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Customer Publications (A total of 1287 papers published)

401
SOX2 and Rb1 in esophageal small-cell carcinoma: their possible involvement in pathogenesis

Ishida H, Kasajima A, Kamei T, Miura T, Oka N, Yazdani S, Ozawa Y, Fujishima F, Sakurada A, Nakamura Y, Tanaka Y, Kurosumi M, Ishikawa Y, Okada Y, Ohuchi N, Sasano H

Modern Pathology (Nature) Japan, 20 January 2017

Pathology

Key words:Esophageal small-cell carcinoma, SOX2 overexpression, squamous-basal markers (CK5/6 and p40), glandular markers (CK18 and CEA)

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

402
Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression

Monika Linke, Ha Thi Thanh Pham, Karl Katholnig, Thomas Schnöller, Anne Miller, Florian Demel, Birgit Schütz, Margit Rosner, Boris Kovacic, Nyamdelger Sukhbaatar, Birgit Niederreiter, Stephan Blüml, Peter Kuess, Veronika Sexl, Mathias Müller, Mario Mikula, Wolfram Weckwerth, Arvand Haschemi, Martin Susani, Markus Hengstschläger, Michael J Gambello and Thomas Weichhart

Nature Immunology (Nature) Austria, 16 January 2017

Pathology

Key words:Hypertrophic macrophages, tuberous sclerosis 2 (Tsc2), mTORC1

Organism: Mouse

Tissue: Lung

Pathological State: Sarcoidosis

403
Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma

Jong Cheon Joo, Jung Hoo Hwang, Eunbi Jo, Young-Rang Kim, Dae Joon Kim, Kyung-Bok Lee, Soo Jung Park, and Ik-Soon Jang

Oncotarget (Impact Journals) South Korea, USA, 14 January 2017

Oncology

Key words:cordycepin, CAV1, JNK, Foxo3a, apoptosis

Organism: Human

Pathological State: Cancer

Cell Line: human lung adenocarcinoma lines A549, HCC827, and PC9

404
Development of a DsRed-expressing HepaRG cell line for real-time monitoring of hepatocyte-like cell differentiation by fluorescence imaging, with application in screening of novel geometric microstructured cell growth substrates

Mihaela Uta,Livia E. Sima,Patrik Hoffmann,Valentina Dinca, Norica Branza-Nichita

Biomedical Microdevices (Springer) Romania, 09 January 2017

Biological Methods

Key words:HepaRG, Hepatocyte-like cells, HBV, Differentiation, Microstructured PDMS

Organism: Human

Cell Line: HepaRG, HeLa, Me290 cells

405
Inhibition of the transcriptional repressor complex Bcl-6/BCoR induces endothelial sprouting but does not promote tumor growth

Elisabeth Buchberger, Dietmar Payrhuber, Miriam El Harchi, Branislav Zagrapan, Katharina Scheuba, Anna Zommer, Edina Bugyik, Balazs Dome, Julia Barbara Kral, Waltraud Cornelia Schrottmaier, Gernot Schabbauer, Peter Petzelbauer, Marion Gröger, Martin Bilban, and Christine Brostjan

Oncotarget (Impact Journals) Austria, 03 January 2017

Oncology

Key words:79-6, Bcl-6, BCoR, colorectal carcinoma, vascular sprouting

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

406
Limited tumor tissue drug penetration contributes to primary resistance against angiogenesis inhibitors

Szilvia Torok, Melinda Rezeli, Olga Kelemen, Akos Vegvari, Kenichi Watanabe, Yutaka Sugihara, Anna Tisza, Timea Marton, Ildiko Kovacs, Jozsef Tovari, Viktoria Laszlo, Thomas H. Helbich, Balazs Hegedus, Thomas Klikovits, Mir Alireza Hoda, Walter Klepetko, Sandor Paku, Gyorgy Marko-Varga, and Balazs Dome

Theranostics (NCBI) Hungary, Austria, Sweden, 01 January 2017

Oncology

Key words:matrix assisted laser desorption ionization, imaging mass spectrometry, angiogenesis, receptor tyrosine kinase inhibitor, resistance, cancer

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

407
Heme Oxygenase-1-Expressing Dendritic Cells Promote Foxp3+ Regulatory T Cell Differentiation and Induce Less Severe Airway Inflammation in Murine Models

Tzu-Hsuan Wong , Hung-An Chen , Rung-Jiun Gau, Jeng-Hsien Yen, Jau-Ling Suen

PLOS ONE (PLOS) Taiwan, 29 December 2016

Immunology

Key words:Dendritic cells (DCs), HO-1, lipopolysaccharide (LPS), Foxp3+

Organism: Mouse

Tissue: Lung

408
Interstitial Fibrosis, Functional Status, and Outcomes in Heart Failure With Preserved Ejection Fraction

Franz Duca, Andreas A. Kammerlander, Caroline Zotter-Tufaro, Stefan Aschauer, Marianne L. Schwaiger, Beatrice A. Marzluf, Diana Bonderman, Julia Mascherbauer

Circulation:Cardiovascular Imaging (AHA Journals) Austria, 14 December 2016

Cardiology

Key words:Magnetic resonance imaging, heart failure, mapping

Organism: Human

Tissue: Heart

Pathological State: Heart Failure

409
Early dissemination seeds metastasis in breast cancer

Hedayatollah Hosseini, Milan M. S. Obradović, Martin Hoffmann, Kathryn L. Harper, Maria Soledad Sosa, Melanie Werner-Klein, Lahiri Kanth Nanduri, Christian Werno, Carolin Ehrl, Matthias Maneck, Nina Patwary, Gundula Haunschild, Miodrag Gužvić, Christian Reimelt, Michael Grauvogl, Norbert Eichner, Florian Weber, Andreas D. Hartkopf, Florin-Andrei Taran, Sara Y. Brucker, Tanja Fehm, Brigitte Rack, Stefan Buchholz, Rainer Spang, Gunter Meister et al.

Nature (Nature) Germany, 14 December 2016

Oncology

Key words:Metastatic dissemination, breast cancer, HER2 , Karyotypic and phenotypic analysis

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

410
Mesenchymal Stem Cells Correct Inappropriate Epithelial–mesenchyme Relation in Pulmonary Fibrosis Using Stanniocalcin-1

Ono M, Ohkouchi S, Kanehira M, Tode N, Kobayashi M, Ebina M, Nukiwa T, Irokawa T, Ogawa H, Akaike T, Okada Y, Kurosawa H, Kikuchi T, Ichinose M

Molecular Therapy (Cell Press) Japan, 14 December 2016

Pulmonology

Key words:Mesenchymal Stem Cells, Epithelial–mesenchyme Relation, Pulmonary Fibrosis, Stanniocalcin-1

Organism: Mouse

Tissue: Lung

Pathological State: Fibrosis

411
Adipose tissue–derived mesenchymal stem cells expressing prodrug-converting enzyme inhibit human prostate tumor growth

Ilaria T Cavarretta, Veronika Altanerova, Miroslava Matuskova, Lucia Kucerova, Zoran Culig, Cestmir Altaner

Molecular Therapy (Cell Press) Austria, Slovakia, 14 December 2016

Stem Cell Research

412
Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury

Dearbhaile Dooley, Evi Lemmens, Tim Vangansewinkel, Debbie Le Blon, Chloé Hoornaert, Peter Ponsaerts, Sven Hendrix

Stem Cell Reports (Elsevier) Belgium, 13 December 2016

Transplantation Medicine

Key words:Mesenchymal stem cells, interleukin-13, spinal cord injury, cell transplantation, microglia, macrophages

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

413
Involvement of Pancreatic Stellate Cells in Regeneration of Remnant Pancreas after Partial Pancreatectomy

Shigenori Ota, Miyuki Nishimura, Yuya Murakami, Naoko Kubo Birukawa, Akihiro Yoneda, Hiroki Nishita, Ryosuke Fujita, Yasushi Sato, Kenjiro Minomi, Keiko Kajiwara, Miyono Miyazaki, Maki Uchiumi, Shintaro Mikuni, Yasuaki Tamura, Toru Mizuguchi, Masafumi Imamura, Makoto Meguro, Yasutoshi Kimura, Koichi Hirata, Yoshiro Niit

PLOS ONE (PLOS) Japan, 09 December 2016

Regenerative Medicine

Key words:Pancreatectomy, siRNA, activated pancreas stellate cells (aPSCs), apoptosis

Organism: Rat

Tissue: Pancreas

Pathological State: Pancreatectomy

414
The 6-chromanol derivate SUL-109 enables prolonged hypothermic storage of adipose tissue-derived stem cells

Ghazaleh Hajmousa, Pieter Vogelaar, Linda A. Brouwer, Adrianus C. van der Graaf, Robert H. Henning, Guido Krenning

Biomaterials (Elsevier) The Netherlands, 09 December 2016

Biological Materials

Key words:Adipose tissue-derived stem cells (ASC), Hypothermia, Cold storage, Mitochondrial damage, Chromanol

Organism: Human

Cell Line: Adipose tissue derived stromal cells (ADSC)

415
Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative

Jun Wei,Hongyan Zhu, Gabriel Lord, Mitra Bhattachayya, Brielle M. Jones, Graham Allaway, Shyam S. Biswal, Benjamin Korman, Roberta G. Marangoni, Warren G. Tourtellotte, John Varga

Translational Research (Elsevier) USA, 09 December 2016

Neuroscience

Key words:Nrf2-nuclear factor erythroid 2–related factor 2, systemic sclerosis, TGF-β, CDDO, TMC

Organism: Human

Tissue: Skin

Pathological State: Systemic Sclerosis

416
Silica-Coated Metal Chelating-Melanin Nanoparticles as a Dual-Modal Contrast Enhancement Imaging and Therapeutic Agent

Soojeong Cho, Wooram Park and Dong-Hyun Kim

Applied Materials and Interfaces (ACS Publications) USA, 08 December 2016

Nanomedicine

Key words:Fluorescence imaging, melanin, metal-chelation,MRI, multimodal image-guidance, silica coating

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

417
Lead-Free Piezoelectric (Ba,Ca)(Zr,Ti)O3 Thin Films for Biocompatible and Flexible Devices

N. D. Scarisoreanu, F. Craciun, V. Ion, R. Birjega, A. Bercea V. Dinc, M. Dinescu, L. E. Sima, M. Icriverzi, A. Roseanu, L. Gruionu, and G. Gruionu

Applied Materials and Interfaces (ACS Publications) Romania, 08 December 2016

Biological Materials

Key words:Biocompatible materials, laser processing, lead-free thin films, mesenchymal stem cells, osteogenic differentiation

Organism: Human

Pathological State: Cancer

Cell Line: HEK 293T and A375 cells (Human epithelial embryonic kidney and human malignant melanoma cells)

418
Nodal metastasis signatures in breast cancer

Kyeongmee ParK, Joo Hyun Lee, Hyun Ho Han, Seong Gyeong Mun, Suki Kang, Youn Jin Cha, Ja-Seung Koo, Min Ju Kim, Hye Sun Lee, Jieun Moon, Nam Hoon Cho

Pathology - Research and Practice (Elsevier) South Korea, 05 December 2016

Oncology

Key words:Breast cancer, node positive ratio, node positive number, ERK, WDR1, c-MET

Organism: Human

Tissue: Breast

Pathological State: Cancer

419
Mast Cells Are Abundant in Primary Cutaneous T-Cell Lymphomas: Results from a Computer-Aided Quantitative Immunohistological Study

Johanna Eder , Radu Rogojanu, Waltraud Jerney, Friedrich Erhart, Alexander Dohnal, Melitta Kitzwögerer, Georg Steiner, Julia Moser, Franz Trautinger

PLOS ONE (PLOS) Austria, 28 November 2016

Oncology

Key words:Mast cells, cutaneous T-cell lymphomas (CTCL), haematopoetic cells

Organism: Human

Tissue: Skin

Pathological State: Cancer

420
Solid stress and elastic energy as measures of tumour mechanopathology

Hadi T. Nia, Hao Liu, Giorgio Seano, Meenal Datta, Dennis Jones, Nuh Rahbari, Joao Incio, Vikash P. Chauhan, Keehoon Jung, John D. Martin, Vasileios Askoxylakis, Timothy P. Padera, Dai Fukumura, Yves Boucher, Francis J. Hornicek, Alan J. Grodzinsky, James W. Baish, Lance L. Munn and Rakesh K. Jain

Nature Biomedical Engineering (Nature) USA, 28 November 2016

Neuroscience

Key words:Solid stress, tissue stiffness, tumour

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

421
Cardiac extracellular matrix is associated with adverse outcome in patients with chronic heart failure

Franz Duca,Caroline Zotter-Tufaro,Andreas A. Kammerlander,Adelheid Panzenböck,Stefan Aschauer,Daniel Dalos,Benedikt Köll,Benedikt Börries,Hermine Agis,Renate Kain,Klaus Aumayr,Florian Klinglmüller,Julia Mascherbauer,Diana Bonderman

European Journal of Heart Failure (Wiley) Austria, 27 November 2016

Cardiology

Key words:Extracellular matrix (ECM), heart failure (HF), endomyocardial biopsy

Organism: Human

Tissue: Heart

Pathological State: Heart Failure

422
Antimicrobial polycaprolactone/ polyethylene glycol embedded lysozyme coatings of Ti implants for osteoblast functional properties in tissue engineering

A. Visan, R. Cristescu, N. Stefan, M. Miroiu, C. Nita, M. Socol, C. Florica, O. Rasoga, I. Zgura, L.E. Sima, M. Chiritoiu, M.C. Chifiriuc, A.M. Holban, I.N. Mihailescu, G. SocoL

Applied Surface Science (Elsevier) Romania, 19 November 2016

Immunology

Key words:MAPLE, Dip coating, Lysozyme, Blends, Antimicrobial, Biocompatible

Organism: Human

Cell Line: Primary osteogenic sarcoma cells (SAOS2), Human mesenchymal stem cells (hMSCs)

423
Rhinophototherapy in persistent allergic rhinitis

Zsolt Bella, Ágnes Kiricsi, Éva Dósa-Rácz Viharosné, Attila Dallos, Ádám Perényi, Mária Kiss, Andrea Koreck, Lajos KeményJózsef JóriLászló Rovó, Edit Kadocsa

European Archives of Oto-Rhino-Laryngology (Springer) Hungary, 18 November 2016

Allergy

Key words:Intercellular adhesion molecule-1 expression, Intranasal phototherapy, Mucociliary clearance, Nasal inspiratory peak flow, Persistent allergic rhinitis, Rhinolight

Organism: Human

Tissue: Nasal Mucosa

Pathological State: Allergy

424
The plasma membrane Ca2+ pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells

Luca Hegedũs,Tamás Garay,Eszter Molnár,Karolina Varga,Ágnes Bilecz,Szilvia Török,Rita Padányi,Katalin Pászty,Matthias Wolf,Michael Grusch,Enikõ Kállay,Balázs Döme,Walter Berger,Balázs Hegedũs,Agnes Enyedi

International Journal of Cancer (Wiley) Austria, 17 November 2016

Oncology

Key words:Ca2+, PMCA4b expression, NRAS mutant melanoma cells

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

425
Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

Debbie Le Blon, Caroline Guglielmetti, Chloé Hoornaert, Alessandra Quarta, Jasmijn Daans, Dearbhaile Dooley, Evi Lemmens, Jelle Praet, Nathalie De Vocht, Kristien Reekmans, Eva Santermans, Niel HensHerman Goossens, Marleen Verhoye, Annemie Van der Linden, Zwi Berneman, Sven Hendrix, Peter Ponsaerts

Journal of Neuroinflammation (Springer) Belgium, 09 November 2016

Neuroscience

Key words:Interleukin 13, Mesenchymal stem cells, Neuroinflammation, Transplantation, Magnetic resonance imaging

Organism: Mouse

Tissue: Brain

Pathological State: Demyelination

426
Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis

Yi-Ching Wang, Hong-Tai Tzeng, Chung-Han Tsai, Yi-Ting Yen, Hung-Chi Cheng, Yi-Chieh Chen, Shih-Wen Pu, Yu-Shiuan Wang, Yan-Shen Shan, Yau-Lin Tseng, Wu-Chou Su, Wu-Wei Lai and Li-Wha Wu

Clinical Cancer Research (AACR Publications) Taiwan, 07 November 2016

Oncology

Key words:Rab37-Mediated, Thrombospondin-1, angiogenesis marker CD31, p-FAK/p-paxillin/p-ERK

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

427
Asxl2−/− Mice Exhibit De Novo Cardiomyocyte Production during Adulthood

R Brunner, HL Lai, Z Deliu, E Melman, DL Geenen, QT Wang

Journal of Developmental Biology (MDPI) USA, 03 November 2016

Reproductive Medicine

Key words:heart; cardiogenic; cardiomyocyte; proliferation; regeneration; chromatin factor; epigenetic

Organism: Mouse

Cell Line: Cardiomyocytes

428
A Single Postnatal Dose of Dexamethasone Enhances Memory of Rat Pups Later in Life

Kuen-Jer Tsai , Chun-I Sze , Yung-Chieh Lin, Yuh-Jyh Lin, Ting-Hui Hsieh, Chyi-Her Lin

PLOS ONE (PLOS) Taiwan, 31 October 2016

Neuroscience

Key words:Postnatal dexamethasone (Dex) therapy, NMDAR, bronchopulmonary dysplasia, chronic lung disease

Organism: Rat

Tissue: Brain

429
An Alternative High-Throughput Platform to Analyze hiPSC Lines

Alberto La Spada, Simona Baronchelli, Linda Ottoboni, Francesca Ruffini, Gianvito Martino, Nunzia Convertino, Aikaterini Ntai, Tobias Steiner, Ida Biunno, Andrea De Blasio

Journal of Histochemistry and Cytochemistry (SAGE Journals) Italy, Austria, 26 October 2016

Biological Methods

Key words:Cell line macroarray, high-throughput screening and quantification, hiPSC clones

Organism: Human

Cell Line: Induced pluripotent cells (iPSCs)

430
Cell Line Macroarray: An Alternative High-Throughput Platform to Analyze hiPSC Lines

Alberto La Spada, Simona Baronchelli, Linda Ottoboni, Francesca Ruffini, Gianvito Martino, Nunzia Convertino, Aikaterini Ntai, Tobias Steiner, Ida Biunno, Andrea De Blasio

Journal of Histochemistry and Cytochemistry (SAGE Journals) Italy, Austria, 26 October 2016

Biological Methods

Key words:cell line macroarray, high-throughput screening and quantification, hiPSC clones

Organism: Human

Cell Line: hiPSCs

431
KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1

Yu Gao, Hongzhao Li, Xin Ma, Yang Fan, Dong Ni, Yu Zhang, Qingbo Huang, Kan Liu, Xintao Li, Lei Wang, Liangyou Gu, Yuanxin Yao, Qing Ai, Qingshan Du, Erlin Song and Xu Zhang

Molecular Cancer Research (AACR Publications) China, 25 October 2016

Oncology

Key words:KLF6 expression, E2F1-mediated epithelial–mesenchymal, cell renal cell carcinoma (ccRCC)

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

432
Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle

Tim Koopmans,Stijn Crutzen,Mark H Menzen,Andrew J Halayko,Tillie-Louise Hackett,Darryl A Knight,Reinoud Gosens

British Journal of Pharmacology (Wiley) USA, The Netherlands, 25 October 2016

Pharmacology

Key words:Asthma, β-catenin, CREB-binding protein (CBP) , TGFβ1

Organism: Mouse

Tissue: Lung

433
TRPV1 attenuates intracranial arteriole remodeling through inhibiting VSMC phenotypic modulation in hypertension

MJ Zhang, Y Liu, ZC Hu, Y Zhou, Y Pi, L Guo, X Wang, X Chen, JC Li, LL Zhang

Histochemistry and Cell Biology (Springer) China, 24 October 2016

Cardiology

Key words:TRPV1, Intracranial arteriole, VSMC, Phenotypic modulation, Hypertension

Organism: Mouse, Rat

Tissue: Blood Vessels, Brain

434
PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

Brasó-Maristany F, Filosto S, Catchpole S, Marlow R, Quist J, Francesch-Domenech E, Plumb DA, Zakka L, Gazinska P, Liccardi G, Meier P, Gris-Oliver A, Cheang MC, Perdrix-Rosell A, Shafat M, Noël E, Patel N, McEachern K, Scaltriti M, Castel P, Noor F, Buus R, Mathew S, Watkins J, Serra V, Marra P, Grigoriadis A, Tutt AN

Nature Medicine (Nature) UK, 24 October 2016

Oncology

Key words:Triple-negative breast cancers (TNBCs), PIM1 proto-oncogene, anti-apoptotic factor BCL2, dynamic BH3

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

435
The fractionation of adipose tissue procedure to obtain stromal vascular fractions for regenerative purposes

Joris A. van Dongen,Hieronymus P. Stevens ,Mojtaba Parvizi ,Berend van der Lei ,Martin C. Harmsen

Wound Repair and Regeneration (Wiley) The Netherlands, 21 October 2016

Regenerative Medicine

Key words:Autologous adipose tissue transplantation, FAT-stromal vascular fraction

Organism: Human

Cell Line: Smooth muscle cells (SMCs)

436
Oncolytic influenza A virus expressing interleukin-15 decreases tumor growth in vivo 

Karin Hock, Johannes Laengle, Irina Kuznetsova,Andrej Egorov, Balazs Hegedus, Balazs Dome, Thomas Wekerle, Monika Sachet, Michael Bergmann

Surgery (Elsevier) Austria, 21 October 2016

Immunology

Key words:Interleukin-15, A virus, T cells,

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

437
Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury

Jill Moser, Joris van Ark, Marcory C. van Dijk, Dale L. Greiner, Leonard D. Shultz, Harry van Goor and Jan-Luuk Hillebrands

Scientific Reports (Nature) USA, The Netherlands, 19 October 2016

Cardiology

Key words:NOD.Cg-PrkdcscidIL2rgtm1Wjl(NSG), Percutaneous coronary interventions (PCIs), BL/6 mice

Organism: Human

Cell Line: Peripheral blood mononuclear cell

438
Aberrant expression of tumor-associated carbohydrate antigen Globo H in thyroid carcinoma

Shih-Ping Cheng ,Po-Sheng Yang ,Ming-Nan Chien ,Ming-Jen Chen ,Jie-Jen Lee ,Chien-Liang Liu

Journal of Surgical Oncology (Wiley) Taiwan, 18 October 2016

Oncology

Key words:Globo H - hexasaccharide glycosphingolipid, Normal or benign thyroid, papillary thyroid cancer

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

439
In Situ Characterization of Tissue-Resident Immune Cells by MALDI Mass Spectrometry Imaging

Matthias Holzlechner, Katharina Strasser, Elitsa Zareva, Luise Steinhäuser, Hanna Birnleitner, Andrea Beer, Michael Bergmann, Rudolf Oehler, and Martina Marchetti-Deschmann

Journal of Proteome Research (ACS Publications) Austria, 18 October 2016

Immunology

Key words:Colon tissue, immune cells, immunohistochemistry, lymphocytes, macrophages, MALDI mass spectrometry imaging, monocytes

Organism: Human

Tissue: Colon

440
Oncostatin M‐preconditioned mesenchymal stem cells alleviate bleomycin‐induced pulmonary fibrosis through paracrine effects of the hepatocyte growth factor

Ying‐Wei Lan, Si‐Min Theng, Tsung‐Teng Huang, Kong‐Bung Choo, Chuan‐Mu Chen, Han‐Pin Kuo, Kowit‐Yu Chong

Stem Cells Translational Medicine (Wiley) Taiwan, Malaysia, 18 October 2016

Stem Cell Research

Key words:Bleomycin-induced pulmonary fibrosis; Hepatocyte growth factor; Oncostatin M; Preconditioning; Stem cells

Organism: Mouse

Tissue: Lung

Pathological State: Fibrosis

441
Ustekinumab treatment in severe atopic dermatitis: Down-regulation of T-helper 2/22 expression 

Doris Weiss, Michaela Schaschinger, Robin Ristl, Robert Gruber, Tamara Kopp, Georg Stingl, Christine Bangert

Journal of the American Academy of Dermatology (Elsevier) Austria, 13 October 2016

Dermatology

Key words:Anti-interleukin-12/-23 p40, atopic dermatitis, cytokines, eczema, inflammatory, T helper 2, T helper 17, T helper 22, ustekinumab

Organism: Human

Tissue: Skin

Pathological State: Dermatitis

442
Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Tahereh Javaheri, Zahra Kazemi, Jan Pencik, Ha TT Pham, Maximilian Kauer, Rahil Noorizadeh, Barbara Sax, Harini Nivarthi, Michaela Schlederer, Barbara Maurer, Maximillian Hofbauer, Dave NT Aryee, Marc Wiedner, Eleni M Tomazou, Malcolm Logan, Christine Hartmann, Jan P Tuckermann, Lukas Kenner, Mario Mikula, Helmut Dolznig, Aykut Üren, Günther H Richter, Florian Grebien, Heinrich Kovar and Richard Moriggl

Cell Death and Disease (Nature) Austria, UK, Germany, 13 October 2016

Oncology

Key words:Apoptosis, Bone cancer, Cell signalling, Sarcoma

Organism: Mouse

Tissue: Whole Organism

443
Intraarticular overexpression of Smad7 ameliorates experimental arthritis

Shih-Yao Chen, Ai-Li Shiau, Chao-Liang Wu and Chrong-Reen Wang

Scientific Reports (Nature) Taiwan, 12 October 2016

Immunology

Key words:Genetic vectors, Translational immunology

Organism: Human

Tissue: Synovial Membrane

444
Hydroxyapatite thin films grown by pulsed laser deposition and matrix assisted pulsed laser evaporation: Comparative study

G. Popescu-Pelin, F. Sima, L.E. Sima, C.N. Mihailescu, C. Luculescu, I. Iordache, M. Socol, G. Socol, I.N. Mihailescu

Applied Surface Science (Elsevier) Romania, 11 October 2016

Tissue Engineering

Key words:Pulsed laser deposition, Matrix assisted pulsed laser evaporation, Hydroxyapatite coatings, Biocompatibility, Cell proliferation and differentiation

Organism: Human

Cell Line: Human mesenchymal stem cells (hMSCs)

445
G-CSF-mobilized Bone Marrow Mesenchymal Stem Cells Replenish Neural Lineages in Alzheimer’s Disease Mice via CXCR4/SDF-1 Chemotaxis

Cheng-Chun WuI-Fang Wang, Po-Min Chiang, Liang-Chao Wang, Che-Kun James Shen, Kuen-Jer Tsai

Molecular Neurobiology (Springer) Taiwan, 05 October 2016

Neuroscience

Key words:G-CSF, Bone marrow stem cells, SDF-1CXCR4, Neurogenesis, Alzheimer’s disease

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s Disease

446
Neuronal prolyl-4-hydroxylase 2 deficiency improves cognitive abilities in a murine model of cerebral hypoperfusion

Daniel Gruneberg, Felipe A. Montellano, Konstanze Plaschke, Lexiao Li, Hugo H. Marti, Reiner Kunze

Experimental Neurology (Elsevier) Germany, 05 October 2016

Neuroscience

Key words:HIF, PHD, Epo, VEGF, Hippocampus, Learning, Memory, Alzheimer's disease

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Hypoperfusion

447
Epithelial cholesterol deficiency attenuates human antigen R-linked pro-inflammatory stimulation via SREBP2-linked circuit

SH Park, J Kim, M Yu, JH Park, YS Kim, Y Moon

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) South Korea, 04 October 2016

Gastroenterology

Key words:cholesterol regulation, inflammation, intestinal epithelium, intestinal metabolism, intestine, mRNA decay

Organism: Mouse, Human

Tissue: Colon

Pathological State: Colitis

448
Houttuynia cordata Thunb Promotes Activation of HIF-1A–FOXO3 and MEF2A Pathways to Induce Apoptosis in Human HepG2 Hepatocellular Carcinoma Cells

Jung Min Kim, In-Hu Hwang, Ik-Soon Jang, Min Kim, In Seok Bang, Soo Jung Park, Yun-Jo Chung, Jong-Cheon Joo, Min-Goo Lee

Integrative Cancer Therapies (SAGE Journals) South Korea, 03 October 2016

Oncology

Key words:Cancer, cell apoptosis, hypoxia-inducible factor (HIF)-1A

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

449
Hyperglycemia induces bioenergetic changes in adipose-derived stromal cells while their pericytic function is retained

Ghazaleh Hajmousa, Alvaro A. Elorza, Vera J.M. Nies, Erik L. Jensen, Ruxandra A. Nagy, and Martin C. Harmsen

Stem Cells and Development (Mary Ann Liebert Inc.) The Netherlands, Chile, 01 October 2016

Stem Cell Research

Key words:Adipose Derived Stromal Cells, Diabetic Retinopathy, Pericyte, Hyperglycemia

Organism: Human

Cell Line: Adipose tissue derived stromal cells (ADSC)

450
NSAID-activated gene 1 mediates pro-inflammatory signaling activation and paclitaxel chemoresistance in type I human epithelial ovarian cancer stem-like …

KH Kim, SH Park, KH Do, J Kim, KU Choi, Y Moon

Histochemistry and Cell Biology (NCBI) South Korea, 30 September 2016

Oncology

Key words:NAG-1, epithelial ovary cancer, paclitaxel, NF-κB, chemoresistance

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

451
Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

Caroline Guglielmetti,Debbie Le Blon, Eva Santermans, Angelica Salas-Perdomo, Jasmijn Daans, Nathalie De Vocht, Disha Shah, Chloé Hoornaert, Jelle Praet, Jurgen Peerlings, Firat Kara, Christian Bigot, Zhenhua Mai, Herman Goossens, Niel Hens, Sven Hendrix, Marleen Verhoye, Anna M. Planas, Zwi Berneman, Annemie van der Linden, Peter Ponsaerts

GLIA (Wiley) Belgium, 29 September 2016

Neuroscience

Key words:IL-13, microglia, macrophages, severe oligodendrocyte loss and demyelination, mouse nodel

Organism: Mouse

Tissue: Brain

Pathological State: Demyelination

452
Comparison of cancer cells cultured in 2D vs 3D reveals differences in AKT/mTOR/S6-kinase signaling and drug response

Angelika Riedl, Michaela Schlederer, Karoline Pudelko, Mira Stadler, Stefanie Walter, Daniela Unterleuthner, Christine Unger, Nina Kramer, Markus Hengstschläger, Lukas Kenner, Dagmar Pfeiffer, Georg Krupitza, Helmut Dolznig

Journal of Cell Science (The Company of Biologists) Austria, 23 September 2016

Oncology

Key words:Cancer cells, colon cancer, AKT/mTOR/S6-kinase, ERK phosphorylation

Organism: Human

Cell Line: LS174T, HT29, SW620, HCT116), Caco2 and DLD1 (Human colon cancer cell lines)

453
Targeted multimodal nano-reporters for pre-procedural MRI and intra-operative image-guidance

Joonseok Lee, Andrew C. Gordon, Hacksung Kim, Wooram Park, Soojeong Cho, Byeongdu Lee, Andrew C. Larson, Elena A. Rozhkova, Dong-Hyun Kim

Biomaterials (Elsevier) USA, 19 September 2016

Medical Imaging

Key words:Upconversion nanoparticles, Medical imaging, Cancer, Interventional radiology, Multimodal probe

Organism: Rat

Tissue: Heart, Liver, Spleen, Lung, Kidney

454
CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer …

Fenne L. Komdeur, Maartje C.A. Wouters, Hagma H. Workel, Aline M. Tijans, Anouk L.J. Terwindt, Kim L. Brunekreeft, Annechien Plat, Harry G. Klip, Florine A. Eggink, Ninke Leffers, Wijnand Helfrich, Douwe F. Samplonius, Edwin Bremer, G. Bea A. Wisman, Toos Daemen, Evelien W. Duiker, Harry Hollema, Hans W. Nijman and Marco de Bruyn

Oncotarget (Impact Journals) The Netherlands, 16 September 2016

Oncology

Key words:tumor-infiltrating lymphocytes, high-grade serous ovarian cancer, CD103, TGF-β, cancer immunotherapy

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

455
Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma

Seunggu J. Han, Gerald Reis, Gary Kohanbash, Shruti Shrivastav, Stephen T. Magill, Annette M. Molinaro, Michael W. McDermott, Philip V. Theodosopoulos, Manish K. Aghi, Mitchel S. Berger, Nicholas A. Butowski, Igor Barani, Joanna J. Phillips, Arie Perry, Hideho Okada

Journal of Neuro-Oncology (Springer) USA, 13 September 2016

Neuroscience

Key words:Meningioma, PD-L1, B7-H1, Immunotherapy, Checkpoint, Lymphocyte, Macrophage

Organism: Human

Tissue: Brain

Pathological State: Cancer

456
Paricalcitol attenuates cardiac fibrosis and expression of endothelial cell transition markers in isoproterenol-induced cardiomyopathic rats

CC Lai, CP Liu, PW Cheng, PJ Lu, M Hsiao, WH Lu, GC Sun, JC Liou, CJ Tseng

Critical Care Medicine (Ingentaconnect) Taiwan, 09 September 2016

Cardiology

Key words:cardiac fibrosis; cardiomyopathy; endothelial-to-mesenchymal cell transition; vitamin D activator

Organism: Rat

Tissue: Heart

Pathological State: Fibrosis

457
The effects of oral and topical corticosteroid in rabbit corneas

Kaoru Araki-Sasaki, Osamu Katsuta, Hidetoshi Mano, Takashi Nagano and Masatsugu Nakamura

BMC Ophthalmology (BioMed Central) Japan, 05 September 2016

Ophthalmology

Key words:Corticosteroid, Keratitis, Cornea, Wound healing, Pharmacokinetics

Organism: Rabbit

Tissue: Eye

Pathological State: Skin Wound

458
Presentation of underglycosylated mucin 1 in pancreatic adenocarcinoma (PDAC) at early stages

ST Lo, P Pantazopouos, Z Medarova, A Moore

American Journal of Cancer Research (NCBI) USA, 01 September 2016

Oncology

Key words:Pancreatic cancer, underglycosylated mucin 1, tumor antigen, immunohistochemistry

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

459
Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation

Yong-Hee Rhee, Sang-Hoon Yi, Joo Yeon Kim, Mi-Yoon Chang, A-Young Jo, Jinyoung Kim, Chang-Hwan Park, Je-Yoel Cho, Young-Jin Choi, Woong Sun and Sang-Hun Lee

Scientific Reports (Nature) South Korea, 24 August 2016

Neuroscience

Key words:Neurology, neural stem cells, Raf-Erk pathway, radial glial cells

Organism: Mouse

Tissue: Brain

460
Degradation of Kidney and Psoas Muscle Proteins as Indicators of Post-Mortem Interval in a Rat Model, with Use of Lateral Flow Technology

Dong-Gi Lee, Kyeong Eun Yang, Jeong Won Hwang, Hwan-Soo Kang, Seung-Yeul Lee, Seoyeon Choi, Joonchul Shin, Ik-Soon Jang, Hyun Joo An, Heesun Chung, Hyo-Il Jung , Jong-Soon Choi

PLOS ONE (PLOS) South Korea, 23 August 2016

Forensic Science

Key words:Post-mortem interval (PMI) markers, kidney, muscle, GAPDH

Organism: Rat

Tissue: Kidney, Muscle

461
Toward the Automated Detection and Characterization of Osteoclasts in Microscopic Images

Andreas Heindl , Martin Schepelmann, Robert Nica, Rupert Ecker, Peter Pietschmann, Alexander K. Seewald, Theresia Thalhammer, Isabella Ellinger

Principles of Osteoimmunology (Springer) Austria, 19 August 2016

Medical Image Analysis

Key words:Osteoimmunology, microscopes, biological samples, automated image segmentation and analysis

462
LIN28A enhances the therapeutic potential of cultured neural stem cells in a Parkinson’s disease model

Yong-Hee Rhee, Tae-Ho Kim, A-Young Jo, Mi-Yoon Chang, Chang-Hwan Park, Sang-Mi Kim, Jae-Jin Song, Sang-Min Oh, Sang-Hoon Yi, Hyeon Ho Kim, Bo-Hyun You, Jin-Wu Nam, Sang-Hun Lee

Brain: A journal of neurology (Oxford University Press) South Korea, 18 August 2016

Neuroscience

Key words:LIN28A, neural stem cell (NSC) culture, repair capacity, Parkinson’s disease

Organism: Rat

Tissue: Brain

Pathological State: Parkinson's Disease

463
Dynamic Modulation of Microglia/Macrophage Polarization by miR-124 after Focal Cerebral Ischemia

Somayyeh Hamzei Taj, Widuri Kho, Markus Aswendt, Franziska M. Collmann, Claudia Green, Joanna Adamczak, Annette Tennstaedt, Mathias Hoehn

Journal of Neuroimmune Pharmacology (Springer) Germany, 18 August 2016

Neuroscience

Key words:Stroke, Microglia/macrophage polarization, Pro-inflammatory and anti-inflammatory phenotypes, miRNA-124, Neuroinflammation

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

464
The antiviral alkaloid berberine reduces chikungunya virus-induced mitogen-activated protein kinase (MAPK) signaling

Finny S. Varghese, Bastian Thaa, Siti Naqiah Amrun, Diane Simarmata, Kai Rausalu, Tuula A. Nyman, Andres Merits, Gerald M. McInerney2, Lisa F.P. Ng, Tero Ahola

Journal of Virology (American Society for Microbiology) Finland, 17 August 2016

Virology

Key words:Chikungunya virus, non-toxic plant alkaloid berberine, mitogen-activated protein kinase

Organism: Mouse

Tissue: Joint

Pathological State: Virus Infection

465
Bradykinin promotes neuron-generating division of neural progenitor cells via ERK activation

Micheli M. Pillat, Claudiana Lameu, Cleber A. Trujillo, Talita Glaser, Angélica R. Cappellari, Priscilla D. Negraes, Ana M. O. Battastini, Telma T. Schwindt, Alysson Muotri, Henning Ulrich

Journal of Cell Science (The Company of Biologists) Brasil, 15 August 2016

Neuroscience

Key words:Bradykinin, neurogenesis, TIS21 (PC3/BTG2) expression

Organism: Mouse

Tissue: Brain

466
G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway

Shih-Ting Cha, Ching-Ting Tan, Cheng-Chi Chang, Chia-Yu Chu, Wei-Jiunn Lee, Been-Zen Lin, Ming-Tsan Lin and Min-Liang Kuo

Nature Cell Biology (Nature) Taiwan, 15 August 2016

Oncology

Key words:Colorectal cancer, cancer-initiating cells phenotypes, K-RAS/β-catenin pathway

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

467
Prevention of Colitis and Colitis-Associated Colorectal Cancer by a Novel Polypharmacological Histone Deacetylase Inhibitor

Tzu-Tang Wei, Yi-Ting Lin, Ruo-Yu Tseng, Chia-Tung Shun, Yu-Chin Lin, Ming-Shiang Wu, Jim-Min Fang, Ching-Chow Chen

Clinical Cancer Research (AACR Publications) Taiwan, 14 August 2016

Oncology

Key words:Colorectal cancer, colitis, HDAC, HMGR

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

468
Localization of TrkB and p75 receptors in peritoneal and deep infiltrating endometriosis: an immunohistochemical study

Agung Dewanto, Jozsef Dudas, Rudolf Glueckert, Sylvia Mechsner, Anneliese Schrott-Fischer, Ludwig Wildt and Beata Seeber

Reproductive Biology and Endocrinology (Springer) Germany, 12 August 2016

Reproductive Medicine

Key words:Neurotrophins, BDNF, endometriosis, immunohistochemistry

Organism: Human

Tissue: Endometrium

Pathological State: Endometriosis

469
Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3

Bethany Baumann , Tomoko Hayashida, Xiaoyan Liang, H. William Schnaper

Kidney International (Elsevier) USA, 05 August 2016

Physiology

Key words:Fibrosis, glomerulus, hypoxia, TGF-β

Organism: Mouse

Tissue: Kidney

470
Role of the immune system in the peritoneal tumor spread of high grade serous ovarian cancer

Katharina Auer, Anna Bachmayr-Heyda, Nyamdelger Sukhbaatar, Stefanie Aust, Klaus G. Schmetterer, Samuel M. Meier, Christopher Gerner, Christoph Grimm, Reinhard Horvat, and Dietmar Pils

Oncotarget (Impact Journals) Austria, 03 August 2016

Oncology

Key words:epithelial ovarian cancer, peritoneal tumor spread, flow cytometry, PD-1, next generation sequencing

Organism: Human

Tissue: Peritoneum, Ovaries

Pathological State: Cancer

471
Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction

Tim Koopmans, Kuldeep Kumawat, Andrew J Halayko, Reinoud Gosens

Scientific Reports (Nature) The Netherlands, 29 July 2016

Cell Biology

Key words:Airway hyperresponsiveness, asthm, intracellular calcium flux, actin polymerisation

Organism: Human

Cell Line: Bronchial smooth muscle cells

472
CD271 regulates the proliferation and motility of hypopharyngeal cancer cells

Mai Mochizuki, Keiichi Tamai, Takayuki Imai, Sayuri Sugawara, Naoko Ogama, Mao Nakamura, Kazuto Matsuura, Kazunori Yamaguchi, Kennichi Satoh, Ikuro Sato, Hozumi Motohashi, Kazuo Sugamura, Nobuyuki Tanaka

Scientific Reports (Nature) Japan, 29 July 2016

Oncology

Key words:CD271 (p75 neurotrophin receptor), human hypopharyngeal cancer, head and neck squamous cell carcinoma

Organism: Human

Tissue: Pharynx

Pathological State: Cancer

473
Sur8 mediates tumorigenesis and metastasis in colorectal cancer

Young-Mi Lee, Saluja Kaduwal, Kug Hwa Lee, Jong-Chan Park, Woo-Jeong Jeong, Kang-Yell Choi

Experimental and Molecular Medicine (Nature) South Korea, 29 July 2016

Oncology

Key words:Scaffold protein, Ras-extracellular signal-regulated kinase, doxycyline, HCT116 cells

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

474
Tissue-Resident CD169+ Macrophages Form a Crucial Front Line against Plasmodium Infection

Pravesh Gupta, Si Min Lai, Jianpeng Sheng, Piotr Tetlak, Akhila Balachander, Carla Claser, Laurent Renia, Klaus Karjalainen, Christiane Ruedl

Cell Reports (Cell Press) Singapore, 28 July 2016

Cell Biology

Key words:Plasmodium berghei ANKA, malaria, myeloid cells, macrophages

Organism: Mouse

Tissue: Brain

Pathological State: Bacterial Infection

475
In situ mapping of innate lymphoid cells in human skin: evidence for remarkable differences between normal and inflamed skin

Marie-Charlotte Brüggen, Wolfgang M. Bauer, Bärbel Reininger, Eduard Clim, Catalin Captarencu Georg E. Steiner, Patrick M. Brunner, Barbara Meier, Lars E. French, Georg Sting

Journal of Investigative Dermatology (Elsevier) Austria, Switzerland, Romania, 22 July 2016

Dermatology

Key words:Lymphoid Cells, Human Skin, Inflamed Skin, atopic dermatitis, psoriasis

Organism: Human

Tissue: Skin

Pathological State: Dermatitis, Psoriasis

476
4 – Proffered Paper: Immunological changes during tumor progression from primary to recurrent glioblastoma

C. Herold-Mende, C. Rapp, R. Warta, A. Unterberg, P. Beckhove

European Journal of Cancer (Elsevier) , 14 July 2016

Oncology

Key words:Cancer, tumor, glioblastoma

Organism: Human

Tissue: Brain

Pathological State: Cancer

477
Multimodal Imaging of Nanocomposite Microspheres for Transcatheter Intra-Arterial Drug Delivery to Liver Tumors

Dong-Hyun Kim, Weiguo Li, Jeane Chen, Zhuoli Zhang, Richard M. Green, Sui Huang and Andrew C. Larson

Scientific Reports (Nature) USA, 13 July 2016

Oncology

Key words:Biomedical materials, cancer imaging, hepatic artery, nanotechnology in cancer, targeted therapies

Organism: Rat

Tissue: Xenograft Tumor, Liver

Pathological State: Cancer

478
Quantitative comparison and reproducibility of pathologist scoring and digital image analysis of estrogen receptor β2 immunohistochemistry in prostate cancer

Anthony E. Rizzardi, Xiaotun Zhang, Rachel Isaksson Vogel, Suzanne Kolb, Milan S. Geybels, Yuet-Kin Leung, Jonathan C. Henriksen, Shuk-Mei Ho, Julianna Kwak, Janet L. Stanford, and Stephen C. Schmechel

Diagnostic Pathology (BioMed Central) USA, 11 July 2016

Pathology

Key words:Prostate cancer, Biomarkers, Digital pathology, Quantification, Estrogen receptor β2

Organism: Human

Tissue: Prostate

Pathological State: Cancer

479
Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice

Dominic Schmidt, Daniel Peterlik, Stefan O. Reber, Anja Lechner, Daniela N. Männel

PLOS ONE (PLOS) Germany, 08 July 2016

Neuroscience

Key words:Chronic subordinate colony, myeloid cells, hypothalamus-pituitary-adrenal, sympathetic nervous system

Organism: Mouse

Tissue: Spleen, Allograft Tumor

Pathological State: Cancer

480
Lesional CD4+ IFN-γ+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis

Takashi Maehara, Hamid Mattoo, Miho Ohta, Vinay S Mahajan, Masafumi Moriyama, Masaki Yamauchi, Jefte Drijvers, Seiji Nakamura, John H Stone, Shiv S Pillai

Annals of the Rheumatic Diseases (BMJ Journals) Japan, 29 June 2016

Rheumatology

Key words:IgG4-related disease, T lymphocytes, Sjögren's syndrome,

Organism: Human

Tissue: Salivary Gland

Pathological State: Cancer

481
Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

Hweixian Leong Penny, Je Lin Sieow, Giulia Adriani, Wei Hseun Yeap, Peter See Chi Ee, Boris San Luis, Bernett Lee, Terence Lee, Shi Ya Mak, Ying Swan Ho, Choon Kiat Ong, Ruby Y J Huang, Florent Ginhoux, Olaf Rotzschke, Roger D. Kamm and Siew, Cheng Wong

OncoImmunology (Taylor and Francis) Singapore, 21 June 2016

Oncology

Key words:Metabolism, macrophages, pancreatic cancer, metastasis

Organism: Human

Pathological State: Cancer

Cell Line: HPAF-II (Pancreatic epithelial tumor cell line)

482
ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments

Rick Conzemius, Haleh Ganjian, Dieter Blaas and Renate Fuchs

Journal of Virology (American Society for Microbiology) Austria, 20 June 2016

Virology

Key words:Human rhinovirus A89 (HRV-A89) and HRV-B14, RNA genome, endocytic recycling compartment (ERC)

Organism: Human

Pathological State: Cancer

Cell Line: HeLA cells

483
Validation of tumor protein marker quantification by two independent automated immunofluorescence image analysis platforms

Amy R Peck, Melanie A Girondo, Chengbao Liu, Albert J Kovatich, Jeffrey A Hooke, Craig D Shriver, Hai Hu, Edith P Mitchell, Boris Freydin, Terry Hyslop, Inna Chervoneva and Hallgeir Rui

Modern Pathology (Nature) USA, 17 June 2016

Medical Image Analysis

Key words:Histology, biomarkers, breast tumor

484
Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells

Chen-Chi Liu, Shih-Pei Lin, Han-Shui Hsu, Shung-Haur Yang, Chiu-Hua Lin, Muh-Hwa Yang, Mien-Chie Hung and Shih-Chieh Hung

Nature Communications (Nature) Taiwan, 16 June 2016

Oncology

Key words:Biological sciences, cancer, cell biology

Organism: Human, Mouse

Tissue: Colon, Xenograft Tumor

Pathological State: Cancer

485
Ribosome inactivation leads to attenuation of intestinal polymeric Ig receptor expression via differential regulation of human antigen R

KH Do, SH Park, J Kim, M Yu, Y Moon

The Journal of Immunology (American Association of Immunologists) South Korea, 15 June 2016

Immunology

Key words:Ribosome ,Polymeric Ig Receptor ,Differential Regulation, Human Antigen R

Organism: Mouse

Tissue: Small Intestine, Colon

486
A new fluorescence/PET probe for targeting intracellular human telomerase reverse transcriptase (hTERT) using Tat peptide-conjugated IgM

Kyung oh Jung, Hyewon Youn , Seung Hoo Kim, Young-Hwa Kim, Keon Wook Kang, June-Key Chunga

Biochemical and Biophysical Research Communications (Elsevier) South Korea, 15 June 2016

Biological Methods

Key words:Intracellular and intranuclear protein, hTERT, tat peptide, IgM antibody, 64Cu, Live cell imaging

Organism: Human

Pathological State: Cancer

Cell Line: HT29, U2OS cells

487
Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine

Norihiro Kishida, Sachiko Matsuda, Osamu ItanoEmail author, Masahiro Shinoda, Minoru Kitago,Hiroshi Yagi, Yuta Abe, Taizo Hibi, Yohei Masugi, Koichi Aiura, Michiie Sakamoto and Yuko Kitagawa

BMC Gastroenterology (BioMed Central) Japan, 13 June 2016

Oncology

Key words:Nonalcoholic steatohepatitis, hepatocellular carcinoma, diethylnitrosamine, high-fat choline-deficient diet, mouse model

Organism: Mouse

Tissue: Liver

Pathological State: Fibrosis

488
Automated muscle fiber type population analysis with ImageJ of whole rat muscles using rapid myosin heavy chain immunohistochemistry

Konstantin D. Bergmeister, Marion Gröger, Martin Aman, Anna Willensdorfer, Krisztina Manzano-Szalai, Stefan Salminger and Oskar C. Aszmann

Muscle and Nerve (Wiley) Austria, 13 June 2016

Medical Image Analysis

Key words:Automated muscle fiber analysis, fiber population, ImageJ, muscle fiber type, myosin heavy chain, rat

Organism: Rat

Tissue: Muscle

489
Clonorchis sinensis omega-class glutathione transferases play major roles in the protection of the reproductive system during maturation and the response to oxidative stress

Jeong-Geun Kim, Chun-Seob Ahn, Seon-Hee Kim, Young-An Bae, Na-Young Kwon, Insug Kang, Hyun-Jong Yang, Woon-Mok Sohn, Yoon Kong

Parasites and Vectors (BioMed Central) South Korea, 13 June 2016

Parasitology

Key words:Clonorchis sinensis, glutathione transferase (GST), omega-class GST, sexual maturation, reproductive system, oxidative stress

Organism: Flatworm

Tissue: Whole Organism

490
Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

Pu-Hyeon Cha, Yong-Hee Cho, Sang-Kyu Lee, JaeHeon Lee, Woo-Jeong Jeong, Byoung-San Moon, Ji-Hye Yun, Jee Sun Yang, Sooho Choi, Juyong Yoon, Hyun-Yi Kim, Mi-Yeon Kim, Saluja Kaduwal, Weontae Lee, Do Sik Min, Hoguen Kim, Gyoonhee Han and Kang-Yell Choi

Nature Chemical Biology (Nature) South Korea, 13 June 2016

Oncology

Key words:Cancer therapy, cell signalling, screening, small molecules

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

491
Epidermal desmoglein 1 expression is reduced in kidney transplant recipients compared to immunocompetent patients

Jodi L. Johnson, Paul Hoover, Borko D. Jovanovic, Kathleen J. Green, John J. Friedewald, June K. Robinson

Journal of Investigative Dermatology (Elsevier) USA, 11 June 2016

Dermatology

Key words:Calcineurin inhibitor, desmoglein, E-cadherin, epidermal growth factor receptor, histone deacetylase inhibitor, immunocompetent patient, K1/10, Keratin 1 or 10, kidney transplant recipient, mycophenolate mofitil, plakoglobin, squamous cell carcinoma;ultraviolet light

Organism: Human

Tissue: Skin

Pathological State: Cancer

492
Amniotic Fluid Cells Proliferation in Normal and Down Syndrome Subjects

A Honcea, R Iulian, AG Pavel, I Ion, LE Sima

ARS Medica Tomitana (Sciendo) Romania, 11 June 2016

Reproductive Medicine

Key words:Down syndrome, Trisomy 21, amniotic fluid-derived stem cells, proliferation, cell cycle

Organism: Human

Cell Line: Amniotic fluid derived cells

493
ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model

Amy M. Archer, Rana Saber, Shawn Rose, Alexander Shaffer, Alexander V. Misharin, FuNien Tsai, G. Kenneth Haines III, Salina Dominguez, Mesut Eren, Douglas E. Vaughan, Carla M. Cuda and Harris Perlman

Journal of Translational Medicine (BioMed Central) USA, 10 June 2016

Immunology

Key words:Arthritis, cholesterol, inflammation, animal models of human disease

Organism: Mouse

Tissue: Joint

Pathological State: Atherosclerosis

494
Infiltration of Macrophages Correlates with Severity of Allograft Rejection and Outcome in Human Kidney Transplantation

Tobias Bergler, Bettina Jung, Felix Bourier, Louisa Kühne, Miriam C. Banas, Petra Rümmele, Simone Wurm, Bernhard Banas

PLOS ONE (PLOS) Germany, 10 June 2016

Transplantation Medicine

Key words:Macropaghes, T-lymphocytes, calcineriurin, inhibitor, renal transplantation

Organism: Human

Tissue: Kidney

Pathological State: Organ Transplantation

495
Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model

Hui-Wen Chiu, Ya-Ling Yeh, Yi-Ching Wang, Wei-Jan Huang, Sheng-Yow Ho, Pinpin Lin, Ying-Jan Wang

Molecular Cancer (Springer) Taiwan, 10 June 2016

Oncology

Key words:Histone deacetylase inhibitor, radiation, triple-negative breast cancer, autophagy

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

496
Gain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer’s Disease

Cheng-Chun Wu, Cheng-Chang Lien, Wen-Hsien Hou, Po-Min Chiang ,Kuen-Jer Tsai

Scientific Reports (Nature) Taiwan, 06 June 2016

Neuroscience

Key words:Dementia, neural stem cells, regeneration and repair in the nervous system, stem-cell research

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s Disease

497
Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model

CY Lin, HY Hsieh, CM Chen, SR Wu, CH Tsai, CY Huang, MY Hua, CK Yeh, HL Liu

Journal of Controlled Release (Elsevier) Taiwan, 26 May 2016

Neuroscience

Key words:Focused ultrasound, Gene therapy, Blood-brain barrier opening, Microbubbles, GDNF

Organism: Mouse

Tissue: Brain

Pathological State: Parkinson's Disease

498
Functional studies on primary tubular epithelial cells indicate a tumor suppressor role of SETD2 in clear cell renal cell carcinoma

J Li, J Kluiver, J Osinga, H Westers, MB van Werkhoven, Marc A Seelen, Rolf H Sijmons, Ankevan den Berg, Klaas Kok

Neoplasia (Elsevier) The Netherlands, 26 May 2016

Oncology

Key words:Primary Tubular Epithelial Cells, Tumor Suppression, SETD2, Renal Cell Carcinoma

Organism: Human

Pathological State: Cancer

Cell Line: PTECs and HKC8 cells

499
GBIQ: a non-arbitrary, non-biased method for quantification of fluorescent images

Youichirou Ninomiya, Wei Zhao,Yumiko Saga

Scientific Reports (Nature) Japan, 23 May 2016

Medical Image Analysis

Key words:Image processing, software

Organism: Mouse

Cell Line: MESCs (Mouse Embryonic stem cells)

500
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

Daniela F. Quail, Robert L. Bowman, Leila Akkari, Marsha L. Quick, Alberto J. Schuhmacher, Jason T. Huse, Eric C. Holland, James C. Sutton, Johanna A. Joyce

Science (American Association for the Advancement of Science) USA, 20 May 2016

Oncology

Key words:Mouse models, glioblastoma multiforme, macrophage

Organism: Mouse

Tissue: Lymphoid Tissue, Connective Tissue

Pathological State: Cancer

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