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Customer Publications (A total of 1287 papers published)

501
Knockout of ho-1 protects the striatum from ferrous iron-induced injury in a male-specific manner in mice

Li-Fang Wang, Kazunari K. Yokoyama, Chih-Lung Lin, Tzu-Yin Chen, Hsiu-Wen Hsiao, Pei-Chi Chiang, Chin Hsu

Scientific Reports (Nature) Taiwan, 20 May 2016

Neuroscience

Key words:Neuronal physiology, reproductive biology

Organism: Mouse

Tissue: Ovaries, Penis, Testis

502
Anti-TGF-β Antibody, 1D11, Ameliorates Glomerular Fibrosis in Mouse Models after the Onset of Proteinuria

Xiaoyan Liang, H. William Schnaper, Taiji Matsusaka, Ira Pastan, Steve Ledbetter,Tomoko Hayashida

PLOS ONE (PLOS) USA, 17 May 2016

Nephrology

Key words:Renal fibrosis

Organism: Mouse

Tissue: Kidney

Pathological State: Nephropathy

503
HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

Niek G.J. Leusa, Petra E. van der Woudena, Thea van den Boscha, Wouter T.R. Hooghiemstraa, Maria E. Ourailidoua, Loes E.M. Kistemakerc, Rainer Bischoffb, Reinoud Gosensc, Hidde J. Haismaa, Frank J. Dekker

Biochemical Pharmacology (Elsevier) The Netherlands, 15 May 2016

Pharmacology

Key words:Lysine acetylation, HDACs, inflammation, NF-κB p65, HDAC inhibitors, lung disease

Organism: Mouse

Tissue: Lung

504
MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains

Marjolein Bijlard, Jenny C. de Jonge, Bert Klunder, Anita Nomden, Dick Hoekstra, Wia Baron

PLOS ONE (PLOS) The Netherlands, 12 May 2016

Neuroscience

Key words:Oligodendrocytes, myelin membrane, rat brain tissue

Organism: Rat

Cell Line: Primary oligodendrocyte, OLN-93, HEPG2 cells

505
In situ hybridization to detect and localize signature cytokines of T-helper (Th) 1 and Th2 immune responses in chicken tissues

Fana Alem Kidane, Ivana Bilic, Taniya Mitra, Patricia Wernsdorf, Michael Hess, Dieter Liebhart

Veterinary Immunology and Immunopathology (Elsevier) Austria, 12 May 2016

Immunology

Key words:In situ hybridization, RNA probes, ChIFN-γ, ChIL-4, ChIL-13

Organism: Chicken

Tissue: Spleen, Liver

Pathological State: Parasitic Infection

506
The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth

Harini Nivarthi, Claire Gordziel, Madeleine Themanns, Nina Kramer, Markus Eberl, Björn Rabe, Michaela Schlederer, Stefan Rose-John, Thomas Knösel, Lukas Kenner, Patricia Freund, Fritz Aberger, Xiaonan Han, Robert Kralovics, Helmut Dolznig, Susanne Jennek, Karlheinz Friedrich, and Richard Moriggl

Oncotarget (Impact Journals) Austria, germany, USA, 12 May 2016

Oncology

Key words:STAT1, STAT3, colorectal cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

507
Exploration of more effective neurorrhaphy in facial nerve reconstruction: A comparison focusing on the difference of neural window size and condition of the …

Kentaro Ono, Yuhei Yamamoto, Ryuji Shichinohe, Naoki Murao, Akihiko Oyama, Emi Funayama, Hiroshi Furukawa

Journal of Plastic, Reconstructive and Aesthetic Surgery (Elsevier) Japan, 12 May 2016

Neuroscience

Key words:Nerve reconstruction, Facial palsy, Side to side, End to side, Rat

Organism: Rat

Tissue: Brain

508
Acidic pH-triggered drug-eluting nanocomposites for magnetic resonance imaging-monitored intra-arterial drug delivery to hepatocellular carcinoma

W Park, J Chen, S Cho, S Park, AC Larson, K Na, DH Kim

Applied Materials and Interfaces (ACS Publications) USA, South Korea, 09 May 2016

Nanomedicine, Oncology

Key words:hepatocellular carcinoma; image-guided therapy; iron oxide nanoparticles; nanocomposite microspheres; pH-responsive materials; sorafenib

Organism: Rat

Tissue: Liver

Pathological State: Cancer

509
Interleukin-25 is detrimental for recovery after spinal cord injury in mice

Dearbhaile Dooley, Evi Lemmens, Peter Ponsaerts, Sven Hendrix

Journal of Neuroinflammation (Springer) Belgium, 06 May 2016

Neuroscience

Key words:IL-25, type 2 immune response, spinal cord injury, basso mouse scale, locomotor recovery Th1 Th2

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

510
CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition

Neeraj Kapur, Hina Mir, Clarence E Clark III, Uma Krishnamurti, Derrick J Beech, James W Lillard and Shailesh Singh

British Journal of Cancer (Nature) USA, 05 May 2016

Oncology

Key words:Colon cancer, Epithelial–mesenchymal transition, Metastasis, Tumour biomarkers

Organism: Human

Tissue: Colon

Pathological State: Cancer

511
PPARγ inhibits VSMC proliferation and migration via attenuating oxidative stress through upregulating UCP2

Y Zhou, MJ Zhang, BH Li, L Chen, Y Pi, YW Yin, CY Long, X Wang, MJ Sun, X Chen, CY Gao, JC Li, LL Zhang

Plos ONE (PLOS) China, 04 May 2016

Cell Biology

Key words:Oxidative stress, Reactive oxygen species ,Carotid arteries ,Mitochondria ,Antioxidants ,MTT assay ,Fluorescence microscopy ,Growth factors

Organism: Mouse

Tissue: Blood Vessels

512
Loss of HIF-1β in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model

Nina Henke, Nerea Ferreirós, Gerd Geisslinger, Martina G. Ding, Silke Essler, Dominik C. Fuhrmann, Theresa Geis, Dmitry Namgaladze, Nathalie Dehne, and Bernhard Brüne

Oncotarget (Impact Journals) Germany, 03 May 2016

Oncology

Key words:xenobiotics, CYP1A1, DNA damage, breast cancer, fibrosarcoma

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

513
449 In situ mapping of innate lymphoid cells in normal and inflamed human skin

M. Brüggen, W. Bauer, B. Reininger, E. Clim, C. Captarencu, B. Meier, P.M. Brunner, L. French, G. Stingl

Journal of Investigative Dermatology (Elsevier) Austria, 01 May 2016

Immunology

Key words:Innate lymphoid cells, atopic dermatitis, psoriasis, normal human skin, immunofluorescence

Organism: Human

Tissue: Skin

Pathological State: Dermatitis, Psoriasis

514
Paracrine Factors from Irradiated Peripheral Blood Mononuclear Cells Improve Skin Regeneration and Angiogenesis in a Porcine Burn Model

Stefan Hacker, Rainer Mittermayr, Stefanie Nickl, Thomas Haider, Diana Lebherz-Eichinger, Lucian Beer, Andreas Mitterbauer, Harald Leiss, Matthias Zimmermann, Thomas Schweiger, Claudia Keibl, Helmut Hofbauer, Christian Gabriel, Mariann Pavone-Gyöngyösi, Heinz Redl, Erwin Tschachler, Michael Mildner, Hendrik Jan Ankersmit

Scientific Reports (Nature) Austria, 29 April 2016

Regenerative Medicine

Key words:Drug development, regeneration, translational research, trauma

Organism: Pig

Tissue: Skin

Pathological State: Burn Wound

515
SIRT2-mediated deacetylation and tetramerization of pyruvate kinase directs glycolysis and tumor growth

David Gius

Cancer Research (AACR Publications) USA, 27 April 2016

Oncology

Key words:Mitochondria, pyruvate kinase, acetylation, mammary tumor cells

Organism: Human

Tissue: Breast

Pathological State: Cancer

516
Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling

Yu-Chih Wang, Cheng-Fang Tsai, Hsiao-Li Chuang, Yi-Chih Chang, Hung-Sheng Chen, Jau-Nan Lee, and Eing-Mei Tsai

Oncotarget (Impact Journals) Taiwan, 26 April 2016

Oncology

Key words:Aryl hydrocarbon receptor, sphingosine kinase 1, sphingosine 1-phosphate, sphingosine-1-phosphate receptor 3, breast cancer stem cells

Organism: Human

Pathological State: Cancer

Cell Line: MCF-7 cells (Breast Cancer Cell line)

517
Tumor-associated B cells in cutaneous primary melanoma and improved clinical outcome

Kanika Garg, Margarita Maurer, Johannes Griss, Marie-Charlotte Brüggen, Ingrid H. Wolf, Christine Wagnera, Niels Willi, Kirsten D. Mertz, Stephan N. Wagner

Human Pathology (Elsevier) Austria, 20 April 2016

Pathology

Key words:CD20, prognosis, melanoma, tumor microenvironment, tumor-associated B cells (TAB), tumor-infiltrating lymphocytes

Organism: Human

Tissue: Skin

Pathological State: Cancer

518
Effectiveness of a Layer-by-Layer Microbubbles-Based Delivery System for Applying Minoxidil to Enhance Hair Growth

Ai-Ho Liao,Ying-Jui Lu, Yi-Chun Lin, Hang-Kang Chen, Huey-Kang Sytwu, Chih-Hung Wang

Theranostics (Ivyspring International Publisher) Taiwan, 11 April 2016

Oncology

Key words:Microbubbles, ultrasound, transdermal drug delivery, minoxidil, chitosan oligosaccharide lactate, hair growth

Organism: Pig, Mouse

Tissue: Skin

519
Dose-escalation study for the targeting of CD44v+cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)

Kohei Shitara, Toshihiko Doi, Osamu Nagano, Chiyo K. Imamura, Takeshi Ozeki, Yuya Ishii, Kenji Tsuchihashi, Shunji Takahashi, Takako E. Nakajima, Shuichi Hironaka, Miki Fukutani, Hiromi Hasegawa, Shogo Nomura, Akihiro Sato, Yasuaki Einaga, Takeshi Kuwata, Hideyuki Saya, Atsushi Ohtsu

Gastric Cancer (Springer) Japan, 07 April 2016

Oncology

Key words:Cancer stem cellCD44 variant positiveGastric cancerSulfasalazinexCT

Organism: Human

Tissue: Stomach

Pathological State: Cancer

520
Biocompatibility Assessment of a New Biodegradable Vascular Graft via In Vitro Co-culture Approaches and In Vivo Model

Marjan Enayati, Magdalena Eilenberg, Christian Grasl, Peter Riedl, Christoph Kaun, Barbara Messner, Ingrid Walter, Robert Liska, Heinrich Schima, Johann Wojta, Bruno K. Podesser, Helga Bergmeister

Annals of Biomedical Engineering (Springer) Austria, 07 April 2016

Tissue Engineering

Key words:Vascular graft, biocompatibility, biodegradable polyurethane, fibroblast-macrophage co-culture

Organism: Rat

Tissue: Blood Vessels

Pathological State: Organ Transplantation

521
Cross-talk between DopaChromeTautomerase and Caveolin-1 is melanoma cell phenotype specific and potentially involved in tumor progression.

Popa IL, Milac AL, Sima LE, Alexandru PR, Pastrama F, Munteanu CV, Negroiu Gabriela

Journal of biological chemistry (American Society for Biochemistry and Molecular Biology) Romania, 06 April 2016

Oncology

Key words:Antigen processing, caveolin, epithelial-mesenchymal transition (EMT), melanoma, structural model

Organism: Human

Tissue: Skin

Pathological State: Cancer

522
Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells

Bernd Schöpf, Georg Schäfer, Anja Weber , Heribert Talasz ,Iris E. Eder , Helmut Klocker , Erich Gnaiger

FEBS Journal (FEBS PRESS) Austria, 06 April 2016

Cell Biology

Key words:electron transfer system, high‐resolution respirometry, mitochondria, oxidative phosphorylation, prostate metabolism

Organism: Human

Tissue: Prostate

523
Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

Jonas Kloeppera,Lars Riedemanna, Zohreh Amoozgara,1, Giorgio Seanoa, Katharina Suseka, Veronica Yua, Nisha Dalviea, Robin L. Amelunga, Meenal Dattaa,Jonathan W. Songa,Vasileios Askoxylakisa, Jennie W. Taylora,Christine Lu-Emersona,Ana Batistaa,Nathaniel D. Kirkpatricka,Keehoon Junga, Matija Snuderla, Alona Muzikanskye, Kay G. Stubenrauchf, Oliver Krieterf, Hiroaki Wakimotog, Lei Xu1, Lance L. Munna, Dan G. Dudaa, Dai Fukumuraa, Tracy T. Batchelorc, Rakesh K. Jaina,

PNAS (PNAS) USA, 04 April 2016

Oncology

Key words:Anti-angiogenic therapy, tumor microenvironment, anti-tumor immunity, macrophage polarization, microglia reprogramming

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

524
CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma

Hagma H. Workel, Fenne L. Komdeur, Maartje C.A. Wouters, Annechien Plat, Harry G. Klip, Florine A. Eggink, G. Bea A. Wisman, Henriette J.G. Arts, Maaike H.M. Oonk, Marian J.E. Mourits, Refika Yigit, Marco Versluis, Evelien W. Duiker, Harry Hollema, Marco de Bruyn, Hans W. Nijman

European Journal of Cancer (Elsevier) The Netherlands, 31 March 2016

Oncology

Key words:Tumour-infiltrating lymphocytes, endometrial cancer, adenocarcinoma, CD103, survival

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

525
Combining ultrasound and lactobacilli treatment for high-fat-diet-induced obesity in mice

A.-H. Liao, C.-B. Jiang, C.-C. Li, H.-C. Chuang, J.-S. Chiang Chiau, W.-T. Chan, C.-Y. Yeung, M.-L. Cheng, H.-C. Lee

Journal of Animal Physiology and Animal Nutrition (Wiley) Taiwan, 29 March 2016

Physiology

Key words:Actobacilli, ultrasound, high-fat-diet-induced obesity mice, micro-CT, fat deposition

Organism: Mouse

Tissue: Liver, Adipose Tissue

Pathological State: Obesity

526
Myeloid PTEN deficiency impairs tumor-immune surveillance via immune-checkpoint inhibition

M Kuttke, E Sahin, J Pisoni, S Percig, A Vogel, D Kraemmer, L Hanzl, J. S Brunner, H Paar, K Soukup, A Halfmann, A. M. Dohnal, C. W. Steiner, S. Blüml, J. Basilio, B. Hochreiter, M. Salzmann, B. Hoesel, G. Lametschwandtner, R. Eferl, J. A. Schmidd and G. Schabbauer

OncoImmunology (Taylor and Francis) Austria, 28 March 2016

Immunology

Key words:Colitis-associated colon cancer, myeloid Pi3K, tumor immune-surveillance

Organism: Mouse

Tissue: Xenograft Tumor, Colon

Pathological State: Cancer

527
Chemotherapy of Colorectal Liver Metastases Induces a Rapid Rise in Intermediate Blood Monocytes which Predicts Treatment Response

Dominic Schauer, Patrick Starlinger, Lejla Alidzanovic, Philipp Zajc, Thomas Maier, Alexandra Feldman, Robin Padickakudy, Elisabeth Buchberger, Vanessa Elleder, Andreas Spittlera, Judith Stift, Lorand Pop, Birgit Gruenberger, Thomas Gruenbergera, Christine Brostjan

OncoImmunology (Taylor and Francis) Austria, 22 March 2016

Immunology

Key words:Chemotherapy, colorectal liver metastase, blood monocytes

Organism: Human

Tissue: Liver

Pathological State: Cancer

528
A specific area of olfactory cortex involved in stress hormone responses to predator odours

Kunio Kondoh, Zhonghua Lu, Xiaolan Ye, David P. Olson, Bradford B. Lowell and Linda B. Buck

Nature (Nature) USA, 21 March 2016

Neuroscience

Key words:Neural circuits, Olfactory cortex, Sensory processing

Organism: Mouse

Tissue: Brain

529
MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

Somayyeh Hamzei Taj, Widuri Kho, Adrien Riou, Dirk Wiedermann, Mathias Hoehn

Biomaterials (Elsevier) The Netherlands, 19 March 2016

Neuroscience

Key words:MicroRNA-124, ischemic stroke, immune cell modulation/polarization, neuroprotection, functional improvement, arginase-1

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

530
Neuronal deficiency of HIF prolyl 4-hydroxylase 2 in mice improves ischemic stroke recovery in an HIF dependent manner

Lexiao Li, Pamela Saliba, Stefan Reischl, Hugo H. Marti, Reiner Kunze

Neurobiology of Disease (Elsevier) Germany, 19 March 2016

Neuroscience

Key words:PHD2, HIF, neuron, focal cerebral ischemia, hypoxia, VEGF, angiogenesis

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

531
Unfractionated bone marrow cells attenuate paraquat-induced glomerular injury and acute renal failure by modulating the inflammatory response

SY Gu, TY Yeh, SY Lin, FC Peng

Scientific Reports (Nature) Taiwan, 18 March 2016

Nephrology

Key words:Acute kidney injury, Bone marrow transplantation

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Injury

532
High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease

S Kapoor, D Rodriguez, K Mitchell, RP Wüthrich

Kidney and Blood Pressure Research (Karger) Switzerland, 17 March 2016

Nephrology

Key words:High resolution diagnostic imaging, Total cyst volume, Polycystic kidney disease, PCK rat, Total kidney volume

Organism: Rat

Tissue: Kidney

Pathological State: Polycystic Kidney Disease

533
Efficient generation of smooth muscle cells from adipose-derived stromal cells by 3D mechanical stimulation can substitute the use of growth factors in vascular tissue engineering

Mojtaba Parvizi, Lydia A.M. Bolhuis-Versteeg, Andrá A. Poot, Martin C. Harmsen

Biotechnology Journal (Wiley) The Netherlands, 15 March 2016

Tissue Engineering

Key words:Adipose tissue-derived stromal cells (ASC), poly(1,3-trimethylene carbonate) (PTMC), smooth muscle cells (SMC), transforming Growth Factor beta 1 (TGF-ß1), vascular tissue engineering

Organism: Human

Cell Line: HUVECs, ASC (Human umbilical vein endothelial cells, Adipose tissue derived stromal cells)

534
Internalization of nanopolymeric tracers does not alter characteristics of placental cells

Paolo Bigini, Elisa R. Zanier, Silvia Saragozza, Simona Maciotta, Pietro Romele, Patrizia Bonassi Signoroni, Antonietta Silini, Francesca Pischiutta, Eliana Sammali, Claudia Balducci, Martina B. Violatto, Laura Talamini, David Garry, Davide Moscatelli, Raffaele Ferrari, Mario Salmona, Maria Grazia De Simoni, Federico Maggi, Giuseppe Simoni, Francesca Romana Grati, Ornella Parolini

Journal of Cellular and Molecular Medicine (Wiley) Italy, 14 March 2016

Cell Biology

Key words:Cell tracing, nanoparticles, mesenchymal stem/stromal cells, placenta, amnion, chorion, hypoxia, ischaemia

Organism: Human

Tissue: Placenta

535
OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia

Taizou Hirano, Toshiaki Kikuchi, Naoki Tode, Arif Santoso, Mitsuhiro Yamada, Yoshiya Mitsuhashi, Riyo Komatsu, Takeshi Kawabe, Takeshi Tanimoto, Naoto Ishii, Yuetsu Tanaka, Hidekazu Nishimura, Toshihiro Nukiwa, Akira Watanabe, Masakazu Ichinose

EMBO Molecular Medicine (Wiley) Japan, 14 March 2016

Pathology

Key words:Bronchioles, glycosylation regeneration, OX40 ligand, viral pneumonia

Organism: Dog

Pathological State: Virus Infection

Cell Line: MDCK cells

536
In primary Sjögren's syndrome high absolute numbers and proportions of B cells in parotid glands predict responsiveness to rituximab as defined by ESSDAI, but not by SSRI

Konstantina Delli, Erlin A Haacke, Frans GM Kroese, Rodney P Pollard, Stephan Ihrler, Bert van der Vegt, Arjan Vissink, Hendrika Bootsma, Frederik KL Spijkervet

Annals of the Rheumatic Diseases (BMJ Journals) The Netherlands, 09 March 2016

Rheumatology

Key words:Sjogren's syndrome, b cells, parotide glands, rituximab

Organism: Human

Tissue: Salivary Gland

Pathological State: Sjögren's Syndrome

537
Acquisition of chemoresistance and other malignancy-related features of colorectal cancer cells are incremented by ribosome-inactivating stress

CK Oh, SJ Lee, SH Park, Y Moon

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) South Korea, 09 March 2016

Oncology

Key words:Ribosome-inactivating stress (RIS); Colorectal cancer; Activating transcription factor 3 (ATF3); Macrophage inhibitory cytokine-1 (MIC-1); Chemosensitivity

Organism: Mouse

Tissue: Allograft Tumor, Colon

Pathological State: Cancer

538
Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach

Anastasia Meshcheryakova, Martin Svoboda, Ammar Tahir, Harald C. Köfeler, Alexander Triebl, Felicitas Mungenast, Georg Heinze, Christopher Gerner, Philip Zimmermann, Markus Jaritz, and Diana Mechtcheriakova

Oncotarget (Impact Journals) Austria, Switzerland, 07 March 2016

Oncology

Key words:sphingolipid-related targets, sphingosine 1-phosphate/ceramide rheostat, multigene signature, epithelial to mesenchymal transition, lung cancer

Organism: Human

Pathological State: Cancer

Cell Line: Lung adenocarcinoma epithelial cell line A549

539
Intrathecal transplantation of embryonic stem cell-derived spinal GABAergic neural precursor cells attenuates neuropathic pain in a spinal cord injury rat model

Insik Hwang, Suk-Chan Hahm Suk-Chan Hahm, Kyung-Ah Choi, Sung-Ho Park, Hyesun Jeong, Ji-Hye Yea, Junesun Kim, Ph.D., Sunghoi Hong, Ph.D.

Cell Transplantation (SAGE Journals) South Korea, 01 March 2016

Regenerative Medicine

Key words:Spinal cord injury (SCI), Neuropathic pain, Spinal GABAergic neurons, Intrathecal transplantation

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

540
Platelet-rich plasma influences expansion and paracrine function of adipose-derived stromal cells in a dose-dependent fashion

Willemsen, Joep C. N.; Spiekman, Maroesjka; Stevens, H. P. Jeroen; van der Lei, Berend; Harmsen, Martin C.

Plastic and Reconstructive Surgery (Ingentaconnect) The Netherlands, 01 March 2016

Regenerative Medicine

Organism: Human

Tissue: Adipose Tissue

541
Double Linear Gradient Biointerfaces for Determining Two-Parameter Dependent Stem Cell Behavior

Patrick Van Rijn, Philipp Kuhn, Qihui Zhou, Torben Van Der Boon, Aneta Schaap-Oziemlak, Theo Van Kooten

ChemNanoMat (Wiley) The Netherlands, 26 February 2016

Biological Methods

Key words:Biointerfaces, gradients, stem cell, wettability, stiffness

Organism: Human

Cell Line: Mesenchymal stem cells from human bone marrow (hBM-MSCs)

542
Fenretinide: a potential treatment for endometriosis

Mary Ellen Pavone, Saurabh S. Malpani, Matthew Dyson, J. Julie Kim, Serdar E. Bulun

Reproductive Sciences (SAGE Journals) USA, 25 February 2016

Reproductive Medicine

Key words:endometriosis, fenretinide, apoptosis, retinol, retinoid, STRA6, retinoic acid

Organism: Mouse

Tissue: Endometrium

Pathological State: Endometriosis

543
Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice

Eva Bauer, Michaela Schlederer, Ruth Scheicher, Jaqueline Horvath, Petra Aigner, Ana-Iris Schiefer, Renate Kain, Heinz Regele, Gregor Hoermann, Günter Steiner, Lukas Kenner, Veronika Sexl, Andreas Villunger, Richard Moriggl, and Dagmar Stoiber

Oncotarget (Impact Journals) Austria, 23 February 2016

Oncology

Key words:ETV6/RUNX1, BCL2, glomerulonephritis, lymphoma, autoimmunity, Immunology and Microbiology Section, Immune response, Immunity

Organism: Mouse

Tissue: Kidney

544
In situ analysis of intrahepatic virological events in chronic hepatitis B virus infection

Xiaonan Zhang, Wei Lu, Ye Zheng, Weixia Wang, Lu Bai, Liang Chen, Yanling Feng, Zhanqing Zhang, and Zhenghong Yuan

The Journal of Clinical Investigation (American Society for Clinical Investigation) China, 22 February 2016

Virology

Key words:intrahepatic virological events, chronic hepatitis B virus infection

Organism: Human

Tissue: Liver

Pathological State: Virus Infection

545
In EXOG-depleted cardiomyocytes cell death is marked by a decreased mitochondrial reserve capacity of the electron transport chain

Wardit Tigchelaar, Anne Margreet De Jong, Wiek H. van Gilst, Rudolf A. De Boer, Herman H.W. Silljé

Inside the Cell (Wiley) The Netherlands, 18 February 2016

Cell Biology

Key words:Cardiomyocyte, cell death, EXOG, hypertrophy, mitochondria

Organism: Rat

Cell Line: NRVC cells ( neonatal rat ventricular cardiomyocytes )

546
Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies

M Sips, M Krykbaeva, T J Diefenbach, M Ghebremichael, B A Bowman, A-S Dugast, A W Boesch, H Streeck, D S Kwon, M E Ackerman, T J Suscovich, P Brouckaert, T W Schacker and G Alter

Mucosal Immunology (Nature) USA, Belgium, Germany, 17 February 2016

Key words:Cell signalling, HIV infections, Phagocytosis, Vaccines

547
Aging has small effects on initial ischemic acute kidney injury development despite changing intrarenal immunologic micromilieu in mice

Hye Ryoun Jang, Ji Hyeon Park, Ghee Young Kwon, Jae Berm Park, Jung Eun Lee, Dae Joong Kim, Yoon-Goo Kim, Sung Joo Kim, Ha Young Oh, Wooseong Huh

American Journal of Physiology (APS Journals) South Korea, 15 February 2016

Physiology

Key words:Aging, ischemic, kidney injury, immunologic, micromilieu

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Injury

548
The in vitro response of tissue stem cells to irradiation with different LETs

Peter W. Nagle, Nynke A. Hosper, Emily M. Ploeg, Marc-Jan van Goethem, Sytze Brandenburg, Johannes A. Langendijk, Roland K. Chiu, Robert P. Coppes

International Journal of Radiation Oncology (Elsevier) The Netherlands, 12 February 2016

Oncology

Key words:In vitro, tissue stem cells, irradiantion, LETs

Organism: Human

Cell Line: HSG cells (human salivary gland cells)

549
Far-infrared promotes burn wound healing by suppressing NLRP3 inflammasome caused by enhanced autophagy

Hui-Wen Chiu, Cheng-Hsien Chen, Jen-Ning Chang, Chien-Hsiung Chen, Yung-Ho Hsu

Journal of Molecular Medicine (Springer) Taiwan, 11 February 2016

Regenerative Medicine

Key words:Far-infrared, burn wound healing, autophagy NLRP3 inflammasome

Organism: Rat

Tissue: Skin

Pathological State: Burn Wound

550
Serum Autoantibodies in Chronic Prostate Inflammation in Prostate Cancer Patients

Bettina Schlick, Petra Massoner, Angelika Lueking, Pornpimol Charoentong, Mirjam Blattner, Georg Schaefer, Klaus Marquart, Carmen Theek, Peter Amersdorfer, Dirk Zielinski, Matthias Kirchner, Zlatko Trajanoski, Mark A. Rubin, Stefan Müllner, Peter Schulz-Knappe, Helmut Klocker

PLOS ONE (PLOS) Austria, 10 February 2016

Oncology

Key words:Prostate cancer, autoantibodies, inflammation, prostate gland, inflammatory diseases, microarrays, prostate diseases, radical prostatectomy

Organism: Human

Tissue: Prostate

Pathological State: Cancer

551
Acquisition of tumorigenic potential and enhancement of angiogenesis in pulmonary stem/progenitor cells through Oct-4 hyperexpression

SY Gu, CC Ho, YK Huang, HW Chen, YC Wang, CY Kuo, SC Teng, WM Fu, PC Yang, CW Wu, FC Peng, TY Ling

Oncotarget (Impact Journals) Taiwan, 09 February 2016

Oncology

Key words:pulmonary stem/progenitor cells, cancer initiating cells, Oct-4, angiogenesis, angiopoietins/Tie2

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

552
MINI ORAL SESSIONS (MINI38.12 Multiplex Immunofluorescence Identifies Differences in Immune Microenvironment and Prognostic Biomarkers between Mesothelioma Subtypes)

Tanguy Seiwert, Stephanie Mcgregor, Chengyi Shu, Igor Feldman, Tong Zi, Zhixiang Zuo, Arun Khattri, Aliya Husain, Hadi Duraid, Wickii T. Vigneswaran,Thomas N. Krausz, Sriram Sathyanarayanan, Hedy Lee Kindle

Journal of Thoracic Oncology (Elsevier) USA, 05 February 2016

Oncology

Key words:Multiplex immunofluorescence, immmune microenvironment, biomarkers, mesothelioma

Organism: Human

Tissue: Mesothelium

Pathological State: Cancer

553
Oxytocin promotes functional coupling between paraventricular nucleus and both sympathetic and parasympathetic cardioregulatory nuclei

Jason R. Yee, William M. Kenkel, Jessie L. Frijling, Sonam Dodhia, Kenneth G. Onishi, Santiago Tovar, Maha J. Saber, Gregory F. Lewis, Wensheng Liu, Stephen W. Porges C. Sue Carter

Hormones and Behavior (Elsevier) USA, 04 February 2016

Endocrinology

Key words:Oxytocin, functional coupling, paraventricular nucleus, cardioregulatory nuclei

Organism: Mouse

Tissue: Brain

554
Characterizing Villitis of Unknown Etiology and Inflammation in Stillbirth

Hayley Derricott, Rebecca L. Jones, Susan L. Greenwood, Gauri Batra, Margaret J. Evans, Alexander E.P. Heazell

The American Journal of Pathology (Elsevier) UK, 03 February 2016

Reproductive Medicine

Key words:Villitis, inflammation, stillbirth

Organism: Human

Tissue: Placenta

Pathological State: Villitis 

555
Prevention of SHIV transmission by topical IFN-β treatment

RS Veazey, HA Pilch-Cooper, TJ Hope, G Alter, AM Carias, M Sips, X Wang, B Rodriguez, SF Sieg, A Reich, P Wilkinson, MJ Cameron and MM Lederman

Mucosal Immunology (Nature) USA, 03 February 2016

Virology

Key words:Drug therapy, HIV infections, Mucosal immunology, Viral transmission

Organism: Monkey

Tissue: Uterus

Pathological State: Virus Infection

556
Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer

Maartje C.A. Wouters, Fenne L. Komdeur1, Hagma H. Workel, Harry G. Klip, Annechien Plat, Neeltje M. Kooi, G. Bea A. Wisman, Marian J.E. Mourits, Henriette J.G. Arts, Maaike H.M. Oonk, Refika Yigit, Steven de Jong, Cornelis J.M. Melief, Harry Hollema, Evelien W. Duiker, Toos Daemen, Marco de Bruyn, Hans W. Nijman

Clinical Cancer Research (High Wire) The Netherlands, 01 February 2016

Oncology

Key words:T-cell diferentiation, tumor-infiltrating lymphocytes, serous ovarian cancer

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

557
FGF2 inhibits endothelial–mesenchymal transition through microRNA-20a-mediated repression of canonical TGF-ß signaling

Ana C. P. Correia, Jan-Renier A. J. Moonen, Marja G. L. Brinker, Guido Krenning

Journal of Cell Science (The Company of Biologists) The Netherlands, 01 February 2016

Cell Biology

Key words:Endothelial–mesenchymal transition, microRNA-20a-mediated repression, canonical TGF-β signaling

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

558
Infiltration of lymphocyte subpopulations into cancer microtissues as a tool for the exploration of immunomodulatory agents and biomarkers

Stefan Koeck , Marit Zwierzina, Julia M. Huber, Mario Bitsche, Edith Lorenz, Gabriele Gamerith, Jozsef Dudas, Jens M. Kelm, Heinz Zwierzina, Arno Amann

Immunobiology (Elsevier) Austria, Switzerland, 01 February 2016

Immunology

Key words:3D, biomarker, co-culture, cancer, immune cells, infiltration, subpopulation

Organism: Human

Pathological State: Cancer

Cell Line: A549, Colo699, Calu-6 cells (human non-small-cell lung cancer cell lines)

559
Injectable extracellular matrix hydrogels as scaffolds for spinal cord injury repair

Dmitry Tukmachev, Serhiy Forostyak, Zuzana Koci, Kristyna Zaviskova, Irena Vackova, Karel Vyborny, Ioanna Sandvig, Axel Sandvig, Christopher J. Medberry, Stephen F. Badylak, Eva Sykova, and Sarka Kubinova

Tissue Engineering Part A (Mary Ann Liebert Inc.) Czech Republic, Norway, UK, Sweden, USA, 28 January 2016

Tissue Engineering

Key words:spinal cord injury; hydrogel; extracellular matrix; scaffold; tissue engineering; stem cells

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

560
Amelioration of Experimental Autoimmune Arthritis Through Targeting of Synovial Fibroblasts by Intraarticular Delivery of MicroRNAs 140-3p and 140-5p

Jia-Shiou Peng, Shih-Yao Chen, Chao-Liang Wu, Hao-Earn Chong, Yun-Chiao Ding, Ai-Li Shiau, Chrong-Reen Wang

Arthritis and Rheumatology (Wiley) Taiwan, 25 January 2016

Rheumatology

Key words:Autoimmune arthritis, synovial fibroblasts, MicroRNAs

Organism: Mouse

Tissue: Joint

Pathological State: Rheumatoid Arthritis

561
Fumaric acid esters promote neuronal survival upon ischemic stress through activation of the Nrf2 but not HIF-1 signaling pathway

Jiemeng Lin-Holderer, Lexiao Li, Daniel Gruneberg, Hugo H. Marti, Reiner Kunze

Neuropharmacology (Elsevier) Germany, 19 January 2016

Neuroscience

Key words:Dimethyl fumarate, monomethyl fumarate, fumaric acid esters, Nrf2, HIF, ischemia

Organism: Mouse

Tissue: Brain

562
Novel technologies and emerging biomarkers for personalized cancer immunotherapy

Jianda Yuan, Priti S. Hegde, Raphael Clynes, Periklis G. Foukas, Alexandre Harari, Thomas O. Kleen, Pia Kvistborg, Cristina Maccalli, Holden T. Maecker, David B. Page, Harlan Robins, Wenru Song, Edward C. Stack, Ena Wang, Theresa L. Whiteside, Yingdong Zhao, Heinz Zwierzina, Lisa H. Butterfield and Bernard A. Fox

Journal for ImmunoTherapy of Cancer (Springer) Qatar, USA, Switzerland, Greece, Germany, The Netherlands, Italy, Austria, 19 January 2016

Oncology

Key words:Immune checkpoint blockade, Cancer immunotherapy, Biomarkers, Task Force, Immune monitoring, Technology, Bioinformatics

Organism: Human

Pathological State: Cancer

563
Software-assisted morphometric and phenotype analyses of human peripheral blood monocyte-derived macrophages induced by a microenvironment model of human esophageal squamous cell carcinoma

Mari Nishio, Naoki Urakawa, Manabu Shigeoka, Nobuhisa Takase, Yumi Ichihara, Noriaki Arai, Yu-ichiro Koma, Hiroshi Yokozaki

Pathology International (Wiley) Japan, 18 January 2016

Pathology

Key words:Esophageal cancer, image analysis, macrophages, tumor microenvironment

Organism: Human

Cell Line: PBMCs (Peripheral blood mononuclear cells )

564
Energy landscapes and functions of supramolecular systems

Faifan Tantakitti, Job Boekhoven, Xin Wang, Roman V. Kazantsev, Tao Yu, Jiahe Li, Ellen Zhuang, Roya Zandi, Julia H. Ortony, Christina J. Newcomb, Liam C. Palmer, Gajendra S. Shekhawat, Monica Olvera de la Cruz, George C. Schatz and Samuel I. Stupp

Nature Materials (Nature) USA, 18 January 2016

Biological Materials

Key words:Bioinspired materials, Materials science

Organism: Mouse

Cell Line: C2C12 Mouse pre-myoblasts

565
Towards personalised treatment in primary Sjögren's syndrome: baseline parotid histopathology predicts responsiveness to rituximab treatment

Konstantina Delli, Erlin A Haacke, Frans G M Kroese, Rodney P Pollard, Stephan Ihrler, Bert van der Vegt, Arjan Vissink, Hendrika Bootsma, Frederik K L Spijkervet

Annals of the Rheumatic Diseases (High Wire) The Netherlands, Germany, 15 January 2016

Rheumatology

Key words:Sjögren's syndrome, parotid histopathology, responsiveness to rituximab treatment

Organism: Human

Tissue: Parotid Gland

Pathological State: Sjögren's Syndrome

566
Low birth weight associates with hippocampal gene expression

J.P. Buschdorf, M.L. Ong, S.X. Ong, J.L. MacIsaac, K. Chng, M.S. Kobor, M.J. Meaney, J.D. Holbrook

Neuroscience (Elsevier) Singapore, Canada, 12 January 2016

Neuroscience

Key words:Low birth weight, hippocampus, DNA methylation, mental disorders, microarray

Organism: Monkey

Tissue: Brain

567
Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease

Meliana Riwanto, Sarika Kapoor, Daniel Rodriguez, Ilka Edenhofer, Stephan Segerer, Rudolf P. Wüthrich

PLOS ONE (PLOS) Switzerland, 11 January 2016

Nephrology

Key words:Kidneys, glycolysis, renal system, epithelial cells, glucose metabolism, apoptosis, ERK signaling cascade, polycystic kidney disease

Organism: Rat

Tissue: Kidney

Pathological State: Polycystic Kidney Disease

568
Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer

Leila Akkari, Vasilena Gocheva, Marsha L. Quick, Jemila C. Kester, Alison K. Spencer, Alfred L. Garfall, Robert L. Bowman, Johanna A. Joyce

Genes and Development (CHS Press) USA, Switzerland, 10 January 2016

Oncology

Key words:Cathepsin protease, compensatory mechanism, cancer

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

569
Toll-Like Receptor 4 Is Essential in the Development of Abdominal Aortic Aneurysm

Chao-Han Lai, Kuan-Chieh Wang, Fang-Tzu Lee, Hung-Wen Tsai, Chih-Yuan Ma, Tsung-Lin Cheng, Bi-Ing Chang, Yu-Jen Yang, Guey-Yueh Shi, Hua-Lin Wu

PLOS ONE (PLOS) Taiwan, 07 January 2016

Immunology

Key words:Macrophages, immune receptor signaling, aneurysms, inflammation, toll-like receptors, aorta, small interfering RNAs, cytokines

Organism: Mouse

Tissue: Kidney

570
The single-chain anti-TNF-a antibody DLX105 induces clinical and biomarker responses upon local administration in patients with chronic plaque-type psoriasis

Athanasios Tsianakas, Patrick M. Brunner, Kamran Ghoreschi, Claudia Berger, Karin Loser, Martin Röcken, Georg Stingl, Thomas Luger, Thomas Jung

Experimental Dermatology (Wiley) Germany, Austria, Switzerland, 06 January 2016

Dermatology

Key words:Psoriasis, TNF-alpha, TNF-alpha-blocker

Organism: Human

Tissue: Skin

Pathological State: Psoriasis

571
3, 4-Dihydroxy-L-phenylalanine as a novel covalent linker of extracellular matrix proteins to polyacrylamide hydrogels with a tunable stiffness

Olaf Y. Wouters, Diana T.A. Ploeger, Sander M. van Putten, and Ruud A. Bank

Tissue Engineering Part C (Mary Ann Liebert Inc.) The Netherlands, 05 January 2016

Tissue Engineering

Key words:Tissue Enigneering, 3,4-Dihydroxy-L-Phenylalanine, Linker, Extracellular Matrix, Hydrogel, Stiffness

Organism: Human

Cell Line: Human dermal fetal fibroblasts

572
T1 Mapping by CMR Imaging : From Histological Validation to Clinical Implication

Andreas A. Kammerlander, Beatrice A. Marzluf, Caroline Zotter-Tufaro, Stefan Aschaue, Franz Duca, Alina Bachman, Klaus Knechtelsdorfer, Matthias Wiesinger, Stefan Pfaffenberge, Andreas Greiser Irene M. Lang, Diana Bonderman, Julia Mascherbauer

JACC: Cardiovascular Imaging (Elsevier) Austria, Germany, 01 January 2016

Cardiology

Key words:CMR imaging, histological validation

Organism: Human

Tissue: Heart

573
N-octanoyl dopamine attenuates the development of transplant vasculopathy in rat aortic allografts via smooth muscle cell protective mechanisms

J Wedel, MC Hottenrott, M Bulthuis, S Huitema, BA Yard, JK Hillebrands

Transplantation (Wolters Kluwer) The Netherlands, Germany, 01 January 2016

Transplantation Medicine

Key words:N-octanoyl Dopamine, Transplant Vasculopathy, Aortic Allografts, Smooth Muscle Cells, Protective Mechanisms

Organism: Rat

Tissue: Blood Vessels

574
The anti-inflammatory compound curcumin enhances locomotor and sensory recovery after spinal cord injury in rats by immunomodulation

Lucia Machova Urdzikova , Kristyna Karova , Jiri Ruzicka , Anna Kloudova , Craig Shannon , Jana Dubisova , Raj Murali , Sarka Kubinova , Eva Sykova , Meena Jhanwar-Uniyal and Pavla Jendelova

International Journal of Molecular Sciences (MDPI) Czech Republic, USA, 31 December 2015

Neuroscience

Key words:spinal cord injury; curcumin; inflammation; cytokines; secondary processes; NF-κB

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

575
Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters

Elisabeth Strak, Isabella Ellinger, Christina Balthasar, Matthias Scheinast, Jasmin Schatz, Tamara Szattler, Sonja Bleichert, Leila Saleh, Martin Knöfler, Harald Zeisler, Markus Hengstschläger, Margit Rosner, Hans Salzer, Claudia Gundacker

Toxicology (Elsevier) Austria, 29 December 2015

Toxicology

Key words:Mercury, placenta, amino acid transporters

Organism: Human

Tissue: Placenta

576
Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals

Martti Maimets, Cecilia Rocchi, Reinier Bron, Sarah Pringle, Jeroen Kuipers, Ben N.G. Giepmans, Robert G.J. Vries, Hans Clevers, Gerald de Haan, Ronald van Os, Robert P. Coppes

Stem Cell Reports (Elsevier) The Netherlands, 24 December 2015

Stem Cell Research

Key words:Stem cells, in vitro expansion, wnt signals

Organism: Human

Tissue: Salivary Gland

577
Long-term in vitro expansion of salivary gland stem cells driven by Wnt signals

Martti Maimets, Cecilia Rocchi, Reinier Bron, Sarah Pringle, Jeroen Kuipers, Ben N.G. Giepmans, Robert G.J. Vries, Hans Clevers, Gerald de Haan, Ronald van Os, Robert P. Coppes

Stem Cell Reports (Elsevier) The Netherlands, 24 December 2015

Stem Cell Research

Key words:In Vitro Expansion, Salivary Gland, Stem Cells, Wnt

Organism: Mouse

Tissue: Salivary Gland

578
Co-culture of placental explants with isolated CD4 and CD8 T cells: a functional model to define the consequences of placental inflammation

Hayley Derricott, Rebecca L. Jones, Alexander E.P. Heazell, Susan L. Greenwood

Journal of Biological Methods (Springer) UK, 22 December 2015

Reproductive Medicine

Key words:inflammation, placenta, T lymphocytes, villitis, VUE

Organism: Human

Cell Line: Placental T-cells

579
Reproductive periodicity, spawning induction, and larval metamorphosis of the hemichordate acorn worm Ptychodera flava

Ching-Yi Lin, Che-Huang Tung, Jr-Kai Yu, Yi-Hsien Su

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution (Wiley) Taiwan, 10 December 2015

Zoology

Key words:Reproductive periodicity, larval metamorphosis, hemichordate

Organism: Acorn worm

Tissue: Penis

580
Mycolic acid-specific T cells protect against Mycobacterium tuberculosis infection in a humanized transgenic mouse model

J Zhao, S Siddiqui, S Shang, Y Bian, S Bagchi, Y He, CR Wang

eLife (eLife Sciences Publications) USA, 10 December 2015

Microbiology

Key words:Mycolic acid-specific T cells, Mycobacterium tuberculosis, humanized transgenic mouse model

Organism: Mouse

Tissue: Lung

Pathological State: Bacterial Infection

581
Low Hodgkin/Reed-Sternberg Cell Density Assessed with Automated Image Analysis Is a Poor Prognostic Factor in Classic Hodgkin Lymphoma Patients

Vit Prochazka, Tereza Dyskova, Zuzana Prouzova, Tomas Papajik, Jiri Minarik, Juraj Duras, Jozef Michalka, Alice Sykorova, Peter Mikula, Ludek Raida and Eva Kriegova

Blood (American Society of Hematology) Czech Republic, 03 December 2015

Oncology

Key words:Cell Density, Automated Image Analysis, Prognostic Factor, Hodgkin Lymphoma

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

582
Quantitative Analysis of Tissue Inflammation and Responses to Treatment in Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked (IPEX) Syndrome and Review of Literature

Chih-An Chen, Wan-Chen Chung, Yuan-Yow Chiou, Yao-Jong Yang, Yung-Chieh Lin, Hans D. Ochs, Dr. Chi-Chang Shieh

Journal of Microbiology, Immunology and Infection (Elsevier) Taiwan, USA, 01 December 2015

Immunology, Microbiology

Key words:Immune dysregulation, polyendocrinopathy, enteropathy, X-Linked (IPEX) syndrome, regulatory T cells, T helper 2 cells

Organism: Human

Tissue: Small Intestine

Pathological State: Endocrinopathy, Enteropathy, X-linked syndrome

583
Hirsutella sinensis mycelium attenuates bleomycin-induced pulmonary inflammation and fibrosis in vivo

TT Huang, HC Lai, YF Ko, DM Ojcius, YW Lan, J Martel, JD Young,

J Cancer Treat Diagnosis (Nature) Taiwan, USA, 26 November 2015

Microbiology

Key words:Drug development, Inflammasome

Organism: Human

Tissue: Lung

Pathological State: Inflammation, Fibrosis

584
Dynamic Trk and G Protein Signalings Regulate Dopaminergic Neurodifferentiation in Human Trophoblast Stem Cells

Eing-Mei Tsai, Yu-Chih Wang, Tony Tung-Yin Lee, Cheng-Fang Tsai, Hung-Sheng Chen, Feng-Jie Lai, Kazunari K. Yokoyama, Tsung-Hsun Hsieh, Ruey-Meei Wu, Jau-nan Lee

PLOS ONE (PLOS) Taiwan, USA, 25 November 2015

Neuroscience

Key words:Neurons, DNA transcription, G-protein signaling, stem cells, genomic signal processing, retinoic acid signaling cascade, retinoid signaling, neuronal differentiation

Organism: Human

Cell Line: hTS cells

585
Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma

Cheng-Fang Tsai, Tsung-Hua Hsieh, Jau-Nan Lee, Chia-Yi Hsu, Yu-Chih Wang, Kung-Kai Kuo, Hua-Lin Wu, Chien-Chih Chiu, Eing-Mei Tsa, and Po-Lin Kuo

Journal of Agricultural Food Chemistry (ACS Publications) Taiwan, 20 November 2015

Oncology

Key words:Phthalate, curcumin, hepatocellular carcinoma, metastasis, side population, cancer stem cells

Organism: Mouse

Tissue: Liver, Lung

586
Alpha-Actinin 4 Is Associated with Cancer Cell Motility and Is a Potential Biomarker in Non–Small Cell Lung Cancer

MC Wang, YH Chang, CC Wu, YC Tyan, HC Chang, YG Goan, WW Lai, PN Cheng, PC Liao

Journal of Thoracic Oncology (Elsevier) Taiwan, 20 November 2015

Oncology

Key words:ACTN4, non–small-cell lung cancers, CL1-0 and CL1-5 cell lines, siRNA

Organism: Human

Tissue: Lung

Pathological State: Cancer

587
MiR-125b is critical for fibroblast-to-myofibroblast transition and cardiac fibrosis

Varun Nagpal , Rahul Rai , Aaron T. Place , Sheila B. Murphy , Suresh K. Verma , Asish K. Ghosh , and Douglas E. Vaughan

Circulation (AHA Journals) USA, 19 November 2015

Cardiology

Key words:RNA sequence, fibrosis, angiotensin II, transforming growth factor, miR-125b

Organism: Mouse

Tissue: Heart

Pathological State: Fibrosis

588
CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow

A Nakamura-Ishizu, K Takubo, H Kobayashi, K Suzuki-Inoue, T Suda

Journal of Experimental Medicine (Rockefeller University Press) Japan, 09 November 2015

Stem Cell Research

Key words:CLEC-2, megakaryocyte, hematopoietic stem cells, bone marrow

Organism: Mouse

Tissue: Bone Marrow

589
IMPS-11 Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma

Seunggu Han, Gerald Reis, Gary Kohanbash, Shruti Srivastav, Stephen Magill, Annette Molinaro, Michael McDermott, Philip Theodosopoulos, Manish Aghi, Mitchel Berger, Igor Barani, Joanna Phillips, Arie Perry, Hideho Okada

Neuro-Oncology (Oxford University Press) USA, 09 November 2015

Oncology

Key words:meningioma, patient prognosis, impact, molecule, programmed cell death 1 ligand 1

Organism: Human

Tissue: Brain

Pathological State: Cancer

590
Transdermal drug targeting and functional imaging of tumor blood vessels in the mouse auricle

H Schröder, D Komljenovic, M Hecker, T Korff

The FASEB Journal (FASEB) Germany, 06 November 2015

Oncology

Key words:angiogenesis • blood vessel growth • bortezomib • mouse model • perfusion

Organism: Mouse

Tissue: Ear

Pathological State: Cancer

591
Melanin pigmentation in rat eyes: in vivo imaging by polarization-sensitive optical coherence tomography and comparison to histology

Bernhard Baumann; Johannes Schirmer; Sabine Rauscher; Stanislava Fialová; Martin Glösmann; Marco Augustin; Michael Pircher; Marion Gröger; Christoph K. Hitzenberger

Investigative Ophthalmology and Visual Science (ARVO Journals) Austria, 01 November 2015

Ophthalmology

Key words:Melanin Pigmentation, Eyes, In Vivo Imaging, Polarization-Sensitive Optical Coherence Tomography

Organism: Rat

Tissue: Eye

592
Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-a Production in Women

Morgane Griesbeck, Susanne Ziegler, Sophie Laffont, Nikaïa Smith, Lise Chauveau, Phillip Tomezsko, Armon Sharei, Georgio Kourjian, Filippos Porichis, Meghan Hart, Christine D. Palmer, Michael Sirignano, Claudia Beisel, Heike Hildebrandt, Claire Cénac, Alexandra-Chloé Villani, Thomas J. Diefenbach, Sylvie Le Gall, Olivier Schwartz, Jean-Philippe Herbeuval, Brigitte Autran, Jean-Charles Guéry, J. Judy Chang, and Marcus Altfeld

Journal of Immunology (American Association of Immunologists) France, Germany, UK, Australia, 30 October 2015

Immunology

Key words:Plasmacytoid dendridic cell levels, IRF5

Organism: Human, Mouse

Cell Line: PBMCs (Peripheral blood mononuclear cells )

593
Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury

Shao-Ming Wang, Jung-Yu C. Hsu, Chiung-Yuan Ko, Nai-En Chiu, Wai-Ming Kan, Ming-Derg Lai, Ju-Ming Wang

Molecular Neurobiology (Springer) Taiwan, 28 October 2015

Neuroscience

Key words:Astrogliosis C/EBPd, MMP-3 RhoA, astrocyte migration

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

594
Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy

Nastasia Wilfinger, Shane Austin, Barbara Scheiber-Mojdehkar, Walter Berger, Siegfried Reipert, Monika Praschberger, Jakob Paur, Robert Trondl, Bernhard K. Keppler, Christoph C. Zielinski, and Karin Nowikovsky

Oncotarget (Impact Journals) Austria, 26 October 2015

Oncology

Key words:cancer, p53, BNIP3L, mitophagy, gallium complex

Organism: Human

Pathological State: Cancer

Cell Line: Human colon carcinoma cells

595
Glucose-regulated protein 94 mediates cancer progression via AKT and eNOS in hepatocellular carcinoma

Chien-Yu Huang, Uyanga Batzorig, Wan-Li Cheng, Ming-Te Huang, Wei- Yu Chen, Po-Li Wei, Yu-Jia Chang

Tumor Biology (Springer) Taiwan, Mongolia, 22 October 2015

Oncology

Key words:GRP94 HCC eNOS AKT Proliferation

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

596
Quantitative Image Analysis of Epithelial and Stromal Area in Histological Sections of Colorectal Cancer: An Emerging Diagnostic Tool.

R. Rogojanu, T. Thalhammer, U. Thiem, A. Heindl, I. Mesteri, A. Seewald, W. Jäger, C. Smochina, I. Ellinger, G. Bises

Biomed Research International (Hindawi Publishing Corporation) Austria, Romania, 22 October 2015

Oncology

Key words:Image analysis, histology, colorectal cancer, diagnosis tool

Organism: Human

Tissue: Colon

Pathological State: Cancer

597
An Emerging Approach for Parallel Quantification of Intracellular Protozoan Parasites and Host Cell Characterization Using TissueFAXS Cytometry

Maximilian Schmid, Bianca Dufner, Julius Dürk, Konstanze Bedal, Kristina Stricker, Lukas Ali Prokoph, Christoph Koch, Anja K. Wege, Henner Zirpel, Ger van Zandbergen, Rupert Ecker, Bogdan Boghiu, Uwe Ritter

PLOS ONE (PLOS) Germany, Austria, 21 October 2015

Parasitology

Key words:Macrophages, parasitic diseases, host cells, leishmania major, DAPI staining, cell staining, host-pathogen interactions, intracellular pathogens

Organism: Mouse

Pathological State: Parasitic Infection

Cell Line: Makrophages

598
Redox Regulation of Pro-IL-1β Processing May Contribute to the Increased Severity of Serum-Induced Arthritis in NOX2-Deficient Mice

Ya-Fang Huang, Pei-Chi Lo, Chia-Liang Yen, Peter Andrija Nigrovic, Wen-Chen Chao, Wei-Zhi Wang, George Chengkang Hsu, Yau-Sheng Tsai, and Chi-Chang Shieh

Antioxidants and Redox Signaling (Mary Ann Liebert Inc.) Taiwan, USA, 21 October 2015

Rheumatology

Key words:Redox Regulation,Pro-IL-1β,Serum-Induced Arthritis, NOX2

Organism: Mouse

Tissue: Joint

Pathological State: Rheumatoid Arthritis

599
The Role of Lysophosphatidic Acid on Airway Epithelial Cell Denudation in a Murine Heterotopic Tracheal Transplant Model

Yukiko Tando, Chiharu Ota, Mitsuhiro Yamada, Satoshi Kamata, Mutsuo Yamaya, Kuniyuki Kano, Shinichi Okudaira, Junken Aoki, and Hiroshi Kubo,

Transplantation (Wolters Kluwer) Japan, 19 October 2015

Transplantation Medicine

Key words:Lysophosphatidic Acid, Airway Epithelial Cells, Denudation, Murine Heterotopic Tracheal Transplant Model

Organism: Mouse

Cell Line: BEAS-2B cells

600
Development of recombinant collagen-peptide-based vehicles for delivery of adipose-derived stromal cells (ADSC)

M. Parvizi, J.A. Plantinga, C. van Spreuwel-Goossens, S. van Dongen, S. G. Kluijtmans, M.C. Harmsen

Journal of Biomedical Materials Research (Wiley) The Netherlands, 14 October 2015

Biological Materials

Key words:Recombinant-Collagen Microspheres, integrin binding motives, crosslinked, ADSC, delivery

Organism: Human

Cell Line: Adipose tissue derived stromal cells (ADSC)

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