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On May 3rd, TissueGnostics surpassed 1,500 scientific reference publications

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 Most of the 1500 research publications referencing TissueGnostics (over 50%) originated in the United States, Austria, Germany, Taiwan (China) and mainland China.

  

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Customer Publications (A total of 1522 papers published)

601
EGFR in Tumor-associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients

Sriram Srivatsa, Mariel C. Paul, Claudia Cardone, Martin Holcmann, Nicole Amberg, Paulina Pathria, Michaela A. Diamanti, Markus Linder, Gerald Timelthaler, Hans P. Dienes, Lukas Kenner, Fritz Wrba, Gerald W. Prager, Stefan Rose-John, Robert Eferl, Giuseppina Liguori, Gerardo Botti, Erika Martinelli, Florian R. Greten, Fortunato Ciardiello, Maria Sibilia

Gastroenterology (Elsevier) Austria, 09 April 2017

Oncology

Key words: Tumor microenvironment, cytokine, CRC, colon cancer

Organism: Human, Mouse

Tissue: Colon

Pathological State: Cancer

602
Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)

Kohei Shitara, Toshihiko Doi, Osamu Nagano, Chiyo K. ImamuraTakeshi OzekiYuya IshiiKenji TsuchihashiShunji TakahashiTakako E. NakajimaShuichi HironakaMiki FukutaniHiromi HasegawaShogo NomuraAkihiro SatoYasuaki EinagaTakeshi KuwataHideyuki SayaEmail authorAtsushi Ohtsu

Gastric Cancer (Springer) Japan, 07 April 2017

Oncology

Key words: Cancer stem cell, CD44 variant positive, Gastric cancer, Sulfasalazine xCT

Organism: Human

Tissue: Stomach

Pathological State: Cancer

603
Surviving murine experimental sepsis affects the function and morphology of the inner ear

Natalie Fischer, Nina Maria Mathonia, Georges Hollerich, Julian Veser, Leyla Pinggera, Daniel Dejaco, Rudolf Glueckert, Anneliese Schrott-Fischer, Peter Lackner, Herbert Riechelmann, Joachim Schmutzhard

Biology Open (The Company of Biologists) Austria, 04 April 2017

Physiology

Key words: Sepsis, Hearing loss, Inner ear, Inflammation, Apoptosis

Organism: Mouse

Pathological State: Sepsis

604
Intracerebral delivery of the M2 polarizing cytokine interleukin 13 using mesenchymal stem cell implants in a model of temporal lobe epilepsy in mice

Idrish Ali, Stephanie Aertgeerts, Debbie Le Blon, Daniele Bertoglio, Chloe Hoornaert, Peter Ponsaerts, Stefanie Dedeurwaerdere

Official Journal of the International League Against Epilsepy (Wiley) Belgium, 04 April 2017

Transplantation Medicine

Key words: IL-13 MSCs, acid–induced status epilepticus, video–electroencephalography, F4/80+ cells

Organism: Mouse

Tissue: Brain

Pathological State: Epilepsy

605
Information Limits of Optical Microscopy: Application to Fluorescent Labelled Tissue Section

Renata Rychtáriková, Georg Steiner, Michael B. Fischer,Dalibor Šty

Bioinformatics and Biomedical Engineering (Springer) Austria, Czech Republic, 01 April 2017

Microscopy

Key words: Electromagnetic centroid, Point divergence gain, Superresolution, 3D structure reconstruction

Organism: Human

Tissue: Prostate

Pathological State: Cancer

606
High expression of CASZ1 is associated with poor prognosis in ovarian cancer

YJ Chuang, YL Liang, YL Chen, TM Hong, KF Hsu

Cancer Research (AACR Publications) Taiwan, 01 April 2017

Oncology

Key words: High expression of CASZ1 is associated with poor prognosis in ovarian cancer

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

607
Brilliant Blue G, but not Fenofibrate, Treatment Reverts Hemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinson's Disease

Enéas G. Ferrazoli, Héllio D.N. De Souza, Isis C. Nascimento, Ágatha Oliveira-Giacomelli, Telma T. Schwindt, Luiz R. Britto, Henning Ulrich

Cell Transplantation (SAGE Journals) Brazil, 01 April 2017

Neuroscience

Key words: Parkinson's disease (PD), P2X7 receptor, brilliant Blue G (BBG), PGC-1α, fenofibrate

Organism: Rat

Tissue: Brain

608
ICAM-1 binding rhinoviruses enter HeLa cells via multiple pathways and travel to distinct intracellular compartments for uncoating

H Ganjian, C Zietz, D Mechtcheriakova, D Blaas, R Fuchs

Viruses (MDPI) Austria, 01 April 2017

Virology

Key words: human rhinoviruses; ICAM-1; productive uncoating; endocytosis; clathrin; dynamin; macropinocytosis; actin; dynein

Organism: Human

Pathological State: Virus Infection

Cell Line: HeLA cells

609
Colibactin contributes to the hypervirulence of pks+ K1 CC23 Klebsiella pneumoniae in mouse meningitis infections

Min-Chi Lu, Ying-Tsong Chen, Ming-Ko Chiang, Yao-Chen Wang, Pei-Yi Hsiao, Yi-Jhen Huang, Ching-Ting Lin, Ching-Chang Cheng, Chih-Lung Liang and Yi-Chyi Lai

Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) Taiwan, 31 March 2017

Microbiology

Key words: Colibactin, pks+ K1 CC23 Klebsiella pneumoniae, Mouse Meningitis

Organism: Mouse

Tissue: Small Intestine, Colon, Liver, Spleen, Brain

Pathological State: Bacterial Infection

610
Early, but not late treatment with human umbilical cord blood-derived mesenchymal stem cells attenuates cisplatin nephrotoxicity through immunomodulation

Ji Hyeon Park, Hye Ryoun Jang, Do Hee Kim, Ghee Young Kwon, Jung Eun Lee, Wooseong Huh, Soo Jin Choi, Wonil Oh, Ha Young Oh, Yoon-Goo Kim

American Journal of Physiology (APS Journals) South Korea, 29 March 2017

Physiology

Key words: Acute kidney injury, Cisplatin nephrotoxicity, immunomodulation, mesenchymal stem cells, regulatory T cells

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Injury

611
HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice

Niek G. J. Leus, Thea van den Bosch, Petra E. van der Wouden, Kim Krist, Maria E. Ourailidou, Nikolaos Eleftheriadis, Loes E. M. Kistemaker, Sophie Bos, Rutger A. F. Gjaltema, Solomon A. Mekonnen, Rainer Bischoff, Reinoud Gosens, Hidde J. Haisma and Frank J. Dekker

Scientific Reports (Nature) The Netherlands, 27 March 2017

Immunology

Key words: Mechanism of action, Pharmacodynamics

Organism: Mouse

Tissue: Lung

Pathological State: Inflammation

612
Non-thermal air plasma promotes the healing of acute skin wounds in rats

S. Kubinova, K. Zaviskova, L. Uherkova, V. Zablotskii, O. Churpita, O. Lunov and A. Dejneka

Scientific Reports (Nature) Czech Republic, 24 March 2017

Regenerative Medicine

Key words: Non-thermal plasma (NTP), skin wound, atmospheric pressure air plasma, histological and gene expression analysis

Organism: Rat

Tissue: Skin

Pathological State: Skin Wound

613
Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure

Franziska Roth-Walter, Cornelia Bergmayr, Sarah Meitz, Stefan Buchleitner, Caroline Stremnitzer, Judit Fazekas, Anna Moskovskich, Mario A. Müller, Georg A. Roth, Krisztina Manzano-Szalai, Zdenek Dvorak, Alina Neunkirchner and Erika Jensen-Jarolim

Scientific Reports (Nature) Austria, 23 March 2017

Immunology

Key words: Acrolein, BALB/c allergy model, T cells , D2F2 tumor cells

Organism: Mouse

Tissue: Lung, Spleen, Allograft Tumor

Pathological State: Cancer

614
Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas

Gary Kohanbash, Diego A. Carrera, Shruti Shrivastav, Brian J. Ahn, Naznin Jahan, Tali Mazor, Zinal S. Chheda, Kira M. Downey, Payal B. Watchmaker, Casey Beppler, Rolf Warta, Nduka A. Amankulor, Christel Herold-Mende, Joseph F. Costello, and Hideho Okada

JCI The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, Germany, 20 March 2017

Oncology, Immunology

Key words: Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

615
Histone Methyltransferase G9a Drives Chemotherapy Resistance by Regulating the Glutamate–Cysteine Ligase Catalytic Subunit in Head and Neck Squamous Cell Carcinoma

Chia-Wen Liu, Kuo-Tai Hua, Kai-Chun Li, Hsiang-Fong Kao, Ruey-Long Hong, Jenq-Yuh Ko, Michael Hsiao, Min-Liang Kuo and Ching-Ting Tan

Molecular Cancer Therapeutics (AACR Publications) Taiwan, 06 March 2017

Oncology

Key words: Neck squamous cell carcinomas (HNSCC), histone methyltransferase, apoptosis, glutamate-cysteine ligase catalytic subunit (GCLC)

Organism: Mouse

Tissue: Head and Neck

Pathological State: Cancer

616
Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK/Slug signaling pathway

Jung Hoo Hwang, Soo Jung Park, Won Gyu Ko, Seong-Mun Kang, Da Bin Lee, Junho Bang, Byung-Joo Park, Chung-Beum Wee, Dae Joon Kim, Ik-Soon Jang, and Jae-Hong Ko

American Journal of Cancer Research (NCBI) South Korea, USA, 01 March 2017

Oncology

Key words: Cordycepin, nitric oxide, ERK, slug, lung cancer, apoptosis

Organism: Human

Pathological State: Cancer

Cell Line: Human lung adenocarcinoma cell lines, A549 and PC9

617
Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Yan-Jiun Huang, Ching-Kuo Yang, Po-Li Wei, Thanh-Tuan Huynh, Jacqueline Whang-Peng, Tzu-Ching Meng, Michael Hsiao, Yew-Ming Tzeng, Alexander TH Wu and Yun Yen

Journal of Hematology and Oncology (Springer) Taiwan, Vietnam, 28 February 2017

Oncology

Key words: M2 tumor-associated macrophages, Colon tumorigenesis, Stemness, YAP1, Ovatodiolide

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

618
Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activation

Ya-Ting Chu, Shu-Wen Wan, Yu-Chang Chang, Chien-Kuo Lee, Betty A Wu-Hsieh, Robert Anderson and Yee-Shin Lin

Laboratory Investigation (Nature) Taiwan, 27 February 2017

Immunology, Virology

Key words: Dengue virus, mast cells, DHF/DSS, chemokines

Organism: Mouse

Tissue: Skin

Pathological State: Virus Infection

619
Tumor specific regulatory T cells in the bone marrow of breast cancer patients selectively upregulate the emigration receptor S1P1

Anchana Rathinasamy, Christoph Domschke, Yingzi GeHans-Henning Böhm, Steffen Dettling, David Jansen, Felix Lasitschka, Ludmila Umansky, Markus H. Gräler, Jennifer Hartmann, Christel Herold-Mende, Florian Schuetz, Philipp Beckhove

Cancer Immunology, Immunotherpay (Springer) Germany, 21 February 2017

Oncology

Key words: Antigen-specific regulatory T cells, Bone marrow, Sphingosine-1-phosphate receptor 1, Exit, Breast cancer patients

Organism: Human

Tissue: Breast

Pathological State: Cancer

620
Ccdc181 is a microtubule binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia

Thomas Schwarza, Barbara Prielera, Johannes A. Schmidb, Pawel Grzmilc, Juergen Neesena

European Journal of Cell Biology (Elsevier) Austria, 20 February 2017

Cell Biology

Key words: Ccdc181, Cilia, Manchette, Microtubules, Motility, Hook1, Spermatogenesis

Organism: Mouse

Tissue: Testis, Lung, Trachea, Brain

621
Diagnostic and prognostic relevance of CP2c and YY1 expression in hepatocellular carcinoma

Ji Sook Kim, Seung Han Son, Min Young Kim, DongHo Choi, Ik-Soon Jang, Seung Sam Paik, Ji Hyung Chae, Vladimir N. Uversky, and Chul Geun Kim

Oncotarget (Impact Journals) South Korea, USA, 17 February 2017

Oncology

Key words: hepatocellular carcinoma (HCC), CP2c, YY1, diagnosis, prognosis

Organism: Human

Tissue: Liver

Pathological State: Cancer

622
Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1

Ee Soo Lee, Llorenç Solé Boldo, Bernadette O. Fernandez, Martin Feelisch and Martin C. Harmsen

Scientific Reports (Nature) The Netherlands, 17 February 2017

Immunology

Key words: Endothelial dysfunction, TAK1 (MAP3K7), ERK5 (MAPK7), TGF-β

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

623
Subcellular probes for neurochemical recording from multiple brain sites

Helen N. Schwerdt, Min Jung Kim, Satoko Amemori, Daigo Homma, Tomoko Yoshida, Hideki Shimazu, Harshita Yerramreddy, Ekin Karasan, Robert Langer, Ann M. Graybiel and Michael J. Cima

Lab on a Chip (Royal Society of Chemistry) USA, 15 February 2017

Nanomedicine

Key words: striatum, voltammetry, implantable sensors, microelectrodes, dopamine

Organism: Rat

Tissue: Brain

624
Editor's highlight: periodic exposure to smartphone-mimic low-luminance blue light induces retina damage through Bcl-2/BAX-dependent apoptosis

Cheng-Hui Lin, Man-Ru Wu, Ching-Hao Li, Hui-Wen Cheng, Shih-Hsuan Huang, Chi-Hao Tsai, Fan-Li Lin, Jau-Der Ho, Jaw-Jou Kang, George Hsiao, Yu-Wen Cheng

Toxicological Sciences (Oxford University Press) Taiwan, 10 February 2017

Toxicology

Key words: blue light, age-related macular degeneration, apoptosis, Bax, Bcl-2, FasL, caspase-3.

Organism: Rat

Tissue: Eye

625
The lymphatic phenotype of lung allografts in patients with bronchiolitis obliterans syndrome and restrictive allograft syndrome

Traxler D, Schweiger T, Schwarz S, Schuster MM, Jaksch P, Lang G, Birner P, Klepetko W, Ankersmit HJ, Hoetzenecker K.

Transplantation (Wolters Kluwer) Austria, 10 February 2017

Transplantation Medicine

Key words: Lymphatic Phenotype, Lung Allograft, Bronchiolitis Obliterans Syndrome, Restrictive Allograft Syndrome

Organism: Human

Tissue: Lung

Pathological State: Bronchiolitis

626
Elatoside C protects against ox-LDL-induced HUVECs injury by FoxO1-mediated autophagy induction

Yun Luo, Xiangbao Meng, Ping Zhou, Shan Lu, Meng Qin, Xudong Xu, Guibo Sun , Xiaobo Sun,

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) China, 09 February 2017

Neuroscience

Key words: Autophagy, apoptosis, Elatoside C, ox-LDL, FoxO1, HUVECs

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

627
Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Wei-Chun HuangFu, Min-Wu Chao, Chun-Chun Cheng, Yu-Chieh Wei, Yi-Wen Wu, Jing-Ping Liou, George Hsiao, Yu-Ching Lee and Chia-Ron Yang

Scientific Reports (Nature) Taiwan, 09 February 2017

Oncology

Key words: Histone deacetylase (HDAC), cell lines HL-60 and MOLT-4, apoptosis

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

628
Diffusion radiomics analysis of intratumoral heterogeneity in a murine prostate cancer model following radiotherapy: Pixelwise correlation with histology

Yu-Chun Lin, Gigin Lin, Ji-Hong Hong, Yi-Ping Lin, Fang-Hsin Chen, Shu-Hang Ng, Chun-Chieh Wang

Journal Of Magnetic Resonance Imaging (Wiley) Taiwan, 08 February 2017

Oncology

Key words: Apparent diffusion coefficient (ADC), TRAMP-C1, tumor,

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

629
Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis

Laura Pasetto, Silvia Pozzi, Mariachiara Castelnovo, Manuela Basso, Alvaro G. Estevez, Stefano Fumagalli, Maria Grazia De Simoni, Valeria Castellaneta, Paolo Bigini, Elena Restelli, Roberto Chiesa, Francesca Trojsi, Maria Rosaria Monsurrò, Leonardo Callea, Miroslav Malešević, Gunter Fischer, Mattia Freschi, Massimo Tortarolo, Caterina Bendotti and Valentina Bonetto

Journal of Neuroscience (Society for Neuroscience) Italy, 08 February 2017

Neuroscience

Key words: Amyotrophic lateral sclerosiscy, clophilin A, neuroinflammation

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Amyotrophic Lateral Sclerosis

630
Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury

HH Chen, H Yuan, H Cho, Y Feng, S Ngoy, ATN Kumar, R Liao, L Josephson, DE Sosnovik

Theranostics (NCBI) USA, 08 February 2017

Cardiology

Key words: NA, RNA, Inflammation, Ischemia, Nanoprobe, Imaging.

Organism: Mouse

Tissue: Heart

Pathological State: Ischemia

631
Laser deposition of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) − Lysozyme microspheres based coatings with anti-microbial properties

V. Grumezescu, A.M. Holban, L.E. Sima, M.B. Chiritoiu, G.N. Chiritoiu, A.M. Grumezescu, L. Ivan, F. Safciuc, F. Antohe, C. Florica, C.R. Luculescu, M.C. Chifiriuc, G. Socol

International Journal of Pharmaceutics (Elsevier) Romania, 07 February 2017

Regenerative Medicine

Key words: Lysozyme, Laser processing, MAPLE thin coatings, Antimicrobial surfaces, Osteoblast and endothelial cell culture

Organism: Human

Pathological State: Cancer

Cell Line: SAOS2 cells (primary osteogenic sarcoma cells)

632
Tumour-infiltrating regulatory T cell density before neoadjuvant chemoradiotherapy for rectal cancer does not predict treatment response

Melanie J. McCoy, Chris Hemmings, Chidozie C. Anyaegbu, Stephanie J. Austin, Tracey F. Lee-Pullen, Timothy J. Miller, Max K. Bulsara, Nikolajs Zeps, Anna K. Nowak, Richard A. Lake, Cameron F. Platell

Oncotarget (Impact Journals) Australia, 03 February 2017

Oncology

Key words: Rectal cancer, regulatory T cells, radiotherapy, chemotherapy, treatment response

Organism: Human

Tissue: Colon

Pathological State: Cancer

633
Abstract P2-04-07: Immune profiling of post neoadjuvant high metastatic risk (RCB-II/III) residual disease in patients with early triple negative breast cancers

S Irshad, M Cheang, P Gazinka, K Naidoo, R Buus, S Pinder, M Dowsett and A Tutt

Cancer Research (AACR Publications) UK, 01 February 2017

Oncology

Organism: Human

Tissue: Breast

Pathological State: Cancer

634
Biocomposite coatings based on Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/calcium phosphates obtained by MAPLE for bone tissue engineering

O. Rașoga, L. Sima, M. Chirițoiu, G. Popescu-Pelin, O. Fufă, d, V. Grumezescu, M. Socol, A. Stănculescu, I. Zgură, G. Socol

Applied Surface Science (Elsevier) Romania, 31 January 2017

Regenerative Medicine

Key words: MAPLE, Calcium phosphates, PHBV, Composite, Hydroxyapatite, β-Tricalcium phosphate

Organism: Human

Cell Line: Human mesenchymal stem cells (hMSCs)

635
Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes

Xianpeng Liu, Bo Zhao, Limin Sun, Karan Bhuripanyo, Yiyang Wang, Yingtao Bi, Ramana V. Davuluri, Duc M. Duong, Dhaval Nanavati, Jun Yin and Hiroaki Kiyokawa

Nature Communications (Nature) USA, 31 January 2017

Cell Biology

Key words: Protein ubiquitination, mammalian cells, polyubiquitination

Organism: Human

Pathological State: Fibrosis

Cell Line: MCF-10A cells ( human female mammary gland cells)

636
Effect of a cocoa diet on the small intestine and gut-associated lymphoid tissue composition in an oral sensitization model in rats ☆

Mariona Camps-Bossacoma, Francisco J. Pérez-Cano, Àngels Franch, Eva Untersmayr, Margarida Castell

Journal of Nutritional Biochemistry (Elsevier) Spain, 23 January 2017

Gastroenterology

Key words: Cholera toxin, Cocoa, Ovalbumin, TCRγδ+ cells, Tolerance

Organism: Rat

Tissue: Small Intestine

637
SOX2 and Rb1 in esophageal small-cell carcinoma: their possible involvement in pathogenesis

Ishida H, Kasajima A, Kamei T, Miura T, Oka N, Yazdani S, Ozawa Y, Fujishima F, Sakurada A, Nakamura Y, Tanaka Y, Kurosumi M, Ishikawa Y, Okada Y, Ohuchi N, Sasano H

Modern Pathology (Nature) Japan, 20 January 2017

Pathology

Key words: Esophageal small-cell carcinoma, SOX2 overexpression, squamous-basal markers (CK5/6 and p40), glandular markers (CK18 and CEA)

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

638
Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression

Monika Linke, Ha Thi Thanh Pham, Karl Katholnig, Thomas Schnöller, Anne Miller, Florian Demel, Birgit Schütz, Margit Rosner, Boris Kovacic, Nyamdelger Sukhbaatar, Birgit Niederreiter, Stephan Blüml, Peter Kuess, Veronika Sexl, Mathias Müller, Mario Mikula, Wolfram Weckwerth, Arvand Haschemi, Martin Susani, Markus Hengstschläger, Michael J Gambello and Thomas Weichhart

Nature Immunology (Nature) Austria, 16 January 2017

Pathology

Key words: Hypertrophic macrophages, tuberous sclerosis 2 (Tsc2), mTORC1

Organism: Mouse

Tissue: Lung

Pathological State: Sarcoidosis

639
Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma

Jong Cheon Joo, Jung Hoo Hwang, Eunbi Jo, Young-Rang Kim, Dae Joon Kim, Kyung-Bok Lee, Soo Jung Park, and Ik-Soon Jang

Oncotarget (Impact Journals) South Korea, USA, 14 January 2017

Oncology

Key words: cordycepin, CAV1, JNK, Foxo3a, apoptosis

Organism: Human

Pathological State: Cancer

Cell Line: human lung adenocarcinoma lines A549, HCC827, and PC9

640
Development of a DsRed-expressing HepaRG cell line for real-time monitoring of hepatocyte-like cell differentiation by fluorescence imaging, with application in screening of novel geometric microstructured cell growth substrates

Mihaela Uta,Livia E. Sima,Patrik Hoffmann,Valentina Dinca, Norica Branza-Nichita

Biomedical Microdevices (Springer) Romania, 09 January 2017

Biological Methods

Key words: HepaRG, Hepatocyte-like cells, HBV, Differentiation, Microstructured PDMS

Organism: Human

Cell Line: HepaRG, HeLa, Me290 cells

641
Inhibition of the transcriptional repressor complex Bcl-6/BCoR induces endothelial sprouting but does not promote tumor growth

Elisabeth Buchberger, Dietmar Payrhuber, Miriam El Harchi, Branislav Zagrapan, Katharina Scheuba, Anna Zommer, Edina Bugyik, Balazs Dome, Julia Barbara Kral, Waltraud Cornelia Schrottmaier, Gernot Schabbauer, Peter Petzelbauer, Marion Gröger, Martin Bilban, and Christine Brostjan

Oncotarget (Impact Journals) Austria, 03 January 2017

Oncology

Key words: 79-6, Bcl-6, BCoR, colorectal carcinoma, vascular sprouting

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

642
Limited tumor tissue drug penetration contributes to primary resistance against angiogenesis inhibitors

Szilvia Torok, Melinda Rezeli, Olga Kelemen, Akos Vegvari, Kenichi Watanabe, Yutaka Sugihara, Anna Tisza, Timea Marton, Ildiko Kovacs, Jozsef Tovari, Viktoria Laszlo, Thomas H. Helbich, Balazs Hegedus, Thomas Klikovits, Mir Alireza Hoda, Walter Klepetko, Sandor Paku, Gyorgy Marko-Varga, and Balazs Dome

Theranostics (NCBI) Hungary, Austria, Sweden, 01 January 2017

Oncology

Key words: matrix assisted laser desorption ionization, imaging mass spectrometry, angiogenesis, receptor tyrosine kinase inhibitor, resistance, cancer

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

643
Heme Oxygenase-1-Expressing Dendritic Cells Promote Foxp3+ Regulatory T Cell Differentiation and Induce Less Severe Airway Inflammation in Murine Models

Tzu-Hsuan Wong , Hung-An Chen , Rung-Jiun Gau, Jeng-Hsien Yen, Jau-Ling Suen

PLoS One (PLOS) Taiwan, 29 December 2016

Immunology

Key words: Dendritic cells (DCs), HO-1, lipopolysaccharide (LPS), Foxp3+

Organism: Mouse

Tissue: Lung

644
Interstitial Fibrosis, Functional Status, and Outcomes in Heart Failure With Preserved Ejection Fraction

Franz Duca, Andreas A. Kammerlander, Caroline Zotter-Tufaro, Stefan Aschauer, Marianne L. Schwaiger, Beatrice A. Marzluf, Diana Bonderman, Julia Mascherbauer

Circulation:Cardiovascular Imaging (AHA Journals) Austria, 14 December 2016

Cardiology

Key words: Magnetic resonance imaging, heart failure, mapping

Organism: Human

Tissue: Heart

Pathological State: Heart Failure

645
Adipose tissue–derived mesenchymal stem cells expressing prodrug-converting enzyme inhibit human prostate tumor growth

Ilaria T Cavarretta, Veronika Altanerova, Miroslava Matuskova, Lucia Kucerova, Zoran Culig, Cestmir Altaner

Molecular Therapy (Cell Press) Austria, Slovakia, 14 December 2016

Stem Cell Research

646
Mesenchymal Stem Cells Correct Inappropriate Epithelial–mesenchyme Relation in Pulmonary Fibrosis Using Stanniocalcin-1

Ono M, Ohkouchi S, Kanehira M, Tode N, Kobayashi M, Ebina M, Nukiwa T, Irokawa T, Ogawa H, Akaike T, Okada Y, Kurosawa H, Kikuchi T, Ichinose M

Molecular Therapy (Cell Press) Japan, 14 December 2016

Pulmonology

Key words: Mesenchymal Stem Cells, Epithelial–mesenchyme Relation, Pulmonary Fibrosis, Stanniocalcin-1

Organism: Mouse

Tissue: Lung

Pathological State: Fibrosis

647
Early dissemination seeds metastasis in breast cancer

Hedayatollah Hosseini, Milan M. S. Obradović, Martin Hoffmann, Kathryn L. Harper, Maria Soledad Sosa, Melanie Werner-Klein, Lahiri Kanth Nanduri, Christian Werno, Carolin Ehrl, Matthias Maneck, Nina Patwary, Gundula Haunschild, Miodrag Gužvić, Christian Reimelt, Michael Grauvogl, Norbert Eichner, Florian Weber, Andreas D. Hartkopf, Florin-Andrei Taran, Sara Y. Brucker, Tanja Fehm, Brigitte Rack, Stefan Buchholz, Rainer Spang, Gunter Meister et al.

Nature (Nature) Germany, 14 December 2016

Oncology

Key words: Metastatic dissemination, breast cancer, HER2 , Karyotypic and phenotypic analysis

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

648
Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury

Dearbhaile Dooley, Evi Lemmens, Tim Vangansewinkel, Debbie Le Blon, Chloé Hoornaert, Peter Ponsaerts, Sven Hendrix

Stem Cell Reports (Elsevier) Belgium, 13 December 2016

Transplantation Medicine

Key words: Mesenchymal stem cells, interleukin-13, spinal cord injury, cell transplantation, microglia, macrophages

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

649
The 6-chromanol derivate SUL-109 enables prolonged hypothermic storage of adipose tissue-derived stem cells

Ghazaleh Hajmousa, Pieter Vogelaar, Linda A. Brouwer, Adrianus C. van der Graaf, Robert H. Henning, Guido Krenning

Biomaterials (Elsevier) The Netherlands, 09 December 2016

Biological Materials

Key words: Adipose tissue-derived stem cells (ASC), Hypothermia, Cold storage, Mitochondrial damage, Chromanol

Organism: Human

Cell Line: Adipose tissue derived stromal cells (ADSC)

650
Involvement of Pancreatic Stellate Cells in Regeneration of Remnant Pancreas after Partial Pancreatectomy

Shigenori Ota, Miyuki Nishimura, Yuya Murakami, Naoko Kubo Birukawa, Akihiro Yoneda, Hiroki Nishita, Ryosuke Fujita, Yasushi Sato, Kenjiro Minomi, Keiko Kajiwara, Miyono Miyazaki, Maki Uchiumi, Shintaro Mikuni, Yasuaki Tamura, Toru Mizuguchi, Masafumi Imamura, Makoto Meguro, Yasutoshi Kimura, Koichi Hirata, Yoshiro Niit

PLoS One (PLOS) Japan, 09 December 2016

Regenerative Medicine

Key words: Pancreatectomy, siRNA, activated pancreas stellate cells (aPSCs), apoptosis

Organism: Rat

Tissue: Pancreas

Pathological State: Pancreatectomy

651
Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative

Jun Wei,Hongyan Zhu, Gabriel Lord, Mitra Bhattachayya, Brielle M. Jones, Graham Allaway, Shyam S. Biswal, Benjamin Korman, Roberta G. Marangoni, Warren G. Tourtellotte, John Varga

Translational Research (Elsevier) USA, 09 December 2016

Neuroscience

Key words: Nrf2-nuclear factor erythroid 2–related factor 2, systemic sclerosis, TGF-β, CDDO, TMC

Organism: Human

Tissue: Skin

Pathological State: Systemic Sclerosis

652
Lead-Free Piezoelectric (Ba,Ca)(Zr,Ti)O3 Thin Films for Biocompatible and Flexible Devices

N. D. Scarisoreanu, F. Craciun, V. Ion, R. Birjega, A. Bercea V. Dinc, M. Dinescu, L. E. Sima, M. Icriverzi, A. Roseanu, L. Gruionu, and G. Gruionu

Applied Materials and Interfaces (ACS Publications) Romania, 08 December 2016

Biological Materials

Key words: Biocompatible materials, laser processing, lead-free thin films, mesenchymal stem cells, osteogenic differentiation

Organism: Human

Pathological State: Cancer

Cell Line: HEK 293T and A375 cells (Human epithelial embryonic kidney and human malignant melanoma cells)

653
Silica-Coated Metal Chelating-Melanin Nanoparticles as a Dual-Modal Contrast Enhancement Imaging and Therapeutic Agent

Soojeong Cho, Wooram Park and Dong-Hyun Kim

Applied Materials and Interfaces (ACS Publications) USA, 08 December 2016

Nanomedicine

Key words: Fluorescence imaging, melanin, metal-chelation,MRI, multimodal image-guidance, silica coating

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

654
Nodal metastasis signatures in breast cancer

Kyeongmee ParK, Joo Hyun Lee, Hyun Ho Han, Seong Gyeong Mun, Suki Kang, Youn Jin Cha, Ja-Seung Koo, Min Ju Kim, Hye Sun Lee, Jieun Moon, Nam Hoon Cho

Pathology - Research and Practice (Elsevier) South Korea, 05 December 2016

Oncology

Key words: Breast cancer, node positive ratio, node positive number, ERK, WDR1, c-MET

Organism: Human

Tissue: Breast

Pathological State: Cancer

655
Solid stress and elastic energy as measures of tumour mechanopathology

Hadi T. Nia, Hao Liu, Giorgio Seano, Meenal Datta, Dennis Jones, Nuh Rahbari, Joao Incio, Vikash P. Chauhan, Keehoon Jung, John D. Martin, Vasileios Askoxylakis, Timothy P. Padera, Dai Fukumura, Yves Boucher, Francis J. Hornicek, Alan J. Grodzinsky, James W. Baish, Lance L. Munn and Rakesh K. Jain

Nature Biomedical Engineering (Nature) USA, 28 November 2016

Neuroscience

Key words: Solid stress, tissue stiffness, tumour

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

656
Mast Cells Are Abundant in Primary Cutaneous T-Cell Lymphomas: Results from a Computer-Aided Quantitative Immunohistological Study

Johanna Eder , Radu Rogojanu, Waltraud Jerney, Friedrich Erhart, Alexander Dohnal, Melitta Kitzwögerer, Georg Steiner, Julia Moser, Franz Trautinger

PLoS One (PLOS) Austria, 28 November 2016

Oncology

Key words: Mast cells, cutaneous T-cell lymphomas (CTCL), haematopoetic cells

Organism: Human

Tissue: Skin

Pathological State: Cancer

657
Cardiac extracellular matrix is associated with adverse outcome in patients with chronic heart failure

Franz Duca,Caroline Zotter-Tufaro,Andreas A. Kammerlander,Adelheid Panzenböck,Stefan Aschauer,Daniel Dalos,Benedikt Köll,Benedikt Börries,Hermine Agis,Renate Kain,Klaus Aumayr,Florian Klinglmüller,Julia Mascherbauer,Diana Bonderman

European Journal of Heart Failure (Wiley) Austria, 27 November 2016

Cardiology

Key words: Extracellular matrix (ECM), heart failure (HF), endomyocardial biopsy

Organism: Human

Tissue: Heart

Pathological State: Heart Failure

658
Antimicrobial polycaprolactone/ polyethylene glycol embedded lysozyme coatings of Ti implants for osteoblast functional properties in tissue engineering

A. Visan, R. Cristescu, N. Stefan, M. Miroiu, C. Nita, M. Socol, C. Florica, O. Rasoga, I. Zgura, L.E. Sima, M. Chiritoiu, M.C. Chifiriuc, A.M. Holban, I.N. Mihailescu, G. SocoL

Applied Surface Science (Elsevier) Romania, 19 November 2016

Immunology

Key words: MAPLE, Dip coating, Lysozyme, Blends, Antimicrobial, Biocompatible

Organism: Human

Cell Line: Primary osteogenic sarcoma cells (SAOS2), Human mesenchymal stem cells (hMSCs)

659
Rhinophototherapy in persistent allergic rhinitis

Zsolt Bella, Ágnes Kiricsi, Éva Dósa-Rácz Viharosné, Attila Dallos, Ádám Perényi, Mária Kiss, Andrea Koreck, Lajos KeményJózsef JóriLászló Rovó, Edit Kadocsa

European Archives of Oto-Rhino-Laryngology (Springer) Hungary, 18 November 2016

Allergy Research

Key words: Intercellular adhesion molecule-1 expression, Intranasal phototherapy, Mucociliary clearance, Nasal inspiratory peak flow, Persistent allergic rhinitis, Rhinolight

Organism: Human

Tissue: Mucosa

Pathological State: Allergy

660
The plasma membrane Ca2+ pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells

Luca Hegedũs,Tamás Garay,Eszter Molnár,Karolina Varga,Ágnes Bilecz,Szilvia Török,Rita Padányi,Katalin Pászty,Matthias Wolf,Michael Grusch,Enikõ Kállay,Balázs Döme,Walter Berger,Balázs Hegedũs,Agnes Enyedi

International Journal of Cancer (Wiley) Austria, 17 November 2016

Oncology

Key words: Ca2+, PMCA4b expression, NRAS mutant melanoma cells

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

661
Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

Debbie Le Blon, Caroline Guglielmetti, Chloé Hoornaert, Alessandra Quarta, Jasmijn Daans, Dearbhaile Dooley, Evi Lemmens, Jelle Praet, Nathalie De Vocht, Kristien Reekmans, Eva Santermans, Niel HensHerman Goossens, Marleen Verhoye, Annemie Van der Linden, Zwi Berneman, Sven Hendrix, Peter Ponsaerts

Journal of Neuroinflammation (Springer) Belgium, 09 November 2016

Neuroscience

Key words: Interleukin 13, Mesenchymal stem cells, Neuroinflammation, Transplantation, Magnetic resonance imaging

Organism: Mouse

Tissue: Brain

Pathological State: Demyelination

662
Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis

Yi-Ching Wang, Hong-Tai Tzeng, Chung-Han Tsai, Yi-Ting Yen, Hung-Chi Cheng, Yi-Chieh Chen, Shih-Wen Pu, Yu-Shiuan Wang, Yan-Shen Shan, Yau-Lin Tseng, Wu-Chou Su, Wu-Wei Lai and Li-Wha Wu

Clinical Cancer Research (AACR Publications) Taiwan, 07 November 2016

Oncology

Key words: Rab37-Mediated, Thrombospondin-1, angiogenesis marker CD31, p-FAK/p-paxillin/p-ERK

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

663
Asxl2−/− Mice Exhibit De Novo Cardiomyocyte Production during Adulthood

R Brunner, HL Lai, Z Deliu, E Melman, DL Geenen, QT Wang

Journal of Developmental Biology (MDPI) USA, 03 November 2016

Reproductive Medicine

Key words: heart; cardiogenic; cardiomyocyte; proliferation; regeneration; chromatin factor; epigenetic

Organism: Mouse

Cell Line: Cardiomyocytes

664
A Single Postnatal Dose of Dexamethasone Enhances Memory of Rat Pups Later in Life

Kuen-Jer Tsai , Chun-I Sze , Yung-Chieh Lin, Yuh-Jyh Lin, Ting-Hui Hsieh, Chyi-Her Lin

PLoS One (PLOS) Taiwan, 31 October 2016

Neuroscience

Key words: Postnatal dexamethasone (Dex) therapy, NMDAR, bronchopulmonary dysplasia, chronic lung disease

Organism: Rat

Tissue: Brain

665
Cell Line Macroarray: An Alternative High-Throughput Platform to Analyze hiPSC Lines

Alberto La Spada, Simona Baronchelli, Linda Ottoboni, Francesca Ruffini, Gianvito Martino, Nunzia Convertino, Aikaterini Ntai, Tobias Steiner, Ida Biunno, Andrea De Blasio

Journal of Histochemistry and Cytochemistry (SAGE Journals) Italy, Austria, 26 October 2016

Biological Methods

Key words: cell line macroarray, high-throughput screening and quantification, hiPSC clones

Organism: Human

Cell Line: hiPSCs

666
An Alternative High-Throughput Platform to Analyze hiPSC Lines

Alberto La Spada, Simona Baronchelli, Linda Ottoboni, Francesca Ruffini, Gianvito Martino, Nunzia Convertino, Aikaterini Ntai, Tobias Steiner, Ida Biunno, Andrea De Blasio

Journal of Histochemistry and Cytochemistry (SAGE Journals) Italy, Austria, 26 October 2016

Biological Methods

Key words: Cell line macroarray, high-throughput screening and quantification, hiPSC clones

Organism: Human

Cell Line: Induced pluripotent cells (iPSCs)

667
Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle

Tim Koopmans,Stijn Crutzen,Mark H Menzen,Andrew J Halayko,Tillie-Louise Hackett,Darryl A Knight,Reinoud Gosens

British Journal of Pharmacology (Wiley) USA, The Netherlands, 25 October 2016

Pharmacology

Key words: Asthma, β-catenin, CREB-binding protein (CBP) , TGFβ1

Organism: Mouse

Tissue: Lung

668
KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1

Yu Gao, Hongzhao Li, Xin Ma, Yang Fan, Dong Ni, Yu Zhang, Qingbo Huang, Kan Liu, Xintao Li, Lei Wang, Liangyou Gu, Yuanxin Yao, Qing Ai, Qingshan Du, Erlin Song and Xu Zhang

Molecular Cancer Research (AACR Publications) China, 25 October 2016

Oncology

Key words: KLF6 expression, E2F1-mediated epithelial–mesenchymal, cell renal cell carcinoma (ccRCC)

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

669
TRPV1 attenuates intracranial arteriole remodeling through inhibiting VSMC phenotypic modulation in hypertension

MJ Zhang, Y Liu, ZC Hu, Y Zhou, Y Pi, L Guo, X Wang, X Chen, JC Li, LL Zhang

Histochemistry and Cell Biology (Springer) China, 24 October 2016

Cardiology

Key words: TRPV1, Intracranial arteriole, VSMC, Phenotypic modulation, Hypertension

Organism: Mouse, Rat

Tissue: Blood Vessels, Brain

670
PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

Brasó-Maristany F, Filosto S, Catchpole S, Marlow R, Quist J, Francesch-Domenech E, Plumb DA, Zakka L, Gazinska P, Liccardi G, Meier P, Gris-Oliver A, Cheang MC, Perdrix-Rosell A, Shafat M, Noël E, Patel N, McEachern K, Scaltriti M, Castel P, Noor F, Buus R, Mathew S, Watkins J, Serra V, Marra P, Grigoriadis A, Tutt AN

Nature Medicine (Nature) UK, 24 October 2016

Oncology

Key words: Triple-negative breast cancers (TNBCs), PIM1 proto-oncogene, anti-apoptotic factor BCL2, dynamic BH3

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

671
Oncolytic influenza A virus expressing interleukin-15 decreases tumor growth in vivo 

Karin Hock, Johannes Laengle, Irina Kuznetsova,Andrej Egorov, Balazs Hegedus, Balazs Dome, Thomas Wekerle, Monika Sachet, Michael Bergmann

Surgery (Elsevier) Austria, 21 October 2016

Immunology

Key words: Interleukin-15, A virus, T cells,

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

672
The fractionation of adipose tissue procedure to obtain stromal vascular fractions for regenerative purposes

Joris A. van Dongen,Hieronymus P. Stevens ,Mojtaba Parvizi ,Berend van der Lei ,Martin C. Harmsen

Wound Repair and Regeneration (Wiley) The Netherlands, 21 October 2016

Regenerative Medicine

Key words: Autologous adipose tissue transplantation, FAT-stromal vascular fraction

Organism: Human

Cell Line: Smooth muscle cells (SMCs)

673
Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury

Jill Moser, Joris van Ark, Marcory C. van Dijk, Dale L. Greiner, Leonard D. Shultz, Harry van Goor and Jan-Luuk Hillebrands

Scientific Reports (Nature) USA, The Netherlands, 19 October 2016

Cardiology

Key words: NOD.Cg-PrkdcscidIL2rgtm1Wjl(NSG), Percutaneous coronary interventions (PCIs), BL/6 mice

Organism: Human

Cell Line: Peripheral blood mononuclear cell

674
In Situ Characterization of Tissue-Resident Immune Cells by MALDI Mass Spectrometry Imaging

Matthias Holzlechner, Katharina Strasser, Elitsa Zareva, Luise Steinhäuser, Hanna Birnleitner, Andrea Beer, Michael Bergmann, Rudolf Oehler, and Martina Marchetti-Deschmann

Journal of Proteome Research (ACS Publications) Austria, 18 October 2016

Immunology

Key words: Colon tissue, immune cells, immunohistochemistry, lymphocytes, macrophages, MALDI mass spectrometry imaging, monocytes

Organism: Human

Tissue: Colon

675
Aberrant expression of tumor-associated carbohydrate antigen Globo H in thyroid carcinoma

Shih-Ping Cheng ,Po-Sheng Yang ,Ming-Nan Chien ,Ming-Jen Chen ,Jie-Jen Lee ,Chien-Liang Liu

Journal of Surgical Oncology (Wiley) Taiwan, 18 October 2016

Oncology

Key words: Globo H - hexasaccharide glycosphingolipid, Normal or benign thyroid, papillary thyroid cancer

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

676
Oncostatin M‐preconditioned mesenchymal stem cells alleviate bleomycin‐induced pulmonary fibrosis through paracrine effects of the hepatocyte growth factor

Ying‐Wei Lan, Si‐Min Theng, Tsung‐Teng Huang, Kong‐Bung Choo, Chuan‐Mu Chen, Han‐Pin Kuo, Kowit‐Yu Chong

Stem Cells Translational Medicine (Wiley) Taiwan, Malaysia, 18 October 2016

Stem Cell Research

Key words: Bleomycin-induced pulmonary fibrosis; Hepatocyte growth factor; Oncostatin M; Preconditioning; Stem cells

Organism: Mouse

Tissue: Lung

Pathological State: Fibrosis

677
Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Tahereh Javaheri, Zahra Kazemi, Jan Pencik, Ha TT Pham, Maximilian Kauer, Rahil Noorizadeh, Barbara Sax, Harini Nivarthi, Michaela Schlederer, Barbara Maurer, Maximillian Hofbauer, Dave NT Aryee, Marc Wiedner, Eleni M Tomazou, Malcolm Logan, Christine Hartmann, Jan P Tuckermann, Lukas Kenner, Mario Mikula, Helmut Dolznig, Aykut Üren, Günther H Richter, Florian Grebien, Heinrich Kovar and Richard Moriggl

Cell Death & Disease (Nature) Austria, UK, Germany, 13 October 2016

Oncology

Key words: Apoptosis, Bone cancer, Cell signalling, Sarcoma

Organism: Mouse

Tissue: Whole Organism

678
Ustekinumab treatment in severe atopic dermatitis: Down-regulation of T-helper 2/22 expression 

Doris Weiss, Michaela Schaschinger, Robin Ristl, Robert Gruber, Tamara Kopp, Georg Stingl, Christine Bangert

Journal of the American Academy of Dermatology (Elsevier) Austria, 13 October 2016

Dermatology

Key words: Anti-interleukin-12/-23 p40, atopic dermatitis, cytokines, eczema, inflammatory, T helper 2, T helper 17, T helper 22, ustekinumab

Organism: Human

Tissue: Skin

Pathological State: Dermatitis

679
Intraarticular overexpression of Smad7 ameliorates experimental arthritis

Shih-Yao Chen, Ai-Li Shiau, Chao-Liang Wu and Chrong-Reen Wang

Scientific Reports (Nature) Taiwan, 12 October 2016

Immunology

Key words: Genetic vectors, Translational immunology

Organism: Human

Tissue: Bone, Connective Tissue

680
Hydroxyapatite thin films grown by pulsed laser deposition and matrix assisted pulsed laser evaporation: Comparative study

G. Popescu-Pelin, F. Sima, L.E. Sima, C.N. Mihailescu, C. Luculescu, I. Iordache, M. Socol, G. Socol, I.N. Mihailescu

Applied Surface Science (Elsevier) Romania, 11 October 2016

Regenerative Medicine

Key words: Pulsed laser deposition, Matrix assisted pulsed laser evaporation, Hydroxyapatite coatings, Biocompatibility, Cell proliferation and differentiation

Organism: Human

Cell Line: Human mesenchymal stem cells (hMSCs)

681
Neuronal prolyl-4-hydroxylase 2 deficiency improves cognitive abilities in a murine model of cerebral hypoperfusion

Daniel Gruneberg, Felipe A. Montellano, Konstanze Plaschke, Lexiao Li, Hugo H. Marti, Reiner Kunze

Experimental Neurology (Elsevier) Germany, 05 October 2016

Neuroscience

Key words: HIF, PHD, Epo, VEGF, Hippocampus, Learning, Memory, Alzheimer's disease

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Hypoperfusion

682
G-CSF-mobilized Bone Marrow Mesenchymal Stem Cells Replenish Neural Lineages in Alzheimer’s Disease Mice via CXCR4/SDF-1 Chemotaxis

Cheng-Chun WuI-Fang Wang, Po-Min Chiang, Liang-Chao Wang, Che-Kun James Shen, Kuen-Jer Tsai

Molecular Neurobiology (Springer) Taiwan, 05 October 2016

Neuroscience

Key words: G-CSF, Bone marrow stem cells, SDF-1CXCR4, Neurogenesis, Alzheimer’s disease

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s Disease

683
Epithelial cholesterol deficiency attenuates human antigen R-linked pro-inflammatory stimulation via SREBP2-linked circuit

SH Park, J Kim, M Yu, JH Park, YS Kim, Y Moon

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) South Korea, 04 October 2016

Gastroenterology

Key words: cholesterol regulation, inflammation, intestinal epithelium, intestinal metabolism, intestine, mRNA decay

Organism: Mouse, Human

Tissue: Colon

Pathological State: Colitis

684
Houttuynia cordata Thunb Promotes Activation of HIF-1A–FOXO3 and MEF2A Pathways to Induce Apoptosis in Human HepG2 Hepatocellular Carcinoma Cells

Jung Min Kim, In-Hu Hwang, Ik-Soon Jang, Min Kim, In Seok Bang, Soo Jung Park, Yun-Jo Chung, Jong-Cheon Joo, Min-Goo Lee

Integrative Cancer Therapies (SAGE Journals) South Korea, 03 October 2016

Oncology

Key words: Cancer, cell apoptosis, hypoxia-inducible factor (HIF)-1A

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

685
Hyperglycemia induces bioenergetic changes in adipose-derived stromal cells while their pericytic function is retained

Ghazaleh Hajmousa, Alvaro A. Elorza, Vera J.M. Nies, Erik L. Jensen, Ruxandra A. Nagy, and Martin C. Harmsen

Stem Cells and Development (Mary Ann Liebert Inc.) The Netherlands, Chile, 01 October 2016

Stem Cell Research

Key words: Adipose Derived Stromal Cells, Diabetic Retinopathy, Pericyte, Hyperglycemia

Organism: Human

Cell Line: Adipose tissue derived stromal cells (ADSC)

686
NSAID-activated gene 1 mediates pro-inflammatory signaling activation and paclitaxel chemoresistance in type I human epithelial ovarian cancer stem-like cells

KH Kim, SH Park, KH Do, J Kim, KU Choi, Y Moon

Histochemistry and Cell Biology (NCBI) South Korea, 30 September 2016

Oncology

Key words: NAG-1, epithelial ovary cancer, paclitaxel, NF-κB, chemoresistance

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

687
Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

Caroline Guglielmetti,Debbie Le Blon, Eva Santermans, Angelica Salas-Perdomo, Jasmijn Daans, Nathalie De Vocht, Disha Shah, Chloé Hoornaert, Jelle Praet, Jurgen Peerlings, Firat Kara, Christian Bigot, Zhenhua Mai, Herman Goossens, Niel Hens, Sven Hendrix, Marleen Verhoye, Anna M. Planas, Zwi Berneman, Annemie van der Linden, Peter Ponsaerts

GLIA (Wiley) Belgium, 29 September 2016

Neuroscience

Key words: IL-13, microglia, macrophages, severe oligodendrocyte loss and demyelination, mouse nodel

Organism: Mouse

Tissue: Brain

Pathological State: Demyelination

688
Comparison of cancer cells cultured in 2D vs 3D reveals differences in AKT/mTOR/S6-kinase signaling and drug response

Angelika Riedl, Michaela Schlederer, Karoline Pudelko, Mira Stadler, Stefanie Walter, Daniela Unterleuthner, Christine Unger, Nina Kramer, Markus Hengstschläger, Lukas Kenner, Dagmar Pfeiffer, Georg Krupitza, Helmut Dolznig

Journal of Cell Science (The Company of Biologists) Austria, 23 September 2016

Oncology

Key words: Cancer cells, colon cancer, AKT/mTOR/S6-kinase, ERK phosphorylation

Organism: Human

Cell Line: LS174T, HT29, SW620, HCT116), Caco2 and DLD1 (Human colon cancer cell lines)

689
Targeted multimodal nano-reporters for pre-procedural MRI and intra-operative image-guidance

Joonseok Lee, Andrew C. Gordon, Hacksung Kim, Wooram Park, Soojeong Cho, Byeongdu Lee, Andrew C. Larson, Elena A. Rozhkova, Dong-Hyun Kim

Biomaterials (Elsevier) USA, 19 September 2016

Medical Imaging

Key words: Upconversion nanoparticles, Medical imaging, Cancer, Interventional radiology, Multimodal probe

Organism: Rat

Tissue: Heart, Liver, Spleen, Lung, Kidney

690
CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy

Fenne L. Komdeur, Maartje C.A. Wouters, Hagma H. Workel, Aline M. Tijans, Anouk L.J. Terwindt, Kim L. Brunekreeft, Annechien Plat, Harry G. Klip, Florine A. Eggink, Ninke Leffers, Wijnand Helfrich, Douwe F. Samplonius, Edwin Bremer, G. Bea A. Wisman, Toos Daemen, Evelien W. Duiker, Harry Hollema, Hans W. Nijman and Marco de Bruyn

Oncotarget (Impact Journals) The Netherlands, 16 September 2016

Oncology

Key words: tumor-infiltrating lymphocytes, high-grade serous ovarian cancer, CD103, TGF-β, cancer immunotherapy

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

691
Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma

Seunggu J. Han, Gerald Reis, Gary Kohanbash, Shruti Shrivastav, Stephen T. Magill, Annette M. Molinaro, Michael W. McDermott, Philip V. Theodosopoulos, Manish K. Aghi, Mitchel S. Berger, Nicholas A. Butowski, Igor Barani, Joanna J. Phillips, Arie Perry, Hideho Okada

Journal of Neuro-Oncology (Springer) USA, 13 September 2016

Neuroscience

Key words: Meningioma, PD-L1, B7-H1, Immunotherapy, Checkpoint, Lymphocyte, Macrophage

Organism: Human

Tissue: Brain

Pathological State: Cancer

692
Paricalcitol attenuates cardiac fibrosis and expression of endothelial cell transition markers in isoproterenol-induced cardiomyopathic rats

CC Lai, CP Liu, PW Cheng, PJ Lu, M Hsiao, WH Lu, GC Sun, JC Liou, CJ Tseng

Critical Care Medicine (Ingentaconnect) Taiwan, 09 September 2016

Cardiology

Key words: cardiac fibrosis; cardiomyopathy; endothelial-to-mesenchymal cell transition; vitamin D activator

Organism: Rat

Tissue: Heart

Pathological State: Fibrosis

693
The effects of oral and topical corticosteroid in rabbit corneas

Kaoru Araki-Sasaki, Osamu Katsuta, Hidetoshi Mano, Takashi Nagano and Masatsugu Nakamura

BMC Ophthalmology (BioMed Central) Japan, 05 September 2016

Ophthalmology

Key words: Corticosteroid, Keratitis, Cornea, Wound healing, Pharmacokinetics

Organism: Rabbit

Tissue: Eye

Pathological State: Skin Wound

694
Presentation of underglycosylated mucin 1 in pancreatic adenocarcinoma (PDAC) at early stages

ST Lo, P Pantazopouos, Z Medarova, A Moore

American Journal of Cancer Research (NCBI) USA, 01 September 2016

Oncology

Key words: Pancreatic cancer, underglycosylated mucin 1, tumor antigen, immunohistochemistry

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

695
Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation

Yong-Hee Rhee, Sang-Hoon Yi, Joo Yeon Kim, Mi-Yoon Chang, A-Young Jo, Jinyoung Kim, Chang-Hwan Park, Je-Yoel Cho, Young-Jin Choi, Woong Sun and Sang-Hun Lee

Scientific Reports (Nature) South Korea, 24 August 2016

Neuroscience

Key words: Neurology, neural stem cells, Raf-Erk pathway, radial glial cells

Organism: Mouse

Tissue: Brain

696
Degradation of Kidney and Psoas Muscle Proteins as Indicators of Post-Mortem Interval in a Rat Model, with Use of Lateral Flow Technology

Dong-Gi Lee, Kyeong Eun Yang, Jeong Won Hwang, Hwan-Soo Kang, Seung-Yeul Lee, Seoyeon Choi, Joonchul Shin, Ik-Soon Jang, Hyun Joo An, Heesun Chung, Hyo-Il Jung , Jong-Soon Choi

PLoS One (PLOS) South Korea, 23 August 2016

Forensic Science

Key words: Post-mortem interval (PMI) markers, kidney, muscle, GAPDH

Organism: Rat

Tissue: Kidney, Muscle

697
Toward the Automated Detection and Characterization of Osteoclasts in Microscopic Images

Andreas Heindl , Martin Schepelmann, Robert Nica, Rupert Ecker, Peter Pietschmann, Alexander K. Seewald, Theresia Thalhammer, Isabella Ellinger

Principles of Osteoimmunology (Springer) Austria, 19 August 2016

Medical Image Analysis

Key words: Osteoimmunology, microscopes, biological samples, automated image segmentation and analysis

698
LIN28A enhances the therapeutic potential of cultured neural stem cells in a Parkinson’s disease model

Yong-Hee Rhee, Tae-Ho Kim, A-Young Jo, Mi-Yoon Chang, Chang-Hwan Park, Sang-Mi Kim, Jae-Jin Song, Sang-Min Oh, Sang-Hoon Yi, Hyeon Ho Kim, Bo-Hyun You, Jin-Wu Nam, Sang-Hun Lee

Brain: A journal of neurology (Oxford University Press) South Korea, 18 August 2016

Neuroscience

Key words: LIN28A, neural stem cell (NSC) culture, repair capacity, Parkinson’s disease

Organism: Rat

Tissue: Brain

Pathological State: Parkinson's Disease

699
Dynamic Modulation of Microglia/Macrophage Polarization by miR-124 after Focal Cerebral Ischemia

Somayyeh Hamzei Taj, Widuri Kho, Markus Aswendt, Franziska M. Collmann, Claudia Green, Joanna Adamczak, Annette Tennstaedt, Mathias Hoehn

Journal of Neuroimmune Pharmacology (Springer) Germany, 18 August 2016

Neuroscience

Key words: Stroke, Microglia/macrophage polarization, Pro-inflammatory and anti-inflammatory phenotypes, miRNA-124, Neuroinflammation

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

700
The antiviral alkaloid berberine reduces chikungunya virus-induced mitogen-activated protein kinase (MAPK) signaling

Finny S. Varghese, Bastian Thaa, Siti Naqiah Amrun, Diane Simarmata, Kai Rausalu, Tuula A. Nyman, Andres Merits, Gerald M. McInerney2, Lisa F.P. Ng, Tero Ahola

Journal of Virology (American Society for Microbiology) Finland, 17 August 2016

Virology

Key words: Chikungunya virus, non-toxic plant alkaloid berberine, mitogen-activated protein kinase

Organism: Mouse

Tissue: Bone, Connective Tissue

Pathological State: Virus Infection

701
Bradykinin promotes neuron-generating division of neural progenitor cells via ERK activation

Micheli M. Pillat, Claudiana Lameu, Cleber A. Trujillo, Talita Glaser, Angélica R. Cappellari, Priscilla D. Negraes, Ana M. O. Battastini, Telma T. Schwindt, Alysson Muotri, Henning Ulrich

Journal of Cell Science (The Company of Biologists) Brazil, 15 August 2016

Neuroscience

Key words: Bradykinin, neurogenesis, TIS21 (PC3/BTG2) expression

Organism: Mouse

Tissue: Brain

702
G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway

Shih-Ting Cha, Ching-Ting Tan, Cheng-Chi Chang, Chia-Yu Chu, Wei-Jiunn Lee, Been-Zen Lin, Ming-Tsan Lin and Min-Liang Kuo

Nature Cell Biology (Nature) Taiwan, 15 August 2016

Oncology

Key words: Colorectal cancer, cancer-initiating cells phenotypes, K-RAS/β-catenin pathway

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

703
Prevention of Colitis and Colitis-Associated Colorectal Cancer by a Novel Polypharmacological Histone Deacetylase Inhibitor

Tzu-Tang Wei, Yi-Ting Lin, Ruo-Yu Tseng, Chia-Tung Shun, Yu-Chin Lin, Ming-Shiang Wu, Jim-Min Fang, Ching-Chow Chen

Clinical Cancer Research (AACR Publications) Taiwan, 14 August 2016

Oncology

Key words: Colorectal cancer, colitis, HDAC, HMGR

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

704
Localization of TrkB and p75 receptors in peritoneal and deep infiltrating endometriosis: an immunohistochemical study

Agung Dewanto, Jozsef Dudas, Rudolf Glueckert, Sylvia Mechsner, Anneliese Schrott-Fischer, Ludwig Wildt and Beata Seeber

Reproductive Biology and Endocrinology (Springer) Germany, 12 August 2016

Reproductive Medicine

Key words: Neurotrophins, BDNF, endometriosis, immunohistochemistry

Organism: Human

Tissue: Endometrium

Pathological State: Endometriosis

705
Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3

Bethany Baumann , Tomoko Hayashida, Xiaoyan Liang, H. William Schnaper

Kidney International (Elsevier) USA, 05 August 2016

Physiology

Key words: Fibrosis, glomerulus, hypoxia, TGF-β

Organism: Mouse

Tissue: Kidney

706
Role of the immune system in the peritoneal tumor spread of high grade serous ovarian cancer

Katharina Auer, Anna Bachmayr-Heyda, Nyamdelger Sukhbaatar, Stefanie Aust, Klaus G. Schmetterer, Samuel M. Meier, Christopher Gerner, Christoph Grimm, Reinhard Horvat, and Dietmar Pils

Oncotarget (Impact Journals) Austria, 03 August 2016

Oncology

Key words: epithelial ovarian cancer, peritoneal tumor spread, flow cytometry, PD-1, next generation sequencing

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

707
Sur8 mediates tumorigenesis and metastasis in colorectal cancer

Young-Mi Lee, Saluja Kaduwal, Kug Hwa Lee, Jong-Chan Park, Woo-Jeong Jeong, Kang-Yell Choi

Experimental and Molecular Medicine (Nature) South Korea, 29 July 2016

Oncology

Key words: Scaffold protein, Ras-extracellular signal-regulated kinase, doxycyline, HCT116 cells

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

708
CD271 regulates the proliferation and motility of hypopharyngeal cancer cells

Mai Mochizuki, Keiichi Tamai, Takayuki Imai, Sayuri Sugawara, Naoko Ogama, Mao Nakamura, Kazuto Matsuura, Kazunori Yamaguchi, Kennichi Satoh, Ikuro Sato, Hozumi Motohashi, Kazuo Sugamura, Nobuyuki Tanaka

Scientific Reports (Nature) Japan, 29 July 2016

Oncology

Key words: CD271 (p75 neurotrophin receptor), human hypopharyngeal cancer, head and neck squamous cell carcinoma

Organism: Human

Pathological State: Cancer

709
Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction

Tim Koopmans, Kuldeep Kumawat, Andrew J Halayko, Reinoud Gosens

Scientific Reports (Nature) The Netherlands, 29 July 2016

Cell Biology

Key words: Airway hyperresponsiveness, asthm, intracellular calcium flux, actin polymerisation

Organism: Human

Cell Line: Bronchial smooth muscle cells

710
Tissue-Resident CD169+ Macrophages Form a Crucial Front Line against Plasmodium Infection

Pravesh Gupta, Si Min Lai, Jianpeng Sheng, Piotr Tetlak, Akhila Balachander, Carla Claser, Laurent Renia, Klaus Karjalainen, Christiane Ruedl

Cell Reports (Cell Press) Singapore, 28 July 2016

Cell Biology

Key words: Plasmodium berghei ANKA, malaria, myeloid cells, macrophages

Organism: Mouse

Tissue: Brain

Pathological State: Bacterial Infection

711
In situ mapping of innate lymphoid cells in human skin: evidence for remarkable differences between normal and inflamed skin

Marie-Charlotte Brüggen, Wolfgang M. Bauer, Bärbel Reininger, Eduard Clim, Catalin Captarencu Georg E. Steiner, Patrick M. Brunner, Barbara Meier, Lars E. French, Georg Sting

Journal of Investigative Dermatology (Elsevier) Austria, Switzerland, Romania, 22 July 2016

Dermatology

Key words: Lymphoid Cells, Human Skin, Inflamed Skin, atopic dermatitis, psoriasis

Organism: Human

Tissue: Skin

Pathological State: Dermatitis, Psoriasis

712
4 – Proffered Paper: Immunological changes during tumor progression from primary to recurrent glioblastoma

C. Herold-Mende, C. Rapp, R. Warta, A. Unterberg, P. Beckhove

European Journal of Cancer (Elsevier) , 14 July 2016

Oncology

Key words: Cancer, tumor, glioblastoma

Organism: Human

Tissue: Brain

Pathological State: Cancer

713
Multimodal Imaging of Nanocomposite Microspheres for Transcatheter Intra-Arterial Drug Delivery to Liver Tumors

Dong-Hyun Kim, Weiguo Li, Jeane Chen, Zhuoli Zhang, Richard M. Green, Sui Huang and Andrew C. Larson

Scientific Reports (Nature) USA, 13 July 2016

Oncology

Key words: Biomedical materials, cancer imaging, hepatic artery, nanotechnology in cancer, targeted therapies

Organism: Rat

Tissue: Xenograft Tumor, Liver

Pathological State: Cancer

714
Quantitative comparison and reproducibility of pathologist scoring and digital image analysis of estrogen receptor β2 immunohistochemistry in prostate cancer

Anthony E. Rizzardi, Xiaotun Zhang, Rachel Isaksson Vogel, Suzanne Kolb, Milan S. Geybels, Yuet-Kin Leung, Jonathan C. Henriksen, Shuk-Mei Ho, Julianna Kwak, Janet L. Stanford, and Stephen C. Schmechel

Diagnostic Pathology (BioMed Central) USA, 11 July 2016

Pathology

Key words: Prostate cancer, Biomarkers, Digital pathology, Quantification, Estrogen receptor β2

Organism: Human

Tissue: Prostate

Pathological State: Cancer

715
Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice

Dominic Schmidt, Daniel Peterlik, Stefan O. Reber, Anja Lechner, Daniela N. Männel

PLoS One (PLOS) Germany, 08 July 2016

Neuroscience

Key words: Chronic subordinate colony, myeloid cells, hypothalamus-pituitary-adrenal, sympathetic nervous system

Organism: Mouse

Tissue: Spleen, Allograft Tumor

Pathological State: Cancer

716
Lesional CD4+ IFN-γ+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis

Takashi Maehara, Hamid Mattoo, Miho Ohta, Vinay S Mahajan, Masafumi Moriyama, Masaki Yamauchi, Jefte Drijvers, Seiji Nakamura, John H Stone, Shiv S Pillai

Annals of the Rheumatic Diseases (BMJ Journals) Japan, 29 June 2016

Rheumatology

Key words: IgG4-related disease, T lymphocytes, Sjögren's syndrome,

Organism: Human

Tissue: Salivary Gland

Pathological State: Cancer

717
Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

Hweixian Leong Penny, Je Lin Sieow, Giulia Adriani, Wei Hseun Yeap, Peter See Chi Ee, Boris San Luis, Bernett Lee, Terence Lee, Shi Ya Mak, Ying Swan Ho, Choon Kiat Ong, Ruby Y J Huang, Florent Ginhoux, Olaf Rotzschke, Roger D. Kamm and Siew, Cheng Wong

OncoImmunology (Taylor and Francis) Singapore, 21 June 2016

Oncology

Key words: Metabolism, macrophages, pancreatic cancer, metastasis

Organism: Human

Pathological State: Cancer

Cell Line: HPAF-II (Pancreatic epithelial tumor cell line)

718
ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments

Rick Conzemius, Haleh Ganjian, Dieter Blaas and Renate Fuchs

Journal of Virology (American Society for Microbiology) Austria, 20 June 2016

Virology

Key words: Human rhinovirus A89 (HRV-A89) and HRV-B14, RNA genome, endocytic recycling compartment (ERC)

Organism: Human

Pathological State: Cancer

Cell Line: HeLA cells

719
Validation of tumor protein marker quantification by two independent automated immunofluorescence image analysis platforms

Amy R Peck, Melanie A Girondo, Chengbao Liu, Albert J Kovatich, Jeffrey A Hooke, Craig D Shriver, Hai Hu, Edith P Mitchell, Boris Freydin, Terry Hyslop, Inna Chervoneva and Hallgeir Rui

Modern Pathology (Nature) USA, 17 June 2016

Medical Image Analysis

Key words: Histology, biomarkers, breast tumor

720
Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells

Chen-Chi Liu, Shih-Pei Lin, Han-Shui Hsu, Shung-Haur Yang, Chiu-Hua Lin, Muh-Hwa Yang, Mien-Chie Hung and Shih-Chieh Hung

Nature Communications (Nature) Taiwan, 16 June 2016

Oncology

Key words: Biological sciences, cancer, cell biology

Organism: Human, Mouse

Tissue: Colon, Xenograft Tumor

Pathological State: Cancer

721
A new fluorescence/PET probe for targeting intracellular human telomerase reverse transcriptase (hTERT) using Tat peptide-conjugated IgM

Kyung oh Jung, Hyewon Youn , Seung Hoo Kim, Young-Hwa Kim, Keon Wook Kang, June-Key Chunga

Biochemical and Biophysical Research Communications (Elsevier) South Korea, 15 June 2016

Biological Methods

Key words: Intracellular and intranuclear protein, hTERT, tat peptide, IgM antibody, 64Cu, Live cell imaging

Organism: Human

Pathological State: Cancer

Cell Line: HT29, U2OS cells

722
Ribosome inactivation leads to attenuation of intestinal polymeric Ig receptor expression via differential regulation of human antigen R

KH Do, SH Park, J Kim, M Yu, Y Moon

The Journal of Immunology (American Association of Immunologists) South Korea, 15 June 2016

Immunology

Key words: Ribosome ,Polymeric Ig Receptor ,Differential Regulation, Human Antigen R

Organism: Mouse

Tissue: Small Intestine, Colon

723
Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine

Norihiro Kishida, Sachiko Matsuda, Osamu ItanoEmail author, Masahiro Shinoda, Minoru Kitago,Hiroshi Yagi, Yuta Abe, Taizo Hibi, Yohei Masugi, Koichi Aiura, Michiie Sakamoto and Yuko Kitagawa

BMC Gastroenterology (BioMed Central) Japan, 13 June 2016

Oncology

Key words: Nonalcoholic steatohepatitis, hepatocellular carcinoma, diethylnitrosamine, high-fat choline-deficient diet, mouse model

Organism: Mouse

Tissue: Liver

Pathological State: Fibrosis

724
Automated muscle fiber type population analysis with ImageJ of whole rat muscles using rapid myosin heavy chain immunohistochemistry

Konstantin D. Bergmeister, Marion Gröger, Martin Aman, Anna Willensdorfer, Krisztina Manzano-Szalai, Stefan Salminger and Oskar C. Aszmann

Muscle and Nerve (Wiley) Austria, 13 June 2016

Medical Image Analysis

Key words: Automated muscle fiber analysis, fiber population, ImageJ, muscle fiber type, myosin heavy chain, rat

Organism: Rat

Tissue: Muscle

725
Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

Pu-Hyeon Cha, Yong-Hee Cho, Sang-Kyu Lee, JaeHeon Lee, Woo-Jeong Jeong, Byoung-San Moon, Ji-Hye Yun, Jee Sun Yang, Sooho Choi, Juyong Yoon, Hyun-Yi Kim, Mi-Yeon Kim, Saluja Kaduwal, Weontae Lee, Do Sik Min, Hoguen Kim, Gyoonhee Han and Kang-Yell Choi

Nature Chemical Biology (Nature) South Korea, 13 June 2016

Oncology

Key words: Cancer therapy, cell signalling, screening, small molecules

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

726
Clonorchis sinensis omega-class glutathione transferases play major roles in the protection of the reproductive system during maturation and the response to oxidative stress

Jeong-Geun Kim, Chun-Seob Ahn, Seon-Hee Kim, Young-An Bae, Na-Young Kwon, Insug Kang, Hyun-Jong Yang, Woon-Mok Sohn, Yoon Kong

Parasites and Vectors (BioMed Central) South Korea, 13 June 2016

Parasitology

Key words: Clonorchis sinensis, glutathione transferase (GST), omega-class GST, sexual maturation, reproductive system, oxidative stress

Organism: Flatworm

Tissue: Whole Organism

727
Amniotic Fluid Cells Proliferation in Normal and Down Syndrome Subjects

A Honcea, R Iulian, AG Pavel, I Ion, LE Sima

ARS Medica Tomitana (Sciendo) Romania, 11 June 2016

Reproductive Medicine

Key words: Down syndrome, Trisomy 21, amniotic fluid-derived stem cells, proliferation, cell cycle

Organism: Human

Cell Line: Amniotic fluid derived cells

728
Epidermal desmoglein 1 expression is reduced in kidney transplant recipients compared to immunocompetent patients

Jodi L. Johnson, Paul Hoover, Borko D. Jovanovic, Kathleen J. Green, John J. Friedewald, June K. Robinson

Journal of Investigative Dermatology (Elsevier) USA, 11 June 2016

Dermatology

Key words: Calcineurin inhibitor, desmoglein, E-cadherin, epidermal growth factor receptor, histone deacetylase inhibitor, immunocompetent patient, K1/10, Keratin 1 or 10, kidney transplant recipient, mycophenolate mofitil, plakoglobin, squamous cell carcinoma;ultraviolet light

Organism: Human

Tissue: Skin

Pathological State: Cancer

729
ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model

Amy M. Archer, Rana Saber, Shawn Rose, Alexander Shaffer, Alexander V. Misharin, FuNien Tsai, G. Kenneth Haines III, Salina Dominguez, Mesut Eren, Douglas E. Vaughan, Carla M. Cuda and Harris Perlman

Journal of Translational Medicine (BioMed Central) USA, 10 June 2016

Immunology

Key words: Arthritis, cholesterol, inflammation, animal models of human disease

Organism: Mouse

Tissue: Bone, Connective Tissue

Pathological State: Atherosclerosis

730
Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model

Hui-Wen Chiu, Ya-Ling Yeh, Yi-Ching Wang, Wei-Jan Huang, Sheng-Yow Ho, Pinpin Lin, Ying-Jan Wang

Molecular Cancer (Springer) Taiwan, 10 June 2016

Oncology

Key words: Histone deacetylase inhibitor, radiation, triple-negative breast cancer, autophagy

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

731
Infiltration of Macrophages Correlates with Severity of Allograft Rejection and Outcome in Human Kidney Transplantation

Tobias Bergler, Bettina Jung, Felix Bourier, Louisa Kühne, Miriam C. Banas, Petra Rümmele, Simone Wurm, Bernhard Banas

PLoS One (PLOS) Germany, 10 June 2016

Transplantation Medicine

Key words: Macropaghes, T-lymphocytes, calcineriurin, inhibitor, renal transplantation

Organism: Human

Tissue: Kidney

Pathological State: Organ Transplantation

732
Gain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer’s Disease

Cheng-Chun Wu, Cheng-Chang Lien, Wen-Hsien Hou, Po-Min Chiang ,Kuen-Jer Tsai

Scientific Reports (Nature) Taiwan, 06 June 2016

Neuroscience

Key words: Dementia, neural stem cells, regeneration and repair in the nervous system, stem-cell research

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s Disease

733
Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model

CY Lin, HY Hsieh, CM Chen, SR Wu, CH Tsai, CY Huang, MY Hua, CK Yeh, HL Liu

Journal of Controlled Release (Elsevier) Taiwan, 26 May 2016

Neuroscience

Key words: Focused ultrasound, Gene therapy, Blood-brain barrier opening, Microbubbles, GDNF

Organism: Mouse

Tissue: Brain

Pathological State: Parkinson's Disease

734
Functional studies on primary tubular epithelial cells indicate a tumor suppressor role of SETD2 in clear cell renal cell carcinoma

J Li, J Kluiver, J Osinga, H Westers, MB van Werkhoven, Marc A Seelen, Rolf H Sijmons, Ankevan den Berg, Klaas Kok

Neoplasia (Elsevier) The Netherlands, 26 May 2016

Oncology

Key words: Primary Tubular Epithelial Cells, Tumor Suppression, SETD2, Renal Cell Carcinoma

Organism: Human

Pathological State: Cancer

Cell Line: PTECs and HKC8 cells

735
GBIQ: a non-arbitrary, non-biased method for quantification of fluorescent images

Youichirou Ninomiya, Wei Zhao,Yumiko Saga

Scientific Reports (Nature) Japan, 23 May 2016

Medical Image Analysis

Key words: Image processing, software

Organism: Mouse

Cell Line: MESCs (Mouse Embryonic stem cells)

736
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

Daniela F. Quail, Robert L. Bowman, Leila Akkari, Marsha L. Quick, Alberto J. Schuhmacher, Jason T. Huse, Eric C. Holland, James C. Sutton, Johanna A. Joyce

Science (American Association for the Advancement of Science) USA, 20 May 2016

Oncology

Key words: Mouse models, glioblastoma multiforme, macrophage

Organism: Mouse

Tissue: Lymphoid Tissue, Connective Tissue

Pathological State: Cancer

737
Knockout of ho-1 protects the striatum from ferrous iron-induced injury in a male-specific manner in mice

Li-Fang Wang, Kazunari K. Yokoyama, Chih-Lung Lin, Tzu-Yin Chen, Hsiu-Wen Hsiao, Pei-Chi Chiang, Chin Hsu

Scientific Reports (Nature) Taiwan, 20 May 2016

Neuroscience

Key words: Neuronal physiology, reproductive biology

Organism: Mouse

Tissue: Ovaries, Penis, Testis

738
Anti-TGF-β Antibody, 1D11, Ameliorates Glomerular Fibrosis in Mouse Models after the Onset of Proteinuria

Xiaoyan Liang, H. William Schnaper, Taiji Matsusaka, Ira Pastan, Steve Ledbetter,Tomoko Hayashida

PLoS One (PLOS) USA, 17 May 2016

Nephrology

Key words: Renal fibrosis

Organism: Mouse

Tissue: Kidney

Pathological State: Nephropathy

739
HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

Niek G.J. Leusa, Petra E. van der Woudena, Thea van den Boscha, Wouter T.R. Hooghiemstraa, Maria E. Ourailidoua, Loes E.M. Kistemakerc, Rainer Bischoffb, Reinoud Gosensc, Hidde J. Haismaa, Frank J. Dekker

Biochemical Pharmacology (Elsevier) The Netherlands, 15 May 2016

Pharmacology

Key words: Lysine acetylation, HDACs, inflammation, NF-κB p65, HDAC inhibitors, lung disease

Organism: Mouse

Tissue: Lung

740
Exploration of more effective neurorrhaphy in facial nerve reconstruction: A comparison focusing on the difference of neural window size and condition of the neurorrhaphy site

Kentaro Ono, Yuhei Yamamoto, Ryuji Shichinohe, Naoki Murao, Akihiko Oyama, Emi Funayama, Hiroshi Furukawa

Journal of Plastic, Reconstructive and Aesthetic Surgery (Elsevier) Japan, 12 May 2016

Neuroscience

Key words: Nerve reconstruction, Facial palsy, Side to side, End to side, Rat

Organism: Rat

Tissue: Brain

741
The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth

Harini Nivarthi, Claire Gordziel, Madeleine Themanns, Nina Kramer, Markus Eberl, Björn Rabe, Michaela Schlederer, Stefan Rose-John, Thomas Knösel, Lukas Kenner, Patricia Freund, Fritz Aberger, Xiaonan Han, Robert Kralovics, Helmut Dolznig, Susanne Jennek, Karlheinz Friedrich, and Richard Moriggl

Oncotarget (Impact Journals) Austria, germany, USA, 12 May 2016

Oncology

Key words: STAT1, STAT3, colorectal cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

742
MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains

Marjolein Bijlard, Jenny C. de Jonge, Bert Klunder, Anita Nomden, Dick Hoekstra, Wia Baron

PLoS One (PLOS) The Netherlands, 12 May 2016

Neuroscience

Key words: Oligodendrocytes, myelin membrane, rat brain tissue

Organism: Rat

Cell Line: Primary oligodendrocyte, OLN-93, HEPG2 cells

743
In situ hybridization to detect and localize signature cytokines of T-helper (Th) 1 and Th2 immune responses in chicken tissues

Fana Alem Kidane, Ivana Bilic, Taniya Mitra, Patricia Wernsdorf, Michael Hess, Dieter Liebhart

Veterinary Immunology and Immunopathology (Elsevier) Austria, 12 May 2016

Immunology

Key words: In situ hybridization, RNA probes, ChIFN-γ, ChIL-4, ChIL-13

Organism: Chicken

Tissue: Spleen, Liver

Pathological State: Parasitic Infection

744
Acidic pH-triggered drug-eluting nanocomposites for magnetic resonance imaging-monitored intra-arterial drug delivery to hepatocellular carcinoma

W Park, J Chen, S Cho, S Park, AC Larson, K Na, DH Kim

Applied Materials and Interfaces (ACS Publications) USA, South Korea, 09 May 2016

Nanomedicine, Oncology

Key words: hepatocellular carcinoma; image-guided therapy; iron oxide nanoparticles; nanocomposite microspheres; pH-responsive materials; sorafenib

Organism: Rat

Tissue: Liver

Pathological State: Cancer

745
Interleukin-25 is detrimental for recovery after spinal cord injury in mice

Dearbhaile Dooley, Evi Lemmens, Peter Ponsaerts, Sven Hendrix

Journal of Neuroinflammation (Springer) Belgium, 06 May 2016

Neuroscience

Key words: IL-25, type 2 immune response, spinal cord injury, basso mouse scale, locomotor recovery Th1 Th2

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

746
CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition

Neeraj Kapur, Hina Mir, Clarence E Clark III, Uma Krishnamurti, Derrick J Beech, James W Lillard and Shailesh Singh

British Journal of Cancer (Nature) USA, 05 May 2016

Oncology

Key words: Colon cancer, Epithelial–mesenchymal transition, Metastasis, Tumour biomarkers

Organism: Human

Tissue: Colon

Pathological State: Cancer

747
PPARγ inhibits VSMC proliferation and migration via attenuating oxidative stress through upregulating UCP2

Y Zhou, MJ Zhang, BH Li, L Chen, Y Pi, YW Yin, CY Long, X Wang, MJ Sun, X Chen, CY Gao, JC Li, LL Zhang

PLoS One (PLOS) China, 04 May 2016

Cell Biology

Key words: Oxidative stress, Reactive oxygen species ,Carotid arteries ,Mitochondria ,Antioxidants ,MTT assay ,Fluorescence microscopy ,Growth factors

Organism: Mouse

Tissue: Blood Vessels

748
Loss of HIF-1β in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model

Nina Henke, Nerea Ferreirós, Gerd Geisslinger, Martina G. Ding, Silke Essler, Dominik C. Fuhrmann, Theresa Geis, Dmitry Namgaladze, Nathalie Dehne, and Bernhard Brüne

Oncotarget (Impact Journals) Germany, 03 May 2016

Oncology

Key words: xenobiotics, CYP1A1, DNA damage, breast cancer, fibrosarcoma

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

749
449 In situ mapping of innate lymphoid cells in normal and inflamed human skin

M. Brüggen, W. Bauer, B. Reininger, E. Clim, C. Captarencu, B. Meier, P.M. Brunner, L. French, G. Stingl

Journal of Investigative Dermatology (Elsevier) Austria, 01 May 2016

Immunology

Key words: Innate lymphoid cells, atopic dermatitis, psoriasis, normal human skin, immunofluorescence

Organism: Human

Tissue: Skin

Pathological State: Dermatitis, Psoriasis

750
Paracrine Factors from Irradiated Peripheral Blood Mononuclear Cells Improve Skin Regeneration and Angiogenesis in a Porcine Burn Model

Stefan Hacker, Rainer Mittermayr, Stefanie Nickl, Thomas Haider, Diana Lebherz-Eichinger, Lucian Beer, Andreas Mitterbauer, Harald Leiss, Matthias Zimmermann, Thomas Schweiger, Claudia Keibl, Helmut Hofbauer, Christian Gabriel, Mariann Pavone-Gyöngyösi, Heinz Redl, Erwin Tschachler, Michael Mildner, Hendrik Jan Ankersmit

Scientific Reports (Nature) Austria, 29 April 2016

Regenerative Medicine

Key words: Drug development, regeneration, translational research, trauma

Organism: Pig

Tissue: Skin

Pathological State: Burn Wound

751
SIRT2-mediated deacetylation and tetramerization of pyruvate kinase directs glycolysis and tumor growth

David Gius

Cancer Research (AACR Publications) USA, 27 April 2016

Oncology

Key words: Mitochondria, pyruvate kinase, acetylation, mammary tumor cells

Organism: Human

Tissue: Breast

Pathological State: Cancer

752
Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling

Yu-Chih Wang, Cheng-Fang Tsai, Hsiao-Li Chuang, Yi-Chih Chang, Hung-Sheng Chen, Jau-Nan Lee, and Eing-Mei Tsai

Oncotarget (Impact Journals) Taiwan, 26 April 2016

Oncology

Key words: Aryl hydrocarbon receptor, sphingosine kinase 1, sphingosine 1-phosphate, sphingosine-1-phosphate receptor 3, breast cancer stem cells

Organism: Human

Pathological State: Cancer

Cell Line: MCF-7 cells (Breast Cancer Cell line)

753
Tumor-associated B cells in cutaneous primary melanoma and improved clinical outcome

Kanika Garg, Margarita Maurer, Johannes Griss, Marie-Charlotte Brüggen, Ingrid H. Wolf, Christine Wagnera, Niels Willi, Kirsten D. Mertz, Stephan N. Wagner

Human Pathology (Elsevier) Austria, 20 April 2016

Pathology

Key words: CD20, prognosis, melanoma, tumor microenvironment, tumor-associated B cells (TAB), tumor-infiltrating lymphocytes

Organism: Human

Tissue: Skin

Pathological State: Cancer

754
Effectiveness of a Layer-by-Layer Microbubbles-Based Delivery System for Applying Minoxidil to Enhance Hair Growth

Ai-Ho Liao,Ying-Jui Lu, Yi-Chun Lin, Hang-Kang Chen, Huey-Kang Sytwu, Chih-Hung Wang

Theranostics (Ivyspring International Publisher) Taiwan, 11 April 2016

Oncology

Key words: Microbubbles, ultrasound, transdermal drug delivery, minoxidil, chitosan oligosaccharide lactate, hair growth

Organism: Pig, Mouse

Tissue: Skin

755
Biocompatibility Assessment of a New Biodegradable Vascular Graft via In Vitro Co-culture Approaches and In Vivo Model

Marjan Enayati, Magdalena Eilenberg, Christian Grasl, Peter Riedl, Christoph Kaun, Barbara Messner, Ingrid Walter, Robert Liska, Heinrich Schima, Johann Wojta, Bruno K. Podesser, Helga Bergmeister

Annals of Biomedical Engineering (Springer) Austria, 07 April 2016

Regenerative Medicine

Key words: Vascular graft, biocompatibility, biodegradable polyurethane, fibroblast-macrophage co-culture

Organism: Rat

Tissue: Blood Vessels

Pathological State: Organ Transplantation

756
Dose-escalation study for the targeting of CD44v+cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)

Kohei Shitara, Toshihiko Doi, Osamu Nagano, Chiyo K. Imamura, Takeshi Ozeki, Yuya Ishii, Kenji Tsuchihashi, Shunji Takahashi, Takako E. Nakajima, Shuichi Hironaka, Miki Fukutani, Hiromi Hasegawa, Shogo Nomura, Akihiro Sato, Yasuaki Einaga, Takeshi Kuwata, Hideyuki Saya, Atsushi Ohtsu

Gastric Cancer (Springer) Japan, 07 April 2016

Oncology

Key words: Cancer stem cellCD44 variant positiveGastric cancerSulfasalazinexCT

Organism: Human

Tissue: Stomach

Pathological State: Cancer

757
Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells

Bernd Schöpf, Georg Schäfer, Anja Weber , Heribert Talasz ,Iris E. Eder , Helmut Klocker , Erich Gnaiger

FEBS Journal (FEBS PRESS) Austria, 06 April 2016

Cell Biology

Key words: electron transfer system, high‐resolution respirometry, mitochondria, oxidative phosphorylation, prostate metabolism

Organism: Human

Tissue: Prostate

758
Cross-talk between DopaChromeTautomerase and Caveolin-1 is melanoma cell phenotype specific and potentially involved in tumor progression.

Popa IL, Milac AL, Sima LE, Alexandru PR, Pastrama F, Munteanu CV, Negroiu Gabriela

Journal of biological chemistry (American Society for Biochemistry and Molecular Biology) Romania, 06 April 2016

Oncology

Key words: Antigen processing, caveolin, epithelial-mesenchymal transition (EMT), melanoma, structural model

Organism: Human

Tissue: Skin

Pathological State: Cancer

759
Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

Jonas Kloeppera,Lars Riedemanna, Zohreh Amoozgara,1, Giorgio Seanoa, Katharina Suseka, Veronica Yua, Nisha Dalviea, Robin L. Amelunga, Meenal Dattaa,Jonathan W. Songa,Vasileios Askoxylakisa, Jennie W. Taylora,Christine Lu-Emersona,Ana Batistaa,Nathaniel D. Kirkpatricka,Keehoon Junga, Matija Snuderla, Alona Muzikanskye, Kay G. Stubenrauchf, Oliver Krieterf, Hiroaki Wakimotog, Lei Xu1, Lance L. Munna, Dan G. Dudaa, Dai Fukumuraa, Tracy T. Batchelorc, Rakesh K. Jaina,

PNAS (PNAS) USA, 04 April 2016

Oncology

Key words: Anti-angiogenic therapy, tumor microenvironment, anti-tumor immunity, macrophage polarization, microglia reprogramming

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

760
CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma

Hagma H. Workel, Fenne L. Komdeur, Maartje C.A. Wouters, Annechien Plat, Harry G. Klip, Florine A. Eggink, G. Bea A. Wisman, Henriette J.G. Arts, Maaike H.M. Oonk, Marian J.E. Mourits, Refika Yigit, Marco Versluis, Evelien W. Duiker, Harry Hollema, Marco de Bruyn, Hans W. Nijman

European Journal of Cancer (Elsevier) The Netherlands, 31 March 2016

Oncology

Key words: Tumour-infiltrating lymphocytes, endometrial cancer, adenocarcinoma, CD103, survival

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

761
Combining ultrasound and lactobacilli treatment for high-fat-diet-induced obesity in mice

A.-H. Liao, C.-B. Jiang, C.-C. Li, H.-C. Chuang, J.-S. Chiang Chiau, W.-T. Chan, C.-Y. Yeung, M.-L. Cheng, H.-C. Lee

Journal of Animal Physiology and Animal Nutrition (Wiley) Taiwan, 29 March 2016

Physiology

Key words: Actobacilli, ultrasound, high-fat-diet-induced obesity mice, micro-CT, fat deposition

Organism: Mouse

Tissue: Liver, Adipose Tissue

Pathological State: Obesity

762
Myeloid PTEN deficiency impairs tumor-immune surveillance via immune-checkpoint inhibition

M Kuttke, E Sahin, J Pisoni, S Percig, A Vogel, D Kraemmer, L Hanzl, J. S Brunner, H Paar, K Soukup, A Halfmann, A. M. Dohnal, C. W. Steiner, S. Blüml, J. Basilio, B. Hochreiter, M. Salzmann, B. Hoesel, G. Lametschwandtner, R. Eferl, J. A. Schmidd and G. Schabbauer

OncoImmunology (Taylor and Francis) Austria, 28 March 2016

Immunology

Key words: Colitis-associated colon cancer, myeloid Pi3K, tumor immune-surveillance

Organism: Mouse

Tissue: Xenograft Tumor, Colon

Pathological State: Cancer

763
Chemotherapy of Colorectal Liver Metastases Induces a Rapid Rise in Intermediate Blood Monocytes which Predicts Treatment Response

Dominic Schauer, Patrick Starlinger, Lejla Alidzanovic, Philipp Zajc, Thomas Maier, Alexandra Feldman, Robin Padickakudy, Elisabeth Buchberger, Vanessa Elleder, Andreas Spittlera, Judith Stift, Lorand Pop, Birgit Gruenberger, Thomas Gruenbergera, Christine Brostjan

OncoImmunology (Taylor and Francis) Austria, 22 March 2016

Immunology

Key words: Chemotherapy, colorectal liver metastase, blood monocytes

Organism: Human

Tissue: Liver

Pathological State: Cancer

764
A specific area of olfactory cortex involved in stress hormone responses to predator odours

Kunio Kondoh, Zhonghua Lu, Xiaolan Ye, David P. Olson, Bradford B. Lowell and Linda B. Buck

Nature (Nature) USA, 21 March 2016

Neuroscience

Key words: Neural circuits, Olfactory cortex, Sensory processing

Organism: Mouse

Tissue: Brain

765
MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

Somayyeh Hamzei Taj, Widuri Kho, Adrien Riou, Dirk Wiedermann, Mathias Hoehn

Biomaterials (Elsevier) The Netherlands, 19 March 2016

Neuroscience

Key words: MicroRNA-124, ischemic stroke, immune cell modulation/polarization, neuroprotection, functional improvement, arginase-1

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

766
Neuronal deficiency of HIF prolyl 4-hydroxylase 2 in mice improves ischemic stroke recovery in an HIF dependent manner

Lexiao Li, Pamela Saliba, Stefan Reischl, Hugo H. Marti, Reiner Kunze

Neurobiology of Disease (Elsevier) Germany, 19 March 2016

Neuroscience

Key words: PHD2, HIF, neuron, focal cerebral ischemia, hypoxia, VEGF, angiogenesis

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

767
Unfractionated bone marrow cells attenuate paraquat-induced glomerular injury and acute renal failure by modulating the inflammatory response

SY Gu, TY Yeh, SY Lin, FC Peng

Scientific Reports (Nature) Taiwan, 18 March 2016

Nephrology

Key words: Acute kidney injury, Bone marrow transplantation

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Injury

768
High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease

S Kapoor, D Rodriguez, K Mitchell, RP Wüthrich

Kidney and Blood Pressure Research (Karger) Switzerland, 17 March 2016

Nephrology

Key words: High resolution diagnostic imaging, Total cyst volume, Polycystic kidney disease, PCK rat, Total kidney volume

Organism: Rat

Tissue: Kidney

Pathological State: Polycystic Kidney Disease

769
Efficient generation of smooth muscle cells from adipose-derived stromal cells by 3D mechanical stimulation can substitute the use of growth factors in vascular tissue engineering

Mojtaba Parvizi, Lydia A.M. Bolhuis-Versteeg, Andrá A. Poot, Martin C. Harmsen

Biotechnology Journal (Wiley) The Netherlands, 15 March 2016

Regenerative Medicine

Key words: Adipose tissue-derived stromal cells (ASC), poly(1,3-trimethylene carbonate) (PTMC), smooth muscle cells (SMC), transforming Growth Factor beta 1 (TGF-ß1), vascular tissue engineering

Organism: Human

Cell Line: HUVECs, ASC (Human umbilical vein endothelial cells, Adipose tissue derived stromal cells)

770
OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia

Taizou Hirano, Toshiaki Kikuchi, Naoki Tode, Arif Santoso, Mitsuhiro Yamada, Yoshiya Mitsuhashi, Riyo Komatsu, Takeshi Kawabe, Takeshi Tanimoto, Naoto Ishii, Yuetsu Tanaka, Hidekazu Nishimura, Toshihiro Nukiwa, Akira Watanabe, Masakazu Ichinose

EMBO Molecular Medicine (Wiley) Japan, 14 March 2016

Pathology

Key words: Bronchioles, glycosylation regeneration, OX40 ligand, viral pneumonia

Organism: Dog

Pathological State: Virus Infection

Cell Line: MDCK cells

771
Internalization of nanopolymeric tracers does not alter characteristics of placental cells

Paolo Bigini, Elisa R. Zanier, Silvia Saragozza, Simona Maciotta, Pietro Romele, Patrizia Bonassi Signoroni, Antonietta Silini, Francesca Pischiutta, Eliana Sammali, Claudia Balducci, Martina B. Violatto, Laura Talamini, David Garry, Davide Moscatelli, Raffaele Ferrari, Mario Salmona, Maria Grazia De Simoni, Federico Maggi, Giuseppe Simoni, Francesca Romana Grati, Ornella Parolini

Journal of Cellular and Molecular Medicine (Wiley) Italy, 14 March 2016

Cell Biology

Key words: Cell tracing, nanoparticles, mesenchymal stem/stromal cells, placenta, amnion, chorion, hypoxia, ischaemia

Organism: Human

Tissue: Placenta

772
In primary Sjögren's syndrome high absolute numbers and proportions of B cells in parotid glands predict responsiveness to rituximab as defined by ESSDAI, but not by SSRI

Konstantina Delli, Erlin A Haacke, Frans GM Kroese, Rodney P Pollard, Stephan Ihrler, Bert van der Vegt, Arjan Vissink, Hendrika Bootsma, Frederik KL Spijkervet

Annals of the Rheumatic Diseases (BMJ Journals) The Netherlands, 09 March 2016

Rheumatology

Key words: Sjogren's syndrome, b cells, parotide glands, rituximab

Organism: Human

Tissue: Salivary Gland

Pathological State: Sjögren's Syndrome

773
Acquisition of chemoresistance and other malignancy-related features of colorectal cancer cells are incremented by ribosome-inactivating stress

CK Oh, SJ Lee, SH Park, Y Moon

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) South Korea, 09 March 2016

Oncology

Key words: Ribosome-inactivating stress (RIS); Colorectal cancer; Activating transcription factor 3 (ATF3); Macrophage inhibitory cytokine-1 (MIC-1); Chemosensitivity

Organism: Mouse

Tissue: Allograft Tumor, Colon

Pathological State: Cancer

774
Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach

Anastasia Meshcheryakova, Martin Svoboda, Ammar Tahir, Harald C. Köfeler, Alexander Triebl, Felicitas Mungenast, Georg Heinze, Christopher Gerner, Philip Zimmermann, Markus Jaritz, and Diana Mechtcheriakova

Oncotarget (Impact Journals) Austria, Switzerland, 07 March 2016

Oncology

Key words: sphingolipid-related targets, sphingosine 1-phosphate/ceramide rheostat, multigene signature, epithelial to mesenchymal transition, lung cancer

Organism: Human

Pathological State: Cancer

Cell Line: Lung adenocarcinoma epithelial cell line A549

775
Intrathecal transplantation of embryonic stem cell-derived spinal GABAergic neural precursor cells attenuates neuropathic pain in a spinal cord injury rat model

Insik Hwang, Suk-Chan Hahm Suk-Chan Hahm, Kyung-Ah Choi, Sung-Ho Park, Hyesun Jeong, Ji-Hye Yea, Junesun Kim, Ph.D., Sunghoi Hong, Ph.D.

Cell Transplantation (SAGE Journals) South Korea, 01 March 2016

Regenerative Medicine

Key words: Spinal cord injury (SCI), Neuropathic pain, Spinal GABAergic neurons, Intrathecal transplantation

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

776
Platelet-rich plasma influences expansion and paracrine function of adipose-derived stromal cells in a dose-dependent fashion

Willemsen, Joep C. N.; Spiekman, Maroesjka; Stevens, H. P. Jeroen; van der Lei, Berend; Harmsen, Martin C.

Plastic and Reconstructive Surgery (Ingentaconnect) The Netherlands, 01 March 2016

Regenerative Medicine

Organism: Human

Tissue: Adipose Tissue

777
Double Linear Gradient Biointerfaces for Determining Two-Parameter Dependent Stem Cell Behavior

Patrick Van Rijn, Philipp Kuhn, Qihui Zhou, Torben Van Der Boon, Aneta Schaap-Oziemlak, Theo Van Kooten

ChemNanoMat (Wiley) The Netherlands, 26 February 2016

Biological Methods

Key words: Biointerfaces, gradients, stem cell, wettability, stiffness

Organism: Human

Cell Line: Mesenchymal stem cells from human bone marrow (hBM-MSCs)

778
Fenretinide: a potential treatment for endometriosis

Mary Ellen Pavone, Saurabh S. Malpani, Matthew Dyson, J. Julie Kim, Serdar E. Bulun

Reproductive Sciences (SAGE Journals) USA, 25 February 2016

Reproductive Medicine

Key words: endometriosis, fenretinide, apoptosis, retinol, retinoid, STRA6, retinoic acid

Organism: Mouse

Tissue: Endometrium

Pathological State: Endometriosis

779
Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice

Eva Bauer, Michaela Schlederer, Ruth Scheicher, Jaqueline Horvath, Petra Aigner, Ana-Iris Schiefer, Renate Kain, Heinz Regele, Gregor Hoermann, Günter Steiner, Lukas Kenner, Veronika Sexl, Andreas Villunger, Richard Moriggl, and Dagmar Stoiber

Oncotarget (Impact Journals) Austria, 23 February 2016

Oncology

Key words: ETV6/RUNX1, BCL2, glomerulonephritis, lymphoma, autoimmunity, Immunology and Microbiology Section, Immune response, Immunity

Organism: Mouse

Tissue: Kidney

780
In situ analysis of intrahepatic virological events in chronic hepatitis B virus infection

Xiaonan Zhang, Wei Lu, Ye Zheng, Weixia Wang, Lu Bai, Liang Chen, Yanling Feng, Zhanqing Zhang, and Zhenghong Yuan

The Journal of Clinical Investigation (American Society for Clinical Investigation) China, 22 February 2016

Virology

Key words: intrahepatic virological events, chronic hepatitis B virus infection

Organism: Human

Tissue: Liver

Pathological State: Virus Infection

781
In EXOG-depleted cardiomyocytes cell death is marked by a decreased mitochondrial reserve capacity of the electron transport chain

Wardit Tigchelaar, Anne Margreet De Jong, Wiek H. van Gilst, Rudolf A. De Boer, Herman H.W. Silljé

Inside the Cell (Wiley) The Netherlands, 18 February 2016

Cell Biology

Key words: Cardiomyocyte, cell death, EXOG, hypertrophy, mitochondria

Organism: Rat

Cell Line: NRVC cells ( neonatal rat ventricular cardiomyocytes )

782
Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies

M Sips, M Krykbaeva, T J Diefenbach, M Ghebremichael, B A Bowman, A-S Dugast, A W Boesch, H Streeck, D S Kwon, M E Ackerman, T J Suscovich, P Brouckaert, T W Schacker and G Alter

Mucosal Immunology (Nature) USA, Belgium, Germany, 17 February 2016

Key words: Cell signalling, HIV infections, Phagocytosis, Vaccines

783
Aging has small effects on initial ischemic acute kidney injury development despite changing intrarenal immunologic micromilieu in mice

Hye Ryoun Jang, Ji Hyeon Park, Ghee Young Kwon, Jae Berm Park, Jung Eun Lee, Dae Joong Kim, Yoon-Goo Kim, Sung Joo Kim, Ha Young Oh, Wooseong Huh

American Journal of Physiology (APS Journals) South Korea, 15 February 2016

Physiology

Key words: Aging, ischemic, kidney injury, immunologic, micromilieu

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Injury

784
The in vitro response of tissue stem cells to irradiation with different LETs

Peter W. Nagle, Nynke A. Hosper, Emily M. Ploeg, Marc-Jan van Goethem, Sytze Brandenburg, Johannes A. Langendijk, Roland K. Chiu, Robert P. Coppes

International Journal of Radiation Oncology (Elsevier) The Netherlands, 12 February 2016

Oncology

Key words: In vitro, tissue stem cells, irradiantion, LETs

Organism: Human

Cell Line: HSG cells (human salivary gland cells)

785
Far-infrared promotes burn wound healing by suppressing NLRP3 inflammasome caused by enhanced autophagy

Hui-Wen Chiu, Cheng-Hsien Chen, Jen-Ning Chang, Chien-Hsiung Chen, Yung-Ho Hsu

Journal of Molecular Medicine (Springer) Taiwan, 11 February 2016

Regenerative Medicine

Key words: Far-infrared, burn wound healing, autophagy NLRP3 inflammasome

Organism: Rat

Tissue: Skin

Pathological State: Burn Wound

786
Serum Autoantibodies in Chronic Prostate Inflammation in Prostate Cancer Patients

Bettina Schlick, Petra Massoner, Angelika Lueking, Pornpimol Charoentong, Mirjam Blattner, Georg Schaefer, Klaus Marquart, Carmen Theek, Peter Amersdorfer, Dirk Zielinski, Matthias Kirchner, Zlatko Trajanoski, Mark A. Rubin, Stefan Müllner, Peter Schulz-Knappe, Helmut Klocker

PLoS One (PLOS) Austria, 10 February 2016

Oncology

Key words: Prostate cancer, autoantibodies, inflammation, prostate gland, inflammatory diseases, microarrays, prostate diseases, radical prostatectomy

Organism: Human

Tissue: Prostate

Pathological State: Cancer

787
Acquisition of tumorigenic potential and enhancement of angiogenesis in pulmonary stem/progenitor cells through Oct-4 hyperexpression

SY Gu, CC Ho, YK Huang, HW Chen, YC Wang, CY Kuo, SC Teng, WM Fu, PC Yang, CW Wu, FC Peng, TY Ling

Oncotarget (Impact Journals) Taiwan, 09 February 2016

Oncology

Key words: pulmonary stem/progenitor cells, cancer initiating cells, Oct-4, angiogenesis, angiopoietins/Tie2

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

788
MINI ORAL SESSIONS (MINI38.12 Multiplex Immunofluorescence Identifies Differences in Immune Microenvironment and Prognostic Biomarkers between Mesothelioma Subtypes)

Tanguy Seiwert, Stephanie Mcgregor, Chengyi Shu, Igor Feldman, Tong Zi, Zhixiang Zuo, Arun Khattri, Aliya Husain, Hadi Duraid, Wickii T. Vigneswaran,Thomas N. Krausz, Sriram Sathyanarayanan, Hedy Lee Kindle

Journal of Thoracic Oncology (Elsevier) USA, 05 February 2016

Oncology

Key words: Multiplex immunofluorescence, immmune microenvironment, biomarkers, mesothelioma

Organism: Human

Pathological State: Cancer

789
Oxytocin promotes functional coupling between paraventricular nucleus and both sympathetic and parasympathetic cardioregulatory nuclei

Jason R. Yee, William M. Kenkel, Jessie L. Frijling, Sonam Dodhia, Kenneth G. Onishi, Santiago Tovar, Maha J. Saber, Gregory F. Lewis, Wensheng Liu, Stephen W. Porges C. Sue Carter

Hormones and Behavior (Elsevier) USA, 04 February 2016

Endocrinology

Key words: Oxytocin, functional coupling, paraventricular nucleus, cardioregulatory nuclei

Organism: Mouse

Tissue: Brain

790
Prevention of SHIV transmission by topical IFN-β treatment

RS Veazey, HA Pilch-Cooper, TJ Hope, G Alter, AM Carias, M Sips, X Wang, B Rodriguez, SF Sieg, A Reich, P Wilkinson, MJ Cameron and MM Lederman

Mucosal Immunology (Nature) USA, 03 February 2016

Virology

Key words: Drug therapy, HIV infections, Mucosal immunology, Viral transmission

Organism: Monkey

Tissue: Uterus

Pathological State: Virus Infection

791
Characterizing Villitis of Unknown Etiology and Inflammation in Stillbirth

Hayley Derricott, Rebecca L. Jones, Susan L. Greenwood, Gauri Batra, Margaret J. Evans, Alexander E.P. Heazell

The American Journal of Pathology (Elsevier) UK, 03 February 2016

Reproductive Medicine

Key words: Villitis, inflammation, stillbirth

Organism: Human

Tissue: Placenta

Pathological State: Villitis 

792
Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer

Maartje C.A. Wouters, Fenne L. Komdeur1, Hagma H. Workel, Harry G. Klip, Annechien Plat, Neeltje M. Kooi, G. Bea A. Wisman, Marian J.E. Mourits, Henriette J.G. Arts, Maaike H.M. Oonk, Refika Yigit, Steven de Jong, Cornelis J.M. Melief, Harry Hollema, Evelien W. Duiker, Toos Daemen, Marco de Bruyn, Hans W. Nijman

Clinical Cancer Research (High Wire) The Netherlands, 01 February 2016

Oncology

Key words: T-cell diferentiation, tumor-infiltrating lymphocytes, serous ovarian cancer

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

793
Infiltration of lymphocyte subpopulations into cancer microtissues as a tool for the exploration of immunomodulatory agents and biomarkers

Stefan Koeck , Marit Zwierzina, Julia M. Huber, Mario Bitsche, Edith Lorenz, Gabriele Gamerith, Jozsef Dudas, Jens M. Kelm, Heinz Zwierzina, Arno Amann

Immunobiology (Elsevier) Austria, Switzerland, 01 February 2016

Immunology

Key words: 3D, biomarker, co-culture, cancer, immune cells, infiltration, subpopulation

Organism: Human

Pathological State: Cancer

Cell Line: A549, Colo699, Calu-6 cells (human non-small-cell lung cancer cell lines)

794
FGF2 inhibits endothelial–mesenchymal transition through microRNA-20a-mediated repression of canonical TGF-ß signaling

Ana C. P. Correia, Jan-Renier A. J. Moonen, Marja G. L. Brinker, Guido Krenning

Journal of Cell Science (The Company of Biologists) The Netherlands, 01 February 2016

Cell Biology

Key words: Endothelial–mesenchymal transition, microRNA-20a-mediated repression, canonical TGF-β signaling

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

795
Injectable extracellular matrix hydrogels as scaffolds for spinal cord injury repair

Dmitry Tukmachev, Serhiy Forostyak, Zuzana Koci, Kristyna Zaviskova, Irena Vackova, Karel Vyborny, Ioanna Sandvig, Axel Sandvig, Christopher J. Medberry, Stephen F. Badylak, Eva Sykova, and Sarka Kubinova

Tissue Engineering Part A (Mary Ann Liebert Inc.) Czech Republic, Norway, UK, Sweden, USA, 28 January 2016

Regenerative Medicine

Key words: spinal cord injury; hydrogel; extracellular matrix; scaffold; tissue engineering; stem cells

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

796
Amelioration of Experimental Autoimmune Arthritis Through Targeting of Synovial Fibroblasts by Intraarticular Delivery of MicroRNAs 140-3p and 140-5p

Jia-Shiou Peng, Shih-Yao Chen, Chao-Liang Wu, Hao-Earn Chong, Yun-Chiao Ding, Ai-Li Shiau, Chrong-Reen Wang

Arthritis & Rheumatology (Wiley) Taiwan, 25 January 2016

Rheumatology

Key words: Autoimmune arthritis, synovial fibroblasts, MicroRNAs

Organism: Mouse

Tissue: Bone, Connective Tissue

Pathological State: Rheumatoid Arthritis

797
Novel technologies and emerging biomarkers for personalized cancer immunotherapy

Jianda Yuan, Priti S. Hegde, Raphael Clynes, Periklis G. Foukas, Alexandre Harari, Thomas O. Kleen, Pia Kvistborg, Cristina Maccalli, Holden T. Maecker, David B. Page, Harlan Robins, Wenru Song, Edward C. Stack, Ena Wang, Theresa L. Whiteside, Yingdong Zhao, Heinz Zwierzina, Lisa H. Butterfield and Bernard A. Fox

Journal for ImmunoTherapy of Cancer (Springer) Qatar, USA, Switzerland, Greece, Germany, The Netherlands, Italy, Austria, 19 January 2016

Oncology

Key words: Immune checkpoint blockade, Cancer immunotherapy, Biomarkers, Task Force, Immune monitoring, Technology, Bioinformatics

Organism: Human

Pathological State: Cancer

798
Fumaric acid esters promote neuronal survival upon ischemic stress through activation of the Nrf2 but not HIF-1 signaling pathway

Jiemeng Lin-Holderer, Lexiao Li, Daniel Gruneberg, Hugo H. Marti, Reiner Kunze

Neuropharmacology (Elsevier) Germany, 19 January 2016

Neuroscience

Key words: Dimethyl fumarate, monomethyl fumarate, fumaric acid esters, Nrf2, HIF, ischemia

Organism: Mouse

Tissue: Brain

799
Energy landscapes and functions of supramolecular systems

Faifan Tantakitti, Job Boekhoven, Xin Wang, Roman V. Kazantsev, Tao Yu, Jiahe Li, Ellen Zhuang, Roya Zandi, Julia H. Ortony, Christina J. Newcomb, Liam C. Palmer, Gajendra S. Shekhawat, Monica Olvera de la Cruz, George C. Schatz and Samuel I. Stupp

Nature Materials (Nature) USA, 18 January 2016

Biological Materials

Key words: Bioinspired materials, Materials science

Organism: Mouse

Cell Line: C2C12 Mouse pre-myoblasts

800
Software-assisted morphometric and phenotype analyses of human peripheral blood monocyte-derived macrophages induced by a microenvironment model of human esophageal squamous cell carcinoma

Mari Nishio, Naoki Urakawa, Manabu Shigeoka, Nobuhisa Takase, Yumi Ichihara, Noriaki Arai, Yu-ichiro Koma, Hiroshi Yokozaki

Pathology International (Wiley) Japan, 18 January 2016

Pathology

Key words: Esophageal cancer, image analysis, macrophages, tumor microenvironment

Organism: Human

Cell Line: PBMCs (Peripheral blood mononuclear cells )

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