April, 2025
Researchers used advanced imaging and analysis tools from TissueGnostics to detect and quantify two cell types, the PD-1+ regulatory T cells (Treg)/PD-1+CD8+ cytotoxic T cells (CTL) ratio, and tertiary lymphoid structure (TLS) presence in tumor tissue.
May, 2025
The evolving understanding of cancer biology underscores the pivotal role of epigenetic modifications - heritable yet reversible changes in gene expression that do not alter the DNA sequence.
Breast cancer continues to affect millions of people around the world—and for most, the diagnosis involves a hormone receptor-positive subtype.1
October, 2025
A recent study, published in Clinical and Translational Medicine, provides new insights into the colorectal cancer (CRC) immune macroenvironment, identifying key clinical biomarkers that could help stratify CRC patients for immune checkpoint inhibitor (ICI) therapies.
October, 2024
The researchers elucidated the role of the B7-H4 ligand in lung cancer, using spatial tissue cytometry solutions.
September, 2024
The team of scientists identified a new CAF subset in HNSCC combining tissue cytometry and spatial transcriptomics
July, 2024
A team from the Medical University of Vienna, Austria, developed an algorithm to automatically detect and quantify osteoclasts within StrataQuest image analysis software.
June, 2024
Spatial transcriptomics and tissue cytometry can be synergistically combined to verify the results or deepen the understanding of TME processes both on mRNA and protein level
April, 2024
The StrataQuest Organoid App provides reliable and efficient high-throughput validation and quantification for organoids co-cultured alongside immune cells.
November, 2023
Using TissueGnostics’ tissue cytometry solutions, a recent study revealed important information on how sustained cytolytic CD8+ T cells are central in determining long-term viral control in lymph nodes (LNs). This further elucidates the mechanisms behind the immune control over cancerous diseases, which may be used to develope treatments strategies for more effective results and better patient outcomes.
October, 2023
A 50-year-old patient with MSS-type CRC and PD-L1-negative recurrent hepatopulmonary metastases underwent complete remission and prolonged benefits from immunotherapy treatments after systematic treatments had previously failed.
November, 2023
In this interview we speak with Dr. Nidhi Dey, University of York, presents her exciting new work on the spatial analysis of IDO1 and PDL1 checkpoints in cutaneous leishmaniasis.
June, 2023
Using TissueFAXS whole-slide imaging and HistoQuest single cell analysis solution, a recent study revealed that xCT inhibition, caused by erastin, may be a promising therapeutic approach for treating HNSCC tumorous cells through the initiation of cell ferroptosis.
October, 2022
Colorectal cancer is the second most common cause of cancer-related mortality. One novel approach in cancer treatment is to target the anti or pro tumoral immune response. It has been reported that CD103+CD39+CD8+ TRM cells are present at higher levels in CRLM relative to adjacent liver tissue. These specific subpopulations of CD8 cells have now been evaluated in detail using the TissueFAXS CHROMA imaging platform and StrataQuest image analysis software.
April, 2019
Research groups from Yale University, USA published a paper in 'Cytometry' focusing on the phenotyping, quantification and visualization of immune cells and immune cell clusters within tissue sections using co-registration and IF multiplexed tissue cytometry.
Febuary, 2015
Groups from Vienna published a paper in 'The Journal of Steroid Biochemistry and Molecular Biology' about Vitamin D potentiating the anti-neoplastic effects of calcium in the colon.
October, 2017
Research groups from Austria, Australia, England and The Netherlands published a paper in 'Nature Communications' about the Tet-transactivator imparing the antigen-induced lymphocyte activation in mice.
July, 2016
Research groups from USA, published a paper in 'Diagnostic Pathology' dealing with quantitative comparison and reproducibility of pathologist scoring and digital image analysis in prostate cancer.
Febuary, 2019
Skilled motor behavior requires the precise exchange of information between the muscles of the body and various levels of the central nervous system (CNS). Motor behavior, limb mechanics and neural control must be precisely coordinated in order to achieve the required movement1.
Febuary, 2017
Groups from Germany (Heidelberg, Jena) published a paper in the Journal 'Cancer Immunology, Immunotherapy' regarding tumor-specifc regulatory T cells in the bone marrow of breast cancer patients.
August, 2020
A groundbreaking publication in the journal Cell suggests that in COVID-19 patients the differentiation of Tfh cells and formation of germinal centers within lymph nodes and spleen is inhibited. Molecules such as Bcl-6 were assessed using the TissueFAXS platform including the analysis applications StrataQuest and TissueQuest.
October, 2020
Febuary, 2021
Learning through affective responses, in which experiences are regarded as having a positive or negative valence (e.g., pleasure or fear, respectively), requires a judgment of the relative value of options. Several studies have linked a cluster of neurons in the subcortical basal ganglia, known as the striatum, to learning these valence-based responses (1,2)
May, 2021
Liver cancer is the fourth leading cause of cancer-related death worldwide, of which hepatocellular carcinoma (HCC) is the most common primary cancer accounting for 75-85% of cases. HCC can be classified into several histological subtypes, reflecting the heterogeneity of the disease. This heterogeneity, including the cancers’ cell plasticity, is known to be, in part, determined by the microenvironment.
July, 2021
September, 2021
Recently Delacher and colleagues were able to redefine the transcriptional and epigenetic signature of tissue-associated regulatory T cells (Treg) in mice and humans (Delacher et al. 2021). They could demonstrate, that Treg cells from healthy tissues share distinct expression patterns with tumor-infiltrating Treg cells.
October, 2021
Surgery, chemotherapy and radiation have formed the mainstay of cancer therapy for many years. However, in addition to destroying tumor cells, these treatments are detrimental to healthy cells giving rise to side effects, which can be severe. During the last two decades, more targeted therapies that specifically destroy cancer cells have been developed to minimize unwanted side effects.
January, 2022
May, 2022
One of the challenges of imaging tissue sections is dealing with their diverse composition. The human body contains hundreds of different cell phenotypes, with many more to be discovered. There is a huge need for multiplexing imaging techniques that can recover imaging information on cell-cell interactions with sufficient resolution to identify various unique phenotypes and is compatible with the diversity of cell species.
June, 2022
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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.
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