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Customer Publications (A total of 1249 papers published)

401
TRPV1 attenuates intracranial arteriole remodeling through inhibiting VSMC phenotypic modulation in hypertension

MJ Zhang, Y Liu, ZC Hu, Y Zhou, Y Pi, L Guo, X Wang, X Chen, JC Li, LL Zhang

Histochemistry and Cell Biology (Springer) China, 24 October 2016

Cardiology

Key words:TRPV1, Intracranial arteriole, VSMC, Phenotypic modulation, Hypertension

Organism: Mouse, Rat

Tissue: Blood Vessels, Brain

402
Oncolytic influenza A virus expressing interleukin-15 decreases tumor growth in vivo 

Karin Hock, Johannes Laengle, Irina Kuznetsova,Andrej Egorov, Balazs Hegedus, Balazs Dome, Thomas Wekerle, Monika Sachet, Michael Bergmann

Surgery (Elsevier) Austria, 21 October 2016

Immunology

Key words:Interleukin-15, A virus, T cells,

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

403
The fractionation of adipose tissue procedure to obtain stromal vascular fractions for regenerative purposes

Joris A. van Dongen,Hieronymus P. Stevens ,Mojtaba Parvizi ,Berend van der Lei ,Martin C. Harmsen

Wound Repair and Regeneration (Wiley) The Netherlands, 21 October 2016

Regenerative Medicine

Key words:Autologous adipose tissue transplantation, FAT-stromal vascular fraction

Organism: Human

Cell Line: Smooth muscle cells

404
Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury

Jill Moser, Joris van Ark, Marcory C. van Dijk, Dale L. Greiner, Leonard D. Shultz, Harry van Goor & Jan-Luuk Hillebrands

Scientific Reports (Nature) USA, The Netherlands, 19 October 2016

Cardiology

Key words:NOD.Cg-PrkdcscidIL2rgtm1Wjl(NSG), Percutaneous coronary interventions (PCIs), BL/6 mice

Organism: Human

Cell Line: Peripheral blood mononuclear cell

405
Aberrant expression of tumor-associated carbohydrate antigen Globo H in thyroid carcinoma

Shih-Ping Cheng ,Po-Sheng Yang ,Ming-Nan Chien ,Ming-Jen Chen ,Jie-Jen Lee ,Chien-Liang Liu

Journal of Surgical Oncology (Wiley) Taiwan, 18 October 2016

Oncology

Key words:Globo H - hexasaccharide glycosphingolipid, Normal or benign thyroid, papillary thyroid cancer

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

406
Oncostatin M‐preconditioned mesenchymal stem cells alleviate bleomycin‐induced pulmonary fibrosis through paracrine effects of the hepatocyte growth factor

Ying‐Wei Lan, Si‐Min Theng, Tsung‐Teng Huang, Kong‐Bung Choo, Chuan‐Mu Chen, Han‐Pin Kuo, Kowit‐Yu Chong

Stem Cells Translational Medicine (Wiley) Taiwan, Malaysia, 18 October 2016

Stem Cell Research

Key words:Bleomycin-induced pulmonary fibrosis; Hepatocyte growth factor; Oncostatin M; Preconditioning; Stem cells

Organism: Mouse

Tissue: Lung

Pathological State: Fibrosis

407
In Situ Characterization of Tissue-Resident Immune Cells by MALDI Mass Spectrometry Imaging

Matthias Holzlechner, Katharina Strasser, Elitsa Zareva, Luise Steinhäuser, Hanna Birnleitner, Andrea Beer, Michael Bergmann, Rudolf Oehler, and Martina Marchetti-Deschmann

Journal of Proteome (ACS Publications) Austria, 18 October 2016

Immunology

Key words:Colon tissue, immune cells, immunohistochemistry, lymphocytes, macrophages, MALDI mass spectrometry imaging, monocytes

Organism: Human

Tissue: Colon

408
Ustekinumab treatment in severe atopic dermatitis: Down-regulation of T-helper 2/22 expression 

Doris Weiss, Michaela Schaschinger, Robin Ristl, Robert Gruber, Tamara Kopp, Georg Stingl, Christine Bangert

Journal of the American Academy of Dermatology (Elsevier) Austria, 13 October 2016

Dermatology

Key words:Anti-interleukin-12/-23 p40, atopic dermatitis, cytokines, eczema, inflammatory, T helper 2, T helper 17, T helper 22, ustekinumab

Organism: Human

Tissue: Skin

Pathological State: Dermatitis

409
Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Tahereh Javaheri, Zahra Kazemi, Jan Pencik, Ha TT Pham, Maximilian Kauer, Rahil Noorizadeh, Barbara Sax, Harini Nivarthi, Michaela Schlederer, Barbara Maurer, Maximillian Hofbauer, Dave NT Aryee, Marc Wiedner, Eleni M Tomazou, Malcolm Logan, Christine Har

Cell Death & Disease (Nature) Austria, UK, Germany, 13 October 2016

Oncology

Key words:Apoptosis, Bone cancer, Cell signalling, Sarcoma

Organism: Mouse

Tissue: Whole Organism

410
Intraarticular overexpression of Smad7 ameliorates experimental arthritis

Shih-Yao Chen, Ai-Li Shiau, Chao-Liang Wu & Chrong-Reen Wang

Scientific Reports (Nature) Taiwan, 12 October 2016

Immunology

Key words:Genetic vectors, Translational immunology

Organism: Human

Tissue: Synovial Membrane

411
Hydroxyapatite thin films grown by pulsed laser deposition and matrix assisted pulsed laser evaporation: Comparative study

G. Popescu-Pelin, F. Sima, L.E. Sima, C.N. Mihailescu, C. Luculescu, I. Iordache, M. Socol, G. Socol, I.N. Mihailescu

Applied Surface Science (Elsevier) Romania, 11 October 2016

Tissue Engineering

Key words:Pulsed laser deposition, Matrix assisted pulsed laser evaporation, Hydroxyapatite coatings, Biocompatibility, Cell proliferation and differentiation

Organism: Human

Cell Line: MSCs (mesenchymal stem cells)

412
G-CSF-mobilized Bone Marrow Mesenchymal Stem Cells Replenish Neural Lineages in Alzheimer’s Disease Mice via CXCR4/SDF-1 Chemotaxis

Cheng-Chun WuI-Fang Wang, Po-Min Chiang, Liang-Chao Wang, Che-Kun James Shen, Kuen-Jer Tsai

Molecular Neurobiology (Springer) Taiwan, 05 October 2016

Neuroscience

Key words:G-CSF, Bone marrow stem cells, SDF-1CXCR4, Neurogenesis, Alzheimer’s disease

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s Disease

413
Neuronal prolyl-4-hydroxylase 2 deficiency improves cognitive abilities in a murine model of cerebral hypoperfusion

Daniel Gruneberg, Felipe A. Montellano, Konstanze Plaschke, Lexiao Li, Hugo H. Marti, Reiner Kunze

Experimental Neurology (Elsevier) Germany, 05 October 2016

Neuroscience

Key words:HIF, PHD, Epo, VEGF, Hippocampus, Learning, Memory, Alzheimer's disease

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Hypoperfusion

414
Epithelial cholesterol deficiency attenuates human antigen R-linked pro-inflammatory stimulation via SREBP2-linked circuit

SH Park, J Kim, M Yu, JH Park, YS Kim…

Journal of Biological Chemistry (ASBMB) South Korea, 04 October 2016

Gastroenterology

Key words:cholesterol regulation, inflammation, intestinal epithelium, intestinal metabolism, intestine, mRNA decay

Organism: Mouse, Human

Tissue: Colon

Pathological State: Colitis

415
Houttuynia cordata Thunb Promotes Activation of HIF-1A–FOXO3 and MEF2A Pathways to Induce Apoptosis in Human HepG2 Hepatocellular Carcinoma Cells

Jung Min Kim, In-Hu Hwang, Ik-Soon Jang, Min Kim, In Seok Bang, Soo Jung Park, Yun-Jo Chung, Jong-Cheon Joo, Min-Goo Lee

Integrative Cancer Therapies (SAGE Journals) South Korea, 03 October 2016

Oncology

Key words:Cancer, cell apoptosis, hypoxia-inducible factor (HIF)-1A

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

416
Hyperglycemia induces bioenergetic changes in adipose-derived stromal cells while their pericytic function is retained

Ghazaleh Hajmousa, Alvaro A. Elorza, Vera J.M. Nies, Erik L. Jensen, Ruxandra A. Nagy, and Martin C. Harmsen

Stem Cells and Development (Mary Ann Libert) The Netherlands, Chile, 01 October 2016

Stem Cell Research

Key words:Adipose Derived Stromal Cells, Diabetic Retinopathy, Pericyte, Hyperglycemia

Organism: Human

Cell Line: Adipose-tissue derived stromal cells (ASC)

417
NSAID-activated gene 1 mediates pro-inflammatory signaling activation and paclitaxel chemoresistance in type I human epithelial ovarian cancer stem-like …

KH Kim, SH Park, KH Do, J Kim, KU Choi, Y Moon

Histochemistry and cell … (NCBI) South Korea, 30 September 2016

Oncology

Key words:NAG-1, epithelial ovary cancer, paclitaxel, NF-κB, chemoresistance

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

418
Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

Caroline Guglielmetti,Debbie Le Blon, Eva Santermans, Angelica Salas-Perdomo, Jasmijn Daans, Nathalie De Vocht, Disha Shah, Chloé Hoornaert, Jelle Praet, Jurgen Peerlings, Firat Kara, Christian Bigot, Zhenhua Mai, Herman Goossens, Niel Hens, Sven Hendrix,

GLIA (Wiley) Belgium, 29 September 2016

Neuroscience

Key words:IL-13, microglia, macrophages, severe oligodendrocyte loss and demyelination, mouse nodel

Organism: Mouse

Tissue: Brain

Pathological State: Demyelination

419
Comparison of cancer cells cultured in 2D vs 3D reveals differences in AKT/mTOR/S6-kinase signaling and drug response

Angelika Riedl, Michaela Schlederer, Karoline Pudelko, Mira Stadler, Stefanie Walter, Daniela Unterleuthner, Christine Unger, Nina Kramer, Markus Hengstschläger, Lukas Kenner, Dagmar Pfeiffer, Georg Krupitza, Helmut Dolznig

Journal of Cell Science (The Company of Biologists) Austria, 23 September 2016

Oncology

Key words:Cancer cells, colon cancer, AKT/mTOR/S6-kinase, ERK phosphorylation

Organism: Human

Cell Line: LS174T, HT29, SW620, HCT116), Caco-2 and DLD-1 (Human colon cancer cell lines)

420
Targeted multimodal nano-reporters for pre-procedural MRI and intra-operative image-guidance

Joonseok Lee, Andrew C. Gordon, Hacksung Kim, Wooram Park, Soojeong Cho, Byeongdu Lee, Andrew C. Larson, Elena A. Rozhkova, Dong-Hyun Kim

Biomaterials (Elsevier) USA, 19 September 2016

Medical Imaging

Key words:Upconversion nanoparticles, Medical imaging, Cancer, Interventional radiology, Multimodal probe

Organism: Rat

Tissue: Heart, Liver, Spleen, Lung, Kidney

421
CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer …

Fenne L. Komdeur, Maartje C.A. Wouters, Hagma H. Workel, Aline M. Tijans, Anouk L.J. Terwindt, Kim L. Brunekreeft, Annechien Plat, Harry G. Klip, Florine A. Eggink, Ninke Leffers, Wijnand Helfrich, Douwe F. Samplonius, Edwin Bremer, G. Bea A. Wisman, Toos

Oncotarget (NCBI) The Netherlands, 16 September 2016

Oncology

Key words:tumor-infiltrating lymphocytes, high-grade serous ovarian cancer, CD103, TGF-β, cancer immunotherapy

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

422
Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma

Seunggu J. Han, Gerald Reis, Gary Kohanbash, Shruti Shrivastav, Stephen T. Magill, Annette M. Molinaro, Michael W. McDermott, Philip V. Theodosopoulos, Manish K. Aghi, Mitchel S. Berger, Nicholas A. Butowski, Igor Barani, Joanna J. Phillips, Arie Perry, H

Journal of Neuro-Oncology (Springer) USA, 13 September 2016

Neuroscience

Key words:Meningioma, PD-L1, B7-H1, Immunotherapy, Checkpoint, Lymphocyte, Macrophage

Organism: Human

Tissue: Brain

Pathological State: Cancer

423
Paricalcitol attenuates cardiac fibrosis and expression of endothelial cell transition markers in isoproterenol-induced cardiomyopathic rats

CC Lai, CP Liu, PW Cheng, PJ Lu, M Hsiao, WH Lu, GC Sun, JC Liou, CJ Tseng

Critical Care Medicine (Ingentaconnect) Taiwan, 09 September 2016

Cardiology

Key words:cardiac fibrosis; cardiomyopathy; endothelial-to-mesenchymal cell transition; vitamin D activator

Organism: Rat

Tissue: Heart

Pathological State: Fibrosis

424
The effects of oral and topical corticosteroid in rabbit corneas

Kaoru Araki-Sasaki, Osamu Katsuta, Hidetoshi Mano, Takashi Nagano and Masatsugu Nakamura

BMC Ophthalmology (BioMed Central) Japan, 05 September 2016

Ophthalmology

Key words:Corticosteroid, Keratitis, Cornea, Wound healing, Pharmacokinetics

Organism: Rabbit

Tissue: Eye

Pathological State: Skin Wound

425
Presentation of underglycosylated mucin 1 in pancreatic adenocarcinoma (PDAC) at early stages

ST Lo, P Pantazopouos, Z Medarova, A Moore

American Journal of Cancer Research (NCBI) USA, 01 September 2016

Oncology

Key words:Pancreatic cancer, underglycosylated mucin 1, tumor antigen, immunohistochemistry

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

426
Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation

Yong-Hee Rhee, Sang-Hoon Yi, Joo Yeon Kim, Mi-Yoon Chang, A-Young Jo, Jinyoung Kim, Chang-Hwan Park, Je-Yoel Cho, Young-Jin Choi, Woong Sun & Sang-Hun Lee

Scientific Reports (Nature) South Korea, 24 August 2016

Neuroscience

Key words:Neurology, neural stem cells, Raf-Erk pathway, radial glial cells

Organism: Mouse

Tissue: Brain

427
Degradation of Kidney and Psoas Muscle Proteins as Indicators of Post-Mortem Interval in a Rat Model, with Use of Lateral Flow Technology

Dong-Gi Lee, Kyeong Eun Yang, Jeong Won Hwang, Hwan-Soo Kang, Seung-Yeul Lee, Seoyeon Choi, Joonchul Shin, Ik-Soon Jang, Hyun Joo An, Heesun Chung, Hyo-Il Jung , Jong-Soon Choi

PLOS ONE (PLOS) South Korea, 23 August 2016

Forensic Science

Key words:Post-mortem interval (PMI) markers, kidney, muscle, GAPDH

Organism: Rat

Tissue: Kidney, Muscle

428
Toward the Automated Detection and Characterization of Osteoclasts in Microscopic Images

Andreas Heindl , Martin Schepelmann, Robert Nica, Rupert Ecker, Peter Pietschmann, Alexander K. Seewald, Theresia Thalhammer, Isabella Ellinger

Principles of Osteoimmunology (Springer) Austria, 19 August 2016

Medical Image Analysis

Key words:Osteoimmunology, microscopes, biological samples, automated image segmentation and analysis

429
Dynamic Modulation of Microglia/Macrophage Polarization by miR-124 after Focal Cerebral Ischemia

Somayyeh Hamzei Taj, Widuri Kho, Markus Aswendt, Franziska M. Collmann, Claudia Green, Joanna Adamczak, Annette Tennstaedt, Mathias Hoehn

Journal of Neuroimmune Pharmacology (Springer) Germany, 18 August 2016

Neuroscience

Key words:Stroke, Microglia/macrophage polarization, Pro-inflammatory and anti-inflammatory phenotypes, miRNA-124, Neuroinflammation

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

430
LIN28A enhances the therapeutic potential of cultured neural stem cells in a Parkinson’s disease model

Yong-Hee Rhee, Tae-Ho Kim, A-Young Jo, Mi-Yoon Chang, Chang-Hwan Park, Sang-Mi Kim, Jae-Jin Song, Sang-Min Oh, Sang-Hoon Yi, Hyeon Ho Kim, Bo-Hyun You, Jin-Wu Nam, Sang-Hun Lee

Brain: A journal of neurology (Oxford Journals) South Korea, 18 August 2016

Neuroscience

Key words:LIN28A, neural stem cell (NSC) culture, repair capacity, Parkinson’s disease

Organism: Rat

Tissue: Brain

Pathological State: Parkinson's Disease

431
The antiviral alkaloid berberine reduces chikungunya virus-induced mitogen-activated protein kinase (MAPK) signaling

Finny S. Varghese, Bastian Thaa, Siti Naqiah Amrun, Diane Simarmata, Kai Rausalu, Tuula A. Nyman, Andres Merits, Gerald M. McInerney2, Lisa F.P. Ng, Tero Ahola

Journal of Virology (ASM) Finland, 17 August 2016

Virology

Key words:Chikungunya virus, non-toxic plant alkaloid berberine, mitogen-activated protein kinase

Organism: Mouse

Tissue: Joint

Pathological State: Virus Infection

432
G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway

Shih-Ting Cha, Ching-Ting Tan, Cheng-Chi Chang, Chia-Yu Chu, Wei-Jiunn Lee, Been-Zen Lin, Ming-Tsan Lin & Min-Liang Kuo

Nature Cell Biology (Nature) Taiwan, 15 August 2016

Oncology

Key words:Colorectal cancer, cancer-initiating cells phenotypes, K-RAS/β-catenin pathway

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

433
Bradykinin promotes neuron-generating division of neural progenitor cells via ERK activation

Micheli M. Pillat, Claudiana Lameu, Cleber A. Trujillo, Talita Glaser, Angélica R. Cappellari, Priscilla D. Negraes, Ana M. O. Battastini, Telma T. Schwindt, Alysson Muotri, Henning Ulrich

Journal of Cell Science (The Company of Biologists) Brasil, 15 August 2016

Neuroscience

Key words:Bradykinin, neurogenesis, TIS21 (PC3/BTG2) expression

Organism: Mouse

Tissue: Brain

434
Prevention of Colitis and Colitis-Associated Colorectal Cancer by a Novel Polypharmacological Histone Deacetylase Inhibitor

Tzu-Tang Wei, Yi-Ting Lin, Ruo-Yu Tseng, Chia-Tung Shun, Yu-Chin Lin, Ming-Shiang Wu, Jim-Min Fang, Ching-Chow Chen

Clinical Cancer Research (AACR) Taiwan, 14 August 2016

Oncology

Key words:Colorectal cancer, colitis, HDAC, HMGR

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

435
Localization of TrkB and p75 receptors in peritoneal and deep infiltrating endometriosis: an immunohistochemical study

Agung Dewanto, Jozsef Dudas, Rudolf Glueckert, Sylvia Mechsner, Anneliese Schrott-Fischer, Ludwig Wildt and Beata Seeber

Reproductive Biology and Endocrinology (Springer) Germany, 12 August 2016

Reproductive Medicine

Key words:Neurotrophins, BDNF, endometriosis, immunohistochemistry

Organism: Human

Tissue: Endometrium

Pathological State: Endometriosis

436
Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3

Bethany Baumann , Tomoko Hayashida, Xiaoyan Liang, H. William Schnaper

Kidney International (Elsevier) USA, 05 August 2016

Physiology

Key words:Fibrosis, glomerulus, hypoxia, TGF-β

Organism: Mouse

Tissue: Kidney

437
Role of the immune system in the peritoneal tumor spread of high grade serous ovarian cancer

Katharina Auer, Anna Bachmayr-Heyda, Nyamdelger Sukhbaatar, Stefanie Aust, Klaus G. Schmetterer, Samuel M. Meier, Christopher Gerner, Christoph Grimm, Reinhard Horvat, and Dietmar Pils

Oncotarget (NCBI) Austria, 03 August 2016

Oncology

Key words:epithelial ovarian cancer, peritoneal tumor spread, flow cytometry, PD-1, next generation sequencing

Organism: Human

Tissue: Peritoneum, Ovaries

Pathological State: Cancer

438
CD271 regulates the proliferation and motility of hypopharyngeal cancer cells

Mai Mochizuki, Keiichi Tamai, Takayuki Imai, Sayuri Sugawara, Naoko Ogama, Mao Nakamura, Kazuto Matsuura, Kazunori Yamaguchi, Kennichi Satoh, Ikuro Sato, Hozumi Motohashi, Kazuo Sugamura, Nobuyuki Tanaka

Scientific Reports (Nature) Japan, 29 July 2016

Oncology

Key words:CD271 (p75 neurotrophin receptor), human hypopharyngeal cancer, head and neck squamous cell carcinoma

Organism: Human

Tissue: Pharynx

Pathological State: Cancer

439
Sur8 mediates tumorigenesis and metastasis in colorectal cancer

Young-Mi Lee, Saluja Kaduwal, Kug Hwa Lee, Jong-Chan Park, Woo-Jeong Jeong, Kang-Yell Choi

Experimental & Molecular Medicine (Nature) South Korea, 29 July 2016

Oncology

Key words:Scaffold protein, Ras-extracellular signal-regulated kinase, doxycyline, HCT116 cells

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

440
Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction

Tim Koopmans, Kuldeep Kumawat, Andrew J Halayko, Reinoud Gosens

Scientific Reports (Nature) The Netherlands, 29 July 2016

Cell Biology

Key words:Airway hyperresponsiveness, asthm, intracellular calcium flux, actin polymerisation

Organism: Human

Cell Line: Bronchial smooth muscle cells

441
Tissue-Resident CD169+ Macrophages Form a Crucial Front Line against Plasmodium Infection

Pravesh Gupta, Si Min Lai, Jianpeng Sheng, Piotr Tetlak, Akhila Balachander, Carla Claser, Laurent Renia, Klaus Karjalainen, Christiane Ruedl

Cell Reports (Elsevier) Singapore, 28 July 2016

Cell Biology

Key words:Plasmodium berghei ANKA, malaria, myeloid cells, macrophages

Organism: Mouse

Tissue: Brain

Pathological State: Bacterial Infection

442
In situ mapping of innate lymphoid cells in human skin: evidence for remarkable differences between normal and inflamed skin

Marie-Charlotte Brüggen, Wolfgang M. Bauer, Bärbel Reininger, Eduard Clim, Catalin Captarencu Georg E. Steiner, Patrick M. Brunner, Barbara Meier, Lars E. French, Georg Sting

Journal of Investigative Dermatology (Elsevier) Austria, Switzerland, Romania, 22 July 2016

Dermatology

Key words:Lymphoid Cells, Human Skin, Inflamed Skin, atopic dermatitis, psoriasis

Organism: Human

Tissue: Skin

Pathological State: Dermatitis, Psoriasis

443
4 – Proffered Paper: Immunological changes during tumor progression from primary to recurrent glioblastoma

C. Herold-Mende, C. Rapp, R. Warta, A. Unterberg, P. Beckhove

European Journal of Cancer (Elsevier) , 14 July 2016

Oncology

Key words:Cancer, tumor, glioblastoma

Organism: Human

Tissue: Brain

Pathological State: Cancer

444
Multimodal Imaging of Nanocomposite Microspheres for Transcatheter Intra-Arterial Drug Delivery to Liver Tumors

Dong-Hyun Kim, Weiguo Li, Jeane Chen, Zhuoli Zhang, Richard M. Green, Sui Huang & Andrew C. Larson

Scientific Reports (Nature) USA, 13 July 2016

Oncology

Key words:Biomedical materials, cancer imaging, hepatic artery, nanotechnology in cancer, targeted therapies

Organism: Rat

Tissue: Xenograft Tumor, Liver

Pathological State: Cancer

445
Quantitative comparison and reproducibility of pathologist scoring and digital image analysis of estrogen receptor β2 immunohistochemistry in prostate cancer

Anthony E. Rizzardi, Xiaotun Zhang, Rachel Isaksson Vogel, Suzanne Kolb, Milan S. Geybels, Yuet-Kin Leung, Jonathan C. Henriksen, Shuk-Mei Ho, Julianna Kwak, Janet L. Stanford, and Stephen C. Schmechel

Diagnostic Pathology (BioMed Central) USA, 11 July 2016

Pathology

Key words:Prostate cancer, Biomarkers, Digital pathology, Quantification, Estrogen receptor β2

Organism: Human

Tissue: Prostate

Pathological State: Cancer

446
Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice

Dominic Schmidt, Daniel Peterlik, Stefan O. Reber, Anja Lechner, Daniela N. Männel

PLOS ONE (PLOS) Germany, 08 July 2016

Neuroscience

Key words:Chronic subordinate colony, myeloid cells, hypothalamus-pituitary-adrenal, sympathetic nervous system

Organism: Mouse

Tissue: Spleen, Allograft Tumor

Pathological State: Cancer

447
Lesional CD4+ IFN-γ+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis

Takashi Maehara, Hamid Mattoo, Miho Ohta, Vinay S Mahajan, Masafumi Moriyama, Masaki Yamauchi, Jefte Drijvers, Seiji Nakamura, John H Stone, Shiv S Pillai

Annals of the Rheumatic Diseases (BMJ) Japan, 29 June 2016

Rheumatology

Key words:IgG4-related disease, T lymphocytes, Sjögren's syndrome,

Organism: Human

Tissue: Salivary Gland

Pathological State: Cancer

448
Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

Hweixian Leong Penny, Je Lin Sieow, Giulia Adriani, Wei Hseun Yeap, Peter See Chi Ee, Boris San Luis, Bernett Lee, Terence Lee, Shi Ya Mak, Ying Swan Ho, Choon Kiat Ong, Ruby Y J Huang, Florent Ginhoux, Olaf Rotzschke, Roger D. Kamm & Siew, Cheng Wong

OncoImmunology (Taylor & Francis) Singapore, 21 June 2016

Oncology

Key words:Metabolism, macrophages, pancreatic cancer, metastasis

Organism: Human

Pathological State: Cancer

Cell Line: HPAF-II (Pancreatic epithelial tumor cell line)

449
ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments

Rick Conzemius, Haleh Ganjian, Dieter Blaas and Renate Fuchs

Journal of Virology (ASM) Austria, 20 June 2016

Virology

Key words:Human rhinovirus A89 (HRV-A89) and HRV-B14, RNA genome, endocytic recycling compartment (ERC)

Organism: Human

Pathological State: Cancer

Cell Line: HeLA cells

450
Validation of tumor protein marker quantification by two independent automated immunofluorescence image analysis platforms

Amy R Peck, Melanie A Girondo, Chengbao Liu, Albert J Kovatich, Jeffrey A Hooke, Craig D Shriver, Hai Hu, Edith P Mitchell, Boris Freydin, Terry Hyslop, Inna Chervoneva and Hallgeir Rui

Modern Pathology (Nature) USA, 17 June 2016

Medical Image Analysis

Key words:Histology, biomarkers, breast tumor

451
Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells

Chen-Chi Liu, Shih-Pei Lin, Han-Shui Hsu, Shung-Haur Yang, Chiu-Hua Lin, Muh-Hwa Yang, Mien-Chie Hung & Shih-Chieh Hung

Nature Communications (Nature) Taiwan, 16 June 2016

Oncology

Key words:Biological sciences, cancer, cell biology

Organism: Human, Mouse

Tissue: Colon, Xenograft Tumor

Pathological State: Cancer

452
A new fluorescence/PET probe for targeting intracellular human telomerase reverse transcriptase (hTERT) using Tat peptide-conjugated IgM

Kyung oh Jung, Hyewon Youn , Seung Hoo Kim, Young-Hwa Kim, Keon Wook Kang, June-Key Chunga

Biochemical and Biophysical Research Communications (Elsevier) South Korea, 15 June 2016

Biological Methods

Key words:Intracellular and intranuclear protein, hTERT, tat peptide, IgM antibody, 64Cu, Live cell imaging

Organism: Human

Pathological State: Cancer

Cell Line: HT29, U2OS cells

453
Ribosome inactivation leads to attenuation of intestinal polymeric Ig receptor expression via differential regulation of human antigen R

KH Do, SH Park, J Kim, M Yu, Y Moon

The Journal of Immunology (American Association of Immunologists) South Korea, 15 June 2016

Immunology

Key words:Ribosome ,Polymeric Ig Receptor ,Differential Regulation, Human Antigen R

Organism: Mouse

Tissue: Small Intestine, Colon

454
Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

Pu-Hyeon Cha, Yong-Hee Cho, Sang-Kyu Lee, JaeHeon Lee, Woo-Jeong Jeong, Byoung-San Moon, Ji-Hye Yun, Jee Sun Yang, Sooho Choi, Juyong Yoon, Hyun-Yi Kim, Mi-Yeon Kim, Saluja Kaduwal, Weontae Lee, Do Sik Min, Hoguen Kim, Gyoonhee Han & Kang-Yell Choi

Nature Chemical Biology (Nature) South Korea, 13 June 2016

Oncology

Key words:Cancer therapy, cell signalling, screening, small molecules

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

455
Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine

Norihiro Kishida, Sachiko Matsuda, Osamu ItanoEmail author, Masahiro Shinoda, Minoru Kitago,Hiroshi Yagi, Yuta Abe, Taizo Hibi, Yohei Masugi, Koichi Aiura, Michiie Sakamoto and Yuko Kitagawa

BMC Gastroenterology (BioMed Central) Japan, 13 June 2016

Oncology

Key words:Nonalcoholic steatohepatitis, hepatocellular carcinoma, diethylnitrosamine, high-fat choline-deficient diet, mouse model

Organism: Mouse

Tissue: Liver

Pathological State: Fibrosis

456
Automated muscle fiber type population analysis with ImageJ of whole rat muscles using rapid myosin heavy chain immunohistochemistry

Konstantin D. Bergmeister, Marion Gröger, Martin Aman, Anna Willensdorfer, Krisztina Manzano-Szalai, Stefan Salminger and Oskar C. Aszmann

Muscle & Nerve (Wiley) Austria, 13 June 2016

Medical Image Analysis

Key words:Automated muscle fiber analysis, fiber population, ImageJ, muscle fiber type, myosin heavy chain, rat

Organism: Rat

Tissue: Muscle

457
Clonorchis sinensis omega-class glutathione transferases play major roles in the protection of the reproductive system during maturation and the response to oxidative stress

Jeong-Geun Kim, Chun-Seob Ahn, Seon-Hee Kim, Young-An Bae, Na-Young Kwon, Insug Kang, Hyun-Jong Yang, Woon-Mok Sohn, Yoon Kong

Parasites & Vectors (BioMed Central) South Korea, 13 June 2016

Parasitology

Key words:Clonorchis sinensis, glutathione transferase (GST), omega-class GST, sexual maturation, reproductive system, oxidative stress

Organism: Flatworm

Tissue: Whole Organism

458
Epidermal desmoglein 1 expression is reduced in kidney transplant recipients compared to immunocompetent patients

Jodi L. Johnson, Paul Hoover, Borko D. Jovanovic, Kathleen J. Green, John J. Friedewald, June K. Robinson

Journal of Investigative Dermatology (Elsevier) USA, 11 June 2016

Dermatology

Key words:Calcineurin inhibitor, desmoglein, E-cadherin, epidermal growth factor receptor, histone deacetylase inhibitor, immunocompetent patient, K1/10, Keratin 1 or 10, kidney transplant recipient, mycophenolate mofitil, plakoglobin, squamous cell carcinoma;

Organism: Human

Tissue: Skin

Pathological State: Cancer

459
Amniotic Fluid Cells Proliferation in Normal and Down Syndrome Subjects

A Honcea, R Iulian, AG Pavel, I Ion, LE Sima

ARS Medica Tomitana (Sciendo) Romania, 11 June 2016

Reproductive Medicine

Key words:Down syndrome, Trisomy 21, amniotic fluid-derived stem cells, proliferation, cell cycle

Organism: Human

Cell Line: Amniotic fluid derived cells

460
ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model

Amy M. Archer, Rana Saber, Shawn Rose, Alexander Shaffer, Alexander V. Misharin, FuNien Tsai, G. Kenneth Haines III, Salina Dominguez, Mesut Eren, Douglas E. Vaughan, Carla M. Cuda and Harris Perlman

Journal of Translational Medicine (BioMed Central) USA, 10 June 2016

Immunology

Key words:Arthritis, cholesterol, inflammation, animal models of human disease

Organism: Mouse

Tissue: Joint

Pathological State: Atherosclerosis

461
Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model

Hui-Wen Chiu, Ya-Ling Yeh, Yi-Ching Wang, Wei-Jan Huang, Sheng-Yow Ho, Pinpin Lin, Ying-Jan Wang

Molecular Cancer (BioMed Central) Taiwan, 10 June 2016

Oncology

Key words:Histone deacetylase inhibitor, radiation, triple-negative breast cancer, autophagy

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

462
Infiltration of Macrophages Correlates with Severity of Allograft Rejection and Outcome in Human Kidney Transplantation

Tobias Bergler, Bettina Jung, Felix Bourier, Louisa Kühne, Miriam C. Banas, Petra Rümmele, Simone Wurm, Bernhard Banas

PLOS ONE (PLOS) Germany, 10 June 2016

Transplantation Medicine

Key words:Macropaghes, T-lymphocytes, calcineriurin, inhibitor, renal transplantation

Organism: Human

Tissue: Kidney

Pathological State: Organ Transplantation

463
Gain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer’s Disease

Cheng-Chun Wu, Cheng-Chang Lien, Wen-Hsien Hou, Po-Min Chiang ,Kuen-Jer Tsai

Scientific reports (Nature) Taiwan, 06 June 2016

Neuroscience

Key words:Dementia, neural stem cells, regeneration and repair in the nervous system, stem-cell research

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s Disease

464
Functional studies on primary tubular epithelial cells indicate a tumor suppressor role of SETD2 in clear cell renal cell carcinoma

J Li, J Kluiver, J Osinga, H Westers, MB van Werkhoven, Marc A Seelen, Rolf H Sijmons, Ankevan den Berg, Klaas Kok

Neoplasia (Elsevier) The Netherlands, 26 May 2016

Oncology

Key words:Primary Tubular Epithelial Cells, Tumor Suppression, SETD2, Renal Cell Carcinoma

Organism: Human

Pathological State: Cancer

Cell Line: PTECs and HKC8 cells

465
Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model

CY Lin, HY Hsieh, CM Chen, SR Wu, CH Tsai, CY Huang, MY Hua, CK Yeh, HL Liu

Journal of Controlled Release (Elsevier) Taiwan, 26 May 2016

Neuroscience

Key words:Focused ultrasound, Gene therapy, Blood-brain barrier opening, Microbubbles, GDNF

Organism: Mouse

Tissue: Brain

Pathological State: Parkinson's Disease

466
GBIQ: a non-arbitrary, non-biased method for quantification of fluorescent images

Youichirou Ninomiya, Wei Zhao,Yumiko Saga

Scientific reports (Nature) Japan, 23 May 2016

Medical Image Analysis

Key words:Image processing, software

Organism: Mouse

Cell Line: MESCs (Mouse Embryyonic stem cells)

467
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

Daniela F. Quail, Robert L. Bowman, Leila Akkari, Marsha L. Quick, Alberto J. Schuhmacher, Jason T. Huse, Eric C. Holland, James C. Sutton, Johanna A. Joyce

Science (AAAS) USA, 20 May 2016

Oncology

Key words:Mouse models, glioblastoma multiforme, macrophage

Organism: Mouse

Tissue: Lymphoid Tissue, Connective Tissue

Pathological State: Cancer

468
Knockout of ho-1 protects the striatum from ferrous iron-induced injury in a male-specific manner in mice

Li-Fang Wang, Kazunari K. Yokoyama, Chih-Lung Lin, Tzu-Yin Chen, Hsiu-Wen Hsiao, Pei-Chi Chiang, Chin Hsu

Scientific reports (Nature) Taiwan, 20 May 2016

Neuroscience

Key words:Neuronal physiology, reproductive biology

Organism: Mouse

Tissue: Ovaries, Penis, Testis

469
Anti-TGF-β Antibody, 1D11, Ameliorates Glomerular Fibrosis in Mouse Models after the Onset of Proteinuria

Xiaoyan Liang, H. William Schnaper, Taiji Matsusaka, Ira Pastan, Steve Ledbetter,Tomoko Hayashida

PLOS ONE (PLOS) USA, 17 May 2016

Nephrology

Key words:Renal fibrosis

Organism: Mouse

Tissue: Kidney

Pathological State: Nephropathy

470
HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

Niek G.J. Leusa, Petra E. van der Woudena, Thea van den Boscha, Wouter T.R. Hooghiemstraa, Maria E. Ourailidoua, Loes E.M. Kistemakerc, Rainer Bischoffb, Reinoud Gosensc, Hidde J. Haismaa, Frank J. Dekker

Biochemical Pharmacology (Elsevier) The Netherlands, 15 May 2016

Pharmacology

Key words:Lysine acetylation, HDACs, inflammation, NF-κB p65, HDAC inhibitors, lung disease

Organism: Mouse

Tissue: Lung

471
The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth

Harini Nivarthi, Claire Gordziel, Madeleine Themanns, Nina Kramer, Markus Eberl, Björn Rabe, Michaela Schlederer, Stefan Rose-John, Thomas Knösel, Lukas Kenner, Patricia Freund, Fritz Aberger, Xiaonan Han, Robert Kralovics, Helmut Dolznig, Susanne Jennek,

Oncotarget (NCBI) Austria, germany, USA, 12 May 2016

Oncology

Key words:STAT1, STAT3, colorectal cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

472
In situ hybridization to detect and localize signature cytokines of T-helper (Th) 1 and Th2 immune responses in chicken tissues

Fana Alem Kidane, Ivana Bilic, Taniya Mitra, Patricia Wernsdorf, Michael Hess, Dieter Liebhart

Veterinary Immunology and Immunopathology (Elsevier) Austria, 12 May 2016

Immunology

Key words:In situ hybridization, RNA probes, ChIFN-γ, ChIL-4, ChIL-13

Organism: Chicken

Tissue: Spleen, Liver

Pathological State: Parasitic Infection

473
Exploration of more effective neurorrhaphy in facial nerve reconstruction: A comparison focusing on the difference of neural window size and condition of the …

Kentaro Ono, Yuhei Yamamoto, Ryuji Shichinohe, Naoki Murao, Akihiko Oyama, Emi Funayama, Hiroshi Furukawa

Journal of Plastic, Reconstructive & Aesthetic Surgery (Elsevier) Japan, 12 May 2016

Neuroscience

Key words:Nerve reconstruction, Facial palsy, Side to side, End to side, Rat

Organism: Rat

Tissue: Brain

474
MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains

Marjolein Bijlard, Jenny C. de Jonge, Bert Klunder, Anita Nomden, Dick Hoekstra, Wia Baron

PLOS ONE (PLOS) The Netherlands, 12 May 2016

Neuroscience

Key words:Oligodendrocytes, myelin membrane, rat brain tissue

Organism: Rat

Cell Line: Primary oligodendrocyte, OLN-93, HEPG2 cells

475
Acidic pH-triggered drug-eluting nanocomposites for magnetic resonance imaging-monitored intra-arterial drug delivery to hepatocellular carcinoma

W Park, J Chen, S Cho, S Park, AC Larson…

ACS Applied Materials & Interfaces (ACS Publications) USA, South Korea, 09 May 2016

Nanomedicine, Oncology

Key words:hepatocellular carcinoma; image-guided therapy; iron oxide nanoparticles; nanocomposite microspheres; pH-responsive materials; sorafenib

Organism: Rat

Tissue: Liver

Pathological State: Cancer

476
Interleukin-25 is detrimental for recovery after spinal cord injury in mice

Dearbhaile Dooley, Evi Lemmens, Peter Ponsaerts, Sven Hendrix

Journal of Neuroinflammation (Springer) Belgium, 06 May 2016

Neuroscience

Key words:IL-25, type 2 immune response, spinal cord injury, basso mouse scale, locomotor recovery Th1 Th2

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

477
CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition

Neeraj Kapur, Hina Mir, Clarence E Clark III, Uma Krishnamurti, Derrick J Beech, James W Lillard & Shailesh Singh

British Journal of Cancer (Nature) USA, 05 May 2016

Oncology

Key words:Colon cancer, Epithelial–mesenchymal transition, Metastasis, Tumour biomarkers

Organism: Human

Tissue: Colon

Pathological State: Cancer

478
PPARγ inhibits VSMC proliferation and migration via attenuating oxidative stress through upregulating UCP2

Y Zhou, MJ Zhang, BH Li, L Chen, Y Pi, YW Yin…

Plos ONE (PLOS) China, 04 May 2016

Cell Biology

Key words:Oxidative stress, Reactive oxygen species ,Carotid arteries ,Mitochondria ,Antioxidants ,MTT assay ,Fluorescence microscopy ,Growth factors

Organism: Mouse

Tissue: Blood Vessels

479
Loss of HIF-1β in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model

Nina Henke, Nerea Ferreirós, Gerd Geisslinger, Martina G. Ding, Silke Essler, Dominik C. Fuhrmann, Theresa Geis, Dmitry Namgaladze, Nathalie Dehne, and Bernhard Brüne

Oncotarget (NCBI) Germany, 03 May 2016

Oncology

Key words:xenobiotics, CYP1A1, DNA damage, breast cancer, fibrosarcoma

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

480
449 In situ mapping of innate lymphoid cells in normal and inflamed human skin

M. Brüggen, W. Bauer, B. Reininger, E. Clim, C. Captarencu, B. Meier, P.M. Brunner, L. French, G. Stingl

Journal of Investigative Dermatology (Elsevier) Austria, 01 May 2016

Immunology

Key words:Innate lymphoid cells, atopic dermatitis, psoriasis, normal human skin, immunofluorescence

Organism: Human

Tissue: Skin

Pathological State: Dermatitis, Psoriasis

481
Paracrine Factors from Irradiated Peripheral Blood Mononuclear Cells Improve Skin Regeneration and Angiogenesis in a Porcine Burn Model

Stefan Hacker, Rainer Mittermayr, Stefanie Nickl, Thomas Haider, Diana Lebherz-Eichinger, Lucian Beer, Andreas Mitterbauer, Harald Leiss, Matthias Zimmermann, Thomas Schweiger, Claudia Keibl, Helmut Hofbauer, Christian Gabriel, Mariann Pavone-Gyöngyösi, H

Scientific reports (Nature) Austria, 29 April 2016

Regenerative Medicine

Key words:Drug development, regeneration, translational research, trauma

Organism: Pig

Tissue: Skin

Pathological State: Burn Wound

482
SIRT2-mediated deacetylation and tetramerization of pyruvate kinase directs glycolysis and tumor growth

David Gius

The Journal of Cancer Research (AACR) USA, 27 April 2016

Oncology

Key words:Mitochondria, pyruvate kinase, acetylation, mammary tumor cells

Organism: Human

Tissue: Breast

Pathological State: Cancer

483
Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling

Yu-Chih Wang, Cheng-Fang Tsai, Hsiao-Li Chuang, Yi-Chih Chang, Hung-Sheng Chen, Jau-Nan Lee, and Eing-Mei Tsai

Oncotarget (NCBI) Taiwan, 26 April 2016

Oncology

Key words:Aryl hydrocarbon receptor, sphingosine kinase 1, sphingosine 1-phosphate, sphingosine-1-phosphate receptor 3, breast cancer stem cells

Organism: Human

Pathological State: Cancer

Cell Line: MCF-7 cells (Breast Cancer Cell line)

484
Tumor-associated B cells in cutaneous primary melanoma and improved clinical outcome

Kanika Garg, Margarita Maurer, Johannes Griss, Marie-Charlotte Brüggen, Ingrid H. Wolf, Christine Wagnera, Niels Willi, Kirsten D. Mertz, Stephan N. Wagner

Human Pathology (Elsevier) Austria, 20 April 2016

Pathology

Key words:CD20, prognosis, melanoma, tumor microenvironment, tumor-associated B cells (TAB), tumor-infiltrating lymphocytes

Organism: Human

Tissue: Skin

Pathological State: Cancer

485
Effectiveness of a Layer-by-Layer Microbubbles-Based Delivery System for Applying Minoxidil to Enhance Hair Growth

Ai-Ho Liao,Ying-Jui Lu, Yi-Chun Lin, Hang-Kang Chen, Huey-Kang Sytwu, Chih-Hung Wang

Theranostics (Ivyspring International Publisher) Taiwan, 11 April 2016

Oncology

Key words:Microbubbles, ultrasound, transdermal drug delivery, minoxidil, chitosan oligosaccharide lactate, hair growth

Organism: Pig, Mouse

Tissue: Skin

486
Dose-escalation study for the targeting of CD44v+cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)

Kohei Shitara, Toshihiko Doi, Osamu Nagano, Chiyo K. Imamura, Takeshi Ozeki, Yuya Ishii, Kenji Tsuchihashi, Shunji Takahashi, Takako E. Nakajima, Shuichi Hironaka, Miki Fukutani, Hiromi Hasegawa, Shogo Nomura, Akihiro Sato, Yasuaki Einaga, Takeshi Kuwata,

Gastric Cancer (Springer) Japan, 07 April 2016

Oncology

Key words:Cancer stem cellCD44 variant positiveGastric cancerSulfasalazinexCT

Organism: Human

Tissue: Stomach

Pathological State: Cancer

487
Biocompatibility Assessment of a New Biodegradable Vascular Graft via In Vitro Co-culture Approaches and In Vivo Model

Marjan Enayati, Magdalena Eilenberg, Christian Grasl, Peter Riedl, Christoph Kaun, Barbara Messner, Ingrid Walter, Robert Liska, Heinrich Schima, Johann Wojta, Bruno K. Podesser, Helga Bergmeister

Annals of Biomedical Engineering (Springer) Austria, 07 April 2016

Tissue Engineering

Key words:Vascular graft, biocompatibility, biodegradable polyurethane, fibroblast-macrophage co-culture

Organism: Rat

Tissue: Blood Vessels

Pathological State: Organ Transplantation

488
Cross-talk between DopaChromeTautomerase and Caveolin-1 is melanoma cell phenotype specific and potentially involved in tumor progression.

Popa IL, Milac AL, Sima LE, Alexandru PR, Pastrama F, Munteanu CV, Negroiu Gabriela

Journal of biological chemistry (The American Society for Biochemistry and Molecular Biology) Romania, 06 April 2016

Oncology

Key words:Antigen processing, caveolin, epithelial-mesenchymal transition (EMT), melanoma, structural model

Organism: Human

Tissue: Skin

Pathological State: Cancer

489
Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells

Bernd Schöpf, Georg Schäfer, Anja Weber , Heribert Talasz ,Iris E. Eder , Helmut Klocker , Erich Gnaiger

FEBS Journal (FEBS PRESS) Austria, 06 April 2016

Cell Biology

Key words:electron transfer system, high‐resolution respirometry, mitochondria, oxidative phosphorylation, prostate metabolism

Organism: Human

Tissue: Prostate

490
Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

Jonas Kloeppera,Lars Riedemanna, Zohreh Amoozgara,1, Giorgio Seanoa, Katharina Suseka, Veronica Yua, Nisha Dalviea, Robin L. Amelunga, Meenal Dattaa,Jonathan W. Songa,Vasileios Askoxylakisa, Jennie W. Taylora,Christine Lu-Emersona,Ana Batistaa,Nathaniel D

PNAS (PNAS) USA, 04 April 2016

Oncology

Key words:Anti-angiogenic therapy, tumor microenvironment, anti-tumor immunity, macrophage polarization, microglia reprogramming

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

491
CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma

Hagma H. Workel, Fenne L. Komdeur, Maartje C.A. Wouters, Annechien Plat, Harry G. Klip, Florine A. Eggink, G. Bea A. Wisman, Henriette J.G. Arts, Maaike H.M. Oonk, Marian J.E. Mourits, Refika Yigit, Marco Versluis, Evelien W. Duiker, Harry Hollema, Marco

European Journal of Cancer (Elsevier) The Netherlands, 31 March 2016

Oncology

Key words:Tumour-infiltrating lymphocytes, endometrial cancer, adenocarcinoma, CD103, survival

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

492
Combining ultrasound and lactobacilli treatment for high-fat-diet-induced obesity in mice

A.-H. Liao, C.-B. Jiang, C.-C. Li, H.-C. Chuang, J.-S. Chiang Chiau, W.-T. Chan, C.-Y. Yeung, M.-L. Cheng, H.-C. Lee

Journal of Animal Physiology and Animal Nutrition (Wiley) Taiwan, 29 March 2016

Physiology

Key words:Actobacilli, ultrasound, high-fat-diet-induced obesity mice, micro-CT, fat deposition

Organism: Mouse

Tissue: Liver, Adipose Tissue

Pathological State: Obesity

493
Myeloid PTEN deficiency impairs tumor-immune surveillance via immune-checkpoint inhibition

M Kuttke, E Sahin, J Pisoni, S Percig, A Vogel, D Kraemmer, L Hanzl, J. S Brunner, H Paar, K Soukup, A Halfmann, A. M. Dohnal, C. W. Steiner, S. Blüml, J. Basilio, B. Hochreiter, M. Salzmann, B. Hoesel, G. Lametschwandtner, R. Eferl, J. A. Schmidd & G. Sc

OncoImmunology (Taylor & Francis) Austria, 28 March 2016

Immunology

Key words:Colitis-associated colon cancer, myeloid Pi3K, tumor immune-surveillance

Organism: Mouse

Tissue: Xenograft Tumor, Colon

Pathological State: Cancer

494
Chemotherapy of Colorectal Liver Metastases Induces a Rapid Rise in Intermediate Blood Monocytes which Predicts Treatment Response

Dominic Schauer, Patrick Starlinger, Lejla Alidzanovic, Philipp Zajc, Thomas Maier, Alexandra Feldman, Robin Padickakudy, Elisabeth Buchberger, Vanessa Elleder, Andreas Spittlera, Judith Stift, Lorand Pop, Birgit Gruenberger, Thomas Gruenbergera, Christin

OncoImmunology (Taylor & Francis) Austria, 22 March 2016

Immunology

Key words:Chemotherapy, colorectal liver metastase, blood monocytes

Organism: Human

Tissue: Liver

Pathological State: Cancer

495
A specific area of olfactory cortex involved in stress hormone responses to predator odours

Kunio Kondoh, Zhonghua Lu, Xiaolan Ye, David P. Olson, Bradford B. Lowell & Linda B. Buck

Nature (Nature) USA, 21 March 2016

Neuroscience

Key words:Neural circuits, Olfactory cortex, Sensory processing

Organism: Mouse

Tissue: Brain

496
MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

Somayyeh Hamzei Taj, Widuri Kho, Adrien Riou, Dirk Wiedermann, Mathias Hoehn

Biomaterials (Elsevier) The Netherlands, 19 March 2016

Neuroscience

Key words:MicroRNA-124, ischemic stroke, immune cell modulation/polarization, neuroprotection, functional improvement, arginase-1

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

497
Neuronal deficiency of HIF prolyl 4-hydroxylase 2 in mice improves ischemic stroke recovery in an HIF dependent manner

Lexiao Li, Pamela Saliba, Stefan Reischl, Hugo H. Marti, Reiner Kunze

Neurobiology of Disease (Elsevier) Germany, 19 March 2016

Neuroscience

Key words:PHD2, HIF, neuron, focal cerebral ischemia, hypoxia, VEGF, angiogenesis

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

498
Unfractionated bone marrow cells attenuate paraquat-induced glomerular injury and acute renal failure by modulating the inflammatory response

SY Gu, TY Yeh, SY Lin, FC Peng

Scientific reports (Nature) Taiwan, 18 March 2016

Nephrology

Key words:Acute kidney injury, Bone marrow transplantation

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Injury

499
High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease

S Kapoor, D Rodriguez, K Mitchell, RP Wüthrich

Kidney & Blood Pressure Research (KARGER) Switzerland, 17 March 2016

Nephrology

Key words:High resolution diagnostic imaging, Total cyst volume, Polycystic kidney disease, PCK rat, Total kidney volume

Organism: Rat

Tissue: Kidney

Pathological State: Polycystic Kidney Disease

500
Efficient generation of smooth muscle cells from adipose-derived stromal cells by 3D mechanical stimulation can substitute the use of growth factors in vascular tissue engineering

Mojtaba Parvizi, Lydia A.M. Bolhuis-Versteeg, Andrá A. Poot, Martin C. Harmsen

Biotechnology Journal (Wiley) The Netherlands, 15 March 2016

Tissue Engineering

Key words:Adipose tissue-derived stromal cells (ASC), poly(1,3-trimethylene carbonate) (PTMC), smooth muscle cells (SMC), transforming Growth Factor beta 1 (TGF-ß1), vascular tissue engineering

Organism: Human

Cell Line: HUVECs, ASC (Human umbilical vein endothelial cells, Adipose tissue derived stromal cells)

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