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Customer Publications (A total of 1320 papers published)

801
Characterization and anti-tumor effects of chondroitin sulfate–chitosan nanoparticles delivery system

Chieh-Shen Hu, Sung-Ling Tang, Chiao-Hsi Chiang, Hossein Hosseinkhani, Po-Da Hong, Ming-Kung Yeh

Journal of Nanoparticle Research (Springer) Taiwan, 07 November 2014

Oncology

Key words:Cell uptake efficiency, hepg2 cell, dox concentration, chondroitin sulfate, encapsulation efficiency, chitosan nanoparticle, anthracycline, gold nanoparticle,disaccharide, hepg2 cell line,entrapment efficiency,tumor volume

802
The Pseudomonas aeruginosa type III translocon is required for biofilm formation at the epithelial barrier

Cindy S. Tran, Stephanie M. Rangel, Henrik Almblad, Arlinet Kierbel, Michael Givskov, Tim Tolker-Nielsen, Alan R. Hauser, Joanne N. Engel

PLoS Pathogens (PLOS) Uruguay, Singapore, Denmark, USA, 06 November 2014

Microbiology

Key words:Bacterial biofilms, Pseudomonas aeruginosa, Pulmonary imaging, Antibiotic resistance, Host cells Cell staining, Confocal microscopy, Mouse models

803
Pharmacological inhibition of TGFβ receptor improves Nkx2.5 cardiomyoblast-mediated regeneration

Wen-Pin Chen, Yuan-Hung Liu, Yi-Jin Ho, Sean M. Wu

Cardiovascular Research (Oxford University Press) Taiwan, USA, 01 November 2014

Regenerative Medicine

Key words:Nkx2.5, Cardiomyoblast, TGFβ, Regeneration, Myocardial infarction

804
GATA2 Regulates Differentiation Of Bone Marrow-Derived Mesenchymal Stem Cells

Mayumi Kamata, Yoko Okitsu, Tohru Fujiwara, Masahiko Kanehira, Shinji Nakajima, Taro Takahashi, Ai Inoue, Noriko Fukuhara, Yasushi Onishi, Kenichi Ishizawa, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae

Haematologica (Ferrata Storti Foundation) Japan, 01 November 2014

Stem Cell Research

Key words:Bone marrow, stem cells

805
The role of cytokines and chemokines in the T-cell-mediated autoimmune process in alopecia areata

Taisuke Ito, Yoshiki Tokura

Experimental Dermatology (Wiley) Japan, 29 October 2014

Dermatology

Key words:Alopecia areata, chemokine, cytokine, immune privilege, swarm of bees

806
Megakaryocytes are essential for HSC quiescence through the production of thrombopoietin

Ayako Nakamura-Ishizua, Keiyo Takubo, Masato Fujioka, Toshio Suda

Biochemical and Biophysical Research Communications (Elsevier) Japan, 24 October 2014

Hematology

Key words:Megakaryocytes, hematopoietic stem cells, thrombopoietin, niche, bone marrow

807
Fenretinide: A Novel Treatment for Endometrial Cancer

Navdha Mittal, Saurabh Malpani, Matthew Dyson, Masanori Ono, John S. Coon, Julie J. Kim, Julian C. Schink, Serdar E. Bulun, Mary Ellen Pavone

Plos One (PLOS) USA, 23 October 2014

Oncology

Key words:Cancer treatment, apoptosis, uterine cancer, vitamin A, gene expression, small interfering RNAs, retinoic acid, cancer therapy

808
Loss of Gsα Early in the Osteoblast Lineage Favors Adipogenic Differentiation of Mesenchymal Progenitors and Committed Osteoblast Precursors

Partha Sinha, Piia Aarnisalo, Rhiannon Chubb, Noriaki Ono, Keertik Fulzele, Martin Selig, Hamid Saeed, Min Chen, Lee S Weinstein, Paola Divieti Pajevic, Henry M Kronenberg, Joy Y Wu

Journal of Bone and Mineral Research (Wiley) USA, Finland, 20 October 2014

Rheumatology

Key words:Osteoblasts, GSA, mesenchymal progenitors, adipocytes

809
Role of fractalkine in the pathogenesis of primary Sjögren syndrome: increased serum levels of fractalkine, its expression in labial salivary glands, and the association …

Jae Ho Lee, Seung-Ki Kwok, Seung Min Jung, Jennifer Lee, Jae-Seon Lee, Seung Ye Baek, Eun-Kyung Kim, Ji Hyeon Ju, Sung-Hwan Park and Ho-Youn Kim

Journal of Rheumatology (jrheum.org) South Korea, 15 October 2014

Rheumatology

Key words:SJÖGREN SYNDROME, FRACTALKINE, CX3CR1

810
Langerhans cells promote early germinal center formation in response to Leishmania-derived cutaneous antigens

Nicole Zimara, Christian Florian, Maximilian Schmid, Bernard Malissen, Adrien Kissenpfennig, Daniela N. Männel, Matthias Edinger, James A. Hutchinson, Petra Hoffmann, Uwe Ritter

European Journal of Immunology (Wiley) Germany, France, UK, 13 October 2014

Immunology

Key words:B cells, follicular helper, germinal center reaction, langerhans cells, leishmania major, T cells

811
The pre- and post-somatic segments of the human type I spiral ganglion neurons – Structural and functional considerations related to cochlear implantation

W. Liu, F. Edin, F. Atturo, G. Rieger, H. Löwenheime, P. Senn, M. Blumer, A. Schrott-Fischer, H. Rask-Andersen, R. Glueckert

Neuroscience (Elsevier) Sweden, Italy, Austria, Germany, Switzerland, 12 October 2014

Neuroscience

Key words:Human cochlea, spiral ganglion neurons, non-myelinated Schwann cells, laminin-ß2, collagen IV, immunohistochemistry

812
Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy

Stefan Brenner, Lukas Klameth, d, Juliane Riha, Madeleine Schölm, Gerhard Hamilton, Erika Bajna, Christoph Ausch, Angelika Reiner, Walter Jäger, Theresia Thalhammer , Veronika Buxhofer-Ausch

Cancer Letters (Elsevier) Austria, 06 October 2014

Oncology

Key words:Small cell lung cancer (SCLC), organic anion transporting polypeptide (OATP), neurogenic marker, chemotherapy, OATP gene expression

813
TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion

JV Joseph, S Conroy, T Tomar, E Eggens-Meijer, K Bhat, S Copray, AME Walenkamp, E Boddeke, V Balasubramanyian, M Wagemakers, WFA den Dunnen and FAE Kruyt

Cell Death and Disease (Nature) The Netherlands, USA, 02 October 2014

Oncology

Key words:Cell signalling, CNS cancer, Transdifferentiation, Transforming growth factor beta

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

814
Adipose tissue–derived stromal cells inhibit TGF-β1–induced differentiation of human dermal fibroblasts and keloid scar–derived fibroblasts in a paracrine fashion

M Spiekman, E Przybyt, JA Plantinga, S Gibbs,B van der Lei, M Harmsen

Plastic and Reconstructive Surgery (Wolters Kluwer) The Netherlands, 01 October 2014

Stem Cell Research

Organism: Human

Cell Line: Dermal Fibroblasts

815
The Inner Foreskin of Healthy Males at Risk of HIV Infection Harbors Epithelial CD4+ CCR5+ Cells and Has Features of an Inflamed Epidermal Barrier

Maria P. Lemos, Javier R. Lama, Shelly T. Karuna, Youyi Fong, Silvia M. Montano, Carmela Ganoza, Raphael Gottardo, Jorge Sanchez, M. Juliana McElrath

Plos One (PLOS) USA, Peru, 30 September 2014

Virology

Key words:Epidermis, inflammation, membrane staining, epithelium, keratinocytes, HIV infections, circumcision HIV

Organism: Human

Tissue: Penis

816
Late effects of local irradiation on the expression of inflammatory markers in the Arteria saphena of C57BL/6 wild-type and ApoE-knockout mice

I. Patties, B. Habelt, B. Rosin, W. Dörr, G. Hildebrandt, A. Glasow

Radiation and Environmental Biophysiscs (Springer) Germany, Austria, 27 September 2014

Immunology

Key words:A. saphe ,inflammation, irradiatin , ApoE-knockout mice, atherosclerosis, macrovasculature

Organism: Mouse

Tissue: Blood Vessels

817
CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease and mediates key steps of metastasis

Pranav Gupta, Praveen K. Sharma, Hina Mir, Rajesh Singh, Nalinaksha Singh, Goetz H. Kloecker, James W. Lillard, and Shailesh Singh

Oncotarget (Impact Journals) USA, India, 25 September 2014

Oncology

Key words:CCR9, CCL25, Chemokine receptor, Non-small cell lung cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

818
Extracellular matrix components of adipose derived stromal cells promote alignment, organization, and maturation of cardiomyocytes in vitro

Ewa Przybyt, Marja J. A. van Luyn andMartin C. Harmsen

Journal of Biomedical Materials Research (Wiley) The Netherlands, 24 September 2014

Transplantation Medicine

Key words:Myocardial infarction, cardiomyocytes, adipose derived stromal cells, extracellular matrix

Organism: Human

Cell Line: Adipose derived stromal cells

819
Myeloid-derived suppressor cell functionality and interaction with Leishmania major parasites differ in C57BL/6 and BALB/c mice

Maximilian Schmid, Nicole Zimara, Anja Kathrin Wege, Uwe Ritter

European Journal of Immunology (Wiley) Germany, 19 September 2014

Immunology

Key words:Arginase-1, bone marrow, inducible nitric oxide synthase, leishmania major, myeloid-derived suppressor cells

Organism: Mouse

Pathological State: Bacterial Infection

Cell Line: Myeloid‐derived suppressor cells

820
Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury

Luisa Morales-Nebreda, Monica Chi, Emilia Lecuona, Navdeep S. Chandel, Laura A. Dada, Karen Ridge, Saul Soberanes, Recep Nigdelioglu, Jacob I. Sznajder, Gökhan M. Mutlu, G.R. Scott Budinger, Kathryn A. Radigan

Journal of Virological Methods (Elsevier) USA, 17 September 2014

Virology

Key words:Influenza A infection, inoculation, mice, lung injury, intratracheal, intranasal

Organism: Mouse

Tissue: Lung

Pathological State: Viral Infection

821
Antigen-loaded dendritic cell migration: MR imaging in a pancreatic carcinoma model

Zhuoli Zhang , Weiguo Li, Daniele Procissi, Kangan Li, Alexander Y. Sheu, Andrew C. Gordon, Yang Guo, Khashayarsha Khazaie, Yi Huan, Guohong Han, Andrew C. Larson

Radiology (Radiological Society of North America) China, 15 September 2014

Oncology

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

822
Role of TRAP1 and estrogen receptor alpha in patients with ovarian cancer -A study of the OVCAD consortium

Stefanie Aust, Anna Bachmayr-Heyda, Petra Pateisky, Dan Tong, Silvia Darb-Esfahani, Carsten Denkert, Radoslav Chekerov, Jalid Sehouli, Sven Mahner, Toon Van Gorp, Ignace Vergote, Paul Speiser, Reinhard Horvat, Robert Zeillinger, Dietmar Pils

Molecular Cancer (Springer) Austria, Germany, Belgium, The Netherlands, 14 September 2014

Oncology

Key words:TRAP1, estrogen receptorImmunohistochemistry, prognosis, ovarian cancer

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

823
Specific roles for dendritic cell subsets during initiation and progression of psoriasis

Elisabeth Glitzner, Ana Korosec, Patrick M Brunner, Barbara Drobits, Nicole Amberg, Helia B Schonthaler, Tamara Kopp, Erwin F Wagner, Georg Stingl, Martin Holcmann,Maria Sibilia

EMBO Molecular Medicine (Wiley) Austria, Spain, 12 September 2014

Dermatology

Key words:AP-1, IL-23, langerhans cells, plasmacytoid dendritic cells, psoriasis

Organism: Human

Tissue: Skin

Pathological State: Psoriasis

824
An Activatable Prodrug for the Treatment of Metastatic Tumors

Eun-Joong Kim, Sankarprasad Bhuniya, Hyunseung Lee, Hyun Min Kim, Chaejoon Cheong, Sukhendu Maiti, Kwan Soo Hong, Jong Seung Kim

Journal of the American Chemical Society (ACS Publications) South Korea, 11 September 2014

Oncology

Key words:Metastatic cancers, tumor cell growth, cellular imaging

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

825
Olfactory Receptor Patterning in a Higher Primate

Lisa F. Horowitz, Luis R. Saraiva, Donghui Kuang, Kyoung-hye Yoon, Linda B. Buck

Journal of Neuroscience (SFN) USA, 10 September 2014

Neuroscience

Key words:Macaque odorant receptor, primate trace-amine associated receptor

Organism: Monkey

Tissue: Nasal Mucosa

826
Late inflammatory and thrombotic changes in irradiated hearts of C57BL/6 wild-type and atherosclerosis-prone ApoE-deficient mice

I. Patties, J. Haagen, W. Dörr, G. Hildebrandt, A. Glasow

Strahlentherapie und Onkologie (Springer) Germany, Austria, 09 September 2014

Radiotherapy

Key words:Irradiatio,n microvasculature, Heart Inflammation, Atheroscrosis Bestrahlung, Mikrovaskulatur, Herz Entzündung Atherosklerose

Organism: Mouse

Tissue: Heart

827
Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets

Teng Zhoua, Bo Zhang, Peng Wei,Yipeng Du, Hejiang Zhou, Meifang Yu, Liang Yan, Wendi Zhang, Guangjun Nie, Chunying Chen, Yaping Tu, Taotao Wei

Biomaterials (Elsevier) China, USA, 08 September 2014

Nanomedicine

Key words:PEG-modified graphene oxide, breast cancer cell, metastasis, cytoskeletal assembly, mitochondrial oxidative phosphorylation

Organism: Mouse

Tissue: Lung

828
STAT3β controls inflammatory responses and early tumor onset in skin and colon experimental cancer models

Francesca Marino, Valeria Orecchia, Gabriella Regis, Monica Musteanu, Beatrice Tassone, Cristina Jon, Marco Forni, Enzo Calautti, Roberto Chiarle, Robert Eferl, and Valeria Poli

American Journal of Cancer Research (NCBI) Italy, Austria, Spain, USA, 06 September 2014

Oncology

Key words:STAT3 isoforms, STAT3β, inflammation, inflammation-driven tumorigenesis, colitis-associated cancer, AOM/DSS protocol, skin tumorigenesis, DMBA/TPA protocol, genetically modified mice

Organism: Human

Tissue: Skin

Pathological State: Cancer

829
Optimisation of the quantitative analysis of inflammatory cell infiltrates in breast cancer/Optimizarea analizei cantitative a infiltratului celular inflamator în cancerul …

AR Vrânceanu, CC Tărniceriu, D Jitaru, C Terinte, F Zugun-Eloae, E Carasevici

Revista Romana de Medicina de Laborator () Romania, 03 September 2014

Oncology

Organism: Human

Tissue: Breast

Pathological State: Cancer

830
NEW INSIGHTS IN PULMONARY HYPERTENSION

European Heart Journal (Oxford University Press) Italy, 31 August 2014

Cardiology

831
Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix

Leila Akkari, Vasilena Gocheva, Jemila C. Kester, Karen E. Hunter, Marsha L. Quick, Lisa Sevenich, Hao-Wei Wang, Christoph Peters, Laura H. Tang, David S. Klimstra, Thomas Reinheckel, Johanna A. Joyce

Genes and Development (CSH Press) USA, Germany, 29 August 2014

Oncology

Key words:Cell invasion, cell migration, tumor microenvironment protease

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

832
Quantitative LA-ICP-MS imaging of platinum in chemotherapy treated human malignant pleural mesothelioma samples using printed patterns as standard

M Bonta, H Lohninger, V Laszlo, B Hegedus, A Limbeck

Journal of Analytical Atomic Spectrometry (Royal Society of Chemistry) Austria, Hungary, 29 August 2014

Oncology

Organism: Human

Tissue: Lung

Pathological State: Cancer

833
Macrophage Migration Inhibitory Factor Triggers Chemotaxis of CD74+CXCR2+ NKT Cells in Chemically Induced IFN-γ–Mediated Skin Inflammation

Chia-Yuan Hsi, Chia-Ling Chen, Yee-Shin Lin, Trai-Ming Yeh, Tsung-Ting Tsai, Ming-Yuan Hong, Chiou-Feng Lin

The Journal of Immunology (American Association of Immunologists) Taiwan, 29 August 2014

Immunology

Key words:Human NK cell, macrophage migration inhibitory factor

Organism: Human

Cell Line: Isolated primary human blood cell

834
Vascularization of primary and secondary ossification centres in the human growth plate

Sonja M Walzer, Erdal Cetin, Ruth Grübl-Barabas, Irene Sulzbacher, Beate Rueger, Werner Girsch, Stefan Toegel, Reinhard Windhager, Michael B Fischer

BMC Developmental Biology (Springer) Austria, 28 August 2014

Developmental Biology

Key words:Growth plate, vascularization, primary ossification centres, secondary ossification centres, progenitor cells

Organism: Human

Tissue: Bone

835
Type I interferons have opposing effects during the emergence and recovery phases of colitis

Isabella Rauch, Eva Hainzl, Felix Rosebrock, Susanne Heider, Clarissa Schwab, David Berry, Dagmar Stoiber, Michael Wagner, Christa Schleper, Alexander Loy, Tim Urich, Mathias Müller, Birgit Strobl, Lukas Kenner,Thomas Decker

European Journal of Immunology (Wiley) Austria, 25 August 2014

Immunology

Key words:Colitis, inflammation, interferons, interleukin-1, microbiota

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

836
Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

Anna M. Weihs, Christiane Fuchs, Andreas H. Teusch, Joachim Hartinger, Paul Slezak, Rainer Mittermayr, Heinz Redl§,Wolfgang G. Junger, Harald H. Sitte, Dominik Rünzler

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) Austria, 12 August 2014

Regenerative Medicine

Key words:ATP Cell proliferation, extracellular signal-regulated kinase (ERK), signal transduction, wound healing, shock wave treatment

Organism: Rat

Tissue: Skin

837
Histological Characterization and Quantification of Cellular Events Following Neural and Fibroblast(-Like) Stem Cell Grafting in Healthy and Demyelinated CNS Tissue

Jelle Praet, Eva Santermans, Kristien Reekmans, Nathalie de Vocht, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Herman Goossens, Zwi Berneman, Niel Hens, Annemie Van der Linden, Peter Ponsaert

Animal Models for Stem Cell Therapy (Springer) Belgium, 04 August 2014

Stem Cell Research

Key words:Neural stem cell, mouse embryonic fibroblasts, cell grafting, cuprizone, quantitative histology, inflammation

838
Analysis of tumour-and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

Lisa Sevenich, Robert L. Bowman, Steven D. Mason, Daniela F. Quail, Franck Rapaport, Benelita T. Elie, Edi Brogi, Priscilla K. Brastianos, William C. Hahn, Leslie J. Holsinger, Joan Massagué, Christina S. Leslie and Johanna A. Joyce

Nature Cell Biology (Nature) USA, 03 August 2014

Oncology

Key words:Cancer microenvironment, Metastasis

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

839
Benzyl butyl phthalate induces migration, invasion, and angiogenesis of Huh7 hepatocellular carcinoma cells through nongenomic AhR/G-protein signaling

Cheng-Fang Tsai, Tsung-Hua Hsieh, Jau-Nan Lee, Chia-Yi Hsu, Yu-Chih Wang, Feng-Jie Lai, Kung-Kai Kuo, Hua-Lin Wu, Eing-Mei Tsai and Po-Lin Kuo

BMC Cancer (Springer) Taiwan, 01 August 2014

Oncology

Key words:Phthalate, Aryl hydrocarbon receptor, Angiogenesis, Migration, Hepatocellular carcinoma

Organism: Mouse

Tissue: Liver, Xenograft Tumor

Pathological State: Cancer

840
The vitamin D system is deregulated in pancreatic diseases

Doris Hummel, Abhishek Aggarwal, Katalin Borka, Erika Bajna, Enikö Kállay, Henrik Csaba Horváth

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Austria, Hungary, Switzerland, 30 July 2014

Oncology

Key words:Vitamin D, CYP24A1, VDR, CaSR, chronic pancreatitis, pancreatic ductal adenocarcinoma, pancreatic cancer

Organism: Human

Tissue: Pancreas

841
Hardware and Software

Yves Sucaet, Wim Waelput

Hardware and Software (Springer) Belgium, 23 July 2014

Medical Imaging

Key words:Digital pathology, slide scanner, tile scanner, line scanner, file format, medical imaging WSI DP MRXS NDPI SVS BIF

842
Single Administration of p2TA (AB103), a CD28 Antagonist Peptide, Prevents Inflammatory and Thrombotic Reactions and Protects against Gastrointestinal Injury in Total-Body Irradiated Mice

Salida Mirzoeva, Tatjana Paunesku, M. Beau Wanzer, Anat Shirvan, Raymond Kaempfer, Gayle E. Woloschak, William Small Jr

Plos One (PLOS) USA, Israel, 23 July 2014

Gastroenterology

Key words:Inflammation, ayclins, fibrinogen, macrophages, gamma rays, cytokines, infrared radiation, small intestine

Organism: Mouse

Tissue: Small Intestine, Lung, Spleen

843
Absence of substance P and the sympathetic nervous system impact on bone structure and chondrocyte differentiation in an adult model of endochondral ossification

Tanja Niedermaira, Volker Kuhn, Fatemeh Doranehgard, Richard Stange, Britta Wieskötter, Johannes Beckmann, Philipp Salmen, Hans-Robert Springorum, Rainer H. Straub, Andreas Zimmer, Joachim Grifka, Susanne Grässel

Matrix Biology (Elsevier) Germany, Austria, 22 July 2014

Neuroscience

Key words:Substance P, sympathetic nerve fibers, fracture callus, bone structure, bone formation, bone resorption, biomechanics, endochondral ossification

Organism: Mouse

Tissue: Bone Marrow

844
Wnt Coreceptor Lrp5 Is a Driver of Idiopathic Pulmonary Fibrosis

Anna P. Lam , Jose D. Herazo-Maya , Joseph A. Sennello , Annette S. Flozak , Susan Russell , Gökhan M. Mutlu , G. R. Scott Budinger , Ramanuj DasGupta , John Varga , Naftali Kaminski , and Cara J. Gottardi

American Journal of Respiratory and Critical Care Medicine (ATS Journals) USA, 15 July 2014

Pulmonology

Key words:lung fibrosis; Wnt/β-catenin signaling; peripheral blood mononuclear cell

Organism: Human

Tissue: Lung

Pathological State: Idiopathic Pulmonary Fibrosis

845
Reliable Quantification of Protein Expression and Cellular Localization in Histological Sections

Michaela Schlederer, Kristina M. Mueller, Johannes Haybaeck, Susanne Heider, Nicole Huttary, Margit Rosner, Markus Hengstschläger, Richard Moriggl, Helmut Dolznig, Lukas Kenner

Plos One (PLOS) Austria, 11 July 2014

Pathology

Key words:Image analysis, pathologists, cell staining, hepatocytes, protein expression, cytoplasmic staining, transcription factors, hepatocellular carcinoma

Organism: Mouse

846
EpCAM is overexpressed in local and metastatic prostate cancer, suppressed by chemotherapy and modulated by MET-associated miRNA-200c/205

P Massoner, T Thomm, B Mack, G Untergasser, A Martowicz, K Bobowski, H Klocker, O Gires and M Puhr

British journal of Cancer (Nature) Austria, Germany, 03 July 2014

Oncology

Key words:Biomarkers, Cancer therapeutic resistance, Oncogenesis, Prostate cancer

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

847
Alteration in the Wnt microenvironment directly regulates molecular events leading to pulmonary senescence

Tamas Kovacs, Veronika Csongei, Diana Feller, David Ernszt, Gabor Smuk, Veronika Sarosi, Laszlo Jakab, Krisztian Kvell, Domokos Bartis Judit E. Pongracz

Aging Cell (Wiley) Hungary, UK, 01 July 2014

Cell Biology

Key words:Molecular biology of aging, pulmonary senescence, Wnt microenvironment

Organism: Human

Tissue: Lung

848
Distinct spatial distribution of microglia and macrophages following mesenchymal stem cell implantation in mouse brain

Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Eva Santermans, Niel Hens, Herman Goossens, Zwi Berneman, Peter Ponsaerts

Immunology and Cell Biology (Wiley) Belgium, 01 July 2014

Immunology

Organism: Mouse

Tissue: Brain

849
Comprehensive assessment of HIV target cells in the distal human gut suggests increasing HIV susceptibility toward the anus

MJ. McElrath, K. Smythe, J. Randolph-Habecker, KR. Melton, TA. Goodpaster, S. Hughes, M. Mack, A. Sato, G. Diaz, G. Steinbach, R. Novak, M. Curlin, JD. Lord, J. Maenza, A. Duerr, N. Frahm, F. Hladik

Journal of acquired immune deficiency Syndrome (NCBI) USA, Germany, 01 July 2014

Virology

Organism: Human

Tissue: Colon

Pathological State: Viral Infection

850
Podocalyxin-like 1 promotes invadopodia formation and metastasis through activation of Rac1/Cdc42/cortactin signaling in breast cancer cells

Cheng-Wei Lin, Min-Shiou Sun, Mei-Ying Liao, Chu-Hung Chung, Yi-Hsuan Chi, Li-Tin Chiou, John Yu, Kuo-Lung Lou, Han-Chung Wu

Carcinogenesis (Oxford University Press) Taiwan, 26 June 2014

Oncology

Key words:Podocalyxin-like 1 invadopodia, cortactin invasion metastasis

Organism: Human

Tissue: Colon, Breast

Pathological State: Cancer

851
Memantine Alleviates Brain Injury and Neurobehavioral Deficits after Experimental Subarachnoid Hemorrhage

Chih-Yuan Huang, Liang-Chao Wang, Hao-Kuang Wang, Chia-Hsin Pan, Ya-Yun Cheng, Yan-Shen Shan, Chung-Ching Chio, Kuen-Jer Tsai

Molecular Neurobiology (Springer) Taiwan, 22 June 2014

Neuroscience

Key words:Blood-brain barrier, memantine, neuroprotection, nitric oxide synthase, subarachnoid hemorrhage

Organism: Rat

Tissue: Brain

Pathological State: Hemorrhage

852
OP0300 Effect of VEGF121-Fibrin on the Expression of VEGF Receptors in Ischemic Lesions of UCD-206 Chickens, an Animal Model for Systemic Sclerosis

S. Allipour-Birgani, H. Dietrich, J. Gruber, O. Distler, A. Zisch, R. Sgonc

Annals of the Rheumatic Diseases (BMJ Journals) Austria, Switzerland, 14 June 2014

Rheumatology

Key words:Systemic sclerosis, perivascular mononuclear cell infiltration, Microvascular injury, angiogenesis, vascular endothelial cell growth factor

Organism: Chicken

Tissue: Skin

853
OP0103 Decreased Lupus Severity in Mir155 Deficient Mice

H. Leiss, W. Salzberger, I. Gessl, N. Kozakowski, S. Blüml, A. Puchner, B. Niederreiter, G. Steiner, J. Smolen, G. Stummvoll

Annals of the Rheumatic Diseases (BMJ Journals) Austria, 14 June 2014

Rheumatology

Key words:MicroRNAs, MiR155-deficient, glomerulonephritis, serum antibody, T helper cell homeostasis

Organism: Mouse

Tissue: Kidney, Lung

Pathological State: Lupus

854
An integrated approach for the systematic evaluation of polymeric nanoparticles in healthy and diseased organisms

Leopoldo Sitia, Katia Paolella, Michela Romano, Martina Bruna Violatto, Raffaele Ferrari, Stefano Fumagalli, Laura Colombo, Ezia Bello, Maria Grazia De Simoni, Maurizio D’Incalci, Massimo Morbidelli, Eugenio Erba, Mario Salmona, Davide Moscatelli, Paolo Bigini

Journal of Nanoparticle Research (Springer) Italy, Switzerland, 12 June 2014

Nanomedicine

Key words:Optical imaging, cellular uptake, protein corona, breast tumor, cell cycle phase, nu nu mouse, atomic force microscopy, lymph node, involvment, intracellular delivery, tumor vasculature

Organism: Human

Cell Line: 4T1 and MDA-MB cells

855
A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling

Andrea Köhler, Ümmühan Demir, Eva Kickstein, Sybille Krauss, Johanna Aigner, Beatriz Aranda-Orgillés, Antonios I Karagiannidis, Clemens Achmüller, Huajie Bu, Andrea Wunderlich, Michal-Ruth Schweiger, Georg Schaefer, Susann Schweiger, Helmut Klocker, Rainer Schneider

Molecular Cancer (Springer) Austria, Germany, UK, 09 June 2014

Oncology

Key words:Androgen receptor, MID1, Translation, Prostate cancer, Reciprocal regulation

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

856
B Cells and Ectopic Follicular Structures: Novel Players in Anti-Tumor Programming with Prognostic Power for Patients with Metastatic Colorectal Cancer

Anastasia Meshcheryakova, Dietmar Tamandl, Erika Bajna, Judith Stift, Martina Mittlboeck, Martin Svoboda, Denise Heiden, Stefan Stremitzer, Erika Jensen-Jarolim, Thomas Grünberger, Michael Bergmann, Diana Mechtcheriakova

Plos One (PLOS) Austria, 06 June 2014

Immunology

Key words:B cells, immune cells, macrophages, cell staining, portal veins, colorectal cancer, DAPI staining, nuclear staining

Organism: Human

Tissue: Colon

Pathological State: Cancer

857
Angiogenesis as prospective molecular biology technique for cancer study

V Ardeleanu, C Georgescu…

Romanian Biotechnological Letters (University of Bucharest) Romania, 03 June 2014

Oncology

Key words:esophagus, tumor, neoangiogenesis, quantitative study

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

858
Circulating Cytokines and Alarmins Associated with Placental Inflammation in High-Risk Pregnancies

Sylvie Girard, Alexander E. P. Heazell, Hayley Derricott, Stuart M. Allan, Colin P. Sibley, Vikki M. Abrahams, Rebecca L. Jones

American Journal of Reproductive Immunology (Wiley) UK, USA, Canada, 28 May 2014

Reproductive Medicine

Key words:High-risk pregnancy, inflammation, placental dysfunction, stillbirth

Organism: Human

Tissue: Placenta

859
A novel rat full-thickness hemi-abdominal wall/hindlimb osteomyocutaneous combined flap: influence of allograft mass and vascularized bone marrow content on vascularized composite allograft survival

Alejandro E. Ramirez, Hui-Yun Cheng3, William W. Lao, Yen-Ling Wang, Chih-Jen Wen, Christopher G. Wallace, Chih-Fan Lin, Ling-Yi Shih, Sheng-Hao Chuang and Fu-Chan Wei

Transplant International (Wiley) Taiwan, Chile, USA, 24 May 2014

Transplantation Medicine

Key words:Abdominal wall transplantation, allograft mass, allograft survival, combined flap, vascularized bone marrow, vascularized composite allotransplantation

Organism: Rat

Tissue: Whole Organism

860
Coexpression of CD44-positive/CD133-positive cancer stem cells and CD204-positive tumor-associated macrophages is a predictor of survival in pancreatic ductal adenocarcinoma

Ya-Chin Hou, Ying-Jui Chao, Hui-Ling Tung, Hao-Chen Wang, Yan-Shen Shan

Cancer (Wiley) Taiwan, 19 May 2014

Oncology

Key words:Pancreatic ductal adenocarcinoma, cancer stem cells, tumor-associated macrophages, tissue microarrays, CD44, CD133, CD204

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

861
Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage

Shin-Shiou Lin, Bing-Hsiean Tzeng,Kuan-Rong Lee, Richard J. H. Smith, Kevin P. Campbell, Chien-Chang Chen

PNAS (PNAS) Taiwan, USA, 13 May 2014

Physiology

Key words:Chondrogenesis, tracheal cartilage, mesenchymal cells, chondrocytes

Organism: Mouse

Tissue: Trachea

862
Cell cycle association and hypoxia regulation of excision repair cross complementation group 1 protein (ERCC1) in tumor cells of head and neck cancer

József Dudás, Volker H. Schartinger, Angela Romani, Gabriele Schweigl, Kristian Kordsmeyer, Patricia Irina Marta, Christoph Url, Florian Kral, Herbert Riechelmann

Tumor Biology (Springer) Austria, 12 May 2014

Oncology

Key words:Gene expression, cell cycle phase, bronchial epithelial cell, nuclear extract

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

863
Relevance of estrogen activating STS and inactivating SULT1E1 enzymes and estrogen receptors [alpha/beta] in patients with advanced ovarian cancer

Felicitas Mungenast, Stefanie Aust, Martin Svoboda, Katharina Ocko, Lukas Klameth, Dan Cacsire Castilo-Tong, Robert Zeillinger, Toon Van Gorp, Ignace Vergote, Ioana Braicu, Jalid Sehouli, Sven Mahner, M Fogel and Theresia Thalhammer

16th European Congress of Endocrinology (Endocrine Abstracts) Austria, Belgium, Germany, Israel, 07 May 2014

Oncology

864
A new rat model for orthotopic abdominal wall allotransplantation

WW Lao, YL Wang, AE Ramirez…

Plastic Reconstruction Surgery Global open (NCBI) Taiwan, 07 May 2014

Oncology

Organism: Rat

Tissue: Muscle

Pathological State: Allotransplantation

865
1172 (pp34) myocardial Biopsy for the Validation of Cardiac Magnetic Resonance T1 Mapping for Quantification of Extracellular Matrix

A Kammerlander; C Tufaro; S Pfaffenberger; B Marzluf; S Aschauer; J Babayev; D Bonderman; J Mascherbauer

European Heart Journal (Oxford University Press) Austria, 01 May 2014

Cardiology

Organism: Human

Tissue: Heart

866
A new fluorescence/PET probe for intracellular human telomerase reverse transcriptase (hTERT) using Tat peptide-conjugated antibody

Kyung Oh Jung, Hyewon Youn, Mi Jeong Kim, Keon Wook Kang, Dong Soo Lee and June-Key Chung

Journal of Nuclear Medicine () South Korea, 01 May 2014

Biological Methods

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

867
Increase of Zinc Finger Protein 179 in Response to CCAAT/Enhancer Binding Protein Delta Conferring an Antiapoptotic Effect in Astrocytes of Alzheimer’s Disease

Shao-Ming Wang, Yi-Chao Lee, Chiung-Yuan Ko, Ming-Derg Lai, Ding-Yen Lin, Ping-Chieh Pao, Jhih-Ying Chi, Yu-Wei Hsiao, Tsung-Lin Liu, Ju-Ming Wang

Molecular Neurobiology (Springer) Taiwan, 01 May 2014

Neuroscience

Key words:Alzheimer's disease CEBPD ZNF179, astrocytes, antiapoptosis

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s Disease

868
PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors

Rieko Ohki, Kozue Saito, Yu Chen, Tatsuya Kawase, Nobuyoshi Hiraoka, Raira Saigawa, Maiko Minegishi, Yukie Aita, Goichi Yanai, Hiroko Shimizu, Shinichi Yachida, Naoaki Sakata, Ryuichiro Doi, Tomoo Kosugi, Kazuaki Shimada, Benjamin Tycko, Toshihiko Tsukada, Yae Kanai, Shoichiro Sumi, Hideo Namiki, Yoichi Taya, Tatsuhiro Shibata, Hitoshi Nakagama

PNAS (PNAS) Japan, 01 May 2014

Oncology

Key words:p53 PH domain everolimus p53 target gene mTOR

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

869
ISAC XXII International Congress

ISAC XXII International Congress

Cytometry (Wiley) , 21 April 2014

Cytometry

870
Epicutaneously applied Der p 2 induces a strong TH2-biased antibody response in C57BL/6 mice, independent of functional TLR4

C. Stremnitzer, K. Manzano-Szalai, P. Starkl, A. Willensdorfer, S. Schrom, J. Singer, U. Reichart, S. Akira, E. Jensen-Jarolim

Allergy (Wiley) Austria, 16 April 2014

Allergy

Key words:Allergic dermatitis, Der p 2, house dust mite, LPS, TLR4

Organism: Mouse

Tissue: Skin

871
Direct comparison of the dynamics of IL-25- and ‘allergen’-induced airways inflammation, remodelling and hypersensitivity in a murine asthma model

X. J. Yao, K. W. Huang, Y. Li, Q. Zhang, J. J. Wang, W. Wang, J. Liu, Z. Lv, Y. Q. An, Y. Z. Ding, C. J. Corrigan, W. Wang, Y. C. Sun, S. Ying

Clinical and Experimental Allergy (Wiley) China, UK, 16 April 2014

Allergy

Key words:Asthma, IL-25, IL-25 receptor, murine model, pathogenesis, remodelling

Organism: Mouse

Tissue: Lung

Pathological State: Fibrosis

872
Poly(lactide-co-glycolide) microspheres for MRI-monitored transcatheter delivery of sorafenib to liver tumors

Jeane Chen, Alexander Y. Sheu, Weiguo Li, Zhuoli Zhang, c, Dong-Hyun Kim, Robert J. Lewandowski, Reed A. Omary, Lonnie D. Shea, Andrew C. Larson

Journal of Controlled Release (Elsevier) USA, 13 April 2014

Oncology

Key words:Sorafenib, hepatocellular carcinoma, magnetic resonance imaging, poly(lactide-co-glycolide)

Organism: Rat

Tissue: Liver

873
Abstract 1662: Towards automated analysis of prostate inflammatory state: Assessing density and distance of infiltrating T-cells (CD3+) to glandular structures in prostate biopsies by a new software

Radu Rogojanu, Bogdan Boghiu, Georg Schaefer, Theresia Thalhammer, Georg Steiner, Rupert Ecker, Bettina Schlick, Thomas Szekeres, Isabella Ellinger

Cancer Research (AACR Publications) Austria, Romania, 09 April 2014

Medical Image Analysis

Key words:Biopsies, automated analysis

Organism: Human

Tissue: Prostate

Pathological State: Cancer

874
T cell-associated α4β7 but not α4β1 integrin is required for the induction and perpetuation of chronic colitis

E Kurmaeva, JD Lord, S Zhang, JR Bao, CG Kevil, MB Grisham and DV Ostanin

Mucosal Immunology (Nature) USA, 09 April 2014

Immunology

Key words:Antibody therapy, Colitis, Crohn's disease, Mucosal immunology

Organism: Human

Tissue: Colon

875
Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3

Irfete S. Fetahu, Julia Höbaus, Abhishek Aggarwal, Doris M. Hummel, Samawansha Tennakoon, Ildiko Mesteri, Sabina Baumgartner-Parzer, Eniko Kállay

International Journal of Cancer (Wiley) Austria, 02 April 2014

Oncology

Key words:Calcium-sensing receptor, DNA methylation, histone acetylation, histone methylation, colorectal cancer

Organism: Human

Cell Line: Coga1, Caco2 and HT29 cells

876
Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth, cell migration and angiogenesis

I Heidegger, J Kern, P Ofer, H Klocker, P Massoner

Oncotarget (Impact Journals) Austria, 02 April 2014

Oncology

Key words:Prostate cancer, IGF targeting therapies, insulin-like growth factor receptor-1 (IGF1R), insulin receptor (INSR)

Organism: Human

Tissue: Prostate

Pathological State: Cancer

877
Transplantation of cyclic stretched fibroblasts accelerates the wound-healing process in streptozotocin-induced diabetic mice

E Lee, DY Kim, E Chung, EA Lee, KS Park, Y Son

Cell Transplantation (SAGE Journals) South Korea, 01 April 2014

Transplantation Medicine

Key words:Cell survival, Cyclic stretch, Mechanical stimulus, Angiogenesis, Wound healing

Organism: Mouse

Pathological State: Diabetes

Cell Line: Fibroblasts

878
Protective effect of magnesium and metformin on endometrium and ovary in experimental diabetes mellitus

C Gales, C Zamfir, D Radulescu, B Stoica, M Nechifor

Magnesium research (John Libbey) Romania, 01 April 2014

Reproductive Medicine

Key words:magnesium, endometrium, ovary, diabetes mellitus

Organism: Mouse

Pathological State: Diabetes

Cell Line: Fibroblasts

879
Muscle–fat MRI: 1.5 tesla and 3.0 tesla versus histology

Andrew C. Smith, Todd B. Parrish, Rebecca Abbott, Mark A. Hoggarth, Karl Mendoza, Yu Fen Chen, James M. Elliott

Muscle and nerve (Wiley) USA, 28 March 2014

Medical Imaging

Key words:MRI, muscle fat infiltrates, muscle imaging, muscle/fat fraction, muscle, fat

Organism: Rabbit

Tissue: Muscle

880
Oxygen therapy does not increase production and damage induced by reactive oxygen species in focal cerebral ischemia

Li Suna, Guido Wolfertsb, Roland Veltkamp

Neuroscience Letters (Elsevier) Germany, 28 March 2014

Neuroscience

Key words:Cerebral ischemia, oxygen therapy, HBO, reactive oxygen species, SOD2

Organism: Mouse

Tissue: Brain

Pathological State: cerebral ischemia

881
Myofibroblasts in Murine Cutaneous Fibrosis Originate From Adiponectin-Positive Intradermal Progenitors

Roberta Goncalves Marangoni, Benjamin D. Korman, Jun Wei, Tammara A. Wood, Lauren V. Grham, Michael L. Whithfield, Philipp E. Scherrr, Warren G. Tourtellott, John Varga

Arthritis and Rheumatology (Wiley) USA, 27 March 2014

Rheumatology

Key words:Myofibroblasts, systemic sclerosis, growth factor β, canonical adipogenic markers

Organism: Mouse

Tissue: Skin

Pathological State: Fibrosis

882
In vivo real-time fluorescence visualization and brain-targeting mechanisms of lipid nanocarriers with different fatty ester:oil ratios

Chih-Jen Wen, Tzu-Chen Yen, Saleh A Al-Suwayeh, Hui-Wen Chang, Jia-You Fang

Future Medicine (FSG) Taiwan, Saudi Arabia, 27 March 2014

Nanomedicine

Key words:Lipid nanocarriers, cetyl palmitate, squalene, sulforhodamine B

Organism: Rat

Tissue: Brain

883
RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis

Marion Lapierre, Sandrine Bonnet, Caroline Bascoul-Mollevi, Imade Ait-Arsa, Stéphan Jalaguier, Maguy Del Rio, Michela Plateroti, Paul Roepman, Marc Ychou, Julie Pannequin, Frédéric Hollande, Malcolm Parker, and Vincent Cavailles1

The Journal of Clinical Investigation (American Society for Clinical Investigation) France, The Netherlands, UK, 25 March 2014

Oncology

Organism: Human

Tissue: Colon

Pathological State: Cancer

884
Ambivalent role of pFAK-Y397 in serous ovarian cancer-a study of the OVCAD consortium

Stefanie Aust, Katharina Auer, Anna Bachmayr-Heyda, Carsten Denkert, Jalid Sehouli, Ioana Braicu, Sven Mahner, Sandrina Lambrechts, Ignace Vergote, Christoph Grimm, Reinhard Horvat, Dan Cacsire Castillo-Tong, Robert Zeillinger Dietmar Pils

Molecular Cancer (Springer) Austria, Germany, Belgium, 21 March 2014

Oncology

Key words:FAK, pFAK, molecular subclassification, immunohistochemistry, prognosis, ovarian cancer

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

885
Protection against Dengue Virus Infection in Mice by Administration of Antibodies against Modified Nonstructural Protein 1

Shu-Wen Wan, Yi-Tien Lu, Chia-Hui Huang, Chiou-Feng Lin, Robert Anderson, Hsiao-Sheng Liu, Trai-Ming Yeh, Yu-Ting Yen, Betty A. Wu-Hsieh , Yee-Shin Lin

Plos One (PLOS) Taiwan, Canada, 21 March 2014

Virology

Key words:Hemorrhage, endothelial cells, platelets, complement system, dengue fever, hematoxylin staining, inoculation, macrophages

Organism: Mouse

Tissue: Skin

Pathological State: Dengue Virus Infection

886
Lamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation

T Kuga, H Nie, T Kazami, M Satoh, K Matsushita, F Nomura, K Maeshima, Y Nakayama and T Tomonaga

Oncogenesis (Nature) Japan, 17 March 2014

Oncology

Key words:Chromosome segregation, Colorectal cancer, Mitotic spindle

Organism: Human

Tissue: Colon

Pathological State: Cancer

887
Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

Veronica T. Campbell, Puviindran Nadesan, S. Amanda Ali, Chang Ye Yale Wang, Heather Whetstone, Raymond Poon, Qingxia Wei, John Keilty, Jennifer Proctor, Lauren W. Wang, Suneel S. Apte, Karen McGovern, Benjamin A. Alman, Jay S. Wunder

Molecular Cancer Therapeutics (AACR Publications) USA, Canada, 14 March 2014

Oncology

Key words:Hedgehog (Hh) pathway, Chondrosarcoma, transmembrane receptor Patched

Organism: Mouse

Tissue: Xenograft Tumor, Cartilage

Pathological State: Cancer

888
Blockade of Fas Signaling in Breast Cancer Cells Suppresses Tumor Growth and Metastasis via Disruption of Fas Signaling-initiated Cancer-related Inflammation

Qiuyan Liu, Qinchun Tan, Yuanyuan Zheng, Kun Chen, Cheng Qia, Nan Li, Qingqing Wang, Xuetao Cao

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) China, 13 March 2014

Oncology

Key words:Breast Cancer, fas inflammation, prostaglandins, tumor metastases IL-6 MDSC PGE2

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

889
Interleukin-1β Attenuates Myofibroblast Formation and Extracellular Matrix Production in Dermal and Lung Fibroblasts Exposed to Transforming Growth Factor-β1

Masum M. Mia, Ruud A. Bank, Miriam Boersema

Plos One (PLOS) The Netherlands, 12 March 2014

Cell Biology

Key words:Fibroblasts, collagens, gene expression, fibrosis, immunofluorescence staining, tissue repair, cytokines, lungs

Organism: Human

Cell Line: HDFa and HLFa cells

890
5th International meeting on angiogenesis

Angiogenesis (Springer) The Netherlands, 08 March 2014

Regenerative Medicine

891
Impact of the Smoothened Inhibitor, IPI-926, on Smoothened Ciliary Localization and Hedgehog Pathway Activity

Marisa O. Peluso, Veronica T. Campbell, Joseph A. Harari, Thomas T. Tibbitts, Jennifer L. Proctor, Nigel Whitebread, James M. Conley, Kerry F. White, Jeffery L. Kutok, Margaret A. Read, Karen McGovern, Kerrie L. Faia

Plos One (PLOS) USA, 07 March 2014

Oncology

Key words:Hedgehog signaling NIH 3T3 cells, cancer treatment, cell binding assay, cilia, gene expression, luciferase, cell staining

Organism: Human

Cell Line: HEPM and NIH-3T3 cells

892
Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease

Z. Su, X. Wang, Gao,Y.Liu, C.Pan, H. Hu, R. P. Beyer, M. Shi, J. Zhou, J. Zhang, A. L. Serra, R. P. Wüthrich, C. Mei

Journal of Internal Medicine (Wiley) China, Switzerland, USA, 02 March 2014

Nephrology

Key words:Autosomal dominant polycystic kidney disease, complement, complement inhibitor, glycoproteomics, urine

Organism: Rat

Tissue: Kidney

Pathological State: Polycystic Kidney Disease

893
AB0206 Altered Expression of Angiopoietins and Tie-2 in Ischemic Lesions of UCD-206 Chickens, an Animal Model for Systemic Sclerosis

S. Allipour Birgani, H. Dietrich, R. Sgonc

Annals of the Rheumatic Diseases (BMJ Journals) Austria, 01 March 2014

Rheumatology

Key words:Systemic sclerosis, vascular endothelial growth factor , endothelial cells

894
Multimodality imaging to assess immediate response to irreversible electroporation in a rat liver tumor model

Yue Zhang, Sarah B. White, Jodi R. Nicolai, Zhuoli Zhang, Derek L. West, Dong-hyun Kim, A. Lee Goodwin, Frank H. Miller, Reed A. Omary, Andrew C. Larson

Radiology (Radiological Society of North America) USA, 18 February 2014

Oncology

Organism: Rat

Tissue: Liver

Pathological State: Cancer

895
Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma

Winnie W. Lo, Jay S. Wunder, Brendan C. Dickson, Veronica Campbell, Karen McGovern , Benjamin A. Alman, Irene L. Andrulis

Cancer (Wiley) Canada, USA, 15 February 2014

Oncology

Key words:Osteosarcoma, hedgehog signaling, ligand-dependent,IPI-926, microenvironment

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

896
Iron deficiency alters megakaryopoiesis and platelet phenotype independent of thrombopoietin

Rayko Evstatiev, Adam Bukaty, Kristine Jimenez, Stefanie Kulnigg-Dabsch, Lidia Surman, Werner Schmid, Robert Eferl, Kathrin Lippert, Barbara Scheiber-Mojdehkar, Hans Michael Kvasnicka, Vineeta Khare, Christoph Gasch

American Journal of Hematology (Wiley) Austria, Germany, 14 February 2014

Hematology

Key words:Iron deficiency

Organism: Rat

Tissue: Bone Marrow

897
NKG2D+ IFN-γ+ CD8+ T Cells Are Responsible for Palladium Allergy

Mitsuko Kawano, Masafumi Nakayama, Yusuke Aoshima, Kyohei Nakamura, Mizuho Ono, Tadashi Nishiya, Syou Nakamura, Yuri Takeda, Akira Dobashi, Akiko Takahashi, Misato Endo, Akiyo Ito, Kyosuke Ueda, Naoki Sato, Shigehito Higuchi, Takeru Kondo, Suguru Hashimoto, Masamichi Watanabe, Makoto Watanabe, Tetsu Takahashi,Keiichi Sasaki, Masanori Nakamura, Takehiko Sasazuki, Takayuki Narushima, Ryuji Suzuki, Kouetsu Ogasawara

Plos One (PLOS) Japan, 12 February 2014

Allergy

Key words:T cells, cytotoxic T cells, allergies, mouse models, adoptive transfer, lymphocytes, allergy immunotherapy, lymph nodes

Organism: Mouse

Tissue: Lymphoid Tissue

Pathological State: Allergy

898
Successful treatment of adult onset Langerhans cell histiocytosis with bi-weekly administration of pegylated interferon-α

Sadanori Furudate, Taku Fujimura, Yumi Kambayashi, Mitsuko Kawano, Kouetsu Ogasawara, Akira Tsukada, Erika Tamabuchi, Takahiro Haga, Akira Hashimoto and Setsuya Aiba

Acta Dermato Venereologica (Ingentaconnect) Japan, 04 February 2014

Dermatology

Organism: Human

Tissue: Skin

Pathological State: Histiocytosis

899
Serum Level of IL-10 Is Increased in Patients with Endometriosis, and IL-10 Promotes the Growth of Lesions in a Murine Model

Jau-Ling Suen, Yu Chang, Pu-Rong Chiu, Tsung-Hua Hsieh, Edward Hsi, Yu-Chieh Chen, Yu-Fang Chen, Eing-Mei Tsai

The American Journal of Pathology (American Society for Investigative Pathology) Taiwan, 01 February 2014

Pathology

Key words:Immune dysregulation, anti-inflammatory cytokine IL-10, Monocyte-derived dendritic cells

Organism: Mouse

Tissue: Uterus

Pathological State: Endometriosis

900
Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells

Ummuhan Demir, Andrea Koehler, Rainer Schneider, Susann Schweiger, Helmut Klocker

BMC Cancer (Springer) Austria, Germany, 31 January 2014

Oncology

Key words:Metformin, Androgen receptor, MID1-α4/PP2A protein complex, AMPK ,Translational regulation, CoIP

Organism: Human

Cell Line: LNCaP, Du-145, VCaP and PC-3 cells

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