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Customer Publications (A total of 1320 papers published)

501
Prevention of Colitis and Colitis-Associated Colorectal Cancer by a Novel Polypharmacological Histone Deacetylase Inhibitor

Tzu-Tang Wei, Yi-Ting Lin, Ruo-Yu Tseng, Chia-Tung Shun, Yu-Chin Lin, Ming-Shiang Wu, Jim-Min Fang, Ching-Chow Chen

Clinical Cancer Research (AACR Publications) Taiwan, 14 August 2016

Oncology

Key words:Colorectal cancer, colitis, HDAC, HMGR

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

502
Localization of TrkB and p75 receptors in peritoneal and deep infiltrating endometriosis: an immunohistochemical study

Agung Dewanto, Jozsef Dudas, Rudolf Glueckert, Sylvia Mechsner, Anneliese Schrott-Fischer, Ludwig Wildt and Beata Seeber

Reproductive Biology and Endocrinology (Springer) Germany, 12 August 2016

Reproductive Medicine

Key words:Neurotrophins, BDNF, endometriosis, immunohistochemistry

Organism: Human

Tissue: Endometrium

Pathological State: Endometriosis

503
Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3

Bethany Baumann , Tomoko Hayashida, Xiaoyan Liang, H. William Schnaper

Kidney International (Elsevier) USA, 05 August 2016

Physiology

Key words:Fibrosis, glomerulus, hypoxia, TGF-β

Organism: Mouse

Tissue: Kidney

504
Role of the immune system in the peritoneal tumor spread of high grade serous ovarian cancer

Katharina Auer, Anna Bachmayr-Heyda, Nyamdelger Sukhbaatar, Stefanie Aust, Klaus G. Schmetterer, Samuel M. Meier, Christopher Gerner, Christoph Grimm, Reinhard Horvat, and Dietmar Pils

Oncotarget (Impact Journals) Austria, 03 August 2016

Oncology

Key words:epithelial ovarian cancer, peritoneal tumor spread, flow cytometry, PD-1, next generation sequencing

Organism: Human

Tissue: Peritoneum, Ovaries

Pathological State: Cancer

505
Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction

Tim Koopmans, Kuldeep Kumawat, Andrew J Halayko, Reinoud Gosens

Scientific Reports (Nature) The Netherlands, 29 July 2016

Cell Biology

Key words:Airway hyperresponsiveness, asthm, intracellular calcium flux, actin polymerisation

Organism: Human

Cell Line: Bronchial smooth muscle cells

506
CD271 regulates the proliferation and motility of hypopharyngeal cancer cells

Mai Mochizuki, Keiichi Tamai, Takayuki Imai, Sayuri Sugawara, Naoko Ogama, Mao Nakamura, Kazuto Matsuura, Kazunori Yamaguchi, Kennichi Satoh, Ikuro Sato, Hozumi Motohashi, Kazuo Sugamura, Nobuyuki Tanaka

Scientific Reports (Nature) Japan, 29 July 2016

Oncology

Key words:CD271 (p75 neurotrophin receptor), human hypopharyngeal cancer, head and neck squamous cell carcinoma

Organism: Human

Tissue: Pharynx

Pathological State: Cancer

507
Sur8 mediates tumorigenesis and metastasis in colorectal cancer

Young-Mi Lee, Saluja Kaduwal, Kug Hwa Lee, Jong-Chan Park, Woo-Jeong Jeong, Kang-Yell Choi

Experimental and Molecular Medicine (Nature) South Korea, 29 July 2016

Oncology

Key words:Scaffold protein, Ras-extracellular signal-regulated kinase, doxycyline, HCT116 cells

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

508
Tissue-Resident CD169+ Macrophages Form a Crucial Front Line against Plasmodium Infection

Pravesh Gupta, Si Min Lai, Jianpeng Sheng, Piotr Tetlak, Akhila Balachander, Carla Claser, Laurent Renia, Klaus Karjalainen, Christiane Ruedl

Cell Reports (Cell Press) Singapore, 28 July 2016

Cell Biology

Key words:Plasmodium berghei ANKA, malaria, myeloid cells, macrophages

Organism: Mouse

Tissue: Brain

Pathological State: Bacterial Infection

509
In situ mapping of innate lymphoid cells in human skin: evidence for remarkable differences between normal and inflamed skin

Marie-Charlotte Brüggen, Wolfgang M. Bauer, Bärbel Reininger, Eduard Clim, Catalin Captarencu Georg E. Steiner, Patrick M. Brunner, Barbara Meier, Lars E. French, Georg Sting

Journal of Investigative Dermatology (Elsevier) Austria, Switzerland, Romania, 22 July 2016

Dermatology

Key words:Lymphoid Cells, Human Skin, Inflamed Skin, atopic dermatitis, psoriasis

Organism: Human

Tissue: Skin

Pathological State: Dermatitis, Psoriasis

510
4 – Proffered Paper: Immunological changes during tumor progression from primary to recurrent glioblastoma

C. Herold-Mende, C. Rapp, R. Warta, A. Unterberg, P. Beckhove

European Journal of Cancer (Elsevier) , 14 July 2016

Oncology

Key words:Cancer, tumor, glioblastoma

Organism: Human

Tissue: Brain

Pathological State: Cancer

511
Multimodal Imaging of Nanocomposite Microspheres for Transcatheter Intra-Arterial Drug Delivery to Liver Tumors

Dong-Hyun Kim, Weiguo Li, Jeane Chen, Zhuoli Zhang, Richard M. Green, Sui Huang and Andrew C. Larson

Scientific Reports (Nature) USA, 13 July 2016

Oncology

Key words:Biomedical materials, cancer imaging, hepatic artery, nanotechnology in cancer, targeted therapies

Organism: Rat

Tissue: Xenograft Tumor, Liver

Pathological State: Cancer

512
Quantitative comparison and reproducibility of pathologist scoring and digital image analysis of estrogen receptor β2 immunohistochemistry in prostate cancer

Anthony E. Rizzardi, Xiaotun Zhang, Rachel Isaksson Vogel, Suzanne Kolb, Milan S. Geybels, Yuet-Kin Leung, Jonathan C. Henriksen, Shuk-Mei Ho, Julianna Kwak, Janet L. Stanford, and Stephen C. Schmechel

Diagnostic Pathology (BioMed Central) USA, 11 July 2016

Pathology

Key words:Prostate cancer, Biomarkers, Digital pathology, Quantification, Estrogen receptor β2

Organism: Human

Tissue: Prostate

Pathological State: Cancer

513
Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice

Dominic Schmidt, Daniel Peterlik, Stefan O. Reber, Anja Lechner, Daniela N. Männel

PLOS ONE (PLOS) Germany, 08 July 2016

Neuroscience

Key words:Chronic subordinate colony, myeloid cells, hypothalamus-pituitary-adrenal, sympathetic nervous system

Organism: Mouse

Tissue: Spleen, Allograft Tumor

Pathological State: Cancer

514
Lesional CD4+ IFN-γ+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis

Takashi Maehara, Hamid Mattoo, Miho Ohta, Vinay S Mahajan, Masafumi Moriyama, Masaki Yamauchi, Jefte Drijvers, Seiji Nakamura, John H Stone, Shiv S Pillai

Annals of the Rheumatic Diseases (BMJ Journals) Japan, 29 June 2016

Rheumatology

Key words:IgG4-related disease, T lymphocytes, Sjögren's syndrome,

Organism: Human

Tissue: Salivary Gland

Pathological State: Cancer

515
Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

Hweixian Leong Penny, Je Lin Sieow, Giulia Adriani, Wei Hseun Yeap, Peter See Chi Ee, Boris San Luis, Bernett Lee, Terence Lee, Shi Ya Mak, Ying Swan Ho, Choon Kiat Ong, Ruby Y J Huang, Florent Ginhoux, Olaf Rotzschke, Roger D. Kamm and Siew, Cheng Wong

OncoImmunology (Taylor and Francis) Singapore, 21 June 2016

Oncology

Key words:Metabolism, macrophages, pancreatic cancer, metastasis

Organism: Human

Pathological State: Cancer

Cell Line: HPAF-II (Pancreatic epithelial tumor cell line)

516
ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments

Rick Conzemius, Haleh Ganjian, Dieter Blaas and Renate Fuchs

Journal of Virology (American Society for Microbiology) Austria, 20 June 2016

Virology

Key words:Human rhinovirus A89 (HRV-A89) and HRV-B14, RNA genome, endocytic recycling compartment (ERC)

Organism: Human

Pathological State: Cancer

Cell Line: HeLA cells

517
Validation of tumor protein marker quantification by two independent automated immunofluorescence image analysis platforms

Amy R Peck, Melanie A Girondo, Chengbao Liu, Albert J Kovatich, Jeffrey A Hooke, Craig D Shriver, Hai Hu, Edith P Mitchell, Boris Freydin, Terry Hyslop, Inna Chervoneva and Hallgeir Rui

Modern Pathology (Nature) USA, 17 June 2016

Medical Image Analysis

Key words:Histology, biomarkers, breast tumor

518
Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells

Chen-Chi Liu, Shih-Pei Lin, Han-Shui Hsu, Shung-Haur Yang, Chiu-Hua Lin, Muh-Hwa Yang, Mien-Chie Hung and Shih-Chieh Hung

Nature Communications (Nature) Taiwan, 16 June 2016

Oncology

Key words:Biological sciences, cancer, cell biology

Organism: Human, Mouse

Tissue: Colon, Xenograft Tumor

Pathological State: Cancer

519
Ribosome inactivation leads to attenuation of intestinal polymeric Ig receptor expression via differential regulation of human antigen R

KH Do, SH Park, J Kim, M Yu, Y Moon

The Journal of Immunology (American Association of Immunologists) South Korea, 15 June 2016

Immunology

Key words:Ribosome ,Polymeric Ig Receptor ,Differential Regulation, Human Antigen R

Organism: Mouse

Tissue: Small Intestine, Colon

520
A new fluorescence/PET probe for targeting intracellular human telomerase reverse transcriptase (hTERT) using Tat peptide-conjugated IgM

Kyung oh Jung, Hyewon Youn , Seung Hoo Kim, Young-Hwa Kim, Keon Wook Kang, June-Key Chunga

Biochemical and Biophysical Research Communications (Elsevier) South Korea, 15 June 2016

Biological Methods

Key words:Intracellular and intranuclear protein, hTERT, tat peptide, IgM antibody, 64Cu, Live cell imaging

Organism: Human

Pathological State: Cancer

Cell Line: HT29, U2OS cells

521
Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine

Norihiro Kishida, Sachiko Matsuda, Osamu ItanoEmail author, Masahiro Shinoda, Minoru Kitago,Hiroshi Yagi, Yuta Abe, Taizo Hibi, Yohei Masugi, Koichi Aiura, Michiie Sakamoto and Yuko Kitagawa

BMC Gastroenterology (BioMed Central) Japan, 13 June 2016

Oncology

Key words:Nonalcoholic steatohepatitis, hepatocellular carcinoma, diethylnitrosamine, high-fat choline-deficient diet, mouse model

Organism: Mouse

Tissue: Liver

Pathological State: Fibrosis

522
Automated muscle fiber type population analysis with ImageJ of whole rat muscles using rapid myosin heavy chain immunohistochemistry

Konstantin D. Bergmeister, Marion Gröger, Martin Aman, Anna Willensdorfer, Krisztina Manzano-Szalai, Stefan Salminger and Oskar C. Aszmann

Muscle and Nerve (Wiley) Austria, 13 June 2016

Medical Image Analysis

Key words:Automated muscle fiber analysis, fiber population, ImageJ, muscle fiber type, myosin heavy chain, rat

Organism: Rat

Tissue: Muscle

523
Clonorchis sinensis omega-class glutathione transferases play major roles in the protection of the reproductive system during maturation and the response to oxidative stress

Jeong-Geun Kim, Chun-Seob Ahn, Seon-Hee Kim, Young-An Bae, Na-Young Kwon, Insug Kang, Hyun-Jong Yang, Woon-Mok Sohn, Yoon Kong

Parasites and Vectors (BioMed Central) South Korea, 13 June 2016

Parasitology

Key words:Clonorchis sinensis, glutathione transferase (GST), omega-class GST, sexual maturation, reproductive system, oxidative stress

Organism: Flatworm

Tissue: Whole Organism

524
Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

Pu-Hyeon Cha, Yong-Hee Cho, Sang-Kyu Lee, JaeHeon Lee, Woo-Jeong Jeong, Byoung-San Moon, Ji-Hye Yun, Jee Sun Yang, Sooho Choi, Juyong Yoon, Hyun-Yi Kim, Mi-Yeon Kim, Saluja Kaduwal, Weontae Lee, Do Sik Min, Hoguen Kim, Gyoonhee Han and Kang-Yell Choi

Nature Chemical Biology (Nature) South Korea, 13 June 2016

Oncology

Key words:Cancer therapy, cell signalling, screening, small molecules

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

525
Epidermal desmoglein 1 expression is reduced in kidney transplant recipients compared to immunocompetent patients

Jodi L. Johnson, Paul Hoover, Borko D. Jovanovic, Kathleen J. Green, John J. Friedewald, June K. Robinson

Journal of Investigative Dermatology (Elsevier) USA, 11 June 2016

Dermatology

Key words:Calcineurin inhibitor, desmoglein, E-cadherin, epidermal growth factor receptor, histone deacetylase inhibitor, immunocompetent patient, K1/10, Keratin 1 or 10, kidney transplant recipient, mycophenolate mofitil, plakoglobin, squamous cell carcinoma;ultraviolet light

Organism: Human

Tissue: Skin

Pathological State: Cancer

526
Amniotic Fluid Cells Proliferation in Normal and Down Syndrome Subjects

A Honcea, R Iulian, AG Pavel, I Ion, LE Sima

ARS Medica Tomitana (Sciendo) Romania, 11 June 2016

Reproductive Medicine

Key words:Down syndrome, Trisomy 21, amniotic fluid-derived stem cells, proliferation, cell cycle

Organism: Human

Cell Line: Amniotic fluid derived cells

527
ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model

Amy M. Archer, Rana Saber, Shawn Rose, Alexander Shaffer, Alexander V. Misharin, FuNien Tsai, G. Kenneth Haines III, Salina Dominguez, Mesut Eren, Douglas E. Vaughan, Carla M. Cuda and Harris Perlman

Journal of Translational Medicine (BioMed Central) USA, 10 June 2016

Immunology

Key words:Arthritis, cholesterol, inflammation, animal models of human disease

Organism: Mouse

Tissue: Joint

Pathological State: Atherosclerosis

528
Infiltration of Macrophages Correlates with Severity of Allograft Rejection and Outcome in Human Kidney Transplantation

Tobias Bergler, Bettina Jung, Felix Bourier, Louisa Kühne, Miriam C. Banas, Petra Rümmele, Simone Wurm, Bernhard Banas

PLOS ONE (PLOS) Germany, 10 June 2016

Transplantation Medicine

Key words:Macropaghes, T-lymphocytes, calcineriurin, inhibitor, renal transplantation

Organism: Human

Tissue: Kidney

Pathological State: Organ Transplantation

529
Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model

Hui-Wen Chiu, Ya-Ling Yeh, Yi-Ching Wang, Wei-Jan Huang, Sheng-Yow Ho, Pinpin Lin, Ying-Jan Wang

Molecular Cancer (Springer) Taiwan, 10 June 2016

Oncology

Key words:Histone deacetylase inhibitor, radiation, triple-negative breast cancer, autophagy

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

530
Gain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer’s Disease

Cheng-Chun Wu, Cheng-Chang Lien, Wen-Hsien Hou, Po-Min Chiang ,Kuen-Jer Tsai

Scientific Reports (Nature) Taiwan, 06 June 2016

Neuroscience

Key words:Dementia, neural stem cells, regeneration and repair in the nervous system, stem-cell research

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s Disease

531
Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model

CY Lin, HY Hsieh, CM Chen, SR Wu, CH Tsai, CY Huang, MY Hua, CK Yeh, HL Liu

Journal of Controlled Release (Elsevier) Taiwan, 26 May 2016

Neuroscience

Key words:Focused ultrasound, Gene therapy, Blood-brain barrier opening, Microbubbles, GDNF

Organism: Mouse

Tissue: Brain

Pathological State: Parkinson's Disease

532
Functional studies on primary tubular epithelial cells indicate a tumor suppressor role of SETD2 in clear cell renal cell carcinoma

J Li, J Kluiver, J Osinga, H Westers, MB van Werkhoven, Marc A Seelen, Rolf H Sijmons, Ankevan den Berg, Klaas Kok

Neoplasia (Elsevier) The Netherlands, 26 May 2016

Oncology

Key words:Primary Tubular Epithelial Cells, Tumor Suppression, SETD2, Renal Cell Carcinoma

Organism: Human

Pathological State: Cancer

Cell Line: PTECs and HKC8 cells

533
GBIQ: a non-arbitrary, non-biased method for quantification of fluorescent images

Youichirou Ninomiya, Wei Zhao,Yumiko Saga

Scientific Reports (Nature) Japan, 23 May 2016

Medical Image Analysis

Key words:Image processing, software

Organism: Mouse

Cell Line: MESCs (Mouse Embryonic stem cells)

534
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

Daniela F. Quail, Robert L. Bowman, Leila Akkari, Marsha L. Quick, Alberto J. Schuhmacher, Jason T. Huse, Eric C. Holland, James C. Sutton, Johanna A. Joyce

Science (American Association for the Advancement of Science) USA, 20 May 2016

Oncology

Key words:Mouse models, glioblastoma multiforme, macrophage

Organism: Mouse

Tissue: Lymphoid Tissue, Connective Tissue

Pathological State: Cancer

535
Knockout of ho-1 protects the striatum from ferrous iron-induced injury in a male-specific manner in mice

Li-Fang Wang, Kazunari K. Yokoyama, Chih-Lung Lin, Tzu-Yin Chen, Hsiu-Wen Hsiao, Pei-Chi Chiang, Chin Hsu

Scientific Reports (Nature) Taiwan, 20 May 2016

Neuroscience

Key words:Neuronal physiology, reproductive biology

Organism: Mouse

Tissue: Ovaries, Penis, Testis

536
Anti-TGF-β Antibody, 1D11, Ameliorates Glomerular Fibrosis in Mouse Models after the Onset of Proteinuria

Xiaoyan Liang, H. William Schnaper, Taiji Matsusaka, Ira Pastan, Steve Ledbetter,Tomoko Hayashida

PLOS ONE (PLOS) USA, 17 May 2016

Nephrology

Key words:Renal fibrosis

Organism: Mouse

Tissue: Kidney

Pathological State: Nephropathy

537
HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

Niek G.J. Leusa, Petra E. van der Woudena, Thea van den Boscha, Wouter T.R. Hooghiemstraa, Maria E. Ourailidoua, Loes E.M. Kistemakerc, Rainer Bischoffb, Reinoud Gosensc, Hidde J. Haismaa, Frank J. Dekker

Biochemical Pharmacology (Elsevier) The Netherlands, 15 May 2016

Pharmacology

Key words:Lysine acetylation, HDACs, inflammation, NF-κB p65, HDAC inhibitors, lung disease

Organism: Mouse

Tissue: Lung

538
MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains

Marjolein Bijlard, Jenny C. de Jonge, Bert Klunder, Anita Nomden, Dick Hoekstra, Wia Baron

PLOS ONE (PLOS) The Netherlands, 12 May 2016

Neuroscience

Key words:Oligodendrocytes, myelin membrane, rat brain tissue

Organism: Rat

Cell Line: Primary oligodendrocyte, OLN-93, HEPG2 cells

539
In situ hybridization to detect and localize signature cytokines of T-helper (Th) 1 and Th2 immune responses in chicken tissues

Fana Alem Kidane, Ivana Bilic, Taniya Mitra, Patricia Wernsdorf, Michael Hess, Dieter Liebhart

Veterinary Immunology and Immunopathology (Elsevier) Austria, 12 May 2016

Immunology

Key words:In situ hybridization, RNA probes, ChIFN-γ, ChIL-4, ChIL-13

Organism: Chicken

Tissue: Spleen, Liver

Pathological State: Parasitic Infection

540
The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth

Harini Nivarthi, Claire Gordziel, Madeleine Themanns, Nina Kramer, Markus Eberl, Björn Rabe, Michaela Schlederer, Stefan Rose-John, Thomas Knösel, Lukas Kenner, Patricia Freund, Fritz Aberger, Xiaonan Han, Robert Kralovics, Helmut Dolznig, Susanne Jennek, Karlheinz Friedrich, and Richard Moriggl

Oncotarget (Impact Journals) Austria, germany, USA, 12 May 2016

Oncology

Key words:STAT1, STAT3, colorectal cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

541
Exploration of more effective neurorrhaphy in facial nerve reconstruction: A comparison focusing on the difference of neural window size and condition of the …

Kentaro Ono, Yuhei Yamamoto, Ryuji Shichinohe, Naoki Murao, Akihiko Oyama, Emi Funayama, Hiroshi Furukawa

Journal of Plastic, Reconstructive and Aesthetic Surgery (Elsevier) Japan, 12 May 2016

Neuroscience

Key words:Nerve reconstruction, Facial palsy, Side to side, End to side, Rat

Organism: Rat

Tissue: Brain

542
Acidic pH-triggered drug-eluting nanocomposites for magnetic resonance imaging-monitored intra-arterial drug delivery to hepatocellular carcinoma

W Park, J Chen, S Cho, S Park, AC Larson, K Na, DH Kim

Applied Materials and Interfaces (ACS Publications) USA, South Korea, 09 May 2016

Nanomedicine, Oncology

Key words:hepatocellular carcinoma; image-guided therapy; iron oxide nanoparticles; nanocomposite microspheres; pH-responsive materials; sorafenib

Organism: Rat

Tissue: Liver

Pathological State: Cancer

543
Interleukin-25 is detrimental for recovery after spinal cord injury in mice

Dearbhaile Dooley, Evi Lemmens, Peter Ponsaerts, Sven Hendrix

Journal of Neuroinflammation (Springer) Belgium, 06 May 2016

Neuroscience

Key words:IL-25, type 2 immune response, spinal cord injury, basso mouse scale, locomotor recovery Th1 Th2

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

544
CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition

Neeraj Kapur, Hina Mir, Clarence E Clark III, Uma Krishnamurti, Derrick J Beech, James W Lillard and Shailesh Singh

British Journal of Cancer (Nature) USA, 05 May 2016

Oncology

Key words:Colon cancer, Epithelial–mesenchymal transition, Metastasis, Tumour biomarkers

Organism: Human

Tissue: Colon

Pathological State: Cancer

545
PPARγ inhibits VSMC proliferation and migration via attenuating oxidative stress through upregulating UCP2

Y Zhou, MJ Zhang, BH Li, L Chen, Y Pi, YW Yin, CY Long, X Wang, MJ Sun, X Chen, CY Gao, JC Li, LL Zhang

Plos ONE (PLOS) China, 04 May 2016

Cell Biology

Key words:Oxidative stress, Reactive oxygen species ,Carotid arteries ,Mitochondria ,Antioxidants ,MTT assay ,Fluorescence microscopy ,Growth factors

Organism: Mouse

Tissue: Blood Vessels

546
Loss of HIF-1β in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model

Nina Henke, Nerea Ferreirós, Gerd Geisslinger, Martina G. Ding, Silke Essler, Dominik C. Fuhrmann, Theresa Geis, Dmitry Namgaladze, Nathalie Dehne, and Bernhard Brüne

Oncotarget (Impact Journals) Germany, 03 May 2016

Oncology

Key words:xenobiotics, CYP1A1, DNA damage, breast cancer, fibrosarcoma

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

547
449 In situ mapping of innate lymphoid cells in normal and inflamed human skin

M. Brüggen, W. Bauer, B. Reininger, E. Clim, C. Captarencu, B. Meier, P.M. Brunner, L. French, G. Stingl

Journal of Investigative Dermatology (Elsevier) Austria, 01 May 2016

Immunology

Key words:Innate lymphoid cells, atopic dermatitis, psoriasis, normal human skin, immunofluorescence

Organism: Human

Tissue: Skin

Pathological State: Dermatitis, Psoriasis

548
Paracrine Factors from Irradiated Peripheral Blood Mononuclear Cells Improve Skin Regeneration and Angiogenesis in a Porcine Burn Model

Stefan Hacker, Rainer Mittermayr, Stefanie Nickl, Thomas Haider, Diana Lebherz-Eichinger, Lucian Beer, Andreas Mitterbauer, Harald Leiss, Matthias Zimmermann, Thomas Schweiger, Claudia Keibl, Helmut Hofbauer, Christian Gabriel, Mariann Pavone-Gyöngyösi, Heinz Redl, Erwin Tschachler, Michael Mildner, Hendrik Jan Ankersmit

Scientific Reports (Nature) Austria, 29 April 2016

Regenerative Medicine

Key words:Drug development, regeneration, translational research, trauma

Organism: Pig

Tissue: Skin

Pathological State: Burn Wound

549
SIRT2-mediated deacetylation and tetramerization of pyruvate kinase directs glycolysis and tumor growth

David Gius

Cancer Research (AACR Publications) USA, 27 April 2016

Oncology

Key words:Mitochondria, pyruvate kinase, acetylation, mammary tumor cells

Organism: Human

Tissue: Breast

Pathological State: Cancer

550
Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling

Yu-Chih Wang, Cheng-Fang Tsai, Hsiao-Li Chuang, Yi-Chih Chang, Hung-Sheng Chen, Jau-Nan Lee, and Eing-Mei Tsai

Oncotarget (Impact Journals) Taiwan, 26 April 2016

Oncology

Key words:Aryl hydrocarbon receptor, sphingosine kinase 1, sphingosine 1-phosphate, sphingosine-1-phosphate receptor 3, breast cancer stem cells

Organism: Human

Pathological State: Cancer

Cell Line: MCF-7 cells (Breast Cancer Cell line)

551
Tumor-associated B cells in cutaneous primary melanoma and improved clinical outcome

Kanika Garg, Margarita Maurer, Johannes Griss, Marie-Charlotte Brüggen, Ingrid H. Wolf, Christine Wagnera, Niels Willi, Kirsten D. Mertz, Stephan N. Wagner

Human Pathology (Elsevier) Austria, 20 April 2016

Pathology

Key words:CD20, prognosis, melanoma, tumor microenvironment, tumor-associated B cells (TAB), tumor-infiltrating lymphocytes

Organism: Human

Tissue: Skin

Pathological State: Cancer

552
Effectiveness of a Layer-by-Layer Microbubbles-Based Delivery System for Applying Minoxidil to Enhance Hair Growth

Ai-Ho Liao,Ying-Jui Lu, Yi-Chun Lin, Hang-Kang Chen, Huey-Kang Sytwu, Chih-Hung Wang

Theranostics (Ivyspring International Publisher) Taiwan, 11 April 2016

Oncology

Key words:Microbubbles, ultrasound, transdermal drug delivery, minoxidil, chitosan oligosaccharide lactate, hair growth

Organism: Pig, Mouse

Tissue: Skin

553
Dose-escalation study for the targeting of CD44v+cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)

Kohei Shitara, Toshihiko Doi, Osamu Nagano, Chiyo K. Imamura, Takeshi Ozeki, Yuya Ishii, Kenji Tsuchihashi, Shunji Takahashi, Takako E. Nakajima, Shuichi Hironaka, Miki Fukutani, Hiromi Hasegawa, Shogo Nomura, Akihiro Sato, Yasuaki Einaga, Takeshi Kuwata, Hideyuki Saya, Atsushi Ohtsu

Gastric Cancer (Springer) Japan, 07 April 2016

Oncology

Key words:Cancer stem cellCD44 variant positiveGastric cancerSulfasalazinexCT

Organism: Human

Tissue: Stomach

Pathological State: Cancer

554
Biocompatibility Assessment of a New Biodegradable Vascular Graft via In Vitro Co-culture Approaches and In Vivo Model

Marjan Enayati, Magdalena Eilenberg, Christian Grasl, Peter Riedl, Christoph Kaun, Barbara Messner, Ingrid Walter, Robert Liska, Heinrich Schima, Johann Wojta, Bruno K. Podesser, Helga Bergmeister

Annals of Biomedical Engineering (Springer) Austria, 07 April 2016

Tissue Engineering

Key words:Vascular graft, biocompatibility, biodegradable polyurethane, fibroblast-macrophage co-culture

Organism: Rat

Tissue: Blood Vessels

Pathological State: Organ Transplantation

555
Cross-talk between DopaChromeTautomerase and Caveolin-1 is melanoma cell phenotype specific and potentially involved in tumor progression.

Popa IL, Milac AL, Sima LE, Alexandru PR, Pastrama F, Munteanu CV, Negroiu Gabriela

Journal of biological chemistry (American Society for Biochemistry and Molecular Biology) Romania, 06 April 2016

Oncology

Key words:Antigen processing, caveolin, epithelial-mesenchymal transition (EMT), melanoma, structural model

Organism: Human

Tissue: Skin

Pathological State: Cancer

556
Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells

Bernd Schöpf, Georg Schäfer, Anja Weber , Heribert Talasz ,Iris E. Eder , Helmut Klocker , Erich Gnaiger

FEBS Journal (FEBS PRESS) Austria, 06 April 2016

Cell Biology

Key words:electron transfer system, high‐resolution respirometry, mitochondria, oxidative phosphorylation, prostate metabolism

Organism: Human

Tissue: Prostate

557
Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

Jonas Kloeppera,Lars Riedemanna, Zohreh Amoozgara,1, Giorgio Seanoa, Katharina Suseka, Veronica Yua, Nisha Dalviea, Robin L. Amelunga, Meenal Dattaa,Jonathan W. Songa,Vasileios Askoxylakisa, Jennie W. Taylora,Christine Lu-Emersona,Ana Batistaa,Nathaniel D. Kirkpatricka,Keehoon Junga, Matija Snuderla, Alona Muzikanskye, Kay G. Stubenrauchf, Oliver Krieterf, Hiroaki Wakimotog, Lei Xu1, Lance L. Munna, Dan G. Dudaa, Dai Fukumuraa, Tracy T. Batchelorc, Rakesh K. Jaina,

PNAS (PNAS) USA, 04 April 2016

Oncology

Key words:Anti-angiogenic therapy, tumor microenvironment, anti-tumor immunity, macrophage polarization, microglia reprogramming

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

558
CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma

Hagma H. Workel, Fenne L. Komdeur, Maartje C.A. Wouters, Annechien Plat, Harry G. Klip, Florine A. Eggink, G. Bea A. Wisman, Henriette J.G. Arts, Maaike H.M. Oonk, Marian J.E. Mourits, Refika Yigit, Marco Versluis, Evelien W. Duiker, Harry Hollema, Marco de Bruyn, Hans W. Nijman

European Journal of Cancer (Elsevier) The Netherlands, 31 March 2016

Oncology

Key words:Tumour-infiltrating lymphocytes, endometrial cancer, adenocarcinoma, CD103, survival

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

559
Combining ultrasound and lactobacilli treatment for high-fat-diet-induced obesity in mice

A.-H. Liao, C.-B. Jiang, C.-C. Li, H.-C. Chuang, J.-S. Chiang Chiau, W.-T. Chan, C.-Y. Yeung, M.-L. Cheng, H.-C. Lee

Journal of Animal Physiology and Animal Nutrition (Wiley) Taiwan, 29 March 2016

Physiology

Key words:Actobacilli, ultrasound, high-fat-diet-induced obesity mice, micro-CT, fat deposition

Organism: Mouse

Tissue: Liver, Adipose Tissue

Pathological State: Obesity

560
Myeloid PTEN deficiency impairs tumor-immune surveillance via immune-checkpoint inhibition

M Kuttke, E Sahin, J Pisoni, S Percig, A Vogel, D Kraemmer, L Hanzl, J. S Brunner, H Paar, K Soukup, A Halfmann, A. M. Dohnal, C. W. Steiner, S. Blüml, J. Basilio, B. Hochreiter, M. Salzmann, B. Hoesel, G. Lametschwandtner, R. Eferl, J. A. Schmidd and G. Schabbauer

OncoImmunology (Taylor and Francis) Austria, 28 March 2016

Immunology

Key words:Colitis-associated colon cancer, myeloid Pi3K, tumor immune-surveillance

Organism: Mouse

Tissue: Xenograft Tumor, Colon

Pathological State: Cancer

561
Chemotherapy of Colorectal Liver Metastases Induces a Rapid Rise in Intermediate Blood Monocytes which Predicts Treatment Response

Dominic Schauer, Patrick Starlinger, Lejla Alidzanovic, Philipp Zajc, Thomas Maier, Alexandra Feldman, Robin Padickakudy, Elisabeth Buchberger, Vanessa Elleder, Andreas Spittlera, Judith Stift, Lorand Pop, Birgit Gruenberger, Thomas Gruenbergera, Christine Brostjan

OncoImmunology (Taylor and Francis) Austria, 22 March 2016

Immunology

Key words:Chemotherapy, colorectal liver metastase, blood monocytes

Organism: Human

Tissue: Liver

Pathological State: Cancer

562
A specific area of olfactory cortex involved in stress hormone responses to predator odours

Kunio Kondoh, Zhonghua Lu, Xiaolan Ye, David P. Olson, Bradford B. Lowell and Linda B. Buck

Nature (Nature) USA, 21 March 2016

Neuroscience

Key words:Neural circuits, Olfactory cortex, Sensory processing

Organism: Mouse

Tissue: Brain

563
MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

Somayyeh Hamzei Taj, Widuri Kho, Adrien Riou, Dirk Wiedermann, Mathias Hoehn

Biomaterials (Elsevier) The Netherlands, 19 March 2016

Neuroscience

Key words:MicroRNA-124, ischemic stroke, immune cell modulation/polarization, neuroprotection, functional improvement, arginase-1

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

564
Neuronal deficiency of HIF prolyl 4-hydroxylase 2 in mice improves ischemic stroke recovery in an HIF dependent manner

Lexiao Li, Pamela Saliba, Stefan Reischl, Hugo H. Marti, Reiner Kunze

Neurobiology of Disease (Elsevier) Germany, 19 March 2016

Neuroscience

Key words:PHD2, HIF, neuron, focal cerebral ischemia, hypoxia, VEGF, angiogenesis

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

565
Unfractionated bone marrow cells attenuate paraquat-induced glomerular injury and acute renal failure by modulating the inflammatory response

SY Gu, TY Yeh, SY Lin, FC Peng

Scientific Reports (Nature) Taiwan, 18 March 2016

Nephrology

Key words:Acute kidney injury, Bone marrow transplantation

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Injury

566
High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease

S Kapoor, D Rodriguez, K Mitchell, RP Wüthrich

Kidney and Blood Pressure Research (Karger) Switzerland, 17 March 2016

Nephrology

Key words:High resolution diagnostic imaging, Total cyst volume, Polycystic kidney disease, PCK rat, Total kidney volume

Organism: Rat

Tissue: Kidney

Pathological State: Polycystic Kidney Disease

567
Efficient generation of smooth muscle cells from adipose-derived stromal cells by 3D mechanical stimulation can substitute the use of growth factors in vascular tissue engineering

Mojtaba Parvizi, Lydia A.M. Bolhuis-Versteeg, Andrá A. Poot, Martin C. Harmsen

Biotechnology Journal (Wiley) The Netherlands, 15 March 2016

Tissue Engineering

Key words:Adipose tissue-derived stromal cells (ASC), poly(1,3-trimethylene carbonate) (PTMC), smooth muscle cells (SMC), transforming Growth Factor beta 1 (TGF-ß1), vascular tissue engineering

Organism: Human

Cell Line: HUVECs, ASC (Human umbilical vein endothelial cells, Adipose tissue derived stromal cells)

568
Internalization of nanopolymeric tracers does not alter characteristics of placental cells

Paolo Bigini, Elisa R. Zanier, Silvia Saragozza, Simona Maciotta, Pietro Romele, Patrizia Bonassi Signoroni, Antonietta Silini, Francesca Pischiutta, Eliana Sammali, Claudia Balducci, Martina B. Violatto, Laura Talamini, David Garry, Davide Moscatelli, Raffaele Ferrari, Mario Salmona, Maria Grazia De Simoni, Federico Maggi, Giuseppe Simoni, Francesca Romana Grati, Ornella Parolini

Journal of Cellular and Molecular Medicine (Wiley) Italy, 14 March 2016

Cell Biology

Key words:Cell tracing, nanoparticles, mesenchymal stem/stromal cells, placenta, amnion, chorion, hypoxia, ischaemia

Organism: Human

Tissue: Placenta

569
OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia

Taizou Hirano, Toshiaki Kikuchi, Naoki Tode, Arif Santoso, Mitsuhiro Yamada, Yoshiya Mitsuhashi, Riyo Komatsu, Takeshi Kawabe, Takeshi Tanimoto, Naoto Ishii, Yuetsu Tanaka, Hidekazu Nishimura, Toshihiro Nukiwa, Akira Watanabe, Masakazu Ichinose

EMBO Molecular Medicine (Wiley) Japan, 14 March 2016

Pathology

Key words:Bronchioles, glycosylation regeneration, OX40 ligand, viral pneumonia

Organism: Dog

Pathological State: Virus Infection

Cell Line: MDCK cells

570
In primary Sjögren's syndrome high absolute numbers and proportions of B cells in parotid glands predict responsiveness to rituximab as defined by ESSDAI, but not by SSRI

Konstantina Delli, Erlin A Haacke, Frans GM Kroese, Rodney P Pollard, Stephan Ihrler, Bert van der Vegt, Arjan Vissink, Hendrika Bootsma, Frederik KL Spijkervet

Annals of the Rheumatic Diseases (BMJ Journals) The Netherlands, 09 March 2016

Rheumatology

Key words:Sjogren's syndrome, b cells, parotide glands, rituximab

Organism: Human

Tissue: Salivary Gland

Pathological State: Sjögren's Syndrome

571
Acquisition of chemoresistance and other malignancy-related features of colorectal cancer cells are incremented by ribosome-inactivating stress

CK Oh, SJ Lee, SH Park, Y Moon

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) South Korea, 09 March 2016

Oncology

Key words:Ribosome-inactivating stress (RIS); Colorectal cancer; Activating transcription factor 3 (ATF3); Macrophage inhibitory cytokine-1 (MIC-1); Chemosensitivity

Organism: Mouse

Tissue: Allograft Tumor, Colon

Pathological State: Cancer

572
Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach

Anastasia Meshcheryakova, Martin Svoboda, Ammar Tahir, Harald C. Köfeler, Alexander Triebl, Felicitas Mungenast, Georg Heinze, Christopher Gerner, Philip Zimmermann, Markus Jaritz, and Diana Mechtcheriakova

Oncotarget (Impact Journals) Austria, Switzerland, 07 March 2016

Oncology

Key words:sphingolipid-related targets, sphingosine 1-phosphate/ceramide rheostat, multigene signature, epithelial to mesenchymal transition, lung cancer

Organism: Human

Pathological State: Cancer

Cell Line: Lung adenocarcinoma epithelial cell line A549

573
Intrathecal transplantation of embryonic stem cell-derived spinal GABAergic neural precursor cells attenuates neuropathic pain in a spinal cord injury rat model

Insik Hwang, Suk-Chan Hahm Suk-Chan Hahm, Kyung-Ah Choi, Sung-Ho Park, Hyesun Jeong, Ji-Hye Yea, Junesun Kim, Ph.D., Sunghoi Hong, Ph.D.

Cell Transplantation (SAGE Journals) South Korea, 01 March 2016

Regenerative Medicine

Key words:Spinal cord injury (SCI), Neuropathic pain, Spinal GABAergic neurons, Intrathecal transplantation

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

574
Platelet-rich plasma influences expansion and paracrine function of adipose-derived stromal cells in a dose-dependent fashion

Willemsen, Joep C. N.; Spiekman, Maroesjka; Stevens, H. P. Jeroen; van der Lei, Berend; Harmsen, Martin C.

Plastic and Reconstructive Surgery (Ingentaconnect) The Netherlands, 01 March 2016

Regenerative Medicine

Organism: Human

Tissue: Adipose Tissue

575
Double Linear Gradient Biointerfaces for Determining Two-Parameter Dependent Stem Cell Behavior

Patrick Van Rijn, Philipp Kuhn, Qihui Zhou, Torben Van Der Boon, Aneta Schaap-Oziemlak, Theo Van Kooten

ChemNanoMat (Wiley) The Netherlands, 26 February 2016

Biological Methods

Key words:Biointerfaces, gradients, stem cell, wettability, stiffness

Organism: Human

Cell Line: Mesenchymal stem cells from human bone marrow (hBM-MSCs)

576
Fenretinide: a potential treatment for endometriosis

Mary Ellen Pavone, Saurabh S. Malpani, Matthew Dyson, J. Julie Kim, Serdar E. Bulun

Reproductive Sciences (SAGE Journals) USA, 25 February 2016

Reproductive Medicine

Key words:endometriosis, fenretinide, apoptosis, retinol, retinoid, STRA6, retinoic acid

Organism: Mouse

Tissue: Endometrium

Pathological State: Endometriosis

577
Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice

Eva Bauer, Michaela Schlederer, Ruth Scheicher, Jaqueline Horvath, Petra Aigner, Ana-Iris Schiefer, Renate Kain, Heinz Regele, Gregor Hoermann, Günter Steiner, Lukas Kenner, Veronika Sexl, Andreas Villunger, Richard Moriggl, and Dagmar Stoiber

Oncotarget (Impact Journals) Austria, 23 February 2016

Oncology

Key words:ETV6/RUNX1, BCL2, glomerulonephritis, lymphoma, autoimmunity, Immunology and Microbiology Section, Immune response, Immunity

Organism: Mouse

Tissue: Kidney

578
In situ analysis of intrahepatic virological events in chronic hepatitis B virus infection

Xiaonan Zhang, Wei Lu, Ye Zheng, Weixia Wang, Lu Bai, Liang Chen, Yanling Feng, Zhanqing Zhang, and Zhenghong Yuan

The Journal of Clinical Investigation (American Society for Clinical Investigation) China, 22 February 2016

Virology

Key words:intrahepatic virological events, chronic hepatitis B virus infection

Organism: Human

Tissue: Liver

Pathological State: Virus Infection

579
In EXOG-depleted cardiomyocytes cell death is marked by a decreased mitochondrial reserve capacity of the electron transport chain

Wardit Tigchelaar, Anne Margreet De Jong, Wiek H. van Gilst, Rudolf A. De Boer, Herman H.W. Silljé

Inside the Cell (Wiley) The Netherlands, 18 February 2016

Cell Biology

Key words:Cardiomyocyte, cell death, EXOG, hypertrophy, mitochondria

Organism: Rat

Cell Line: NRVC cells ( neonatal rat ventricular cardiomyocytes )

580
Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies

M Sips, M Krykbaeva, T J Diefenbach, M Ghebremichael, B A Bowman, A-S Dugast, A W Boesch, H Streeck, D S Kwon, M E Ackerman, T J Suscovich, P Brouckaert, T W Schacker and G Alter

Mucosal Immunology (Nature) USA, Belgium, Germany, 17 February 2016

Key words:Cell signalling, HIV infections, Phagocytosis, Vaccines

581
Aging has small effects on initial ischemic acute kidney injury development despite changing intrarenal immunologic micromilieu in mice

Hye Ryoun Jang, Ji Hyeon Park, Ghee Young Kwon, Jae Berm Park, Jung Eun Lee, Dae Joong Kim, Yoon-Goo Kim, Sung Joo Kim, Ha Young Oh, Wooseong Huh

American Journal of Physiology (APS Journals) South Korea, 15 February 2016

Physiology

Key words:Aging, ischemic, kidney injury, immunologic, micromilieu

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Injury

582
The in vitro response of tissue stem cells to irradiation with different LETs

Peter W. Nagle, Nynke A. Hosper, Emily M. Ploeg, Marc-Jan van Goethem, Sytze Brandenburg, Johannes A. Langendijk, Roland K. Chiu, Robert P. Coppes

International Journal of Radiation Oncology (Elsevier) The Netherlands, 12 February 2016

Oncology

Key words:In vitro, tissue stem cells, irradiantion, LETs

Organism: Human

Cell Line: HSG cells (human salivary gland cells)

583
Far-infrared promotes burn wound healing by suppressing NLRP3 inflammasome caused by enhanced autophagy

Hui-Wen Chiu, Cheng-Hsien Chen, Jen-Ning Chang, Chien-Hsiung Chen, Yung-Ho Hsu

Journal of Molecular Medicine (Springer) Taiwan, 11 February 2016

Regenerative Medicine

Key words:Far-infrared, burn wound healing, autophagy NLRP3 inflammasome

Organism: Rat

Tissue: Skin

Pathological State: Burn Wound

584
Serum Autoantibodies in Chronic Prostate Inflammation in Prostate Cancer Patients

Bettina Schlick, Petra Massoner, Angelika Lueking, Pornpimol Charoentong, Mirjam Blattner, Georg Schaefer, Klaus Marquart, Carmen Theek, Peter Amersdorfer, Dirk Zielinski, Matthias Kirchner, Zlatko Trajanoski, Mark A. Rubin, Stefan Müllner, Peter Schulz-Knappe, Helmut Klocker

PLOS ONE (PLOS) Austria, 10 February 2016

Oncology

Key words:Prostate cancer, autoantibodies, inflammation, prostate gland, inflammatory diseases, microarrays, prostate diseases, radical prostatectomy

Organism: Human

Tissue: Prostate

Pathological State: Cancer

585
Acquisition of tumorigenic potential and enhancement of angiogenesis in pulmonary stem/progenitor cells through Oct-4 hyperexpression

SY Gu, CC Ho, YK Huang, HW Chen, YC Wang, CY Kuo, SC Teng, WM Fu, PC Yang, CW Wu, FC Peng, TY Ling

Oncotarget (Impact Journals) Taiwan, 09 February 2016

Oncology

Key words:pulmonary stem/progenitor cells, cancer initiating cells, Oct-4, angiogenesis, angiopoietins/Tie2

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

586
MINI ORAL SESSIONS (MINI38.12 Multiplex Immunofluorescence Identifies Differences in Immune Microenvironment and Prognostic Biomarkers between Mesothelioma Subtypes)

Tanguy Seiwert, Stephanie Mcgregor, Chengyi Shu, Igor Feldman, Tong Zi, Zhixiang Zuo, Arun Khattri, Aliya Husain, Hadi Duraid, Wickii T. Vigneswaran,Thomas N. Krausz, Sriram Sathyanarayanan, Hedy Lee Kindle

Journal of Thoracic Oncology (Elsevier) USA, 05 February 2016

Oncology

Key words:Multiplex immunofluorescence, immmune microenvironment, biomarkers, mesothelioma

Organism: Human

Tissue: Mesothelium

Pathological State: Cancer

587
Oxytocin promotes functional coupling between paraventricular nucleus and both sympathetic and parasympathetic cardioregulatory nuclei

Jason R. Yee, William M. Kenkel, Jessie L. Frijling, Sonam Dodhia, Kenneth G. Onishi, Santiago Tovar, Maha J. Saber, Gregory F. Lewis, Wensheng Liu, Stephen W. Porges C. Sue Carter

Hormones and Behavior (Elsevier) USA, 04 February 2016

Endocrinology

Key words:Oxytocin, functional coupling, paraventricular nucleus, cardioregulatory nuclei

Organism: Mouse

Tissue: Brain

588
Characterizing Villitis of Unknown Etiology and Inflammation in Stillbirth

Hayley Derricott, Rebecca L. Jones, Susan L. Greenwood, Gauri Batra, Margaret J. Evans, Alexander E.P. Heazell

The American Journal of Pathology (Elsevier) UK, 03 February 2016

Reproductive Medicine

Key words:Villitis, inflammation, stillbirth

Organism: Human

Tissue: Placenta

Pathological State: Villitis 

589
Prevention of SHIV transmission by topical IFN-β treatment

RS Veazey, HA Pilch-Cooper, TJ Hope, G Alter, AM Carias, M Sips, X Wang, B Rodriguez, SF Sieg, A Reich, P Wilkinson, MJ Cameron and MM Lederman

Mucosal Immunology (Nature) USA, 03 February 2016

Virology

Key words:Drug therapy, HIV infections, Mucosal immunology, Viral transmission

Organism: Monkey

Tissue: Uterus

Pathological State: Virus Infection

590
Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer

Maartje C.A. Wouters, Fenne L. Komdeur1, Hagma H. Workel, Harry G. Klip, Annechien Plat, Neeltje M. Kooi, G. Bea A. Wisman, Marian J.E. Mourits, Henriette J.G. Arts, Maaike H.M. Oonk, Refika Yigit, Steven de Jong, Cornelis J.M. Melief, Harry Hollema, Evelien W. Duiker, Toos Daemen, Marco de Bruyn, Hans W. Nijman

Clinical Cancer Research (High Wire) The Netherlands, 01 February 2016

Oncology

Key words:T-cell diferentiation, tumor-infiltrating lymphocytes, serous ovarian cancer

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

591
FGF2 inhibits endothelial–mesenchymal transition through microRNA-20a-mediated repression of canonical TGF-ß signaling

Ana C. P. Correia, Jan-Renier A. J. Moonen, Marja G. L. Brinker, Guido Krenning

Journal of Cell Science (The Company of Biologists) The Netherlands, 01 February 2016

Cell Biology

Key words:Endothelial–mesenchymal transition, microRNA-20a-mediated repression, canonical TGF-β signaling

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

592
Infiltration of lymphocyte subpopulations into cancer microtissues as a tool for the exploration of immunomodulatory agents and biomarkers

Stefan Koeck , Marit Zwierzina, Julia M. Huber, Mario Bitsche, Edith Lorenz, Gabriele Gamerith, Jozsef Dudas, Jens M. Kelm, Heinz Zwierzina, Arno Amann

Immunobiology (Elsevier) Austria, Switzerland, 01 February 2016

Immunology

Key words:3D, biomarker, co-culture, cancer, immune cells, infiltration, subpopulation

Organism: Human

Pathological State: Cancer

Cell Line: A549, Colo699, Calu-6 cells (human non-small-cell lung cancer cell lines)

593
Injectable extracellular matrix hydrogels as scaffolds for spinal cord injury repair

Dmitry Tukmachev, Serhiy Forostyak, Zuzana Koci, Kristyna Zaviskova, Irena Vackova, Karel Vyborny, Ioanna Sandvig, Axel Sandvig, Christopher J. Medberry, Stephen F. Badylak, Eva Sykova, and Sarka Kubinova

Tissue Engineering Part A (Mary Ann Liebert Inc.) Czech Republic, Norway, UK, Sweden, USA, 28 January 2016

Tissue Engineering

Key words:spinal cord injury; hydrogel; extracellular matrix; scaffold; tissue engineering; stem cells

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

594
Amelioration of Experimental Autoimmune Arthritis Through Targeting of Synovial Fibroblasts by Intraarticular Delivery of MicroRNAs 140-3p and 140-5p

Jia-Shiou Peng, Shih-Yao Chen, Chao-Liang Wu, Hao-Earn Chong, Yun-Chiao Ding, Ai-Li Shiau, Chrong-Reen Wang

Arthritis and Rheumatology (Wiley) Taiwan, 25 January 2016

Rheumatology

Key words:Autoimmune arthritis, synovial fibroblasts, MicroRNAs

Organism: Mouse

Tissue: Joint

Pathological State: Rheumatoid Arthritis

595
Fumaric acid esters promote neuronal survival upon ischemic stress through activation of the Nrf2 but not HIF-1 signaling pathway

Jiemeng Lin-Holderer, Lexiao Li, Daniel Gruneberg, Hugo H. Marti, Reiner Kunze

Neuropharmacology (Elsevier) Germany, 19 January 2016

Neuroscience

Key words:Dimethyl fumarate, monomethyl fumarate, fumaric acid esters, Nrf2, HIF, ischemia

Organism: Mouse

Tissue: Brain

596
Novel technologies and emerging biomarkers for personalized cancer immunotherapy

Jianda Yuan, Priti S. Hegde, Raphael Clynes, Periklis G. Foukas, Alexandre Harari, Thomas O. Kleen, Pia Kvistborg, Cristina Maccalli, Holden T. Maecker, David B. Page, Harlan Robins, Wenru Song, Edward C. Stack, Ena Wang, Theresa L. Whiteside, Yingdong Zhao, Heinz Zwierzina, Lisa H. Butterfield and Bernard A. Fox

Journal for ImmunoTherapy of Cancer (Springer) Qatar, USA, Switzerland, Greece, Germany, The Netherlands, Italy, Austria, 19 January 2016

Oncology

Key words:Immune checkpoint blockade, Cancer immunotherapy, Biomarkers, Task Force, Immune monitoring, Technology, Bioinformatics

Organism: Human

Pathological State: Cancer

597
Software-assisted morphometric and phenotype analyses of human peripheral blood monocyte-derived macrophages induced by a microenvironment model of human esophageal squamous cell carcinoma

Mari Nishio, Naoki Urakawa, Manabu Shigeoka, Nobuhisa Takase, Yumi Ichihara, Noriaki Arai, Yu-ichiro Koma, Hiroshi Yokozaki

Pathology International (Wiley) Japan, 18 January 2016

Pathology

Key words:Esophageal cancer, image analysis, macrophages, tumor microenvironment

Organism: Human

Cell Line: PBMCs (Peripheral blood mononuclear cells )

598
Energy landscapes and functions of supramolecular systems

Faifan Tantakitti, Job Boekhoven, Xin Wang, Roman V. Kazantsev, Tao Yu, Jiahe Li, Ellen Zhuang, Roya Zandi, Julia H. Ortony, Christina J. Newcomb, Liam C. Palmer, Gajendra S. Shekhawat, Monica Olvera de la Cruz, George C. Schatz and Samuel I. Stupp

Nature Materials (Nature) USA, 18 January 2016

Biological Materials

Key words:Bioinspired materials, Materials science

Organism: Mouse

Cell Line: C2C12 Mouse pre-myoblasts

599
Towards personalised treatment in primary Sjögren's syndrome: baseline parotid histopathology predicts responsiveness to rituximab treatment

Konstantina Delli, Erlin A Haacke, Frans G M Kroese, Rodney P Pollard, Stephan Ihrler, Bert van der Vegt, Arjan Vissink, Hendrika Bootsma, Frederik K L Spijkervet

Annals of the Rheumatic Diseases (High Wire) The Netherlands, Germany, 15 January 2016

Rheumatology

Key words:Sjögren's syndrome, parotid histopathology, responsiveness to rituximab treatment

Organism: Human

Tissue: Parotid Gland

Pathological State: Sjögren's Syndrome

600
Low birth weight associates with hippocampal gene expression

J.P. Buschdorf, M.L. Ong, S.X. Ong, J.L. MacIsaac, K. Chng, M.S. Kobor, M.J. Meaney, J.D. Holbrook

Neuroscience (Elsevier) Singapore, Canada, 12 January 2016

Neuroscience

Key words:Low birth weight, hippocampus, DNA methylation, mental disorders, microarray

Organism: Monkey

Tissue: Brain

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