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Customer Publications (A total of 1287 papers published)

301
Zika virus infects renal proximal tubular epithelial cells with prolonged persistency and cytopathic effects

Jian Chen, Yi-feng Yang, Jun Chen, Xiaohui Zhou, Zhaoguang Dong, Tianyue Chen, Yu Yang, Peng Zou, Biao Jiang, Yunwen Hu, Lu Lu, Xiaoyan Zhang, Jia Liu, Jianqing Xu and Tongyu Zhu

Emerging Microbes and Infections (Nature) China, 23 August 2017

Immunology, Virology

Key words:Cytopathic effects, prolonged persistency, renal proximal tubular epithelial cells, urinary system, Zika virus

Organism: Mouse

Tissue: Kidney

Pathological State: Virus Infection

302
Efficient cell death induction in human glioblastoma cells by photodynamic treatment with Tetrahydroporphyrin-Tetratosylat (THPTS) and ionizing irradiation

Peter Hambsch, Yury P. Istomin, Dimitri A. Tzerkovsky, Ina Patties, Jochen Neuhaus, Rolf-Dieter Kortmann, Stanislav Schastak, and Annegret Glasow

Oncotarget (Impact Journals) Germany, Belarus, 23 August 2017

Oncology

Key words:photodynamic therapy, glioblastoma, THPTS, combination, ionizing radiation

Organism: Human

Cell Line: Human authenticated GBM cell lines (A-172, U-87 MG, and DBTRG-05MG)

303
Reactive oxygen species–mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression

Chia-Ling Hsieh, Che-Ming Liu, Hsin-An Chen, Shun-Tai Yang, Katsumi Shigemura, Koichi Kitagawa, Fukashi Yamamichi, Masato Fujisawa, Yun-Ru Liu, Wei-Hua Lee, Kuan-Chou Chen, Chia-Ning Shen, Cheng-Chieh Lin, Leland W. K. Chung and Shian-Ying Sung

Scientific Reports (Nature) Taiwan, 22 August 2017

Oncology

Key words:Stromelysin 1 (MMP-3) and 2 (MMP-10), prostate cancer-associated stromal fibroblasts (CAFs),extracellular matrix (ECM)

Organism: Human

Tissue: Prostate

Pathological State: Cancer

304
Screening platform for cell contact guidance based on inorganic biomaterial micro/nanotopographical gradients

Qihui Zhou, Olga Castañeda Ocampo, Carlos Guimarães, Philipp Kuhn, Theo van Kooten, and Patrick van Rijn

Applied Materials and Interfaces (ACS Publications) The Netherlands, 21 August 2017

Stem Cell Research

Key words:Biomimetic surface, high-throughput screening, inorganic biomaterials, stem cell behavior, topographical gradient

Organism: Human

Cell Line: Mesenchymal stem cells from human bone marrow (hBM-MSCs)

305
Bifidobacterium Infantis Ameliorates Chemotherapy-Induced Intestinal Mucositis Via Regulating T Cell Immunity in Colorectal Cancer Rats

Mi H, Dong Y, Zhang B, Wang H, Peter C.C.K, Gao P,Fu H, Gao Y

Celular Physiology And Biochemistry (Karger) China, 18 August 2017

Oncology

Key words:Bifidobacterium infantis, intestinal mucositis, 5-fluorouracil, oxaliplatin, CD4+CD25+Foxp3+ Tregs, CD4+CD17A+ cells, colorectal cancer

Organism: Rat

Tissue: Allograft Tumor

Pathological State: Cancer

306
An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis

Logan A. Walsh, Mariano J. Alvarez, Erich Y. Sabio, Marsha Reyngold, Vladimir Makarov, Suranjit Mukherjee, Ken-Wing Lee, Alexis Desrichard, Şevin Turcan, Martin G. Dalin, Vinagolu K. Rajasekhar, Shuibing Chen, Linda T. Vahdat, Andrea Califano, Timothy A. Chan

Cell Reports (Cell Press) USA, 15 August 2017

Oncology

Key words:ARACNe, MARINa, VIPER, breast, cancer, metastasis, transcription, TRIM25, EFP

Organism: Mouse

Tissue: Allograft Tumor, Lung

Pathological State: Cancer

307
Impact of Type III Secretion Effectors and of Phenoxyacetamide Inhibitors of Type III Secretion on Abscess Formation in a Mouse Model of Pseudomonas aeruginosa Infection

Bryan J. Berubea, Katherine R. Murphya, Matthew C. Torhanc, Nicholas O. Bowlinc, John D. Williamsc, Terry L. Bowlinc, Donald T. Moirc and Alan R. Hausera,b

Antimicrobial Agents and Chemotherapy (American Society for Microbiology) USA, 14 August 2017

Microbiology

Key words:Pseudomonas aeruginosa, abscesses, neutrophils, phenoxyacetamide inhibitors, type III secretion

Organism: Mouse

Tissue: Liver, Spleen

Pathological State: Abscess

308
Effects of sulfur mustard on mesenchymal stem cells

Annette Schmidt, Dirk Steinritz, Simone Rothmiller, Horst Thiermann, A. Michael Scherer

Toxicology Letters (Elsevier) Germany, 14 August 2017

Toxicology

Key words:Sulfur mustard, mesenchymal stem cells, senescence, apoptosis, proliferation

Organism: Human

Cell Line: Mesenchymal stem cells from human bone marrow (hBM-MSCs)

309
Attenuation of Follicular Helper T Cell–Dependent B Cell Hyperactivity by Abatacept Treatment in Primary Sjögren's Syndrome

Gwenny M. Verstappen,Petra M. Meiners,Odilia B. J. Corneth,Annie Visser,Suzanne Arends,Wayel H. Abdulahad,Rudi W. Hendriks,Arjan Vissink,Frans G. M. Kroese,Hendrika Bootsma

Arthritis and Rheumatology (Wiley) The Netherlands, 13 August 2017

Rheumatology

Key words:CTLA-4Ig, CD4+ T cell , Sjögren's syndrome, marker ICOS

Organism: Human

Tissue: Parotid Gland

Pathological State: Sjögren's Syndrome

310
Role of glial-cell-derived neurotrophic factor in salivary gland stem cell response to irradiation

Xiaohong Peng, Kärt Varendi, Martti Maimets, Jaan-Olle Andressoo, Rob P.Coppes

Radiotherapy and Oncology (Elsevier) The Netherlands, 04 August 2017

Oncology

Key words:Salivary glands, GDNF, stem cells, spheres, radiation-induced xerostomia

Organism: Human

Tissue: Salivary Gland

311
Traditional Chinese medicine Danggui Buxue Tang inhibits colorectal cancer growth through induction of autophagic cell death

ST Chen, TY Lee, TH Tsai, YC Huang, YC Lin, CP Lin, HR Shieh, ML Hsu, CW Chi, MC Le, HH Chang, YJ Chen

Oncotarget (Impact Journals) Taiwan, 03 August 2017

Oncology

Key words:Danggui Buxue Tang, colorectal cancer, autophagy, traditional Chinese medicine, mammalian target of rapamycin (mTOR)

Organism: Mouse

Tissue: Colon, Xenograft Tumor

Pathological State: Cancer

312
The Prognostic Role of T1 Mapping Sequences: Can T1 Mapping Parameters Have a Role in Risk Stratification?

EY Choi, CH Park, TH Kim

Cardiovascular Imaging Asia (Kamje Press) South Korea, 31 July 2017

Cardiology

Key words:Cardiac magnetic resonance imaging; T1 mapping; Prognosis

Organism: Human

Tissue: Heart

313
Parathyroid hormone regulates fates of murine osteoblast precursors in vivo

DH Balani, N Ono, HM Kronenberg

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, 31 July 2017

Stem Cell Research

Key words:Parathyroid hormone, osteoblast precursors, bone biology, stem cells

Organism: Mouse

Tissue: Bone

314
Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas

D Yan, J Kowal, L Akkari, A J Schuhmacher, J T Huse, B L West and J A Joyce

Oncogene (Nature) USA, Switzerland, 31 July 2017

Oncology

Key words:Glioblastomas, tumor microenvironment (TME)-mediated extrinsic resistance, PDGF-B-driven proneural glioma mouse model

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

315
Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBPβ Signaling

Jinlong Yin, Young Taek Oh, Jeong-Yub Kim, Sung Soo Kim, Eunji Choi, Tae Hoon Kim, Jun Hee Hong, Nakho Chang, Hee Jin Cho, Jason K. Sa, Jeong Cheol Kim, Hyung Joon Kwon, Saewhan Park, Weiwei Lin, Ichiro Nakano, Ho-Shin Gwak, Heon Yoo, Seung-Hoon Lee, Jeongwu Lee, Jong Heon Kim, Soo-Youl Kim, Do-Hyun Nam, Myung-Jin Park and Jong Bae Park

Cancer Research (AACR Publications) South Korea, 28 July 2017

Oncology

Key words:Necrosis, glioblastoma, transglutaminase 2 (TGM2), transcription factors (TF)

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

316
Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis

Johannes J. Kovarik, Elisabeth Kernbauer, Markus A. Hölzl, Johannes Hofer, Guido A. Gualdoni, Klaus G. Schmetterer, Fitore Miftari, Yury Sobanov, Anastasia Meshcheryakova, Diana Mechtcheriakova, Nadine Witzeneder, Georg Greiner, Anna Ohradanova-Repic, Petra Waidhofer-Söllner, Marcus D. Säemann, Thomas Decker, Gerhard J. Zlabinge

PLOS ONE (PLOS) Austria, 24 July 2017

Immunology

Key words:Cell metabolism, mammalian target of rapamycin (mTOR), interleukin (IL)-12 and anti-inflammatory IL-10

Organism: Mouse

Tissue: Liver, Spleen

317
CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer

Fenne L. Komdeur, Thalina M. Prins, Stephanie van de Wall, Annechien Plat, G. Bea A. Wisman, Harry Hollema, Toos Daemen , David N. Church, Marco de Bruyn, The Netherlands and Hans W. Nijman

OncoImmunology (Taylor and Francis) The Netherlands, 24 July 2017

Oncology

Key words:CD103, cervical cancer, intraepithelial T cells, therapeutic vaccination, tumor-infiltrating lymphocytes

Organism: Human

Tissue: Uterus

Pathological State: Cancer

318
Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning

Julia Herbert, Horst Thiermann, Franz Worek,Timo Wille

Toxicology (Elsevier) Germany, 22 July 2017

Toxicology

Key words:Chemical warfare agents, nerve agents, pesticide,lung, PCLS, precision cut lung slices

Organism: Rat

Tissue: Lung

319
Large-scale 3-dimensional quantitative imaging of tissues: state-of-the-art and translational implications

SethWinfree, Michael J.Ferkowicz, Pierre C.Dagher, Katherine J.Kelly, Michael T.Eadon, Timothy A.Sutton, Troy A.Markel, Mervin C.Yoder, Kenneth W.Dunn, Tarek M.El-Achkar

Translational Research (Elsevier) USA, 22 July 2017

Medical Imaging

Key words:2D2 dimensional, 3D3 dimensional, LSM- light sheet microscopy, IHCS- imaging high content screening, VTEA -Volumetric tissue exploration and analysis, 3DTC-3 dimensional tissue cytometry

320
Neuron-Specific Fluorescence Reporter-Based Live Cell Tracing for Transdifferentiation of Mesenchymal Stem Cells into Neurons by Chemical Compound

Do Won Hwang, Hyun Woo Kwon, Jaeho Jang, Hee Jung Jung, Kwang Rok Kim, and Dong Soo Lee

Stem Cells International (Hindawi Publishing Corporation) South Korea, 20 July 2017

Stem Cell Research

321
The c.1085A>G genetic variant of CSF1R gene regulates tumor immunity by altering the proliferation, polarization, and function of macrophages

Yu-Min Yeh, Shan-Ju Hsu, Peng-Chan Lin, Keng-Fu Hsu, Pei-Ying Wu, Wu-Chou Su, Jang-Yang Chang and Meng-Ru Shen

Clinical Cancer Research (AACR Publications) Taiwan, 19 July 2017

Oncology

Key words:Tumor, CSF1R, low VEGF expression, altering the polarization and function of macrophages

Organism: Human

Tissue: Colon, Ovaries, Endometrium

Pathological State: Cancer

322
Production of reactive persulfide species in chronic obstructive pulmonary disease

Tadahisa Numakura, Hisatoshi Sugiura, Takaaki Akaike, Tomoaki Ida, Shigemoto Fujii, Akira Koarai, Mitsuhiro Yamada, Katsuhiro Onodera, Yuichiro Hashimoto, Rie Tanaka, Kei Sato, Yutaka Shishikura, Taizou Hirano, Satoru Yanagisawa, Naoya Fujino, Tatsuma Okazaki, Tsutomu Tamada, Yasushi Hoshikawa, Yoshinori Okada, Masakazu Ichinose

Thorax (BMJ Journals) Japan, 19 July 2017

Pulmonology

Key words:Oxidative Stress

Organism: Human

Tissue: Lung

Pathological State: Chronic Obstructive Pulmonary Disease

323
Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration

Settimio Pacelli, Sayantani Basu, Jonathan Whitlow, Aparna Chakravarti, Francisca Acost, Arushi Varshney, Saman Modaresia, Cory Berkland, Arghya Paul

Advanced Drug Delivery Reviews (Elsevier) USA, 19 July 2017

Regenerative Medicine

Key words:Stem cell homing, growth factor delivery, chemoattractant gradients, endothelialization, extracellular matrix, bone graft substitutes, myocardial regeneration

Organism: Human

Cell Line: Human mesenchymal stem cells (hMSCs)

324
MicroRNA 155-deficiency leads to decreased autoantibody levels and reduced severity of nephritis and pneumonitis in pristaneinduced lupus

Harald Leiss, Wilhelm Salzberger, Barbara Jacobs, Irina Gessl, Nicolas Kozakowski, Stephan Bluml, Antonia Puchner, Attila Kiss, Bruno K. Podesser, Josef S. Smolen,Georg H. Stummvoll

PLOS ONE (PLOS) Austria, 18 July 2017

Immunology

Key words:Systemic lupus, miR155-deficient, PBS-injected mice, glomerulonephritis, pneumonitis

Organism: Mouse

Tissue: Kidney

Pathological State: Lupus

325
Analysis of cysteine-X-cysteine motif chemokine ligands 9, 10, and 11, their receptor CXCR3, and their possible role on the recruitment of immune cells at the maternal–conceptus interface in pigs†

Jisoo Han, Min Jeong Gu, Inkyu Yoo, Yohan Cho,i Hwanhee Jang, Minjeong Kim, Cheol-Heui Yun, Hakhyun Ka

Biology of Reproduction (Oxford University Press) South Korea, 15 July 2017

Immunology

Key words:Pig, pregnancy, uterus, endometrium, CXCL9, CXCL10, CXCL11

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

326
Expansion of BCR/ABL1+ cells requires PAK2 but not PAK1

Leo Edlinger, Angelika Berger-Becvar, Ingeborg Menzl, Gregor Hoermann, Georg Greiner, Eva Grundschober, Zsuzsanna Bago-Horvath, Wael Al-Zoughbi, Gerald Hoefler, Christine Brostjan, Lars Gille, Richard Moriggl, Andreas Spittler, Veronika Sexl, Andrea Hoelbl-Kovacic

British Journal of Haematology (Wiley) Austria, 14 July 2017

Oncology

Key words:The p21-activated kinases (PAKs), BCR/ABL1+ haematopoietic malignancy, leukaemic cells

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

327
Placental homing peptide-microRNA inhibitor conjugates for targeted enhancement of intrinsic placental growth signaling

F Beards, LE Jones, J Charnock, K Forbes, LK Harris

Theranostics (NCBI) UK, 14 July 2017

Reproductive Medicine

Key words:fetal growth restriction, IGF-II, microRNA, placenta, proliferation, pregnancy

Organism: Human

Tissue: Placenta

328
Small cell lung cancer: model of circulating tumor cell tumorospheres in chemoresistance

Lukas Klameth, Barbara Rath, Maximilian Hochmaier, Doris Moser, Marlene Redl, Felicitas Mungenast, Katharina Gelles, Ernst Ulsperger, Robert Zeillinger and Gerhard Hamilton

Scientific Reports (Nature) Austria, 13 July 2017

Oncology

Key words:Small cell lung cancer (SCLC), circulating tumor cells (CTCs), Ki67 and carbonic anhydrase 9 (CAIX)

Organism: Human

Tissue: Lung

Pathological State: Cancer

329
RIP3 attenuates the pancreatic damage induced by deletion of ATG7

Xiaodong Zhou, Li Xie, Leizhou Xia, Frank Bergmann, Markus W Büchler, Guido Kroemer, Thilo Hackert and Franco Fortunato

Cell Death and Disease (Nature) Germany, 13 July 2017

Gastroenterology

Key words:Pancreatitis, Rip3, acinar cells, autophagy and necroptosis

Organism: Human, Mouse

Tissue: Pancreas

330
Tailor-made purified human platelet lysate concentrated in neurotrophins for treatment of Parkinson's disease

Ming-Li Choua, Joe-Wei Wu, Flore Gouel, Aurélie Jonneaux, Kelly Timmerman, Ting-Yi Renn, Charlotte Laloux, Hung-Ming Chang, Liang-Tzung Lin, Jean-Christophe Devedjian, David Devos , Thierry Burnou

Biomaterials (Elsevier) Taiwan, 12 July 2017

Biological Materials

Key words:Platelet lysate, neuroprotection, parkinson, MPTP, neurotrophins, growth factors

Organism: Mouse

Tissue: Brain

331
CCAAT/enhancer-binding protein delta promotes intracellular lipid accumulation in M1 macrophages of vascular lesions

Hong-Yue Lai, Ling-Wei Hsu, Hsin-Hwa Tsai, Yu-Chih Lo, Shang-Hsun, Yang Ping-Yen Liu, Ju-Ming Wang

Cardiovascular Research (Oxford University Press) Taiwan, 11 July 2017

Cardiology

Key words:CEBPD, inflammation, macrophages, PTX3, statins

Organism: Mouse

Pathological State: Vascular lesions

Cell Line: Macrophages and nile red-positive cells

332
Instructing cells with programmable peptide DNA hybrids

Ronit Freeman, Nicholas Stephanopoulos, Zaida Álvarez, Jacob A Lewis, Shantanu Sur, Chris M Serrano, Job Boekhoven, Sungsoo S. Lee and Samuel I. Stupp

Nature Communications (Nature) USA, 10 July 2017

Cell Biology

Key words:Native extracellular matrix, peptide-DNA (P-DNA)

Organism: Mouse

Cell Line: NIH-3T3 mouse embryonic fibroblasts

333
Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis

Mirella Tanori, Arianna Casciati, Francesco Berardinelli, Simona Leonardi, Emanuela Pasquali, Francesca Antonelli, Barbara Tanno, Paola Giardullo, Alessandro Pannicelli, Gabriele Babini, Ilaria De Stefano, Antonella Sgura, Mariateresa Mancuso, Anna Saran, and Simonetta Pazzaglia

Oncotarget (Impact Journals) Italy, 07 July 2017

Oncology

Key words:cerebellum, expression profiles, medulloblastoma, apoptosis, senescence

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

334
Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion

Tereza Vanova, Zaneta Konecna, Zuzana Zbonakova, Giuseppe La Venuta, Karolina Zoufalova, Sarka Jelinkova,Miroslav Varecha, Vladimir Rotrekl, Pavel Krejci, Walter Nickel, Petr Dvorak, Michaela Kunova Bosakova

Stem Cells (Wiley) Czech Republic, 06 July 2017

Stem Cell Research

Key words:Human pluripotent stem cells (hPSCs), fibroblast growth factor (FGF) receptors, hepatocellular carcinoma (TEC)

Organism: Human

Cell Line: hPSCs (Human pluripotent stem cells)

335
A novel in vitro model of villitis of unknown etiology demonstrates altered placental hormone and cytokine profile

Hayley Derricott, Alexander E.P. Heazell, Susan L. Greenwood, Rebecca L. Jones

American Journal of Reproductive Immunology (Wiley) UK, 06 July 2017

Reproductive Medicine

Key words:Placental dysfunction, villitis of unknown etiology, T cell, fetal growth restriction

Organism: Human

Cell Line: Placental explant culture

336
Increased migration of antigen presenting cells to newly-formed lymphatic vessels in transplanted kidneys by glycol-split heparin

Ditmer T. Talsma, Kirankumar Katta, Miriam Boersema, Saritha Adepu,Annamaria Naggi, Giangiacomo Torri, Coen Stegeman, Gerjan Navis, Harry van Goor,Jan-Luuk Hillebrands,Saleh Yazdani, Jacob van den Born

PLOS ONE (PLOS) The Netherlands, 30 June 2017

Transplantation Medicine

Key words:Chronic renal transplant, lymphatic chemokine-proteoglycan, renal graft

Organism: Rat

Tissue: Kidney

Pathological State: Organ Transplantation

337
Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation

Tao Peng, R. Savanh Chanthaphavong, Sijie Sun, James A. Trigilio, Khamsone Phasouk, Lei Jin, Erik D. Layton, Alvason Z. Li, Colin E. Correnti, Willem De van der Schueren, Julio Vazquez, Diana R. O’Day, Ian A. Glass, David M. Knipe, Anna Wald, Lawrence Corey, Jia Zhu

Journal Of Experimental Medicine (Rockefeller University Press) USA, 29 June 2017

Neuroscience

Key words:Herpes simplex virus (HSV), keratinocytes, IL-17c , nervous system

Organism: Human

Tissue: Skin

Cell Line: Keratinocytes

338
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells

Dong Hoon Kang, Doo Jae Lee, Sunmi Lee, So-Young Lee, Yukyung Jun, Yerin Kim, Youngeun Kim, Ju-Seog Lee, Dae-Kee Lee, Sanghyuk Lee, Eek-Hoon Jho, Dae-Yeul Yu and Sang Won Kang

Nature Communications (Nature) South Korea, 28 June 2017

Oncology

Key words:Colon cancer, mechanisms of disease

Organism: Mouse

Tissue: Small Intestine

339
Hinokitiol up-regulates miR-494-3p to suppress BMI1 expression and inhibits self-renewal of breast cancer stem/progenitor cells

Shih-Ming Chen, Bing-Yen Wang, Che-Hsin Lee, Hsueh-Te Lee, Jung-Jung Li, Guan-Ci Hong, Yu-Chieh Hung, Peng-Ju Chien, Che-Ying Chang, Li-Sung Hsu, and Wen-Wei Chang

Oncotarget (Impact Journals) Taiwan, 27 June 2017

Oncology

Key words:hinokitiol, miR-494-3p, BMI1, breast cancer, cancer stem cells

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

340
The bile acid receptor FXR attenuates acinar cell autophagy in chronic pancreatitis

Xiaodong Zhou, Li Xie, Frank Bergmann, Volker Endris, Oliver Strobel, Markus W Büchler, Guido Kroemer, Thilo Hackert and Franco Fortunato

Cell Death Discovery (Nature) Germany, 19 June 2017

Gastroenterology

Key words:Apoptosis, chronic pancreatitis, macroautophagy, necroptosis

Organism: Human, Mouse

Tissue: Pancreas

Pathological State: Pancreatitis

341
Breviscapine (BVP) inhibits prostate cancer progression through damaging DNA by minichromosome maintenance protein-7 (MCM-7) modulation

Yang-boGuan, Dong-rongYang, Shao-junNong, JianNi, Chun-huiHu, JianLi, JinZhu, Yu-xiShan

Biomedicine and Pharmacotherapy (Elsevier) China, 17 June 2017

Oncology

Key words:Breviscapine, human prostate cancer, DNA damage, MCM-7, Apoptosis

Organism: Human, Mouse

Tissue: Prostate, Xenograft Tumor

Pathological State: Cancer

342
Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation

Pounami Samadder, Tereza Suchánková, Ondřej Hylse, Prashant Khirsariya, Fedor Nikulenkov, Stanislav Drápela, Nicol Straková, Petr Vaňhara, Kateřina Vašíčková, Hana Kolářová, Lucia Binó, Miroslava Bittová, Petra Ovesná, Peter Kollár, Radek Fedr, Milan Ešner, Josef Jaroš, Aleš Hampl, Lumír Krejčí, Kamil Paruch and Karel Souček

Molecular Cancer Therapeutics (AACR Publications) Czech Republic, 15 June 2017

Oncology

Key words:Tumor cells, serine threonine kinase, DNA antimetabolites

Organism: Human, Mouse

Tissue: Skin, Xenograft Tumor

Pathological State: Cancer

343
Inhibition of the NOD-like receptor protein 3 inflammasome is protective in juvenile influenza A virus infection

Bria M. Coates, imageKelly L. Staricha, imageNandini Ravindran, imageClarissa M. Koch, imageYuan Cheng, imageJennifer M. Davis, imageDale K. Shumaker and imageKaren M. Ridge

Frontiers in Immunology (Frontiers Media S.A.) USA, 10 June 2017

Immunology

Key words:Inhibition of the NOD-Like Receptor Protein 3 Inflammasome Is Protective in Juvenile Influenza A Virus Infection

Organism: Mouse

Tissue: Lung

Pathological State: Virus Infection

344
Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer

Felicitas Mungenast, Stefanie Aust, Ignace Vergote, Adriaan Vanderstichele, Jalid Sehouli, Elena Braicu, Sven Mahner, Dan Cacsire Castillo-Tong, Robert Zeillinger, and Theresia Thalhammer1

Oncology Letters (Spandidos Publications) Austria, Belgium, Germany, 03 June 2017

Oncology

Key words:pithelial ovarian cancer, estrogen, estrogen metabolizing enzymes, STS, sulfotransferase, SULT1E1, E2, ovarian cancer

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

345
Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy

Valerie N Babinsky, Fadil M Hannan, Reshma D Ramracheya, Quan Zhang, M Andrew Nesbit, Alison Hugill, Liz Bentley , Tertius A Hough , Elizabeth Joynson Michelle Stewart, Abhishek Aggarwal, Maximilian Prinz-Wohlgenannt, Caroline M Gorvin, Enikö Kallay, Sara Wells, Roger D Cox , Duncan Richards, Patrik Rorsman, Rajesh V Thakker

Endocrinology (Oxford University Press) UK, 02 June 2017

Endocrinology

Key words:Calcium-Sensing Receptor, CaSR, Hyperglycemia, Calcilytic Therapy, glucose homeostasis, Diabetes

Organism: Mouse

Tissue: Xenograft Tumor, Pancreas

Pathological State: Cancer

346
Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice

Tse-Hung Huang, Chin-Chang Chen, Hsuan-Miao Liu, Tzung-Yan Lee and Sue-Heui Shieh

Scientific Reports (Nature) Taiwan, 02 June 2017

Immunology, Virology

Key words:Age-related autoimmune hepatitis, cell senescence, apoptosis, concanavalin A (Con A),

Organism: Mouse

Tissue: Liver

347
Extracellular matrix hydrogel derived from human umbilical cord as a scaffold for neural tissue repair and its comparison with extracellular matrix from porcine tissues

Zuzana Kočí, Karel Výborný, Jana Dubišová, Irena Vacková, Aleš Jäger, Oleg Lunov, Klára Jiráková, and Šárka Kubinová

Tissue Engineering Part C (Mary Ann Liebert Inc.) Czech Republic, 01 June 2017

Tissue Engineering

Key words:Hydrogel, Umbilical Cord, Neural Tissue Repair, Extracellular Matrix, Porcine Tissues

Organism: Rat

Tissue: Spinal Cord

Cell Line: Dorsal root ganglia

348
Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

Andrea E. Calvert, Alexandra Chalastanis, Yongfei Wu, Lisa A. Hurley, Fotini M. Kouri, Yingtao Bi, Maureen Kachman, Jasmine L. May, Elizabeth Bartom, Youjia Hua, Rama K. Mishra, Gary E. Schiltz, Oleksii Dubrovskyi, Andrew P. Mazar, Marcus E. Peter, Hongwu Zheng, C. David James, Charles F. Burant, Navdeep S. Chandel, Ramana V. Davuluri, Craig Horbinski, Alexander H. Stegh

Cell Reports (Cell Press) USA, 30 May 2017

Oncology

Key words:wild-type IDH1; GBM; metabolism; differentiation; NADPH; lipids; reactive oxygen species (ROS); EGFR; targeted therapy

Organism: Mouse

Pathological State: Cancer

Cell Line: GIC-20 (Glioma initiating cells)

349
Automated Image Analysis of HER2 Fluorescence In Situ Hybridization to Refine Definitions of Genetic Heterogeneity in Breast Cancer Tissue

Gedmante Radziuviene, Allan Rasmusson, Renaldas Augulis, Daiva Lesciute-Krilaviciene, Aida Laurinaviciene, Eduard Clim, and Arvydas Laurinavicius

BioMed Research International (Hindawi Publishing Corporation) Lithuania, Austria, 28 May 2017

Medical Image Analysis

Key words:Automated Image Analysis, HER2 FISH, Genetic Heterogeneity, Breast Cancer

Organism: Human

Tissue: Breast

Pathological State: Cancer

350
Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling

Yu-Ching Huang, Ming-ShiunTsai, Pei-Chi Hsieh, Jheng-Hong Shih, Tsu-Shing Wang, Yi-Chun Wang, Ting-Hui Lin, Sue-Hong Wang

Toxicology and Applied Pharmacology (Elsevier) China, 27 May 2017

Oncology

Key words:Cisplatin nephrotoxicity; ERK; Galangin; Inflammation; NF-κB; Oxidative stress

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Injury

351
Hepatic IFIT3 predicts interferon-α therapeutic response in patients of hepatocellular carcinoma

Yingyun Yang,Ye Zhou,Jin Hou,Chunmei Bai,Zhenyang Li,Jia Fan,Irene O.L. Ng,Weiping Zhou,Huichuan Sun,Qiongzhu Dong,Joyce M.F. Lee,Chung-Mau Lo,Kwan Man,Yun Yang,Nan Li,Guoshan Ding,Yizhi Yu,Xuetao Cao

Hepathology (Wiley) China, 26 May 2017

Oncology

Key words:Adjuvant interferon-α (IFN-α), hepatocellular carcinoma (HCC), IFIT3,

Organism: Human

Tissue: Liver

Pathological State: Cancer

352
QUICK FIRE CASES- SESSION III

European Heart Journal (Oxford University Press) Denmark, 25 May 2017

Cardiology

Key words:Myocardium, diagnosis, fire - disaster,s fire - physical, phenomenon cardiac, mri

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

353
SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor

Xianghui Zou, Yueming Zhu, Seong-Hoon Park, Guoxiang Liu, Joseph O'Brien, Haiyan Jiang and David Gius

Cancer Research (AACR Publications) USA, 23 May 2017

Oncology

Key words:Isocitrate dehydrogenase IDH2, α-ketoglutarate,cancer cells, SIRT3

Organism: Human

Tissue: Breast

Pathological State: Cancer

354
Single allele Lmbrd1 knockout results in cardiac hypertrophy

Tseng LT, Lin CL, Pan KH, Tzen KY, Su MJ, Tsai CT, Li YH, Li PC, Chiang FT, Chang SC, Chang MF

Journal of the Formosan Medical Association (Elsevier) Taiwan, 23 May 2017

Cardiology

Key words:Cardiac hypertrophy, Disease animal model, Gene knockout, Mouse Lmbrd1 gene, Human LMBRD1 gene, LMBD1 protein

Organism: Mouse

Tissue: Heart

Pathological State: Hypertrophy

355
MicroRNA-146a governs fibroblast activation and joint pathology in arthritis

Victoria Saferdinga, Antonia Puchnera, Eliana Goncalves-Alvesa, Melanie Hofmanna, Michael Bonellia, Julia S. Brunnerb, Emine Sahinb, Birgit Niederreitera, Silvia Hayera, Hans P. Kienera, Elisa Einwallnerc, Ramzi Nehmard, Raphael Carapitod, Philippe Georgeld, Marije I. Koenderse, Mark Boldinf, Gernot Schabbauerb, Mariola Kurowska-Stolarskag, Günter Steinera, h, Josef S. Smolena, Kurt Redlicha, Stephan Blüml

Journal of Autoimmunity (Elsevier) Austria, 22 May 2017

Rheumatology

Key words:Synovial fibroblasts, miR-146a, tumor necrosis factor (TNF) receptor, factor 6 (TRAF6), osteoprotegerin (OPG)

Organism: Human

Tissue: Bone

Pathological State: Rheumatoid Arthritis

356
Significance of B10 cell in patients with thymoma complicated with myasthenia gravis

Y Lu, F Meng, Y Yang, L Li, D Wang, Y Cui, S Dong, W Wang

Oncotarget (Impact Journals) China, 17 May 2017

Oncology

Key words:regulatory B cell, B10 cell, thymoma, myasthenia gravis, autoimmune abnormality

Organism: Human

Tissue: Thymus

Pathological State: Cancer

357
Enhanced Bruton's Tyrosine Kinase Activity in Peripheral Blood B Lymphocytes From Patients With Autoimmune Disease

Odilia B. J. Corneth,Gwenny M. P. Verstappen,Sandra M. J. Paulissen,Marjolein J. W. de Bruijn,Jasper Rip,Melanie Lukkes,Jan Piet van Hamburg,Erik Lubberts,Hendrika Bootsma,Frans G. M. Kroese,Rudi W. Hendriks

Arthritis and Rheumatology (Wiley) The Netherlands, 10 May 2017

Rheumatology

Key words:Bruton's tyrosine kinase (BTK), B cell receptor (BCR), Sjögren's syndrome (SS), BTK phosphorylation

Organism: Human

Tissue: Salivary Gland

Pathological State: Sjögren's Syndrome

358
Hyaluronan keeps mesenchymal stem cells quiescent and maintains the differentiation potential over time

Tzyy Yue Wong,Chiung-Hsin Chang,Chen-Hsiang Yu,Lynn L. H. Huang

Aging Cell (Wiley) Taiwan, 04 May 2017

Stem Cell Research

Key words:Hyaluronan (HA), mesenchymal stem cells (MSCs), cellular aging, human placenta-derived MSCs (PDMSC)

Organism: Human

Cell Line: Human mesenchymal stem cells (hMSCs)

359
CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice

Sreya Bagchi, Ying He, Hong Zhang, Liang Cao, Ildiko Van Rhijn, D. Branch Moody, Johann E. Gudjonsson, and Chyung-Ru Wang

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, 02 May 2017

Immunology

Key words:Autoimmunity, Immunology

Organism: Mouse

Tissue: Heart, Skin

360
A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

Yuan-Hua Wu, Chi-Wei Hong, Yi-Ching Wang, Wei-Jan Huang, Ya-Ling Yeh, Bour-Jr Wang1, Ying-Jan Wang, Hui-Wen Chiu

Cancer Letters (Elsevier) Taiwan, 24 April 2017

Oncology

Key words:DNA damage, DNA repair, Ubiquitin–proteasome system, Triple-negative breast cancer

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

361
Cytotoxicity of Natural Killer Cells Activated Through NKG2D Contributes to the Development of Bronchiolitis Obliterans in a Murine Heterotopic Tracheal Transplant Model

T. Kawakami,K. Ito,Y. Matsuda,M. Noda,A. Sakurada,Y. Hoshikawa,Y. Okada,K. Ogasawara

American Journal of Transplantation (Wiley) Japan, 21 April 2017

Transplantation Medicine

Key words:Basic (laboratory) research/science, lung transplantation/pulmonology, bronchiolitis obliterans (BOS), natural killer (NK) cells/NK receptors

Organism: Mouse

Tissue: Trachea

Pathological State: Organ Transplantation

362
Two different, mutually exclusively distributed, TP53 mutations in ovarian and peritoneal tumor tissues of a serous ovarian cancer patient: indicative for tumor origin?

Nyamdelger Sukhbaatar, Anna Bachmayr-Heyda, Katharina Auer, Stefanie Aust, Simon Deycmar, Reinhard Horvat and Dietmar Pils

Molecular Case Studies (CSH Press) Austria, 14 April 2017

Oncology

Key words:Mutually exclusive p53 mutations in ovarian cancer

Organism: Human

Tissue: Ovaries, Peritoneum

Pathological State: Cancer

363
Immunomodulatory Magnetic Microspheres for Augmenting Tumor-Specific Infiltration of Natural Killer (NK) Cells

Wooram Park , Andrew C. Gordon, Soojeong Cho, Xiaoke Huang, Kathleen R. Harris, Andrew C. Larson, and Dong-Hyun Kim

Applied Materials and Interfaces (ACS Publications) USA, 13 April 2017

Oncology

Key words:And image-guided therapy, cancer immunotherapy interferon-gamma (IFN-γ), microspheres, natural killer (NK) cells infiltration

Organism: Human

364
Extravillous Trophoblast and Endothelial Cell Crosstalk Mediates Leukocyte Infiltration to the Early Remodeling Decidual Spiral Arteriole Wall

Ruhul H. Choudhury, Caroline E. Dunk, Stephen J. Lye, John D. Aplin, Lynda K. Harris and Rebecca L. Jones

The Journal of Immunology (American Association of Immunologists) UK, Canada, 10 April 2017

Immunology

Key words:Decidual spiral arteriole (SpA), uterine decidual NK (dNK) cells, extravillous trophoblasts (EVTs), chemokines

Organism: Human

Tissue: Endometrium

365
EGFR in Tumor-associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients

Sriram Srivatsa, Mariel C. Paul, Claudia Cardone, Martin Holcmann, Nicole Amberg, Paulina Pathria, Michaela A. Diamanti, Markus Linder, Gerald Timelthaler, Hans P. Dienes, Lukas Kenner, Fritz Wrba, Gerald W. Prager, Stefan Rose-John, Robert Eferl, Giuseppina Liguori, Gerardo Botti, Erika Martinelli, Florian R. Greten, Fortunato Ciardiello, Maria Sibilia

Gastroenterology (Elsevier) Austria, 09 April 2017

Oncology

Key words:Tumor microenvironment, cytokine, CRC, colon cancer

Organism: Human, Mouse

Tissue: Colon

Pathological State: Cancer

366
Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)

Kohei Shitara, Toshihiko Doi, Osamu Nagano, Chiyo K. ImamuraTakeshi OzekiYuya IshiiKenji TsuchihashiShunji TakahashiTakako E. NakajimaShuichi HironakaMiki FukutaniHiromi HasegawaShogo NomuraAkihiro SatoYasuaki EinagaTakeshi KuwataHideyuki SayaEmail authorAtsushi Ohtsu

Gastric Cancer (Springer) Japan, 07 April 2017

Oncology

Key words:Cancer stem cell, CD44 variant positive, Gastric cancer, Sulfasalazine xCT

Organism: Human

Tissue: Stomach

Pathological State: Cancer

367
Surviving murine experimental sepsis affects the function and morphology of the inner ear

Natalie Fischer, Nina Maria Mathonia, Georges Hollerich, Julian Veser, Leyla Pinggera, Daniel Dejaco, Rudolf Glueckert, Anneliese Schrott-Fischer, Peter Lackner, Herbert Riechelmann, Joachim Schmutzhard

Biology Open (The Company of Biologists) Austria, 04 April 2017

Physiology

Key words:Sepsis, Hearing loss, Inner ear, Inflammation, Apoptosis

Organism: Mouse

Tissue: Ear

Pathological State: Sepsis

368
Intracerebral delivery of the M2 polarizing cytokine interleukin 13 using mesenchymal stem cell implants in a model of temporal lobe epilepsy in mice

Idrish Ali, Stephanie Aertgeerts, Debbie Le Blon, Daniele Bertoglio, Chloe Hoornaert, Peter Ponsaerts, Stefanie Dedeurwaerdere

Official Journal of the International League Against Epilsepy (Wiley) Belgium, 04 April 2017

Transplantation Medicine

Key words:IL-13 MSCs, acid–induced status epilepticus, video–electroencephalography, F4/80+ cells

Organism: Mouse

Tissue: Brain

Pathological State: Epilepsy

369
High expression of CASZ1 is associated with poor prognosis in ovarian cancer

YJ Chuang, YL Liang, YL Chen, TM Hong, KF Hsu

Cancer Research (AACR Publications) Taiwan, 01 April 2017

Oncology

Key words:High expression of CASZ1 is associated with poor prognosis in ovarian cancer

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

370
Brilliant Blue G, but not Fenofibrate, Treatment Reverts Hemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinson's Disease

Enéas G. Ferrazoli, Héllio D.N. De Souza, Isis C. Nascimento, Ágatha Oliveira-Giacomelli, Telma T. Schwindt, Luiz R. Britto, Henning Ulrich

Cell Transplantation (SAGE Journals) Brazil, 01 April 2017

Neuroscience

Key words:Parkinson's disease (PD), P2X7 receptor, brilliant Blue G (BBG), PGC-1α, fenofibrate

Organism: Rat

Tissue: Brain

371
Information Limits of Optical Microscopy: Application to Fluorescent Labelled Tissue Section

Renata Rychtáriková, Georg Steiner, Michael B. Fischer,Dalibor Šty

Bioinformatics and Biomedical Engineering (Springer) Austria, Czech Republic, 01 April 2017

Microscopy

Key words:Electromagnetic centroid, Point divergence gain, Superresolution, 3D structure reconstruction

Organism: Human

Tissue: Prostate

Pathological State: Cancer

372
ICAM-1 binding rhinoviruses enter HeLa cells via multiple pathways and travel to distinct intracellular compartments for uncoating

H Ganjian, C Zietz, D Mechtcheriakova, D Blaas, R Fuchs

Viruses (MDPI) Austria, 01 April 2017

Virology

Key words:human rhinoviruses; ICAM-1; productive uncoating; endocytosis; clathrin; dynamin; macropinocytosis; actin; dynein

Organism: Human

Pathological State: Virus Infection

Cell Line: HeLA cells

373
Colibactin contributes to the hypervirulence of pks+ K1 CC23 Klebsiella pneumoniae in mouse meningitis infections

Min-Chi Lu, Ying-Tsong Chen, Ming-Ko Chiang, Yao-Chen Wang, Pei-Yi Hsiao, Yi-Jhen Huang, Ching-Ting Lin, Ching-Chang Cheng, Chih-Lung Liang and Yi-Chyi Lai

Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) Taiwan, 31 March 2017

Microbiology

Key words:Colibactin, pks+ K1 CC23 Klebsiella pneumoniae, Mouse Meningitis

Organism: Mouse

Tissue: Small Intestine, Colon, Liver, Spleen, Brain, Blood

Pathological State: Bacterial Infection

374
Early, but not late treatment with human umbilical cord blood-derived mesenchymal stem cells attenuates cisplatin nephrotoxicity through immunomodulation

Ji Hyeon Park, Hye Ryoun Jang, Do Hee Kim, Ghee Young Kwon, Jung Eun Lee, Wooseong Huh, Soo Jin Choi, Wonil Oh, Ha Young Oh, Yoon-Goo Kim

American Journal of Physiology (APS Journals) South Korea, 29 March 2017

Physiology

Key words:Acute kidney injury, Cisplatin nephrotoxicity, immunomodulation, mesenchymal stem cells, regulatory T cells

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Injury

375
HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice

Niek G. J. Leus, Thea van den Bosch, Petra E. van der Wouden, Kim Krist, Maria E. Ourailidou, Nikolaos Eleftheriadis, Loes E. M. Kistemaker, Sophie Bos, Rutger A. F. Gjaltema, Solomon A. Mekonnen, Rainer Bischoff, Reinoud Gosens, Hidde J. Haisma and Frank J. Dekker

Scientific Reports (Nature) The Netherlands, 27 March 2017

Immunology

Key words:Mechanism of action, Pharmacodynamics

Organism: Mouse

Tissue: Lung

Pathological State: Inflammation

376
Non-thermal air plasma promotes the healing of acute skin wounds in rats

S. Kubinova, K. Zaviskova, L. Uherkova, V. Zablotskii, O. Churpita, O. Lunov and A. Dejneka

Scientific Reports (Nature) Czech Republic, 24 March 2017

Regenerative Medicine

Key words:Non-thermal plasma (NTP), skin wound, atmospheric pressure air plasma, histological and gene expression analysis

Organism: Rat

Tissue: Skin

Pathological State: Skin Wound

377
Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure

Franziska Roth-Walter, Cornelia Bergmayr, Sarah Meitz, Stefan Buchleitner, Caroline Stremnitzer, Judit Fazekas, Anna Moskovskich, Mario A. Müller, Georg A. Roth, Krisztina Manzano-Szalai, Zdenek Dvorak, Alina Neunkirchner and Erika Jensen-Jarolim

Scientific Reports (Nature) Austria, 23 March 2017

Immunology

Key words:Acrolein, BALB/c allergy model, T cells , D2F2 tumor cells

Organism: Mouse

Tissue: Lung, Spleen, Allograft Tumor

Pathological State: Cancer

378
Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas

Gary Kohanbash, Diego A. Carrera, Shruti Shrivastav, Brian J. Ahn, Naznin Jahan, Tali Mazor, Zinal S. Chheda, Kira M. Downey, Payal B. Watchmaker, Casey Beppler, Rolf Warta, Nduka A. Amankulor, Christel Herold-Mende, Joseph F. Costello, and Hideho Okada

JCI The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, Germany, 20 March 2017

Oncology, Immunology

Key words:Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

379
Histone Methyltransferase G9a Drives Chemotherapy Resistance by Regulating the Glutamate–Cysteine Ligase Catalytic Subunit in Head and Neck Squamous Cell Carcinoma

Chia-Wen Liu, Kuo-Tai Hua, Kai-Chun Li, Hsiang-Fong Kao, Ruey-Long Hong, Jenq-Yuh Ko, Michael Hsiao, Min-Liang Kuo and Ching-Ting Tan

Molecular Cancer Therapeutics (AACR Publications) Taiwan, 06 March 2017

Oncology

Key words:Neck squamous cell carcinomas (HNSCC), histone methyltransferase, apoptosis, glutamate-cysteine ligase catalytic subunit (GCLC)

Organism: Mouse

Tissue: Head, Neck

Pathological State: Cancer

380
Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK/Slug signaling pathway

Jung Hoo Hwang, Soo Jung Park, Won Gyu Ko, Seong-Mun Kang, Da Bin Lee, Junho Bang, Byung-Joo Park, Chung-Beum Wee, Dae Joon Kim, Ik-Soon Jang, and Jae-Hong Ko

American Journal of Cancer Research (NCBI) South Korea, USA, 01 March 2017

Oncology

Key words:Cordycepin, nitric oxide, ERK, slug, lung cancer, apoptosis

Organism: Human

Pathological State: Cancer

Cell Line: Human lung adenocarcinoma cell lines, A549 and PC9

381
Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Yan-Jiun Huang, Ching-Kuo Yang, Po-Li Wei, Thanh-Tuan Huynh, Jacqueline Whang-Peng, Tzu-Ching Meng, Michael Hsiao, Yew-Ming Tzeng, Alexander TH Wu and Yun Yen

Journal of Hematology and Oncology (Springer) Taiwan, Vietnam, 28 February 2017

Oncology

Key words:M2 tumor-associated macrophages, Colon tumorigenesis, Stemness, YAP1, Ovatodiolide

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

382
Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activation

Ya-Ting Chu, Shu-Wen Wan, Yu-Chang Chang, Chien-Kuo Lee, Betty A Wu-Hsieh, Robert Anderson and Yee-Shin Lin

Laboratory Investigation (Nature) Taiwan, 27 February 2017

Immunology, Virology

Key words:Dengue virus, mast cells, DHF/DSS, chemokines

Organism: Mouse

Tissue: Skin

Pathological State: Virus Infection

383
Tumor specific regulatory T cells in the bone marrow of breast cancer patients selectively upregulate the emigration receptor S1P1

Anchana Rathinasamy, Christoph Domschke, Yingzi GeHans-Henning Böhm, Steffen Dettling, David Jansen, Felix Lasitschka, Ludmila Umansky, Markus H. Gräler, Jennifer Hartmann, Christel Herold-Mende, Florian Schuetz, Philipp Beckhove

Cancer Immunology, Immunotherpay (Springer) Germany, 21 February 2017

Oncology

Key words:Antigen-specific regulatory T cells, Bone marrow, Sphingosine-1-phosphate receptor 1, Exit, Breast cancer patients

Organism: Human

Tissue: Breast

Pathological State: Cancer

384
Ccdc181 is a microtubule binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia

Thomas Schwarza, Barbara Prielera, Johannes A. Schmidb, Pawel Grzmilc, Juergen Neesena

European Journal of Cell Biology (Elsevier) Austria, 20 February 2017

Cell Biology

Key words:Ccdc181, Cilia, Manchette, Microtubules, Motility, Hook1, Spermatogenesis

Organism: Mouse

Tissue: Testis, Lung, Trachea, Brain

385
Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1

Ee Soo Lee, Llorenç Solé Boldo, Bernadette O. Fernandez, Martin Feelisch and Martin C. Harmsen

Scientific Reports (Nature) The Netherlands, 17 February 2017

Immunology

Key words:Endothelial dysfunction, TAK1 (MAP3K7), ERK5 (MAPK7), TGF-β

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

386
Diagnostic and prognostic relevance of CP2c and YY1 expression in hepatocellular carcinoma

Ji Sook Kim, Seung Han Son, Min Young Kim, DongHo Choi, Ik-Soon Jang, Seung Sam Paik, Ji Hyung Chae, Vladimir N. Uversky, and Chul Geun Kim

Oncotarget (Impact Journals) South Korea, USA, 17 February 2017

Oncology

Key words:hepatocellular carcinoma (HCC), CP2c, YY1, diagnosis, prognosis

Organism: Human

Tissue: Liver

Pathological State: Cancer

387
Subcellular probes for neurochemical recording from multiple brain sites

Helen N. Schwerdt, Min Jung Kim, Satoko Amemori, Daigo Homma, Tomoko Yoshida, Hideki Shimazu, Harshita Yerramreddy, Ekin Karasan, Robert Langer, Ann M. Graybiel and Michael J. Cima

Lab on a Chip (Royal Society of Chemistry) USA, 15 February 2017

Nanomedicine

Key words:striatum, voltammetry, implantable sensors, microelectrodes, dopamine

Organism: Rat

Tissue: Brain

388
Editor's highlight: periodic exposure to smartphone-mimic low-luminance blue light induces retina damage through Bcl-2/BAX-dependent apoptosis

Cheng-Hui Lin, Man-Ru Wu, Ching-Hao Li, Hui-Wen Cheng, Shih-Hsuan Huang, Chi-Hao Tsai, Fan-Li Lin, Jau-Der Ho, Jaw-Jou Kang, George Hsiao, Yu-Wen Cheng

Toxicological Sciences (Oxford University Press) Taiwan, 10 February 2017

Toxicology

Key words:blue light, age-related macular degeneration, apoptosis, Bax, Bcl-2, FasL, caspase-3.

Organism: Rat

Tissue: Eye

389
The lymphatic phenotype of lung allografts in patients with bronchiolitis obliterans syndrome and restrictive allograft syndrome

Traxler D, Schweiger T, Schwarz S, Schuster MM, Jaksch P, Lang G, Birner P, Klepetko W, Ankersmit HJ, Hoetzenecker K.

Transplantation (Wolters Kluwer) Austria, 10 February 2017

Transplantation Medicine

Key words:Lymphatic Phenotype, Lung Allograft, Bronchiolitis Obliterans Syndrome, Restrictive Allograft Syndrome

Organism: Human

Tissue: Lung

Pathological State: Bronchiolitis

390
Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Wei-Chun HuangFu, Min-Wu Chao, Chun-Chun Cheng, Yu-Chieh Wei, Yi-Wen Wu, Jing-Ping Liou, George Hsiao, Yu-Ching Lee and Chia-Ron Yang

Scientific Reports (Nature) Taiwan, 09 February 2017

Oncology

Key words:Histone deacetylase (HDAC), cell lines HL-60 and MOLT-4, apoptosis

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

391
Elatoside C protects against ox-LDL-induced HUVECs injury by FoxO1-mediated autophagy induction

Yun Luo, Xiangbao Meng, Ping Zhou, Shan Lu, Meng Qin, Xudong Xu, Guibo Sun , Xiaobo Sun,

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) China, 09 February 2017

Neuroscience

Key words:Autophagy, apoptosis, Elatoside C, ox-LDL, FoxO1, HUVECs

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

392
Diffusion radiomics analysis of intratumoral heterogeneity in a murine prostate cancer model following radiotherapy: Pixelwise correlation with histology

Yu-Chun Lin, Gigin Lin, Ji-Hong Hong, Yi-Ping Lin, Fang-Hsin Chen, Shu-Hang Ng, Chun-Chieh Wang

Journal Of Magnetic Resonance Imaging (Wiley) Taiwan, 08 February 2017

Oncology

Key words:Apparent diffusion coefficient (ADC), TRAMP-C1, tumor,

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

393
Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis

Laura Pasetto, Silvia Pozzi, Mariachiara Castelnovo, Manuela Basso, Alvaro G. Estevez, Stefano Fumagalli, Maria Grazia De Simoni, Valeria Castellaneta, Paolo Bigini, Elena Restelli, Roberto Chiesa, Francesca Trojsi, Maria Rosaria Monsurrò, Leonardo Callea, Miroslav Malešević, Gunter Fischer, Mattia Freschi, Massimo Tortarolo, Caterina Bendotti and Valentina Bonetto

Journal of Neuroscience (Society for Neuroscience) Italy, 08 February 2017

Neuroscience

Key words:Amyotrophic lateral sclerosiscy, clophilin A, neuroinflammation

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Amyotrophic Lateral Sclerosis

394
Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury

HH Chen, H Yuan, H Cho, Y Feng, S Ngoy, ATN Kumar, R Liao, L Josephson, DE Sosnovik

Theranostics (NCBI) USA, 08 February 2017

Cardiology

Key words:NA, RNA, Inflammation, Ischemia, Nanoprobe, Imaging.

Organism: Mouse

Tissue: Heart

Pathological State: Ischemia

395
Laser deposition of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) − Lysozyme microspheres based coatings with anti-microbial properties

V. Grumezescu, A.M. Holban, L.E. Sima, M.B. Chiritoiu, G.N. Chiritoiu, A.M. Grumezescu, L. Ivan, F. Safciuc, F. Antohe, C. Florica, C.R. Luculescu, M.C. Chifiriuc, G. Socol

International Journal of Pharmaceutics (Elsevier) Romania, 07 February 2017

Tissue Engineering

Key words:Lysozyme, Laser processing, MAPLE thin coatings, Antimicrobial surfaces, Osteoblast and endothelial cell culture

Organism: Human

Pathological State: Cancer

Cell Line: SAOS2 cells (primary osteogenic sarcoma cells)

396
Tumour-infiltrating regulatory T cell density before neoadjuvant chemoradiotherapy for rectal cancer does not predict treatment response

Melanie J. McCoy, Chris Hemmings, Chidozie C. Anyaegbu, Stephanie J. Austin, Tracey F. Lee-Pullen, Timothy J. Miller, Max K. Bulsara, Nikolajs Zeps, Anna K. Nowak, Richard A. Lake, Cameron F. Platell

Oncotarget (Impact Journals) Australia, 03 February 2017

Oncology

Key words:Rectal cancer, regulatory T cells, radiotherapy, chemotherapy, treatment response

Organism: Human

Tissue: Rectum

Pathological State: Cancer

397
Abstract P2-04-07: Immune profiling of post neoadjuvant high metastatic risk (RCB-II/III) residual disease in patients with early triple negative breast cancers

S Irshad, M Cheang, P Gazinka, K Naidoo, R Buus, S Pinder, M Dowsett and A Tutt

Cancer Research (AACR Publications) UK, 01 February 2017

Oncology

Organism: Human

Tissue: Breast

Pathological State: Cancer

398
Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes

Xianpeng Liu, Bo Zhao, Limin Sun, Karan Bhuripanyo, Yiyang Wang, Yingtao Bi, Ramana V. Davuluri, Duc M. Duong, Dhaval Nanavati, Jun Yin and Hiroaki Kiyokawa

Nature Communications (Nature) USA, 31 January 2017

Cell Biology

Key words:Protein ubiquitination, mammalian cells, polyubiquitination

Organism: Human

Pathological State: Fibrosis

Cell Line: MCF-10A cells ( human female mammary gland cells)

399
Biocomposite coatings based on Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/calcium phosphates obtained by MAPLE for bone tissue engineering

O. Rașoga, L. Sima, M. Chirițoiu, G. Popescu-Pelin, O. Fufă, d, V. Grumezescu, M. Socol, A. Stănculescu, I. Zgură, G. Socol

Applied Surface Science (Elsevier) Romania, 31 January 2017

Tissue Engineering

Key words:MAPLE, Calcium phosphates, PHBV, Composite, Hydroxyapatite, β-Tricalcium phosphate

Organism: Human

Cell Line: Human mesenchymal stem cells (hMSCs)

400
Effect of a cocoa diet on the small intestine and gut-associated lymphoid tissue composition in an oral sensitization model in rats ☆

Mariona Camps-Bossacoma, Francisco J. Pérez-Cano, Àngels Franch, Eva Untersmayr, Margarida Castell

Journal of Nutritional Biochemistry (Elsevier) Spain, 23 January 2017

Gastroenterology

Key words:Cholera toxin, Cocoa, Ovalbumin, TCRγδ+ cells, Tolerance

Organism: Rat

Tissue: Small Intestine

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