsiao, Pei-Chi Chiang, Ya-Ching Hsieh, Steven Lo, Chin Hsu

PLoS One (PLOS) Taiwan, USA, 06 July 2015

Neuroscience

Key words: Autophagic cell death, neurons, neostriatum, neuronal tuning, histology, DNA fragmentation, mice, ovariectomy

Organism: Mouse

Tissue: Brain

Pathological State: Stratial Injury

884
T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine

Kristen L. Dennis, Abdulrahman Saadalla, Nichole R. Blatner, Shuya Wang, Vysak Venkateswaran, Fotini Gounari, Hilde Cheroutre, Casey T. Weaver, Axel Roers, Nejat K. Egilmez, Khashayarsha Khazaie

Cancer Immunology Research (AACR Publications) USA, Germany, 01 July 2015

Oncology

Key words: T -cell, IL10, tumor immune surveillance, small intestine

Organism: Mouse

Tissue: Small Intestine

885
Membrane-bound Klotho is not expressed endogenously in healthy or uraemic human vascular tissue

Rik Mencke, Geert Harms, Katarina Mirkovic, Joyce Struik, Joris Van Ark, Ellen Van Loon, Melissa Verkaik, Martin H. De Borst, Clark J. Zeebregts, Joost G. Hoenderop, Marc G. Vervloet, Jan-Luuk Hillebrands

Cardiovascular Research (Oxford University Press) The Netherlands, 01 July 2015

Cardiology

Key words: Membrane-bound Klotho, uraemic human vascular tissue

Organism: Human

Tissue: Kidney, Blood Vessels

886
miR-22 and miR-29a are members of the androgen receptor cistrome modulating LAMC1 and Mcl-1 in prostate cancer

Lorenza Pasqualini, Huajie Bu, Martin Puhr, Narisu Narisu, Johannes Rainer, Bettina Schlick, Georg Schäfer, Mihaela Angelova, Zlatko Trajanoski, Stefan T. Börno, Michal R. Schweiger, Christian Fuchsberger, Helmut Klocker

Molecular Endocrinology (Oxford University Press) Austria, USA, Italy, Germany, 01 July 2015

Endocrinology, Oncology

Key words: miR-22 , miR-29a ,Androgen Receptor Cistrome, LAMC1, Mcl-1, Prostate Cancer

Organism: Human

Tissue: Prostate

Pathological State: Cancer

887
Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons

Isabella Rauch, Felix Rosebrock, Eva Hainzl, Susanne Heider, Andrea Majoros, Sebastian Wienerroither, Birgit Strobl, Silvia Stockinger, Lukas Kenner, Mathias Müller, Thomas Decker

Mollecular and Cellular Biology (ASM) Austria, 01 July 2015

Immunology

Key words: IRF9, intestinal inflammation, interferons

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

888
Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo

Fariba Poosti, Bao Tung Pham, Dorenda Oosterhuis, Klaas Poelstra, Harry van Goor, Peter Olinga, Jan-Luuk Hillebrands

Disease Models and Mechanisms (The Company of Biologists) The Netherlands, 24 June 2015

Nephrology

Key words: Drug targeting, Fibrosis, Kidney, Tissue slices

Organism: Mouse

Tissue: Kidney

Pathological State: Fibrosis

889
Lanreotide-conjugated PEG-DSPE micelles: an efficient nanocarrier targeting to somatostatin receptor positive tumors

Nan Zheng, Wenbing Dai, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Kun Wang, Jian Lia, Qiang Zhang

Journal of Drug Targeting (Taylor and Francis) China, 24 June 2015

Oncology

Key words: Lanreotide, over-express somatostatin receptor 2, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (poly-(ethylene glycol))-2000]

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

890
Memantine attenuates delayed vasospasm after experimental subarachnoid hemorrhage via modulating endothelial nitric oxide synthase

CY Huang, LC Wang, YS Shan, CH Pan, KJ Tsai

International Journal of Molecular Sciences (MDPI) Taiwan, 23 June 2015

Neuroscience

Key words: memantine; nitric oxide synthase; subarachnoid hemorrhage; vasospasm

Organism: Rat

Tissue: Brain

Pathological State: Vasospasm

891
STAT3 regulated ARF expression suppresses prostate cancer metastasis

Jan Pencik, Michaela Schlederer, Wolfgang Gruber, Christine Unger, Steven M. Walker, Athena Chalaris, Isabelle J. Marié, Melanie R. Hassler, Tahereh Javaheri, Osman Aksoy, Jaine K. Blayney, Nicole Prutsch, Anna Skucha, Merima Herac, Oliver H. Krämer, Peter Mazal, Florian Grebien, Gerda Egger, Valeria Poli, Wolfgang Mikulits et al.

Nature Communications (Nature) Austria, UK, Germany, USA, Italy, Sweden, 22 June 2015

Oncology

Key words: STAT3 and p14ARF expression, PI3K–AKT–mTOR signalling pathway, ARF–Mdm2–p53 tumour suppressor axis

Organism: Mouse

Tissue: Xenograft Tumor, Colon

Pathological State: Cancer

892
The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia

Stephanie M. Rangel, Maureen H. Diaz, Claire A. Knoten, Angelica Zhang, Alan R. Hauser

Plos Pathogens (PLOS) USA, 19 June 2015

Pulmonology

Key words: Pneumocytes, pneumonia, bacterial pathogens, pseudomonas aeruginosa, pulmonary imaging, cell staining, phagocytes, blood

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia

893
Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress

Jan-Renier A.J. Moonen, Ee Soo Lee, Marc Schmidt, Monika Maleszewska, Jasper A. Koerts, Linda A. Brouwer, Theo G. Van Kooten, Marja J.A. Van Luyn, Clark J. Zeebregts, Guido Krenning, Martin C. Harmsen

Cardiovascular Research (Oxford University Press) The Netherlands, Germany, 17 June 2015

Cardiology

Key words: LRRFIP1, EMT, Wnt/β-catenin signaling, β-catenin destruction complex, Reverse EMT

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

894
Left Shift 1+ flag for the detection of band neutrophils: interlaboratory variations and recommendations for the routine laboratory

F. WEERKAMP, P. H. TAAL, B. A. De BOER and ON BEHALF OF THE ADdifVIA WORKING GROUP

International Journal of Laboratory Hematology (Wiley) The Netherlands, 16 June 2015

Hematology

Key words: Differential leukocyte count, left shift flag, band neutrophils, routine laboratory

Organism: Human

Cell Line: Blood

895
Image analysis for accurately counting CD4+ and CD8+ T cells in human tissue

Kurt Diema, Amalia Magaret, Alexis Klock, Lei Jina, Jia Zhu, Lawrence Corey

Journal of Virological Methods (Elsevier) USA, 12 June 2015

Virology

Key words: Cell counting, immunohistochemistry (IHC), software cell counting, HSV-2, cellProfiler

Organism: Human

Tissue: Penis

Pathological State: Virus Infection

896
298 MAST CELLS ARE ABUNDANT IN CUTANEOUS T‐CELL LYMPHOMAS AND CORRELATE WITH DISEASE STAGE

P. Gorniak, B. Budziszewska, B. Pula, M. Wasylecka, K. Borg, G. Nowak, H. Makuch - Lasica, E. Lech - Maranda, K. Warzocha, P. Juszczynski

Hematological Oncology (Wiley) Poland, 09 June 2015

Oncology

Key words: Cerebral ischemia–reperfusion injury, oxidative stress, apoptosis, superoxide, NADPH oxidase

Organism: Human

Tissue: Lymphoid Tissue

897
Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition

Tung-Hung Su, Chung-Wai Shiau, Ping Jao, Chen-Hua Liu, Chun-Jen Liu, Wei-Tien Tai, Yung-Ming Jeng, Hung-Chih Yang, Tai-Chung Tseng, Hsiang-Po Huang, Huei-Ru Cheng, Pei-Jer Chen, Kuen-Feng Chen, Jia-Horng Kao, Ding-Shinn Chen

PNAS (PNAS) Taiwan, 09 June 2015

Cell Biology

Key words: Hepatic stellate, cell STAT3 SHP-1, hepatitis B, liver fibrosis

898
ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors

Liem T. Nguyen, Maria S. Tretiakova, Mark R. Silvis, Jared Lucas, Olga Klezovitch, Ilsa Coleman, Hamid Bolouri, Vassily I. Kutyavin, Colm Morrissey, Lawrence D. True, Peter S. Nelson, Valeri Vasioukhin

Cancer Cell (Cell Press) USA, 08 June 2015

Oncology

Key words: Prostate cancer, actin cytoskeleton

Organism: Human

Tissue: Prostate

Pathological State: Cancer

899
CD47 blockade inhibits tumor progression human osteosarcoma in xenograft models

JF Xu, XH Pan, SJ Zhang, C Zhao, BS Qiu, HF Gu, JF Hong, L Cao, Y Chen, B Xia, Q Bi, YP Wang

Oncotarget (Impact Journals) China, 08 June 2015

Oncology

Key words: osteosarcoma, CD47, antibody, immunotherapy

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

900
The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing

Soung-Hoon Lee, Mi-Yeon Kim, Hyun-Yi Kim, Young-Mi Lee, Heesu Kim, Kyoung Ae Nam, Mi Ryung Roh, Do Sik Min, Kee Yang Chung, Kang-Yell Choi

The Journal of Experimental Medicine (Rockefeller University Press) South Korea, 08 June 2015

Regenerative Medicine

Key words: Idiopathic pulmonary fibrosis, mesenchymal stem cell, mitochondrial membrane

Organism: Human

Tissue: Skin

Pathological State: Skin Wound

901
AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis

Jino Park, Michaela Schlederer, Martin Schreiber, Ryan Ice, Olaf Merkel, Martin Bilban, Sebastian Hofbauer, Soojin Kim, Joseph Addison, Jie Zou, Chunyan Ji, Silvia T. Bunting, Zhengqi Wang, Menachem Shoham, Gang Huang, Zsuzsanna Bago-Horvath, Laura F. Gibson, Yon Rojanasakul, Scot Remick, Alexey Ivanov, Elena Pugacheva, Kevin D. Bunting, Richard Moriggl, Lukas Kenner, William Tse

Oncotarget (Impact Journals) USA, Austria, Germany, China, 07 June 2015

Oncology

Key words: AF1q, TCF7, CD44, Wnt, metastasis

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

902
Atopic donor status does not influence the uptake of the major grass pollen allergen, Phl p 5, by dendritic cells

Kazem Ashjaei, Dieter Palmberger, Merima Bublin, Erika Bajna, Heimo Breiteneder, Reingard Grabherr, Isabella Ellinger, Karin Hoffmann-Sommergruber

Journal of Immunological Methods (Elsevier) Austria, 05 June 2015

Immunology

Key words: Allergen; Endocytosis; Grass pollen; Monocyte derived dendritic cells; Phl p 5; SF-nsLTP

Organism: Human

Pathological State: Allergy

Cell Line: Blood

903
Synergistic antitumor effects of radiation and proteasome inhibitor treatment in pancreatic cancer through the induction of autophagy and the downregulation of TRAF6

Hui-Wen Chiu, Shu-Wen Lin, Li-Ching Lin, Yung-Ho Hsu, Yuh-Feng Lin, Sheng-Yow Ho, Yuan-Hua Wu, Ying-Jan Wang

Cancer Letters (Elsevier) Taiwan, 04 June 2015

Oncology

Key words: Radiation; Proteasome inhibitor; Autophagy; Endoplasmic reticulum stress; Pancreatic cancer

Organism: Mouse

Tissue: Xenograft Tumor, Pancreas

Pathological State: Cancer

904
Mast cell-macrophage dynamics in modulation of dengue virus infection in skin

Ya-Ting Chu, Shu-Wen Wan, Robert Anderson, Yee-Shin Lin

Immunology (Wiley) Taiwan, Canada, 04 June 2015

Immunology

Key words: Dengue virus, KitW-sh/W-sh mice, macrophage, mast cell

Organism: Mouse

Tissue: Skin

Pathological State: Virus Infection

905
Silencing of LRRFIP1 reverses the epithelial–mesenchymal transition via inhibition of the Wnt/β-catenin signaling pathway

Daisuke Douchi, Hideo Ohtsuka, Kyohei Ariake, Kunihiro Masuda, Shuhei Kawasaki, Kei Kawaguchi, Koji Fukase, Masaya Oikawa, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose, Shinichi Egawa, Michiaki Unno

Cancer Letters (Elsevier) Japan, 03 June 2015

Oncology

Key words: LRRFIP1; EMT; Wnt/β-catenin signaling; β-catenin destruction complex; Reverse EMT

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

906
Prognostic Significance and Determinants of the 6-Min Walk Test in Patients With Heart Failure and Preserved Ejection Fraction

Caroline Zotter-Tufaro, Julia Mascherbaue, Franz Duca, Benedikt Koell, Stefan Aschaue, Andreas A. Kammerlande, Adelheid Panzenboeck, Roela Sadushi-Kolici, Christine Bangert, Daniela Laimer, Robin Ristl, Irene M. Lang, Diana Bonderman

JACC: Heart Failure (Elsevier) Austria, 01 June 2015

Cardiology

Key words: cardiac catheterization; exercise test; extracellular matrix; pulmonary circulation

Organism: Human

Tissue: Heart

Pathological State: Fibrosis

907
Mastocytosis: the new differential diagnosis of CD30-positive neoplasms

Irina Maric, Katherine R. Calvoa

Leukemia and Lymphoma (Taylor and Francis) USA, 01 June 2015

Oncology

Key words: Mastocytosis disease

908
Clinically applicable magnetic-labeling of natural killer cells for MRI of transcatheter delivery to liver tumors: preclinical validation for clinical translation

Kangan Li, Andrew C Gordon, Linfeng Zheng, Weiguo Li, Yang Guo, Jing Sun, Guixiang Zhang, Guohong Han, Andrew C Larson, Zhuoli Zhang

Nanomedicine (Future Medicine) China, USA, 01 June 2015

Nanomedicine

Key words: Intraportal vein, heparin-protamine-ferumoxytol, HPF-labeled NK cells

Organism: Rat

Tissue: Xenograft Tumor, Liver

Pathological State: Cancer

909
Paracrine factors of human amniotic fluid-derived mesenchymal stem cells show strong anti-fibrotic properties by inhibiting myofibroblast differentiation and collagen synthesis

MM Mia, RA Bank

Journal of Stem Cell Research and Therapy (OMICS) The Netherlands, 21 May 2015

Stem Cell Research

Key words: Fibrosis; Fibroblasts; Myofibroblasts; TGFβ1; Mesenchymal stem cells; Extracellular matrix

Organism: Human

Cell Line: Adipose tissue derived stromal cells (ADSC)

910
Suppression of NADPH oxidase- and mitochondrion-derived superoxide by Notoginsenoside R1 protects against cerebral ischemia–reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways

X. Meng, M. Wang, X. Wang, G. Sun, J. Ye, H. Xu, X. Sun

Free Radical Research (Taylor and Francis) China, 20 May 2015

Neuroscience

Key words: Cerebral ischemia–reperfusion injury, oxidative stress, apoptosis, superoxide, NADPH oxidase

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

911
Hypoxia-preconditioned mesenchymal stem cells attenuate bleomycin-induced pulmonary fibrosis

Ying-Wei Lan, Kong-Bung Choo, Chuan-Mu Chen, Tsai-Hsien Hung, Young-Bin Chen, Chung-Hsing Hsieh, Han-Pin Kuo, Kowit-Yu Chong

Stem Cell Research and Therapy (Springer) China, Malaysia, 20 May 2015

Stem Cell Research

Key words: Bleomycin, diopathic pulmonary fibrosis, hypoxia-inducible factor, hepatocyte growth factor, connective tissue growth factor

Organism: Mouse

Tissue: Lung

Pathological State: Fibrosis

912
Texture analysis of 125I-A5B7 anti-CEA antibody SPECT differentiates metastatic colorectal cancer model phenotypes and anti-vascular therapy response

V Rajkumar, V Goh, M Siddique, M Robson, G Boxer, RB Pedley, GJR Cook

British Journal of Cancer (Wiley) UK, 19 May 2015

Oncology

Key words: Cancer models, Colorectal cancer Computed tomography Tumour heterogeneity

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

913
Intracellular calcium levels as screening tool for nanoparticle toxicity

Claudia Meindl, Tatjana Kueznik, Martina Bösch, Eva Roblegg, Eleonore Fröhlich

Journal of Applied Toxicology (Wiley) Austria, 14 May 2015

Toxicology

Key words: Nanoparticles, cytotoxicity, apoptosis, lysosomes, calcium imaging

Organism: Human

Cell Line: EAhy926 cells (Human endothelial cell line)

914
Expression of Interferon γ by Decidual Cells and Natural Killer Cells at the Human Implantation Site

Chie-Pein Chen,Longzhu Piao, Xilin Chen, Jianhua Yu, Rachel Masch, Frederick Schatz, Charles J. Lockwood, S. Joseph Huang

Reproductive Sciences (SAGE Journals) Taiwan, USA, 11 May 2015

Reproductive Medicine

Key words: Interferon γ, NK cells, decidual cells

Organism: Human

Tissue: Endometrium

915
K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis

KH Koo, WJ Jeong, YH Cho, JC Park, DS Min, KY Choi

Oncotarget (Impact Journals) South Korea, 08 May 2015

Oncology

Key words: endometrial cancer, estrogen, tumorigenesis, K-Ras, PKCδ

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

916
The systemic multiplication of Gallibacterium anatis in experimentally infected chickens is promoted by immunosuppressive drugs which have a less specific effect on the depletion of leukocytes

Surya Paudel, Claudia Hess, Patricia Wernsdorf, Tobias Käser, Sarah Meitz, Erika Jensen-Jarolim, Michael Hess, Dieter Liebhart

Veterinary Immunology and Immunopathology (Elsevier) Austria, 08 May 2015

Immunology

Key words: Gallibacterium anatis, chickensc, leukocyte quantification, non-selective immunosuppression

Organism: Chicken

Tissue: Spleen

Pathological State: Bacterial Infection

917
siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown

Pratik S. Randeria, Mark A. Seeger, Xiao-Qi Wang, Heather Wilson, Desmond Shipp, Chad A. Mirkin, Amy S. Paller

PNAS (PNAS) USA, 05 May 2015

Dermatology

Key words: SNA, nanoparticle, siRNA, GM3 synthase, diabetic wound healing

Organism: Mouse

Tissue: Adipose Tissue, Muscle

Pathological State: Obesity, Diabetes

918
CCL7 contributes to the TNF-alpha-dependent inflammation of lesional psoriatic skin

Patrick M. Brunner, Elisabeth Glitzner, Baerbel Reininger, Irene Klein, Georg Stary, Michael Mildner, Pavel Uhrin, Maria Sibilia, Georg Stingl

Experimental Dermatology (Wiley) Austria, 04 May 2015

Dermatology

Key words: CCL7, chemokines, myeloid cells, psoriasis, TNF-α

Organism: Human

Tissue: Skin

Pathological State: Psoriasis

919
Effect of Sodium-Glucose Cotransport Inhibition on Polycystic Kidney Disease Progression in PCK Rats

Sarika Kapoor, Daniel Rodriguez, Meliana Riwanto, Ilka Edenhofer, Stephan Segerer, Katharyn Mitchell, Rudolf P. Wüthrich

PLoS One (PLOS) Switzerland, 30 April 2015

Nephrology

Key words: sodium-glucose-cotransporter-2 (SGLT2), polycystic kidney disease, aquaretic drug tolvaptan

Organism: Rat

Tissue: Kidney

Pathological State: Polycystic Kidney Disease

920
Frontal cortex and hippocampus neurotransmitter receptor complex level parallels spatial memory performance in the radial arm maze

Bharanidharan Shanmugasundaram, Ajinkya Sase, András G. Miklosi, Fernando J. Sialana, Saraswathi Subramaniyan, Yogesh D. Aher, Marion Gröger, Harald Höger, Keiryn L. Bennett, Gert Lubec

Behavioural Brain Research (Elsevier) Austria, 28 April 2015

Neuroscience

Key words: Radial arm maze; Neurotransmitter receptor complex; Blue native PAGE; Spatial memory; D1-GluN1 complex

Organism: Rat

Tissue: Brain

921
Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation

Olaf Merkel, Frank Hamacher, Robert Griessl, Lisa Grabner, Ana-Iris Schiefer, Nicole Prutsch, Constance Baer, Gerda Egger, Michaela Schlederer, Peter William Krenn, Tanja Nicole Hartmann, Ingrid Simonitsch-Klupp, Christoph Plass, Philipp Bernhard Staber, Richard Moriggl, Suzanne D Turner, Richard Greil, Lukas Kenner

Journal of Pathology (Wiley) Germany, Austria, UK, 27 April 2015

Oncology

Key words: miR-155, ALCL, ALK kinase, cytokines, IL-21, IL-22, IL-10

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

922
Enhancer of zeste homolog-2 (EZH2) methyltransferase regulates transgelin/smooth muscle-22α expression in endothelial cells in response to interleukin-1β and transforming growth factor-β2

Monika Maleszewska, Rutger A.F. Gjaltema, Guido Krenning, Martin C. Harmsen

Cellular Signalling (Elsevier) The Netherlands, 24 April 2015

Cell Biology

Key words: Endothelial cell, EZH2; SM22α, inflammation, fibrosis, chromatin

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

923
Deoxycholate bile acid directed synthesis of branched Au nanostructures for near infrared photothermal ablation

Dong-Hyun Kima, Andrew C. Larson

Biomaterials (Elsevier) USA, 17 April 2015

Nanomedicine

Key words: Gold nanoparticles, bile acid, green chemistry, photothermal treatment, nanomedicine

Organism: Mouse

Tissue: Xenograft Tumor, Pancreas

Pathological State: Cancer

924
A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle

Wilfred J. Poppinga, Irene H. Heijink, Laura J. Holtzer, Philipp Skroblin, Enno Klussmann, Andrew J. Halayko, Wim Timens, Harm Maarsingh, Martina Schmidt

American Journal of Physiology (APS Journals) The Netherlands, Germany, Canada, USA, 15 April 2015

Pulmonology

Key words: CX3CR1, cuprizone, demyelination, spectroscopy, MRI

Organism: Human

Tissue: Lung

Pathological State: Chronic Obstructive Pulmonary Disease

925
Cytotoxity of nanoparticles is influenced by size, proliferation and embryonic origin of the cells used for testing

Eleonore Fröhlich, Claudia Meindl, Eva Roblegg, Antonia Griesbacher, Thomas R. Pieber

Nanotoxicology (Taylor and Francis) Austria, 13 April 2015

Toxicology

Key words: Calcium-sensing receptor, tumor suppressor, colon Inflammation, cancer EMT, cancer stem cell, calcimimetic

Organism: Human

Cell Line: EAhy926 cells (Human endothelial cell line)

926
Der p2 internalization by epithelium synergistically augments toll-like receptor-mediated proinflammatory signaling

SC Yin, EC Liao, CL Chiu, CY Chang, JJ Tsai

Allergy, Asthma and Immunology Research (Kamje Press) Taiwan, 10 April 2015

Allergy Research

Key words: Internalization; Der p2; human airway epithelium; Toll-like receptor 2; inflammation; calcitriol

Organism: Human

Tissue: Mucosa

927
Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation

Caroline Stremnitzer, Krisztina Manzano-Szalai, Anna Willensdorfer, Philipp Starkl, Mario Pieper, Peter König, Michael Mildner, Erwin Tschachler, Ursula Reichart, Erika Jensen-Jarolim

Journal of Investigative Dermatology (Elsevier) Austria, Germany, 09 April 2015

Dermatology

Key words: Dermatophagoides pteronyssinus, transepidermal water loss, phosphate-buffered saline, Toll-like receptor 4

Organism: Mouse

Tissue: Skin

928
EBV Oncogene N-LMP1 Induces CD4 T Cell–Mediated Angiogenic Blockade in the Murine Tumor Model

The Journal of Immunology (American Association of Immunologists) China, 06 April 2015

Oncology

Key words: Antiangiogenic N-LMP1–specific T cell, Tumor single cells, In vivo angiogenesis assays

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

929
Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis

Luisa I. Morales-Nebreda, Micah R. Rogel, Jessica L. Eisenberg, Kevin J. Hamill, Saul Soberanes, Recep Nigdelioglu, Monica Chi, Takugo Cho, Kathryn A. Radigan, Karen M. Ridge, Alexander V. Misharin, Alex Woychek, Susan Hopkinson, Harris Perlman, Gokhan M. Mutlu, Annie Pardo, Moises Selman, Jonathan C. R. Jones, and G. R. Scott Budinger

American Journal of Respiratory Cell and Molecular Biology (ATS Journals) USA, Mexico, 01 April 2015

Pulmonology

Key words: laminin; matrix; pulmonary fibrosis; development

Organism: Mouse

Tissue: Lung

Pathological State: Fibrosis

930
Molecular characterization of whole mount prostate specimens using 5-color fluorescence labeling, virtual slide technology and automated image analysis

Georg E. Steiner, Gwenaelle Gaillard, Karina Pfeil, Claudia Strele, Christine Linder, Vincent Laurain, Radu Rogojanu, Rupert C. Ecker, Katja Oesterreicher, Lukas Kenner, Johannes Schmid, Helmut Klocker

Cancer Research (AACR Publications) Austria, 01 April 2015

Medical Image Analysis

Key words: Prostate tissue samples, tubular epithelial ducts, epithelial and non-epithelial cells

931
Chondroitin sulfate-polyethylenimine copolymer-coated superparamagnetic iron oxide nanoparticles as an efficient magneto-gene carrier for microRNA-encoding plasmid DNA delivery

YL Lo, HL Chou, ZX Liao, SJ Huang, JH Ke, YS Liu, CC Chiu, LF Wang

Nanoscale (Royal Society of Chemistry) Taiwan, 01 April 2015

Nanomedicine

Key words: Magnetofection, MicroRNA, Glioblastoma, Gene delivery

Organism: Human

Pathological State: Cancer

Cell Line: U87 cells

932
nk4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis

Ryo Seishima, Takeyuki Wada, Kenji Tsuchihashi, Shogo Okazaki, Momoko Yoshikawa, Hiroko Oshima, Masanobu Oshima, Toshiro Sato, Hirotoshi Hasegawa, Yuko Kitagawa, James R. Goldenring, Hideyuki Saya, Osamu Nagano

Cancer Prevention Research (AACR Publications) Japan, USA, 26 March 2015

Oncology

Key words: Spasmolytic polypeptide–expressing metaplasia, reactive oxygen species, parietal cells

Organism: Mouse

Tissue: Stomach

933
Trained immunity in newborn infants of HBV-infected mothers

Michelle Hong, Elena Sandalova, Diana Low, Adam J. Gehring, Stefania Fieni, Barbara Amadei, Simonetta Urbani, Yap-Seng Chong, Ernesto Guccione, Antonio Bertoletti

Nature Communications (Nature) Singapore, Italy, UK, 25 March 2015

Immunology, Virology

Key words: Calcium-sensing receptor, colon cancer, calcium, vitamin D, chemoprevention, calcimimetic

Organism: Human

Pathological State: Virus Infection

Cell Line: CD2- cells (non-T non-NK cells)

934
Low-dose irradiation affects expression of inflammatory markers in the heart of ApoE-/-mice

Daniel Mathias, Ronald E. J. Mitchel, Mirela Barclay, Heather Wyatt, Michelle Bugden, Nicholas D. Priest, Stewart C. Whitman †, Markus Scholz, Guido Hildebrandt, Manja Kamprad, Annegret Glasow

PLoS One (PLOS) Germany, Canada, 23 March 2015

Cardiology

Key words: Collagens, Dosimetry, Inflammation ,Fibrinogen ,Blood plasma ,Heart ,White blood cells ,Endothelial cells

Organism: Mouse

Tissue: Heart

935
Reproductive Sciences

Reproductive Sciences (SAGE Journals) , 22 March 2015

Reproductive Medicine

936
Tissue Microarrays for Translational Research

Ronald Simon, Martina Mirlacher

Microarrays in Diagnostics and Biomarker Development (Springer) Germany, 19 March 2015

Biological Methods

Key words: Tissue microarray,

937
Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra

Jelle Praet, Jasmien Orije, Firat Kara, Caroline Guglielmetti, Eva Santermans, Jasmijn Daans, Niel Hens, Marleen Verhoye, Zwi Berneman, Peter Ponsaerts, Annemie Van der Linden

NMR in Biomedicine (Wiley) Belgium, 19 March 2015

Oncology

Key words: GDF10/BMP3b, TGFBR3, oral cancer, prognostic marker, EMT, chemotherapy resistance

Organism: Mouse

Tissue: Brain

Pathological State: Demyelination

938
CD20+ T cells have a predominantly Tc1 effector memory phenotype and are expanded in the ascites of patients with ovarian cancer

Marco de Bruyn, Valerie R Wiersma, Maartje C A Wouters, Douwe F Samplonius, Harry G Klip, Wijnand Helfrich, Hans W Nijman, Paul Eggletonc, Edwin Bremer

OncoImmunology (Taylor and Francis) The Netherlands, UK, Canada, 19 March 2015

Immunology

Key words: Ascites, cancer immunology, CD20, ovarian cancer, trogocytosis, APC, Antigen-Presenting Cell, CTL, Cytotoxic T Lymphocyte, FSC, Forward Scatter, OC, Ovarian Cancer, PBMC, Peripheral Blood Mononuclear Cell, SCC, Side Scatter, TC, Cytotoxic T cell, TCM, Central Memory T cell, TEM, Effector Memory T cell, TH, Helper T cell, TIL, Tumor Infiltrating T cell, TNaïve, Naïve T cell, Treg, Regulatory T cell, TTD, Terminally Differentiated T cell

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

939
The calcium-sensing receptor suppresses epithelial-to-mesenchymal transition and stem cell- like phenotype in the colon

Abhishek Aggarwal, Maximilian Prinz-Wohlgenannt, Charlotte Gröschel, Samawansha Tennakoon, Anastasia Meshcheryakova, Wenhan Chang, Edward M Brown, Diana Mechtcheriakova, Enikö Kállay

Molecular Cancer (Springer) Austria, USA, 18 March 2015

Oncology

Key words: EVI1, MS4A3, transcriptional repression, myeloid leukemia, tumor growth

Organism: Mouse, Human

Tissue: Colon

Pathological State: Cancer

Cell Line: HT29 cells (colon cancer cell line)

940
MAP4K4 regulates integrin-FERM binding to control endothelial cell motility

Philip Vitorino, Stacey Yeung, Ailey Crow, Jesse Bakke, Tanya Smyczek, Kristina West, Erin McNamara, Jeffrey Eastham-Anderson, Stephen Gould, Seth F. Harris, Chudi Ndubaku and Weilan Ye

Nature (Nature) USA, 18 March 2015

Cell Biology

Key words: Focal adhesion

Organism: Mouse

Pathological State: Cancer

941
CARDIAC MAGNETIC RESONANCE T1 MAPPING FOR QUANTIFICATION OF EXTRACELLULAR MATRIX - VALIDATION BY MYOCARDIAL BIOPSY

Andreas Anselm Kammerlander, Caroline Tufaro, Alina Bachmann, Beatrice Marzluf, Stefan Aschauer, Andreas Greiser, Diana Bonderman, Julia Mascherbauer

Journal of the American College of Cardiology (Elsevier) Austria, 16 March 2015

Cardiology

Key words: Diffuse myocardial fibrosis, extracellular matrix expansion, cardiac magnetic resonance

Organism: Human

Tissue: Heart

Pathological State: Heart Failure

942
The Upregulation of LAG-3 on T Cells Defines a Subpopulation with Functional Exhaustion and Correlates with Disease Progression in HIV-Infected Subjects

The Journal of Immunology (American Association of Immunologists) China, 16 March 2015

Immunology, Virology

Key words: Plasmodium infection, virus–specific CD8+ T cells, human embryonic kidney cells

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Virus Infection

943
Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells

Charlotte Gröschel, Abhishek Aggarwal, Samawansha Tennakoon, Julia Höbaus, Maximilian Prinz-Wohlgenannt, Brigitte Marian, Petra Heffeter, Walter Berger, Eniko Kállay

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Austria, 14 March 2015

Oncology

Key words: 1,25-Dihydroxyvitamin D3, colorectal cancer, chemoprevention, wnt pathway, LGR5

Organism: Human

Tissue: Colon

Pathological State: Cancer

944
Vimentin regulates activation of the NLRP3 inflammasome

Gimena dos Santos, Micah R. Rogel, Margaret A. Baker, James R. Troken, Daniela Urich, Luisa Morales-Nebreda, Joseph A. Sennello, Mikhail A. Kutuzov, Albert Sitikov, Jennifer M. Davis, Anna P. Lam, Paul Cheresh, David Kamp, Dale K. Shumaker, G. R. Scott Budinger and Karen M. Ridge

Nature Communications (Nature) USA, 12 March 2015

Cell Biology

Key words: Cytoskeletal proteins, Inflammasome, NOD-like receptors, Respiratory tract diseases

Organism: Mouse

Tissue: Heart, Lung

945
Nitric Oxide Prevents Alveolar Senescence and Emphysema in a Mouse Model

Amanda E. Boe, Mesut Eren, Luisa Morales-Nebreda, Sheila B. Murphy, G. R. Scott Budinger, Gökhan M. Mutlu, Toshio Miyata, Douglas E. Vaughan

PLoS One (PLOS) USA, Japan, 10 March 2015

Pulmonology

Key words: Nω-nitro-L-arginine methyl ester, alveolar tissue destruction, plasminogen activator inhibitor-1

Organism: Mouse

Tissue: Lung

Pathological State: Chronic Obstructive Pulmonary Disease

946
Clinical improvement in psoriasis with specific targeting of interleukin-23

Tamara Kopp, Elisabeth Riedl, Christine Bangert, Edward P. Bowman, Elli Greisenegger, Ann Horowitz, Harald Kittler, Wendy M. Blumenschein, Terrill K. McClanahan, Thomas Marbury, Claus Zachariae, Danlin Xu, Xiaoli Shirley Hou, Anish Mehta, Anthe S. Zandvliet, Diana Montgomery, Frank van Aarle and Sauzanne Khalilieh

Nature (Nature) Austria, USA, Denmark, 09 March 2015

Dermatology

Key words: Psoriasis, interleukin-23

947
Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer

TT Wei, YC Lin, PH Lin, JY Shih, CW Chou, WJ Huang, YC Yang, PW Hsiao, CC Chen

Oncotarget (Impact Journals) Taiwan, 08 March 2015

Oncology

Key words: c-Cbl, EGFR, HDAC inhibitors, lung cancer

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

948
Active vitamin D potentiates the anti-neoplastic effects of calcium in the colon: A cross talk through the calcium-sensing receptor

Abhishek Aggarwal, Julia Höbaus, Samawansha Tennakoon, Maximilian Prinz-Wohlgenannt, João Graça, Sally A. Price, Petra Heffeter, Walter Berger, Sabina Baumgartner-Parzer, Enikö Kállay

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Austria, UK, 07 March 2015

Oncology

Key words: Calcium-sensing receptor, Colon cancer, Calcium, Vitamin D, Chemoprevention, Calcimimetic

Organism: Mouse

Tissue: Colon

949
Zileuton, 5-Lipoxygenase Inhibitor, Acts as a Chemopreventive Agent in Intestinal Polyposis, by Modulating Polyp and Systemic Inflammation

Elias Gounaris, Michael J. Heiferman, Jeffrey R. Heiferman, Manisha Shrivastav, Dominic Vitello, Nichole R. Blatner, Lawrence M. Knab, Joseph D. Phillips, Eric C. Cheon, Paul J. Grippo, Khashayarsha Khazaie, Hidayatullah G. Munshi, David J. Bentrem

PLoS One (PLOS) USA, 06 March 2015

Oncology

Key words: Calcium-sensing receptor, tumor suppressor, colorectal cancer, colon, calcium, calcimimetic, calcilytic

Organism: Mouse

Tissue: Small Intestine

Pathological State: Cancer

950
Disruption of ​STAT3 signalling promotes ​KRAS-induced lung tumorigenesis

Beatrice Grabner, Daniel Schramek, Kristina M. Mueller, Herwig P. Moll, Jasmin Svinka, Thomas Hoffmann, Eva Bauer, Leander Blaas, Natascha Hruschka, Katalin Zboray, Patricia Stiedl, Harini Nivarthi, Edith Bogner, Wolfgang Gruber, Thomas Mohr, Ralf Harun Zwick, Lukas Kenner, Valeria Poli, Fritz Aberger, Dagmar Stoiber, Gerda Egger, Harald Esterbauer, Johannes Zuber, Richard Moriggl, Robert Eferl, Balázs Gy?rffy, Josef M. Penninger, Helmut Popper ,Emilio Casanova

Nature Communications (Nature) Austria, USA, Italy, Hungary, 03 March 2015

Oncology

Key words: Interleukin-6, oncostatin-M, epidermal growth factor, Lung cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

951
16 Dectin-2 is essentially involved in innate immune response of experimental arthritis

V Stögner, T Shvets, B Niederreiter, M Koenders, WB van den Berg, JS Smolen, K Redlich, S Hayer

Annals of the Rheumatic Diseases (BMJ Journals) Austria, The Netherlands, 01 March 2015

Rheumatology

Key words: C-type lectin receptor Dectin-2, Toll-like receptors, myeloid cells

Organism: Mouse

Pathological State: Rheumatoid Arthritis

952
Comparative Proteomic Analysis Reveals Activation of Mucosal Innate Immune Signaling Pathways during Cholera

Crystal N. Ellis,Regina C. LaRocquea, Taher Uddin, Bryan Krastins, Leslie M. Mayo-Smith, David Sarracino, Elinor K. Karlsson, Atiqur Rahman, Tahmina Shirin, Taufiqur R. Bhuiyan, Fahima Chowdhury, Ashraful Islam Khan, Edward T. Ryan,, Stephen B. Calderwood, Firdausi Qadri Jason B. Harris

Infection and Immunity (ASM) USA, Bangladesh, 01 March 2015

Immunology

Key words: Tissue microarray, Tissue cores, Population studies, Virtual microscopy, Data exchange, Standards Validation studies, Quality assurance, Donor block, Recipient block, Multitumo,r Tissue microarray, Progression tissue microarray, Prognosis tissue microarray, Normal tissue microarray, Frozen tissue microarray, Cell line tissue microarray, Xenograft tissue microarray, Cutting edge matrix assembly tissue microarray, Immunohistochemistry , Chromogenic in situ hybridization (CISH), Fluorescent in situ hybridization (FISH), Quantum dots, Multiplex immunoblotting, Hierarchical clustering analysis, Hierarchical naïve, Bayes model, Random forest clustering

Organism: Human

Tissue: Small Intestine

Pathological State: Bacterial Infection

953
EVI1 promotes tumor growth via transcriptional repression of MS4A3

Gerwin Heller, Anna Rommer, Katarina Steinleitner, Julia Etzler, Hubert Hackl, Petra Heffeter, Erwin Tomasich, Martin Filipits, Birgit Steinmetz, Thais Topakian, Simone Klingenbrunner, Barbara Ziegler, Andreas Spittler, Sabine Zöchbauer-Müller, Walter Berger, Rotraud Wieser

Journal of Hematology and Oncology (Springer) Austria, 01 March 2015

Oncology

Key words: EVI1, MS4A3, Transcriptional repression, Myeloid leukemia, Tumor growth

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

954
Loss of GDF10/BMP3b as a prognostic marker collaborates with TGFBR3 to enhance chemotherapy resistance and epithelial-mesenchymal transition in oral squamous cell carcinoma

Chieh-Wen Cheng, Jenn-Ren Hsiao, Chi-Chen Fan, Yu-Kang Lo, Chi-Yuan Tzen, Li-Wha Wu, Wei-Yu Fang, Ann-Joy Cheng, Chung-Hsing Chen, I-Shou Chang, Shih Sheng Jiang, Jang-Yang Chang, Alan Yueh-Luen Lee

Molecular Carcinogenesis (Wiley) Taiwan, 01 March 2015

Oncology

Key words: Growth differentiation factor-10, transforming growth factor-β (TGF-β) superfamily, oral squamous cell carcinoma

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

955
Poly(lactide-co-glycolide) microspheres for MRI-monitored delivery of sorafenib in a rabbit VX2 model

Jeane Chena, Sarah B. White, Kathleen R. Harris, Weiguo Li, Jonathan W.T. Yap, Dong-Hyun Kim, Robert J. Lewandowski, Lonnie D. Shea, Andrew C. Larson

Biomaterials (Elsevier) USA, 25 February 2015

Nanomedicine

Key words: Sorafenib, hepatocellular carcinoma, poly(lactide-co-glycolide), magnetic resonance imaging

Organism: Rabbit

Tissue: Liver, Stomach, Lung

956
Regulatory T cell-deficient scurfy mice develop systemic autoimmune features resembling lupus-like disease

Eva N Hadaschik, Xiaoying Wei, Harald Leiss, Britta Heckmann, Birgit Niederreiter, Günter Steiner, Walter Ulrich, Alexander H Enk, Josef S Smolen, Georg H Stummvoll

Arthritis Research and Therapy (BioMed Central) Germany, China, Austria, 23 February 2015

Rheumatology

Key words: Systemic lupus erythematosus, severe interface dermatitis, arthritis, mesangioproliferative glomerulonephritis

Organism: Mouse

Tissue: Bone, Connective Tissue

Pathological State: Lupus

957
The calcium-sensing receptor: A promising target for prevention of colorectal cancer

Abhishek Aggarwal, Maximilian Prinz-Wohlgenannt, Samawansha Tennakoona, Julia Höbaus, Cedric Boudot, Romuald Mentaverri, Edward M. Brown, Sabina Baumgartner-Parzer, Enikö Kállay

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (Elsevier) Austria, France, USA, 18 February 2015

Oncology

Key words: Calcium-sensing receptor, tumor suppressor, colorectal cancer, colon, calcium, calcimimetic, calcilytic

Organism: Human

Pathological State: Cancer

Cell Line: Caco2 cells, HT29 cells

958
MRI visible drug eluting magnetic microspheres for transcatheter intra-arterial delivery to liver tumors

DH Kim, J Chen, RA Omary, AC Larson

Theranostics (NCBI) USA, 07 February 2015

Oncology, Nanomedicine

Key words: MRI, microspheres, liver tumors

Organism: Rat

Tissue: Liver

Pathological State: Cancer

959
Tissue Microarray

Myra L. Wilkerson, Stephen M. Hewitt

Handbook of Practical Immunohistochemistry (Springer) USA, 05 February 2015

Biological Methods

Key words: Tissue microarray, tissue cores, population studies, virtual microscopy, data exchange, standards, validation studies, quality assurance, donor block, recipient block, multitumor, tissue microarray, progression tissue microarray, prognosis tissue microarray, normal tissue microarray, frozen tissue microarray, cell line tissue microarray, xenograft tissue microarray, cutting edge matrix assembly tissue microarray, immunohistochemistry, chromogenic in situ hybridization (CISH), fluorescent in situ hybridization (FISH), quantum dots, multiplex immunoblotting, hierarchical clustering analysis, hierarchical naïve Bayes model, random forest clustering

960
Generation of an anti-EpCAM antibody and epigenetic regulation of EpCAM in colorectal cancer

Mei-Ying Liao, Mark Yen-Ping Kuo, Tung-Ying Lu, Yi-Ping Wang, Han-Chung Wu

International Journal of Oncology (Spandidos Publications) Taiwan, 05 February 2015

Oncology

Key words: epigenetic regulation, EpCAM, colorectal cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

961
Extracellular matrix expansion by cardiac magnetic resonance T1 mapping- validation with myocardial biopsy

Andreas Kammerlander, Caroline Tufaro, Alina F Bachmann, Beatrice A Marzluf, Stefan Aschauer, Andreas Greiser, Diana Bonderman, Julia Mascherbauer

Journal of Cardiovascular Magnetic Resonance (Springer) Austria, Germany, 03 February 2015

Cardiology

Key words: Cardiology, angiology, imaging/radiology

Organism: Human

Tissue: Heart

Pathological State: Heart Failure

962
Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain

Costa R, Bergwerf I, Santermans E, De Vocht N, Praet J, Daans J, Le Blon D, Hoornaert C, Reekmans K, Hens N, Goossens H, Berneman Z, Parolini O, Alviano F, Ponsaerts P.

Cell Transplantation (SAGE Journals) Italy, 01 February 2015

Transplantation Medicine

Key words: Fetal membrane-derived stromal cells, Embryonic fibroblasts, Immunomodulation, Transplantation, Brain, Angiogenesis

Organism: Mouse

Tissue: Brain

963
The expression of thymic stromal lymphopoietin in primary tumors of breast cancer is associated with prognosis

Yu H, Yang J, Li Y, Jiao S

Chinese journal of cellular and molecular immunology (NCBI) China, 01 February 2015

Oncology

Key words: Rythymic stromal lymphopoietin, disease-free survival, Univariate LOG-RANK

Organism: Human

Tissue: Breast

Pathological State: Cancer

964
Biomarkers in Lung Diseaes: from Pathogenesis to Prediction to New Therapies: A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle

Wilfred J. Poppinga, Irene H. Heijink, Laura J. Holtzer, Philipp Skroblin, Enno Klussmann, Andrew J. Halayko, Wim Timens, Harm Maarsingh, Martina Schmidt

American Journal of Physiology (APS Journals) The Netherlands, Germany, Canada, USA, 30 January 2015

Pulmonology

Key words: Compartmentalization, A-kinase-anchoring protein, inflammation, cyclic AMP, chronic obstructive pulmonary disease

Organism: Human

Cell Line: Human bronchial ASM cells

965
The Major Birch Pollen Allergen Bet v 1 Induces Different Responses in Dendritic Cells of Birch Pollen Allergic and Healthy Individuals

Ursula Smole, Christian Radauer, Nina Lengger, Martin Svoboda, Neil Rigby, Merima Bublin, Sonja Gaier, Karin Hoffmann-Sommergruber, Erika Jensen-Jarolim, Diana Mechtcheriakova , Heimo Breiteneder

PLoS One (PLOS) USA, Austria, UK, 30 January 2015

Allergy Research

Key words: Allergens, cytokines, gene expression, pollen, immune response, fluorescence competition, monocytes, chemokines

Organism: Human

Pathological State: Allergy

Cell Line: iMoDCs ( immature monocyte-derived dendritic cells)

966
Correlation of circular RNA abundance with proliferation–exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues

Anna Bachmayr-Heyda, Agnes T. Reiner, Katharina Auer, Nyamdelger Sukhbaatar, Stefanie Aust, Thomas Bachleitner-Hofmann, Ildiko Mesteri, Thomas W. Grunt, Robert Zeillinger and Dietmar Pils

Scientific Reports (Nature) Austria, 27 January 2015

Oncology

Key words: Cancer genetics, Epigenetics

Organism: Human

Tissue: Colon

Pathological State: Cancer

967
Mapping spatial heterogeneity in the tumor microenvironment: a new era for digital pathology

Andreas Heindl, Sidra Nawaz, Yinyin Yuan

Nature (Nature) UK, 19 January 2015

Oncology

Key words: Tumor, digital pathology, mapping, spatial heterogeneity

968
Loss of mitochondrial exo/endonuclease EXOG affects mitochondrial respiration and induces ROS-mediated cardiomyocyte hypertrophy

Wardit Tigchelaar, Hongjuan Yu, Anne Margreet de Jong, Wiek H. van Gilst, Pim van der Harst, B. Daan Westenbrink, Rudolf A. de Boer, Herman H. W. Silljé

Cell Physiology (APS Journals) The Netherlands, China, 15 January 2015

Cardiology

Key words: Cardiomyocytes, hypertrophy, mitochondria, mitochondrial respiration, ROS

Organism: Rat

Pathological State: Hypertrophy

Cell Line: NRVCs (neonatal rat ventricular cardiomyocytes)

969
Down-regulation of TIMP-1 inhibits cell migration, invasion, and metastatic colonization in lung adenocarcinoma

Ying-Hua Chang, Yi-Jen Chiu, Hung-Chi Cheng, Fang-Ju Liu, Wu-Wei Lai, Hsiao-Jen Chang, Pao-Chi Liao

Tumor Biology (Springer) Taiwan, USA, 13 January 2015

Oncology

Key words: TIMP-1, migration, invasion,metastatic colonization, pericellular fibronectin assembly, lung adenocarcinoma

Organism: Human

Tissue: Lung

Pathological State: Cancer

970
Localization of sunitinib, its metabolites and its target receptors in tumour-bearing mice: a MALDI-MS imaging study

S Torok, A Vegvari, M Rezeli, T E Fehniger, J Tovari, S Paku, V Laszlo, B Hegedus, A Rozsas, B Dome, G. Marko-Varga

British Journal of Pharmacology (Wiley) Hungary, Austria, Sweden, Japan, 12 January 2015

Pharmacology

Key words: C-26 adenocarcinoma cells, matrix-assisted laser desorption ionization MS imaging, VEGF receptor-2

Organism: Mouse

Tissue: Allograft Tumor, Colon

Pathological State: Cancer

971
Epitope topography controls bioactivity in supramolecular nanofibers

S Sur, F Tantakitti, JB Matson, SI Stupp

Biomaterials Science (Royal Society of Chemistry) USA, 09 January 2015

Nanomedicine

Key words: Epitope topography, bioactivity, nanofibers

Organism: Mouse

Cell Line: Mouse embryonic fibroblasts

972
A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis

Tine Verreet, Roel Quintens, Debby Van Dam, Mieke Verslegers, Mirella Tanori, Arianna Casciati, Mieke Neefs, Liselotte Leysen, Arlette Michaux, Ann Janssen, Emiliano D’Agostino, Greetje Vande Velde, Sarah Baatout, Lieve Moons, Simonetta Pazzaglia, Anna Saran, Uwe Himmelreich, Peter Paul De Deyn, Mohammed Abderrafi Benotmane

Journal of Neurodevelopmental Disorders (Springer) Belgium, Italy, The Netherlands, 09 January 2015

Neuroscience

Key words: Apoptosis, Brain development, Cognitive dysfunction, MRI, Radiation

Organism: Mouse

Tissue: Brain

973
SMAD2 and p38 signaling pathways act in concert to determine XY primordial germ cell fate in mice

Q Wu, K Fukuda, M Weinstein, JM Graff, Y Saga

Development (The Company of Biologists) Japan, USA, 01 January 2015

Developmental Biology

Key words: sex determination,,Meiosis, SMAD2 signaling, p38 signaling, Nanos2, Smad2/3 conditional knockout mice

Organism: Mouse

Tissue: Testis

974
Zinc and pioglitazone effects on ovaries and endometrium in diabetes

C Gales, C Zamfir, B Stoica, M Nechifor

Farmacia () Romania, 01 January 2015

Reproductive Medicine

Key words: diabetes, zinc, pioglitazone, endometrium

Organism: Rat

Tissue: Uterus, Ovaries

Pathological State: Diabetes

975
Relationship between Apoptosis Imaging and Radioiodine Therapy in Tumor Cells with Different Sodium Iodide Symporter Gene Expression

Kyung Oh Jung, Hyewon Youn, Young-Hwa Kim, Seunghoo Kim, Juri Na, Yong-Il Kim, Jin Woo Park, Keon Wook Kang, Dong Soo Lee, June-Key Chung

Molecular Imaging (SAGE Journals) South Korea, 01 January 2015

Oncology

Key words: Apoptosis Imaging, Radioiodine Therapy, Tumor Cells, Sodium Iodide Symporter

Organism: Human

Pathological State: Cancer

Cell Line: Human colorectal adenocarcinoma cell line (HT29)

976
Comparative assessment of biocompatibility of NiCr and CoCr alloys used in metalfused-to-ceramic technology

RALUCA MONICA COMANEANU, VIOLETA HANCU, HORIA MIHAIL BARBU, COSTIN COMAN, COSMIN MIHAI COTRUT, MIHAIL TARCOLEA, ANA MARIA HOLICOV, ALINA ORMENISAN

REVISTA DE CHIMIE () Romania, 01 January 2015

Biological Methods

Key words: NiCr and CoCr alloys, metal-fused-to-ceramic restoration, biomaterial, biocompatibility

Organism: Human

Cell Line: Human Osteosarcoma cell line (HOS)

977
MRI-Monitored Intra-Tumoral Injection of Iron-Oxide Labeled Clostridium novyi-NT Anaerobes in Pancreatic Carcinoma Mouse Model

Linfeng Zheng, Zhuoli Zhang, Khashayarsha Khazaie, Saurabh Saha, Robert J. Lewandowski, Guixiang Zhang, Andrew C. Larson

PLoS One (PLOS) USA, China, 30 December 2014

Oncology

Key words: Magnetic resonance imaging, catheters, anaerobic bacteria, gram staining, fluorescence microscopy, transmission electron microscopy, in vivo imaging, nanoparticles

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

978
Coronary Neutrophil Extracellular Trap Burden and Deoxyribonuclease Activity in ST-Elevation Acute Coronary Syndrome Are Predictors of ST-Segment Resolution and Infarct Size

Andreas Mangold, Sherin Alias, Thomas Scherz, Thomas Hofbauer, Johannes Jakowitsch, Adelheid Panzenböck, Daniel Simon, Daniela Laimer, Christine Bangert, Andreas Kammerlander, Julia Mascherbauer, Max-Paul Winter, Klaus Distelmaier, Christopher Adlbrecht, Klaus T. Preissner, Irene M. Lang

Circulation Research (AHA Journals) Germany, Austria, 29 December 2014

Cardiology

Key words: Atherosclerosis, coronary occlusion, coronary thrombosis, deoxyribonucleases, extracellular traps, myocardial infarction, neutrophils

Organism: Human

Tissue: Blood Vessels

979
PIAS1 is a crucial factor for prostate cancer cell survival and a valid target in docetaxel resistant cells

Martin Puhr, Julia Hoefer, Hannes Neuwirt, Iris E. Eder, Johann Kern, Georg Schäfer, Stephan Geley, Isabel Heidegger, Helmut Klocker, Zoran Culig

Oncotarget (Impact Journals) Austria, 24 December 2014

Oncology

Key words: prostate cancer, PIAS1, docetaxel, chemotherapy resistance, apoptosis

Organism: Human

Tissue: Prostate

Pathological State: Cancer

980
TLR4-mediated inflammation promotes foam cell formation of vascular smooth muscle cell by upregulating ACAT1 expression

Y-W Yin, S-Q Liao, M-J Zhang, Y Liu, B-H Li, Y Zhou, L Chen, C-Y Gao, J-C Li and L-L Zhang

Cell Death & Disease (Nature) China, 18 December 2014

Cardiology

Key words: Atherosclerosis, Cell signalling, Foam cells, Inflammation

Organism: Mouse

Tissue: Blood Vessels

981
Epidermal Elafin Expression Is an Indicator of Poor Prognosis in Cutaneous Graft-versus-Host Disease

Marie-Charlotte Brüggen, Peter Petzelbauer, Hildegard Greinix, Emmanuel Contassot, Dragana Jankovic, Lars French, Gérard Socié, Werner Rabitsch, Zoya Kuzmina, Peter Kalhs, Robert Knobler, Georg Stingl, Georg Stary

Journal of Investigative Dermatology (Elsevier) Austria, Switzerland, France, 18 December 2014

Dermatology

Key words: Epidermal elafin, cutaneous graft, host disease

Organism: Human

Tissue: Skin

Pathological State: Graft-versus-Host Disease

982
The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation

Stefan J Kempf, Arianna Casciati, Sonja Buratovic, Dirk Janik, Christine von Toerne, Marius Ueffing, Frauke Neff, Simone Moertl, Bo Stenerlöw, Anna Saran, Michael J Atkinson, Per Eriksson, Simonetta Pazzaglia, Soile Tapio

Molecular Neurodegeneration (BioMed Central) Germany, Italy, Sweden, 16 December 2014

Neuroscience

Key words: Dendritic spines, hippocampus, cortex, CREB, miR-132, ionising radiation, proteomics, Rac1, cofilin, alzheimer

Organism: Mouse

Tissue: Brain

983
Quantitative measurement of cancer tissue biomarkers in the lab and in the clinic

Daniel E Carvajal-Hausdorf, Kurt A Schalper, Veronique M Neumeister and David L Rimm

Laboratory Investigation (Nature) USA, 15 December 2014

Oncology

Key words: Breast cancer

984
Carboxylated Short Single-Walled Carbon Nanotubes But Not Plain and Multi-Walled Short Carbon Nanotubes Show in vitro Genotoxicity

Maria Mrakovcic, Claudia Meindl, Gerd Leitinger, Eva Roblegg, Eleonore Fröhlich

Toxicological Sciences (Oxford University Press) Austria, 10 December 2014

Toxicology

Key words: Carbon nanotubes, cytotoxicity, genotoxicity, oxidative stress, HPRT mutation, assay micronucleus

Cell Line: V79 cells

985
Pharmacodynamic and Therapeutic Investigation of Focused Ultrasound-Induced Blood-Brain Barrier Opening for Enhanced Temozolomide Delivery in Glioma Treatment

Hao-Li Liu, Chiung-Yin Huang, Ju-Yu Chen, Hay-Yan Jack Wang, Pin-Yuan Chen, Kuo-Chen Wei

PLoS One (PLOS) Taiwan, 09 December 2014

Oncology

Key words: Cancer treatment, magnetic resonance imaging, glioma, drug therapy, pharmacodynamics, blood plasma, liquid chromatography-mass spectrometry, glioma cells

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

986
Effects of azithromycin and tanomastat on experimental bronchiolitis obliterans

Katharina Krenn, Matthias Gmeiner, Patrick Paulus, Nezir Sela, Linda Torres, Karin Zins, Gerhard Dekan, Seyedhossein Aharinejad

Journal of thoracic and cardiovascular surgery (Elsevier) Austria, Germany, 04 December 2014

Pulmonology

Key words: Azithromycin, tanomastat

Organism: Rat

Tissue: Lung

Pathological State: Bronchiolitis Obliterans

987
Clec4n Is Essentially Involved in Innate Immune Response of Experimental Arthritis

V. Stögner, T. Shvets, B. Niederreiter, M. Koenders, W. van den Berg,J. Smolen, K. Redlich, S. Hayer

Rehabilitation () The Netherlands, 04 December 2014

Rheumatology

988
TonEBP/NFAT5 regulates ACTBL2 expression in biomechanically activated vascular smooth muscle cells

M Hödebeck, C Scherer, AH Wagner, M Hecker, T Korff

Frontiers in Physiology (Frontiers Media S.A.) Germany, 03 December 2014

Physiology

Organism: Human

Cell Line: HUASMCs

989
Selective delivery of IFN-γ to renal interstitial myofibroblasts: a novel strategy for the treatment of renal fibrosis

Fariba Poosti, Ruchi Bansal, Saleh Yazdani, Jai Prakash, Eduard Post, Pieter Klok, Jacob van den Born, Martin H. de Borst, Harry van Goor, Klaas Poelstra, Jan-Luuk Hillebrands

FASEB Journal (FASEB) The Netherlands, 02 December 2014

Nephrology

Key words: Drug targeting, PDGFRβ, kidney, unilateral ureteral obstruction

Organism: Mouse

Cell Line: NIH3T3 Fibroblasts

990
Prognostic Significance and Determinants of the 6-minute Walk Test in Patients with Pulmonary Hypertension Associated with Heart Failure and Preserved Ejection Fraction

C Tufaro, J Mascherbauer, F Duca, S Aschauer, A Panzenboeck, C Bangert, D Laimer, I Lang, D Bonderman

Pneumologie (Thieme) Austria, 01 December 2014

Pulmonology

Key words: Exertional fatigue, dyspnea, pulmonary hypertension, heart failure with preserved ejection fraction

991
Stat5 gene dosage in T cells modulates CD8+ T-cell homeostasis and attenuates contact hypersensitivity response in mice

H. Nivarthi, M. Prchal-Murphy, A. Swoboda, M. Hager, M. Schlederer, L. Kenner, J. Tuckermann, V. Sexl, R. Moriggl, O. Ermakova

Allergy (Wiley) Austria, Germany, Italy, 30 November 2014

Allergy Research

Key words: Allergic contact dermatitis, Stat5,T cells

Organism: Mouse

Tissue: Ear

992
Protection of Shengmai Recipe on Improving Cardiac Function and Attenuating Kidney Injury in Pressure Overload Rats

Feng-jiao Sun, Peng-wei Zhuang, Yu Wang, Jin-bao Zhang, Zhi-qiang Lu, Yan Wang, Mi-xia Zhang, Jin Wu, Zhuo Chen, Meng Sun, Yan-jun Zhang

Chinese Herbal Medicines (Elsevier) China, 27 November 2014

Cardiology

Key words: Chronic heart failure, left ventricular systolic function, myocardial fibrosis, renal ischemia lesion, Shengmai Recipe

Organism: Mouse

Tissue: Heart, Kidney

Pathological State: Kidney Injury

993
A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones

N Ono, W Ono, T Nagasawa, HM Kronenberg

Nature Cell Biology (Nature) USA, Japan, 24 November 2014

Stem Cell Research

Key words: Bone development, Mesenchymal stem cells

Organism: Mouse

Tissue: Bone

994
CD16+ monocytes with smooth muscle cell characteristics are reduced in human renal chronic transplant dysfunction

M. Boersema, J.C. van den Born, J. van Ark, G. Harms, M.A. Seelen, M.C.R.F. van Dijk, H. van Goor, G.J. Navis, E.R. Popa, J.L. Hillebrands

Immunobiology (Elsevier) The Netherlands, 21 November 2014

Immunology

Key words: Chronic transplant dysfunction, Kidney, Monocytes, Monocyte heterogeneity, Smooth-muscle-like cells, Transplantation

Organism: Human

Tissue: Kidney

Pathological State: Renal Chronic Transplant Dysfunction

995
CD16⁺ monocytes with smooth muscle cell characteristics are reduced in human renal chronic transplant dysfunction.

M Boersema, J van Ark, MA Seelen, MCRF van Dijk, H van Goor, GJ navis, ER Popa, JL Hillebrands

Immunobiology (Elsevier) The Netherlands, 21 November 2014

Transplantation Medicine

Key words: Chronic transplant dysfunction, Kidney, Monocytes, Monocyte heterogeneity, Smooth-muscle-like cells, Transplantation

Organism: Human

Tissue: Kidney

Pathological State: Renal Chronic Transplant Dysfunction

996
Hepatic stellate cells secretes type I collagen to trigger epithelial mesenchymal transition of hepatoma cells

MC Yang, CJ Wang, PC Liao, CJ Yen, YS Shan

American Journal of Cancer Research (NCBI) China, Taiwan, 19 November 2014

Oncology

Key words: Hepatic stellate cell, collagen type I, epithelial-mesenchymal transition

Organism: Human

Tissue: Liver

997
Comparison of CD163+ macrophages and CD206+ cells in lesional skin of CD30+ lymphoproliferative disorders of lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma

Aya Kakizaki, Taku Fujimura, Yumi Kambayashi, Sadanori Furudate, Mitsuko Kawano, Kouetsu Ogasawara, Setsuya Aiba

Acta Dermato Venereologica (Ingentaconnect) Japan, 18 November 2014

Dermatology

Key words: CD163+ Macrophages, CD206+ Cells, Skin Lesion, CD30+ LymphoproliferativeDisorders, Lymphomatoid Papulosis, Primary Cutaneous Anaplastic Large-cell Lymphoma

Organism: Human

Tissue: Skin

Pathological State: Lymphomatoid Papulosis, Cancer

998
Effect of preemptive treatment with human umbilical cord blood-derived mesenchymal stem cells on the development of renal ischemia-reperfusion injury in mice

Hye Ryoun Jang, Ji Hyeon Park, Ghee Young Kwon, Jung Eun Lee, Wooseong Huh, Hye Jin Jin, Soo Jin Choi, Wonil Oh, Ha Young Oh, Yoon-Goo Kim

American Journal of Physiology - Renal Physiology (APS Journals) South Korea, 15 November 2014

Nephrology

Key words: Mesenchymal stem cells, inflammation, renal ischemia-reperfusion injury, human umbilical cord blood-derived mesenchymal stem cells

Organism: Mouse

Tissue: Kidney

Pathological State: Renal Ischemia-Reperfusion Injury

999
Generation of induced pluripotent stem cells without genetic defects by small molecules

Hang-Soo Parka, Insik Hwanga, Kyung-Ah Choia, Hyesun Jeonga, Ji-Yun Leeb, Sunghoi Hong

Biomaterials (Elsevier) South Korea, 15 November 2014

Biological Materials

Key words: Induced pluripotent stem cells, small molecules, genomic stability, DNA double-strand breaks

Organism: Mouse

Cell Line: Fibroblasts and iPSCs

1000
An increase in integrin-linked kinase non-canonically confers NF-κB-mediated growth advantages to gastric cancer cells by activating ERK1/2

Po-Chun Tseng, Chia-Ling Chen, Yan-Shen Shan, Wen-Teng Chang, Hsiao-Sheng Liu, Tse-Ming Hong, Chia-Yuan Hsieh, Sheng-Hsiang Lin, Chiou-Feng Lin

Cell Communication and Signaling (Springer) Taiwan, 15 November 2014

Oncology

Key words: ILK, Cell growth, IQGAP1, ERK1/2, NK-κB

Organism: Human

Tissue: Stomach

Pathological State: Cancer

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