TissueGnostics will be at the ASI 2025 meeting, 1–5 December in Perth, Australia. Join one of the region’s largest immunology events and meet our team to discuss your imaging needs.

TissueGnostics’ industry session at IUIS 2025 was a success, uniting immunologists around advances in spatial biology and AI-powered imaging. Thanks to Dr. Ecker, A/Prof. Mechtcheriakova, Prof. Batra, and all who joined us. Until next time!

Chronic inflammatory diseases (CIDs) involve prolonged inflammation causing tissue damage and dysfunction.

Dr. Uwe Ritter, LIT, reports on studies of Tregs in wound healing using 3D skin models and CD8+ T cells in tissue regeneration. He further describes the development of a co-cultured organoid detection pipeline published recently.

Dr. Diana Mechtcheriakova, Medical University of Vienna, presents research on lymphoid structures in systemic immunity and anti-cancer responses, with applications in colorectal cancer.

A new study shows PD-1+ Treg/CTL ratio combined with TLS predicts prognosis and treatment response in gastric cancer using mIF, TissueFAXS, and StrataQuest.

Researchers demonstrate TCL1A+ B cells drive TLS formation in OSCC and serve as a positive prognostic factor using mIF and TissueFAXS imaging.

Multiplex fluorescence imaging of tonsil tissue analyzed in StrataQuest to quantify and map T-cell subsets within and around germinal centers.

This webinar explores how tissue cytometry enables investigation of fatty liver disease, providing insights into liver pathology and immune interactions.

Felix Tsai, TG-AP Business Manager, shared an article featuring TLS as a key player in cancer and solutions to invesigate them.

The StrataQuest Organoid App provides reliable and efficient high-throughput validation and quantification for organoids co-cultured alongside immune cells.

A new study shows that combining type I interferon (MxA) expression with CD8+ T cell density can predict patient response to neoadjuvant treatment in rectal adenocarcinoma. TissueFAXS CHROMA and StrataQuest enabled precise multispectral imaging and analysis.

Dr. Nidhi S. Dey (University of York) presents her work on spatial analysis of IDO1 and PD-L1 in cutaneous leishmaniasis, uncovering immune checkpoint targets for treating this neglected parasitic disease.

Heij et al. show that checkpoint molecule co-expression (PD-L1, TIGIT) in intrahepatic cholangiocarcinoma correlates with metastases and poor prognosis. TissueFAXS + StrataQuest enabled high-resolution mIF imaging and protein expression analysis.

Nadine Bayer, PhD (MedUni Vienna), presents her Leukemia (Nature) paper on microbial skin recolonization and immune response after allogeneic stem cell transfer.

Zambrano et al. characterized neutrophil extracellular traps (NETs) and NETotic cells in vaginal discharges of women with vaginitis using TissueFAXS i PLUS. The study highlights an underexplored aspect of public health.

Kaneko et al. (Scientific Reports, Nature) investigated CD4+ and CD8+ T-cell subsets in salivary glands of Sjögren’s syndrome patients using TissueFAXS with TissueQuest and StrataQuest for in-depth quantitative tissue cytometry.

Dr. Thomas Diefenbach, The Ragon Institute Boston, presents various approaches for multiplexing IF, utilizing the power of TissueFAXS high-throughput automated slide scanning and StrataQuest powered high-end image analysis.