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Customer Publications (A total of 906 papers published )

201
Small cell lung cancer: model of circulating tumor cell tumorospheres in chemoresistance

Lukas Klameth, Barbara Rath, Maximilian Hochmaier, Doris Moser, Marlene Redl, Felicitas Mungenast, Katharina Gelles, Ernst Ulsperger, Robert Zeillinger & Gerhard Hamilton

Scientific Reports (Nature) Austria, 13 July 2017

Oncology

Key words: Small cell lung cancer (SCLC), circulating tumor cells (CTCs), Ki67 and carbonic anhydrase 9 (CAIX)

Organism: Human

Tissue: Lung

Pathological State: Cancer

Cell Line:

202
RIP3 attenuates the pancreatic damage induced by deletion of ATG7

Xiaodong Zhou, Li Xie, Leizhou Xia, Frank Bergmann, Markus W Büchler, Guido Kroemer, Thilo Hackert and Franco Fortunato

Cell Death and Disease (Nature) Germany, 13 July 2017

Gastroenterology

Key words: Pancreatitis, Rip3, acinar cells, autophagy and necroptosis

Organism: Human, Mouse

Tissue: Pancreas

Pathological State:

Cell Line:

203
Tailor-made purified human platelet lysate concentrated in neurotrophins for treatment of Parkinson's disease

Ming-Li Choua, Joe-Wei Wu, Flore Gouel, Aurélie Jonneaux, Kelly Timmerman, Ting-Yi Renn, Charlotte Laloux, Hung-Ming Chang, Liang-Tzung Lin, Jean-Christophe Devedjian, David Devos , Thierry Burnou

Biomaterials (Elsevier) Taiwan, 12 July 2017

Biological Materials

Key words: Platelet lysate, neuroprotection, parkinson, MPTP, neurotrophins, growth factors

Organism: Mouse

Tissue: Brain

Pathological State:

Cell Line:

204
CCAAT/enhancer-binding protein delta promotes intracellular lipid accumulation in M1 macrophages of vascular lesions

Hong-Yue Lai, Ling-Wei Hsu, Hsin-Hwa Tsai, Yu-Chih Lo, Shang-Hsun, Yang Ping-Yen Liu, Ju-Ming Wang

Cardiovascular Research (Oxford Academic) Taiwan, 11 July 2017

Cardiology

Key words: CEBPD, inflammation, macrophages, PTX3, statins

Organism: Mouse

Tissue:

Pathological State: Vascular lesions

Cell Line: Macrophages and nile red-positive cells

205
Instructing cells with programmable peptide DNA hybrids

Ronit Freeman, Nicholas Stephanopoulos, Zaida Álvarez, Jacob A Lewis, Shantanu Sur, Chris M Serrano, Job Boekhoven, Sungsoo S. Lee & Samuel I. Stupp

Nature Communications (Nature) USA, 10 July 2017

Cell Biology

Key words: Native extracellular matrix, peptide-DNA (P-DNA)

Organism: Mouse

Tissue:

Pathological State:

Cell Line: NIH-3T3 mouse embryonic fibroblasts

206
Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion

Tereza Vanova, Zaneta Konecna, Zuzana Zbonakova, Giuseppe La Venuta, Karolina Zoufalova, Sarka Jelinkova,Miroslav Varecha, Vladimir Rotrekl, Pavel Krejci, Walter Nickel, Petr Dvorak, Michaela Kunova Bosakova

Stem Cells (Wiley) Czech Republic, 06 July 2017

Stem cells

Key words: Human pluripotent stem cells (hPSCs), fibroblast growth factor (FGF) receptors, hepatocellular carcinoma (TEC)

Organism: Human

Tissue:

Pathological State:

Cell Line: hPSCs (Human pluripotent stem cells)

207
A novel in vitro model of villitis of unknown etiology demonstrates altered placental hormone and cytokine profile

Hayley Derricott, Alexander E.P. Heazell, Susan L. Greenwood, Rebecca L. Jones

American Journal of Reproductive Immunology (Wiley) UK, 06 July 2017

Reproductive medicine

Key words: Placental dysfunction, villitis of unknown etiology, T cell, fetal growth restriction

Organism: Human

Tissue: Placental explant culture

Pathological State:

Cell Line:

208
Increased migration of antigen presenting cells to newly-formed lymphatic vessels in transplanted kidneys by glycol-split heparin

Ditmer T. Talsma, Kirankumar Katta, Miriam Boersema, Saritha Adepu,Annamaria Naggi, Giangiacomo Torri, Coen Stegeman, Gerjan Navis, Harry van Goor,Jan-Luuk Hillebrands,Saleh Yazdani, Jacob van den Born

PLOS ONE (PLOS) The Netherlands, 30 June 2017

Transplantation Medicine

Key words: Chronic renal transplant, lymphatic chemokine-proteoglycan, renal graft

Organism: Rat

Tissue: Kindney

Pathological State: Organ Transplantation

Cell Line:

209
Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation

Tao Peng, R. Savanh Chanthaphavong, Sijie Sun, James A. Trigilio, Khamsone Phasouk, Lei Jin, Erik D. Layton, Alvason Z. Li, Colin E. Correnti, Willem De van der Schueren, Julio Vazquez, Diana R. O’Day, Ian A. Glass, David M. Knipe, Anna Wald, Lawrence

Journal Of Experimental Medicine (The Rockefeller University Press) USA, 29 June 2017

Neurology

Key words: Herpes simplex virus (HSV), keratinocytes, IL-17c , nervous system

Organism: Human

Tissue: Skin

Pathological State:

Cell Line: Keratinocytes

210
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells

Dong Hoon Kang, Doo Jae Lee, Sunmi Lee, So-Young Lee, Yukyung Jun, Yerin Kim, Youngeun Kim, Ju-Seog Lee, Dae-Kee Lee, Sanghyuk Lee, Eek-Hoon Jho, Dae-Yeul Yu & Sang Won Kang

Nature Communications (Nature) Korea, 28 June 2017

Oncology

Key words: Colon cancer, mechanisms of disease

Organism: Mouse

Tissue: Colon, Small Intestine

Pathological State:

Cell Line:

211
The bile acid receptor FXR attenuates acinar cell autophagy in chronic pancreatitis

Xiaodong Zhou, Li Xie, Frank Bergmann, Volker Endris, Oliver Strobel, Markus W Büchler, Guido Kroemer, Thilo Hackert & Franco Fortunato

CellDeath Discovery (Nature) Germany, 19 June 2017

Gastroenterology

Key words: Apoptosis, chronic pancreatitis, macroautophagy, necroptosis

Organism: Human, Mouse

Tissue: Pancreas

Pathological State: Pancreatitis

Cell Line:

212
Breviscapine (BVP) inhibits prostate cancer progression through damaging DNA by minichromosome maintenance protein-7 (MCM-7) modulation

Yang-boGuan, Dong-rongYang, Shao-junNong, JianNi, Chun-huiHu, JianLi, JinZhu, Yu-xiShan

Biomedicine & Pharmacotherapy (Elsevier) China, 17 June 2017

Oncology

Key words: Breviscapine, human prostate cancer, DNA damage, MCM-7, Apoptosis

Organism: Human, Mouse

Tissue: Prostate, Xenograft Tumor (LNCap and PC3)

Pathological State: Cancer

Cell Line:

213
Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation

Pounami Samadder, Tereza Suchánková, Ondřej Hylse, Prashant Khirsariya, Fedor Nikulenkov, Stanislav Drápela, Nicol Straková, Petr Vaňhara, Kateřina Vašíčková, Hana Kolářová, Lucia Binó, Miroslava Bittová, Petra Ovesná, Peter Kollár, Radek Fedr, Milan Ešne

Molecular Cancer Therapeutics (AACR) Czech Republic, 15 June 2017

Oncology

Key words: Tumor cells, serine threonine kinase, DNA antimetabolites

Organism: Human, Mouse

Tissue: Skin, Xenograft Tumor (A2780 cells, MiaPaCa2 luc cells)

Pathological State: Cancer

Cell Line:

214
Initial graft size and not the innate immune response limit survival of engrafted neural stem cells

Stefanie Vogel,Markus Aswendt,Melanie Nelles,Nadine Henn,Gabriele Schneider,Mathias Hoehn

Journal of Tissue Engineering and Regenrative Medicine (Wiley) Germany, 09 June 2017

Neurology

Key words: Transplantation of neural stem cells (NSCs), bioluminescence imaging (BLI), innate immune system

Organism: Mouse

Tissue: Brain

Pathological State:

Cell Line:

215
Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice

Tse-Hung Huang, Chin-Chang Chen, Hsuan-Miao Liu, Tzung-Yan Lee & Sue-Heui Shieh

Scientific Reports (Nature) Taiwan, 02 June 2017

Immunology/ Virology

Key words: Age-related autoimmune hepatitis, cell senescence, apoptosis, concanavalin A (Con A),

Organism: Mouse

Tissue: Liver

Pathological State:

Cell Line:

216
Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy

Valerie N Babinsky, Fadil M Hannan, Reshma D Ramracheya, Quan Zhang, M Andrew Nesbit, Alison Hugill, Liz Bentley , Tertius A Hough , Elizabeth Joynson Michelle Stewart, Abhishek Aggarwal, Maximilian Prinz-Wohlgenannt, Caroline M Gorvin, Enikö Kall

Endocrinology (Oxford Academic) UK, 02 June 2017

Endocrinology

Key words:

Organism: Mouse

Tissue: Xenograft Pancreas Tumor (Human embryonic kidney 293 cells)

Pathological State: Cancer

Cell Line:

217
Attenuation of Follicular Helper T Cell–Dependent B Cell Hyperactivity by Abatacept Treatment in Primary Sjögren's Syndrome

Gwenny M. Verstappen,Petra M. Meiners ,Odilia B.J. Corneth,Annie Visser,Suzanne Arends,Wayel H. Abdulahad, Rudi W. Hendriks,Arjan Vissink,Frans G.M. Kroese,Hendrika Bootsma

Arthritis & Rheumatology (Wiley) The Netherlands, 31 May 2017

Rheumatology

Key words: CTLA-4-Ig, CD4+ T-cell, programmed death-1 (PD-1), inducible costimulator (ICOS), FoxP3

Organism: Human

Tissue: Salivary gland

Pathological State: Sjögren's Syndrome

Cell Line:

218
Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

Andrea E. Calvert, Alexandra Chalastanis, Yongfei Wu, Lisa A. Hurley, Fotini M. Kouri, Yingtao Bi, Maureen Kachman, Jasmine L. May, Elizabeth Bartom, Youjia Hua, Rama K. Mishra, Gary E. Schiltz, Oleksii Dubrovskyi, Andrew P. Mazar, Marcus E. Peter, Hongwu

Cell Reports (Elsevier) USA, 30 May 2017

Oncology

Key words: wild-type IDH1; GBM; metabolism; differentiation; NADPH; lipids; reactive oxygen species (ROS); EGFR; targeted therapy

Organism: Mouse

Tissue:

Pathological State: Cancer

Cell Line: GIC-20 (Glioma initiating cells)

219
Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling

Yu-Ching Huang, Ming-ShiunTsai, Pei-Chi Hsieh, Jheng-Hong Shih, Tsu-Shing Wang, Yi-Chun Wang, Ting-Hui Lin, Sue-Hong Wang

Toxicology and Applied Pharmacology (Elsevier) China, 27 May 2017

Oncology

Key words: Cisplatin nephrotoxicity; ERK; Galangin; Inflammation; NF-κB; Oxidative stress

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney injury

Cell Line:

220
Hepatic IFIT3 predicts interferon-α therapeutic response in patients of hepatocellular carcinoma

Yingyun Yang,Ye Zhou,Jin Hou,Chunmei Bai,Zhenyang Li,Jia Fan,Irene O.L. Ng,Weiping Zhou,Huichuan Sun,Qiongzhu Dong,Joyce M.F. Lee,Chung-Mau Lo,Kwan Man,Yun Yang,Nan Li,Guoshan Ding,Yizhi Yu,Xuetao Cao

Hepatology (Wiley) China, 26 May 2017

Oncology

Key words: Adjuvant interferon-α (IFN-α), hepatocellular carcinoma (HCC), IFIT3,

Organism: Human

Tissue: Liver

Pathological State: Cancer

Cell Line:

221
QUICK FIRE CASES- SESSION III

European Heart Journal (Oxford University Press) , 25 May 2017

Cardiology

Key words: Myocardium, diagnosis, fire - disaster,s fire - physical, phenomenon cardiac, mri

Organism: Mouse

Tissue: Xenograft Tumor (4T1 cell line)

Pathological State: Cancer

Cell Line:

222
SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor

Xianghui Zou, Yueming Zhu, Seong-Hoon Park, Guoxiang Liu, Joseph O'Brien, Haiyan Jiang and David Gius

Cancer Research (AACR) USA, 23 May 2017

Oncology

Key words: Isocitrate dehydrogenase IDH2, α-ketoglutarate,cancer cells, SIRT3

Organism: Human

Tissue: Breast

Pathological State: Cancer

Cell Line:

223
MicroRNA-146a governs fibroblast activation and joint pathology in arthritis

Victoria Saferdinga, Antonia Puchnera, Eliana Goncalves-Alvesa, Melanie Hofmanna, Michael Bonellia, Julia S. Brunnerb, Emine Sahinb, Birgit Niederreitera, Silvia Hayera, Hans P. Kienera, Elisa Einwallnerc, Ramzi Nehmard, Raphael Carapitod, Philippe George

Journal of Autoimmunity (Elsevier) Austria, 22 May 2017

Rheumatology

Key words: Synovial fibroblasts, miR-146a, tumor necrosis factor (TNF) receptor, factor 6 (TRAF6), osteoprotegerin (OPG)

Organism: Human

Tissue: Bone

Pathological State: Arthritis

Cell Line:

224
Enhanced Bruton's Tyrosine Kinase Activity in Peripheral Blood B Lymphocytes From Patients With Autoimmune Disease

Odilia B. J. Corneth,Gwenny M. P. Verstappen,Sandra M. J. Paulissen,Marjolein J. W. de Bruijn,Jasper Rip,Melanie Lukkes,Jan Piet van Hamburg,Erik Lubberts,Hendrika Bootsma,Frans G. M. Kroese,Rudi W. Hendriks

Arthritis & Rheumatology (Wiley) The Netherlands, 10 May 2017

Rheumatology

Key words: Bruton's tyrosine kinase (BTK), B cell receptor (BCR), Sjögren's syndrome (SS), BTK phosphorylation

Organism: Human

Tissue: Salivary gland

Pathological State: Sjögren's Syndrome

Cell Line:

225
Hyaluronan keeps mesenchymal stem cells quiescent and maintains the differentiation potential over time

Tzyy Yue Wong,Chiung-Hsin Chang,Chen-Hsiang Yu,Lynn L. H. Huang

Aging Cell (Wiley) Taiwan, 04 May 2017

Stem cells

Key words: Hyaluronan (HA), mesenchymal stem cells (MSCs), cellular aging, human placenta-derived MSCs (PDMSC)

Organism: Human

Tissue:

Pathological State:

Cell Line: MSCs (mesenchymal stem cells)

226
A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

Yuan-Hua Wu, Chi-Wei Hong, Yi-Ching Wang, Wei-Jan Huang, Ya-Ling Yeh, Bour-Jr Wang1, Ying-Jan Wang, Hui-Wen Chiu

Cancer Letters (Elsevier) Taiwan, 24 April 2017

Oncology

Key words: DNA damage, DNA repair, Ubiquitin–proteasome system, Triple-negative breast cancer

Organism: Mouse

Tissue: Xenograft Tumor (4T1-Luc cells)

Pathological State: Cancer

Cell Line:

227
Cytotoxicity of Natural Killer Cells Activated Through NKG2D Contributes to the Development of Bronchiolitis Obliterans in a Murine Heterotopic Tracheal Transplant Model

T. Kawakami,K. Ito,Y. Matsuda,M. Noda,A. Sakurada,Y. Hoshikawa,Y. Okada,K. Ogasawara

American Journal of Transplantation (Wiley) Japan, 21 April 2017

Transplantation Medicine

Key words: Basic (laboratory) research/science, lung transplantation/pulmonology, bronchiolitis obliterans (BOS), natural killer (NK) cells/NK receptors

Organism: Mouse

Tissue: Trachea

Pathological State: Organ Transplantation

Cell Line:

228
Immunomodulatory Magnetic Microspheres for Augmenting Tumor-Specific Infiltration of Natural Killer (NK) Cells

Wooram Park , Andrew C. Gordon, Soojeong Cho, Xiaoke Huang, Kathleen R. Harris, Andrew C. Larson, and Dong-Hyun Kim

Applied Materials & Interfaces (ACS) USA, 13 April 2017

Oncology

Key words: And image-guided therapy, cancer immunotherapy interferon-gamma (IFN-γ), microspheres, natural killer (NK) cells infiltration

Organism: Human

Tissue:

Pathological State:

Cell Line:

229
Extravillous Trophoblast and Endothelial Cell Crosstalk Mediates Leukocyte Infiltration to the Early Remodeling Decidual Spiral Arteriole Wall

Ruhul H. Choudhury, Caroline E. Dunk, Stephen J. Lye, John D. Aplin, Lynda K. Harris and Rebecca L. Jones

The Journal of Immunology (AIA) UK, Canada, 10 April 2017

Immunology

Key words: Decidual spiral arteriole (SpA), uterine decidual NK (dNK) cells, extravillous trophoblasts (EVTs), chemokines

Organism: Human

Tissue: Decidua

Pathological State:

Cell Line:

230
EGFR in Tumor-associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients

Sriram Srivatsa, Mariel C. Paul, Claudia Cardone, Martin Holcmann, Nicole Amberg, Paulina Pathria, Michaela A. Diamanti, Markus Linder, Gerald Timelthaler, Hans P. Dienes, Lukas Kenner, Fritz Wrba, Gerald W. Prager, Stefan Rose-John, Robert Eferl, Giusepp

Gastroenterology (Elsevier) Austria, 09 April 2017

Oncology

Key words: Tumor microenvironment, cytokine, CRC, colon cancer

Organism: Human, Mouse

Tissue: Colon

Pathological State: Cancer

Cell Line:

231
Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)

Kohei Shitara, Toshihiko Doi, Osamu Nagano, Chiyo K. ImamuraTakeshi OzekiYuya IshiiKenji TsuchihashiShunji TakahashiTakako E. NakajimaShuichi HironakaMiki FukutaniHiromi HasegawaShogo NomuraAkihiro SatoYasuaki EinagaTakeshi KuwataHideyuki SayaEmail author

Gastric Cancer (Springer) Japan, 07 April 2017

Oncology

Key words: Cancer stem cell, CD44 variant positive, Gastric cancer, Sulfasalazine xCT

Organism: Human

Tissue: Stomach

Pathological State: Cancer

Cell Line:

232
Intracerebral delivery of the M2 polarizing cytokine interleukin 13 using mesenchymal stem cell implants in a model of temporal lobe epilepsy in mice

Idrish Ali, Stephanie Aertgeerts, Debbie Le Blon, Daniele Bertoglio, Chloe Hoornaert, Peter Ponsaerts, Stefanie Dedeurwaerdere

Official Journal of the International League Against Epilsepy (Wiley) Belgium, 04 April 2017

Transplantation Medicine

Key words: IL-13 MSCs, acid–induced status epilepticus, video–electroencephalography, F4/80+ cells

Organism: Mouse

Tissue: Brain

Pathological State: Epilepsy

Cell Line:

233
Brilliant Blue G, but not Fenofibrate, Treatment Reverts Hemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinson's Disease

Enéas G. Ferrazoli, Héllio D.N. De Souza, Isis C. Nascimento, Ágatha Oliveira-Giacomelli, Telma T. Schwindt, Luiz R. Britto, Henning Ulrich

Cell Transplantation (Sage Journals) Brazil, 01 April 2017

Neurology

Key words: Parkinson's disease (PD), P2X7 receptor, brilliant Blue G (BBG), PGC-1α, fenofibrate

Organism: Rat

Tissue: Brain

Pathological State:

Cell Line:

234
Information Limits of Optical Microscopy: Application to Fluorescent Labelled Tissue Section

Renata Rychtáriková, Georg Steiner, Michael B. Fischer,Dalibor Šty

Bioinformatics and Biomedical Engineering (Springer) Austria, Czech Republic, 01 April 2017

Microscopy

Key words: Electromagnetic centroid, Point divergence gain, Superresolution, 3D structure reconstruction

Organism: Human

Tissue: Prostate

Pathological State: Cancer

Cell Line:

235
Early, but not late treatment with human umbilical cord blood-derived mesenchymal stem cells attenuates cisplatin nephrotoxicity through immunomodulation

Ji Hyeon Park, Hye Ryoun Jang, Do Hee Kim, Ghee Young Kwon, Jung Eun Lee, Wooseong Huh, Soo Jin Choi, Wonil Oh, Ha Young Oh, Yoon-Goo Kim

American Journal of Physiology (APS) Korea, 29 March 2017

Physiology

Key words: Acute kidney injury, Cisplatin nephrotoxicity, immunomodulation, mesenchymal stem cells, regulatory T cells

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney damage

Cell Line:

236
Non-thermal air plasma promotes the healing of acute skin wounds in rats

S. Kubinova, K. Zaviskova, L. Uherkova, V. Zablotskii, O. Churpita, O. Lunov & A. Dejneka

Scientific Reports (Nature) Czech Republic, 24 March 2017

Regenerative Medicine

Key words: Non-thermal plasma (NTP), skin wound, atmospheric pressure air plasma, histological and gene expression analysis

Organism: Rat

Tissue: Skin

Pathological State: Skin Wound

Cell Line:

237
Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure

Franziska Roth-Walter, Cornelia Bergmayr, Sarah Meitz, Stefan Buchleitner, Caroline Stremnitzer, Judit Fazekas, Anna Moskovskich, Mario A. Müller, Georg A. Roth, Krisztina Manzano-Szalai, Zdenek Dvorak, Alina Neunkirchner & Erika Jensen-Jarolim

Scientific Reports (nature) Austria, 23 March 2017

Immunology

Key words: Acrolein, BALB/c allergy model, T cells , D2F2 tumor cells

Organism: Mouse

Tissue: Lung, Spleen, Allograft Tumor (D2F2 cells)

Pathological State: Cancer

Cell Line:

238
Histone Methyltransferase G9a Drives Chemotherapy Resistance by Regulating the Glutamate–Cysteine Ligase Catalytic Subunit in Head and Neck Squamous Cell Carcinoma

Chia-Wen Liu, Kuo-Tai Hua, Kai-Chun Li, Hsiang-Fong Kao, Ruey-Long Hong, Jenq-Yuh Ko, Michael Hsiao, Min-Liang Kuo and Ching-Ting Tan

Molecular Cancer Therapeutics (AACR) Taiwan, 06 March 2017

Oncology

Key words: Neck squamous cell carcinomas (HNSCC), histone methyltransferase, apoptosis, glutamate-cysteine ligase catalytic subunit (GCLC)

Organism: Mouse

Tissue: Head, Neck

Pathological State: Cancer

Cell Line:

239
Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activation

Ya-Ting Chu, Shu-Wen Wan, Yu-Chang Chang, Chien-Kuo Lee, Betty A Wu-Hsieh, Robert Anderson and Yee-Shin Lin

Laboratory Investigation (Nature) Taiwan, 27 February 2017

Immunology/ Virology

Key words: Dengue virus, mast cells, DHF/DSS, chemokines

Organism: Mouse

Tissue: Skin

Pathological State: Dengue Virus Infection

Cell Line:

240
Tumor specific regulatory T cells in the bone marrow of breast cancer patients selectively upregulate the emigration receptor S1P1

Anchana Rathinasamy, Christoph Domschke, Yingzi GeHans-Henning Böhm, Steffen Dettling, David Jansen, Felix Lasitschka, Ludmila Umansky, Markus H. Gräler, Jennifer Hartmann, Christel Herold-Mende, Florian Schuetz, Philipp Beckhove

Cancer Immunology, Immunotherpay (Springer) Germany, 21 February 2017

Oncology

Key words: Antigen-specific regulatory T cells, Bone marrow, Sphingosine-1-phosphate receptor 1, Exit, Breast cancer patients

Organism: Human

Tissue: Breast

Pathological State: Cancer

Cell Line:

241
Ccdc181 is a microtubule binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia

Thomas Schwarza, Barbara Prielera, Johannes A. Schmidb, Pawel Grzmilc, Juergen Neesena

European Journal of Cell Biology (Elsevier) Austria, 20 February 2017

Cell Biology

Key words: Ccdc181, Cilia, Manchette, Microtubules, Motility, Hook1, Spermatogenesis

Organism: Mouse

Tissue: Testis, Lung, Trachea, Brain

Pathological State:

Cell Line:

242
Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1

Ee Soo Lee, Llorenç Solé Boldo, Bernadette O. Fernandez, Martin Feelisch & Martin C. Harmsen

Scientific Reports (Nature) The Netherlands, 17 February 2017

Immunology

Key words: Endothelial dysfunction, TAK1 (MAP3K7), ERK5 (MAPK7), TGF-β

Organism: Human

Tissue:

Pathological State:

Cell Line: HUVECs (Human umbilical vein endothelial cells)

243
Elatoside C protects against ox-LDL-induced HUVECs injury by FoxO1-mediated autophagy induction

Yun Luo, Xiangbao Meng, Ping Zhou, Shan Lu, Meng Qin, Xudong Xu, Guibo Sun , Xiaobo Sun,

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (Elsevier) China, 09 February 2017

Neurology

Key words: Autophagy, apoptosis, Elatoside C, ox-LDL, FoxO1, HUVECs

Organism: Human

Tissue:

Pathological State:

Cell Line: HUVECs (Human umbilical vein endothelial cells)

244
Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Wei-Chun HuangFu, Min-Wu Chao, Chun-Chun Cheng, Yu-Chieh Wei, Yi-Wen Wu, Jing-Ping Liou, George Hsiao, Yu-Ching Lee & Chia-Ron Yang

Scientific Reports (Nature) Taiwan, 09 February 2017

Oncology

Key words: Histone deacetylase (HDAC), cell lines HL-60 and MOLT-4, apoptosis

Organism: Mouse

Tissue: Xenograft Tumor (HL-60 and MOLT-4)

Pathological State: Cancer

Cell Line:

245
Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis

Laura Pasetto, Silvia Pozzi, Mariachiara Castelnovo, Manuela Basso, Alvaro G. Estevez, Stefano Fumagalli, Maria Grazia De Simoni, Valeria Castellaneta, Paolo Bigini, Elena Restelli, Roberto Chiesa, Francesca Trojsi, Maria Rosaria Monsurrò, Leonardo Callea

Journal of Neuroscience (Society for Neuroscience) Italy, 08 February 2017

Neurology

Key words: Amyotrophic lateral sclerosiscy, clophilin A, neuroinflammation

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Amyotrophic lateral sclerosis

Cell Line:

246
Diffusion radiomics analysis of intratumoral heterogeneity in a murine prostate cancer model following radiotherapy: Pixelwise correlation with histology

Yu-Chun Lin, Gigin Lin, Ji-Hong Hong, Yi-Ping Lin, Fang-Hsin Chen, Shu-Hang Ng, Chun-Chieh Wang

Journal Of Magnetic Resonance Imaging (Wiley) Taiwan, 08 February 2017

Oncology

Key words: Apparent diffusion coefficient (ADC), TRAMP-C1, tumor,

Organism: Mouse

Tissue: Allograft Tumor ((TRAMP)-C1 cells)

Pathological State: Cancer

Cell Line:

247
Laser deposition of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) − Lysozyme microspheres based coatings with anti-microbial properties

V. Grumezescu, A.M. Holban, L.E. Sima, M.B. Chiritoiu, G.N. Chiritoiu, A.M. Grumezescu, L. Ivan, F. Safciuc, F. Antohe, C. Florica, C.R. Luculescu, M.C. Chifiriuc, G. Socol

International Journal of Pharmaceutics (Elsevier) Romania, 07 February 2017

Tissue Engineering

Key words: Lysozyme, Laser processing, MAPLE thin coatings, Antimicrobial surfaces, Osteoblast and endothelial cell culture

Organism: Human

Tissue:

Pathological State: Cancer

Cell Line: SAOS2 cells (primary osteogenic sarcoma cells)

248
Tumour-infiltrating regulatory T cell density before neoadjuvant chemoradiotherapy for rectal cancer does not predict treatment response

Melanie J. McCoy, Chris Hemmings, Chidozie C. Anyaegbu, Stephanie J. Austin, Tracey F. Lee-Pullen, Timothy J. Miller, Max K. Bulsara, Nikolajs Zeps, Anna K. Nowak, Richard A. Lake, Cameron F. Platell

Oncotarget (Impact Journals) Australia, 03 February 2017

Oncology

Key words: Rectal cancer, regulatory T cells, radiotherapy, chemotherapy, treatment response

Organism: Human

Tissue: Rectum

Pathological State: Cancer

Cell Line:

249
Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes

Xianpeng Liu, Bo Zhao, Limin Sun, Karan Bhuripanyo, Yiyang Wang, Yingtao Bi, Ramana V. Davuluri, Duc M. Duong, Dhaval Nanavati, Jun Yin & Hiroaki Kiyokawa

Nature Communications (Nature) USA, 31 January 2017

Cell Biology

Key words: Protein ubiquitination, mammalian cells, polyubiquitination

Organism: Human

Tissue:

Pathological State: Fibrocystic Disease

Cell Line: MCF-10A cells ( human female mammary gland cells)

250
Biocomposite coatings based on Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/calcium phosphates obtained by MAPLE for bone tissue engineering

O. Rașoga, L. Sima, M. Chirițoiu, G. Popescu-Pelin, O. Fufă, d, V. Grumezescu, M. Socol, A. Stănculescu, I. Zgură, G. Socol

Applied Surface Science (Elsevier) Romania, 31 January 2017

Tissue Engineering

Key words: MAPLE, Calcium phosphates, PHBV, Composite, Hydroxyapatite, β-Tricalcium phosphate

Organism: Human

Tissue:

Pathological State:

Cell Line: MSCs (mesenchymal stem cells)

251
Effect of a cocoa diet on the small intestine and gut-associated lymphoid tissue composition in an oral sensitization model in rats ☆

Mariona Camps-Bossacoma, Francisco J. Pérez-Cano, Àngels Franch, Eva Untersmayr, Margarida Castell

The Journal of Nutritional Biochemistry (Elsevier) Spain, 23 January 2017

Gastroenterology

Key words: Cholera toxin, Cocoa, Ovalbumin, TCRγδ+ cells, Tolerance

Organism: Rat

Tissue: Small Intestine

Pathological State:

Cell Line:

252
SOX2 and Rb1 in esophageal small-cell carcinoma: their possible involvement in pathogenesis

Ishida H, Kasajima A, Kamei T, Miura T, Oka N, Yazdani S, Ozawa Y, Fujishima F, Sakurada A, Nakamura Y, Tanaka Y, Kurosumi M, Ishikawa Y, Okada Y, Ohuchi N, Sasano H

Modern Pathology (Nature) Japan, 20 January 2017

Pathology

Key words: Esophageal small-cell carcinoma, SOX2 overexpression, squamous-basal markers (CK5/6 and p40), glandular markers (CK18 and CEA)

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

Cell Line:

253
Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression

Monika Linke, Ha Thi Thanh Pham, Karl Katholnig, Thomas Schnöller, Anne Miller, Florian Demel, Birgit Schütz, Margit Rosner, Boris Kovacic, Nyamdelger Sukhbaatar, Birgit Niederreiter, Stephan Blüml, Peter Kuess, Veronika Sexl, Mathias Müller, Mario Mikula

Nature Immunology (Nature) Austria, 16 January 2017

Pathology

Key words: Hypertrophic macrophages, tuberous sclerosis 2 (Tsc2), mTORC1

Organism: Mouse

Tissue: Lung

Pathological State: Sarcoidosis

Cell Line:

254
Development of a DsRed-expressing HepaRG cell line for real-time monitoring of hepatocyte-like cell differentiation by fluorescence imaging, with application in screening of novel geometric microstructured cell growth substrates

Mihaela Uta,Livia E. Sima,Patrik Hoffmann,Valentina Dinca, Norica Branza-Nichita

Biomedical Microdevices (Springer) Romania, 09 January 2017

Biological Methods

Key words: HepaRG, Hepatocyte-like cells, HBV, Differentiation, Microstructured PDMS

Organism: Human

Tissue:

Pathological State:

Cell Line: HepaRG, HeLa, Me290 cells

255
Heme Oxygenase-1-Expressing Dendritic Cells Promote Foxp3+ Regulatory T Cell Differentiation and Induce Less Severe Airway Inflammation in Murine Models

Tzu-Hsuan Wong , Hung-An Chen , Rung-Jiun Gau, Jeng-Hsien Yen, Jau-Ling Suen

PLOS ONE (PLOS) Taiwan, 29 December 2016

Immunology

Key words: Dendritic cells (DCs), HO-1, lipopolysaccharide (LPS), Foxp3+

Organism: Mouse

Tissue: Lung

Pathological State:

Cell Line:

256
Early dissemination seeds metastasis in breast cancer

Hedayatollah Hosseini, Milan M. S. Obradović, Martin Hoffmann, Kathryn L. Harper, Maria Soledad Sosa, Melanie Werner-Klein, Lahiri Kanth Nanduri, Christian Werno, Carolin Ehrl, Matthias Maneck, Nina Patwary, Gundula Haunschild, Miodrag Gužvić, Christian R

Nature (Nature) Germany, 14 December 2016

Oncology

Key words: Metastatic dissemination, breast cancer, HER2 , Karyotypic and phenotypic analysis

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

Cell Line:

257
Interstitial Fibrosis, Functional Status, and Outcomes in Heart Failure With Preserved Ejection Fraction

Franz Duca, Andreas A. Kammerlander, Caroline Zotter-Tufaro, Stefan Aschauer, Marianne L. Schwaiger, Beatrice A. Marzluf, Diana Bonderman, Julia Mascherbauer

Circulation:Cardiovascular Imaging (AHA) Austria, 14 December 2016

Cardiology

Key words: Magnetic resonance imaging, heart failure, mapping

Organism: Human

Tissue: Heart

Pathological State: Heart Failure

Cell Line:

258
Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury

Dearbhaile Dooley, Evi Lemmens, Tim Vangansewinkel, Debbie Le Blon, Chloé Hoornaert, Peter Ponsaerts, Sven Hendrix

Stem Cell Reports (Elsevier) Belgium, 13 December 2016

Transplantation Medicine

Key words: Mesenchymal stem cells, interleukin-13, spinal cord injury, cell transplantation, microglia, macrophages

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

Cell Line:

259
The 6-chromanol derivate SUL-109 enables prolonged hypothermic storage of adipose tissue-derived stem cells

Ghazaleh Hajmousa, Pieter Vogelaar, Linda A. Brouwer, Adrianus C. van der Graaf, Robert H. Henning, Guido Krenning

Biomaterials (Elsevier) The Netherlands, 09 December 2016

Biological Materials

Key words: Adipose tissue-derived stem cells (ASC), Hypothermia, Cold storage, Mitochondrial damage, Chromanol

Organism: Human

Tissue:

Pathological State:

Cell Line: Adipose tissue derived stromal cells (ADSC)

260
Involvement of Pancreatic Stellate Cells in Regeneration of Remnant Pancreas after Partial Pancreatectomy

Shigenori Ota, Miyuki Nishimura, Yuya Murakami, Naoko Kubo Birukawa, Akihiro Yoneda, Hiroki Nishita, Ryosuke Fujita, Yasushi Sato, Kenjiro Minomi, Keiko Kajiwara, Miyono Miyazaki, Maki Uchiumi, Shintaro Mikuni, Yasuaki Tamura, Toru Mizuguchi, Masafumi Ima

PLOS ONE (PLOS) Japan, 09 December 2016

Regenerative Medicine

Key words: Pancreatectomy, siRNA, activated pancreas stellate cells (aPSCs), apoptosis

Organism: Rat

Tissue: Pancreas

Pathological State: Pancreatectomy

Cell Line:

261
Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative

Jun Wei,Hongyan Zhu, Gabriel Lord, Mitra Bhattachayya, Brielle M. Jones, Graham Allaway, Shyam S. Biswal, Benjamin Korman, Roberta G. Marangoni, Warren G. Tourtellotte, John Varga

Translational Research (Elsevier) USA, 09 December 2016

Neurology

Key words: Nrf2-nuclear factor erythroid 2–related factor 2, systemic sclerosis, TGF-β, CDDO, TMC

Organism: Human

Tissue: Skin

Pathological State: Systemic sclerosis

Cell Line:

262
Lead-Free Piezoelectric (Ba,Ca)(Zr,Ti)O3 Thin Films for Biocompatible and Flexible Devices

N. D. Scarisoreanu, F. Craciun, V. Ion, R. Birjega, A. Bercea V. Dinc, M. Dinescu, L. E. Sima, M. Icriverzi, A. Roseanu, L. Gruionu, and G. Gruionu

Applied Materials & Interfaces (ACS) Romania, 08 December 2016

Biological Materials

Key words: Biocompatible materials, laser processing, lead-free thin films, mesenchymal stem cells, osteogenic differentiation

Organism: Human

Tissue:

Pathological State: Cancer

Cell Line: HEK 293T and A375 cells (Human epithelial embryonic kidney and human malignant melanoma cells)

263
Silica-Coated Metal Chelating-Melanin Nanoparticles as a Dual-Modal Contrast Enhancement Imaging and Therapeutic Agent

Soojeong Cho, Wooram Park and Dong-Hyun Kim

Applied Materials & Interfaces (ACS) USA, 08 December 2016

Nanomedicine

Key words: Fluorescence imaging, melanin, metal-chelation,MRI, multimodal image-guidance, silica coating

Organism: Mouse

Tissue: Xenograft Tumor (PC-3)

Pathological State: Cancer

Cell Line:

264
Nodal metastasis signatures in breast cancer

Kyeongmee ParK, Joo Hyun Lee, Hyun Ho Han, Seong Gyeong Mun, Suki Kang, Youn Jin Cha, Ja-Seung Koo, Min Ju Kim, Hye Sun Lee, Jieun Moon, Nam Hoon Cho

Pathology - Research and Practice (Elsevier) Korea, 05 December 2016

Oncology

Key words: Breast cancer, node positive ratio, node positive number, ERK, WDR1, c-MET

Organism: Human

Tissue: Breast

Pathological State: Cancer

Cell Line:

265
Mast Cells Are Abundant in Primary Cutaneous T-Cell Lymphomas: Results from a Computer-Aided Quantitative Immunohistological Study

Johanna Eder , Radu Rogojanu, Waltraud Jerney, Friedrich Erhart, Alexander Dohnal, Melitta Kitzwögerer, Georg Steiner, Julia Moser, Franz Trautinger

PLOS ONE (PLOS) Austria, 28 November 2016

Oncology

Key words: Mast cells, cutaneous T-cell lymphomas (CTCL), haematopoetic cells

Organism: Human

Tissue: Skin

Pathological State: Cancer

Cell Line:

266
Solid stress and elastic energy as measures of tumour mechanopathology

Hadi T. Nia, Hao Liu, Giorgio Seano, Meenal Datta, Dennis Jones, Nuh Rahbari, Joao Incio, Vikash P. Chauhan, Keehoon Jung, John D. Martin, Vasileios Askoxylakis, Timothy P. Padera, Dai Fukumura, Yves Boucher, Francis J. Hornicek, Alan J. Grodzinsky, James

Nature Biomedical Engineering (Nature) USA, 28 November 2016

Neurology

Key words: Solid stress, tissue stiffness, tumour

Organism: Mouse

Tissue: Xenograft Tumor (4T1 cells)

Pathological State: Cancer

Cell Line:

267
Cardiac extracellular matrix is associated with adverse outcome in patients with chronic heart failure

Franz Duca,Caroline Zotter-Tufaro,Andreas A. Kammerlander,Adelheid Panzenböck,Stefan Aschauer,Daniel Dalos,Benedikt Köll,Benedikt Börries,Hermine Agis,Renate Kain,Klaus Aumayr,Florian Klinglmüller,Julia Mascherbauer,Diana Bonderman

European Journal of Heart Failure (Wiley) Austria, 27 November 2016

Cardiology

Key words: Extracellular matrix (ECM), heart failure (HF), endomyocardial biopsy

Organism: Human

Tissue: Heart

Pathological State: Heart Failure

Cell Line:

268
Antimicrobial polycaprolactone/ polyethylene glycol embedded lysozyme coatings of Ti implants for osteoblast functional properties in tissue engineering

A. Visan, R. Cristescu, N. Stefan, M. Miroiu, C. Nita, M. Socol, C. Florica, O. Rasoga, I. Zgura, L.E. Sima, M. Chiritoiu, M.C. Chifiriuc, A.M. Holban, I.N. Mihailescu, G. SocoL

Applied Surface Science (Elsevier) Romania, 19 November 2016

Immunology

Key words: MAPLE, Dip coating, Lysozyme, Blends, Antimicrobial, Biocompatible

Organism: Human

Tissue:

Pathological State:

Cell Line: SAOS2 cells and MSCs (primary osteogenic sarcoma cells and mesenchymal stem cells)

269
Rhinophototherapy in persistent allergic rhinitis

Zsolt Bella, Ágnes Kiricsi, Éva Dósa-Rácz Viharosné, Attila Dallos, Ádám Perényi, Mária Kiss, Andrea Koreck, Lajos KeményJózsef JóriLászló Rovó, Edit Kadocsa

European Archives of Oto-Rhino-Laryngology (Springer) Hungary, 18 November 2016

Allergy

Key words: Intercellular adhesion molecule-1 expression, Intranasal phototherapy, Mucociliary clearance, Nasal inspiratory peak flow, Persistent allergic rhinitis, Rhinolight

Organism: Human

Tissue: Nasal Mucosa

Pathological State: Persistent allergic rhinitis

Cell Line:

270
The plasma membrane Ca2+ pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells

Luca Hegedũs,Tamás Garay,Eszter Molnár,Karolina Varga,Ágnes Bilecz,Szilvia Török,Rita Padányi,Katalin Pászty,Matthias Wolf,Michael Grusch,Enikõ Kállay,Balázs Döme,Walter Berger,Balázs Hegedũs,Agnes Enyedi

International Journal of Cancer (Wiley) Austria, 17 November 2016

Oncology

Key words: Ca2+, PMCA4b expression, NRAS mutant melanoma cells

Organism: Mouse

Tissue: Xenograft Tumor (A375 and PMCA4bl cells)

Pathological State: Cancer

Cell Line:

271
Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

Debbie Le Blon, Caroline Guglielmetti, Chloé Hoornaert, Alessandra Quarta, Jasmijn Daans, Dearbhaile Dooley, Evi Lemmens, Jelle Praet, Nathalie De Vocht, Kristien Reekmans, Eva Santermans, Niel HensHerman Goossens, Marleen Verhoye, Annemie Van der Linden,

Journal of Neuroinflammation (Springer) Belgium, 09 November 2016

Neurology

Key words: Interleukin 13, Mesenchymal stem cells, Neuroinflammation, Transplantation, Magnetic resonance imaging

Organism: Mouse

Tissue: Brain

Pathological State: Demyelination

Cell Line:

272
Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis

Yi-Ching Wang, Hong-Tai Tzeng, Chung-Han Tsai, Yi-Ting Yen, Hung-Chi Cheng, Yi-Chieh Chen, Shih-Wen Pu, Yu-Shiuan Wang, Yan-Shen Shan, Yau-Lin Tseng, Wu-Chou Su, Wu-Wei Lai and Li-Wha Wu

Clinical Cancer Research (AACR) Taiwan, 07 November 2016

Oncology

Key words: Rab37-Mediated, Thrombospondin-1, angiogenesis marker CD31, p-FAK/p-paxillin/p-ERK

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

Cell Line:

273
A Single Postnatal Dose of Dexamethasone Enhances Memory of Rat Pups Later in Life

Kuen-Jer Tsai , Chun-I Sze , Yung-Chieh Lin, Yuh-Jyh Lin, Ting-Hui Hsieh, Chyi-Her Lin

PLOS ONE (PLOS) Taiwan, 31 October 2016

Neurology

Key words: Postnatal dexamethasone (Dex) therapy, NMDAR, bronchopulmonary dysplasia, chronic lung disease

Organism: Rat

Tissue: Brain

Pathological State:

Cell Line:

274
An Alternative High-Throughput Platform to Analyze hiPSC Lines

Alberto La Spada, Simona Baronchelli, Linda Ottoboni, Francesca Ruffini, Gianvito Martino, Nunzia Convertino, Aikaterini Ntai, Tobias Steiner, Ida Biunno, Andrea De Blasio

Journal of Histochemistry & Cytochemistry (Sage Journals) , 26 October 2016

Biological Methods

Key words: Cell line macroarray, high-throughput screening and quantification, hiPSC clones

Organism: Human

Tissue:

Pathological State:

Cell Line: iPSCs (induced pluripotent cells)

275
KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1

Yu Gao, Hongzhao Li, Xin Ma, Yang Fan, Dong Ni, Yu Zhang, Qingbo Huang, Kan Liu, Xintao Li, Lei Wang, Liangyou Gu, Yuanxin Yao, Qing Ai, Qingshan Du, Erlin Song and Xu Zhang

Molecular Cancer (AACR) China, 25 October 2016

Oncology

Key words: KLF6 expression, E2F1-mediated epithelial–mesenchymal, cell renal cell carcinoma (ccRCC)

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

Cell Line:

276
Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle

Tim Koopmans,Stijn Crutzen,Mark H Menzen,Andrew J Halayko,Tillie-Louise Hackett,Darryl A Knight,Reinoud Gosens

British Journal of Pharmacology (Wiley) USA, The Netherlands, 25 October 2016

Pharmacology

Key words: Asthma, β-catenin, CREB-binding protein (CBP) , TGFβ1

Organism: Mouse

Tissue: Lung

Pathological State:

Cell Line:

277
PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

Brasó-Maristany F, Filosto S, Catchpole S, Marlow R, Quist J, Francesch-Domenech E, Plumb DA, Zakka L, Gazinska P, Liccardi G, Meier P, Gris-Oliver A, Cheang MC, Perdrix-Rosell A, Shafat M, Noël E, Patel N, McEachern K, Scaltriti M, Castel P, Noor F, Buus

Nature Medicine (Nature) UK, 24 October 2016

Oncology

Key words: Triple-negative breast cancers (TNBCs), PIM1 proto-oncogene, anti-apoptotic factor BCL2, dynamic BH3

Organism: Mouse

Tissue: Xenograft Tumor (MB-231 or SUM149 cells)

Pathological State: Cancer

Cell Line:

278
The fractionation of adipose tissue procedure to obtain stromal vascular fractions for regenerative purposes

Joris A. van Dongen,Hieronymus P. Stevens ,Mojtaba Parvizi ,Berend van der Lei ,Martin C. Harmsen

Wound Repair and Regeneration (Wiley) The Netherlands, 21 October 2016

Regenerative Medicine

Key words: Autologous adipose tissue transplantation, FAT-stromal vascular fraction

Organism: Human

Tissue:

Pathological State:

Cell Line: Smooth muscle cells

279
Oncolytic influenza A virus expressing interleukin-15 decreases tumor growth in vivo 

Karin Hock, Johannes Laengle, Irina Kuznetsova,Andrej Egorov, Balazs Hegedus, Balazs Dome, Thomas Wekerle, Monika Sachet, Michael Bergmann

Surgery (Elsevier) Austria, 21 October 2016

Immunology

Key words: Interleukin-15, A virus, T cells,

Organism: Mouse

Tissue: Allograft Tumor (B16-F1 cells)

Pathological State: Cancer

Cell Line:

280
Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury

Jill Moser, Joris van Ark, Marcory C. van Dijk, Dale L. Greiner, Leonard D. Shultz, Harry van Goor & Jan-Luuk Hillebrands

Scientific Reports (Nature) USA, The Netherlands, 19 October 2016

Cardiology

Key words: NOD.Cg-PrkdcscidIL2rgtm1Wjl(NSG), Percutaneous coronary interventions (PCIs), BL/6 mice

Organism: Human

Tissue:

Pathological State:

Cell Line: Peripheral blood mononuclear cell

281
In Situ Characterization of Tissue-Resident Immune Cells by MALDI Mass Spectrometry Imaging

Matthias Holzlechner, Katharina Strasser, Elitsa Zareva, Luise Steinhäuser, Hanna Birnleitner, Andrea Beer, Michael Bergmann, Rudolf Oehler, and Martina Marchetti-Deschmann

Journal of Proteome (ACS) Austria, 18 October 2016

Immunology

Key words: Colon tissue, immune cells, immunohistochemistry, lymphocytes, macrophages, MALDI mass spectrometry imaging, monocytes

Organism: Human

Tissue: Colon

Pathological State:

Cell Line:

282
Aberrant expression of tumor-associated carbohydrate antigen Globo H in thyroid carcinoma

Shih-Ping Cheng ,Po-Sheng Yang ,Ming-Nan Chien ,Ming-Jen Chen ,Jie-Jen Lee ,Chien-Liang Liu

Journal of Surgical Oncology (Wiley) Taiwan, 18 October 2016

Oncology

Key words: Globo H - hexasaccharide glycosphingolipid, Normal or benign thyroid, papillary thyroid cancer

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

Cell Line:

283
Ustekinumab treatment in severe atopic dermatitis: Down-regulation of T-helper 2/22 expression 

Doris Weiss, Michaela Schaschinger, Robin Ristl, Robert Gruber, Tamara Kopp, Georg Stingl, Christine Bangert

Journal of the American Academy of Dermatology (Elsevier) Austria, 13 October 2016

Dermatology

Key words: Anti-interleukin-12/-23 p40, atopic dermatitis, cytokines, eczema, inflammatory, T helper 2, T helper 17, T helper 22, ustekinumab

Organism: Human

Tissue: Skin

Pathological State: Severe atopic dermatitis

Cell Line:

284
Intraarticular overexpression of Smad7 ameliorates experimental arthritis

Shih-Yao Chen, Ai-Li Shiau, Chao-Liang Wu & Chrong-Reen Wang

Scientific Reports (Nature) Taiwan, 12 October 2016

Immunology

Key words: Genetic vectors, Translational immunology

Organism: Human

Tissue: Synovial membrane

Pathological State:

Cell Line:

285
Hydroxyapatite thin films grown by pulsed laser deposition and matrix assisted pulsed laser evaporation: Comparative study

G. Popescu-Pelin, F. Sima, L.E. Sima, C.N. Mihailescu, C. Luculescu, I. Iordache, M. Socol, G. Socol, I.N. Mihailescu

Applied Surface Science (Elsevier) Romania, 11 October 2016

Tissue Engineering

Key words: Pulsed laser deposition, Matrix assisted pulsed laser evaporation, Hydroxyapatite coatings, Biocompatibility, Cell proliferation and differentiation

Organism: Human

Tissue:

Pathological State:

Cell Line: MSCs (mesenchymal stem cells)

286
G-CSF-mobilized Bone Marrow Mesenchymal Stem Cells Replenish Neural Lineages in Alzheimer’s Disease Mice via CXCR4/SDF-1 Chemotaxis

Cheng-Chun WuI-Fang Wang, Po-Min Chiang, Liang-Chao Wang, Che-Kun James Shen, Kuen-Jer Tsai

Molecular Neurobiology (Springer) Taiwan, 05 October 2016

Neurology

Key words: G-CSF, Bone marrow stem cells, SDF-1CXCR4, Neurogenesis, Alzheimer’s disease

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s Disease

Cell Line:

287
Neuronal prolyl-4-hydroxylase 2 deficiency improves cognitive abilities in a murine model of cerebral hypoperfusion

Daniel Gruneberg, Felipe A. Montellano, Konstanze Plaschke, Lexiao Li, Hugo H. Marti, Reiner Kunze

Experimental Neurology (Elsevier) Germany, 05 October 2016

Neurology

Key words: HIF, PHD, Epo, VEGF, Hippocampus, Learning, Memory, Alzheimer's disease

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral hypoperfusion

Cell Line:

288
Houttuynia cordata Thunb Promotes Activation of HIF-1A–FOXO3 and MEF2A Pathways to Induce Apoptosis in Human HepG2 Hepatocellular Carcinoma Cells

Jung Min Kim, In-Hu Hwang, Ik-Soon Jang, Min Kim, In Seok Bang, Soo Jung Park, Yun-Jo Chung, Jong-Cheon Joo, Min-Goo Lee

Integrative Cancer Therapies (Sage Journals) Korea, 03 October 2016

Oncology

Key words: Cancer, cell apoptosis, hypoxia-inducible factor (HIF)-1A

Organism: Mouse

Tissue: Xenograft Tumor (HepG2 cells)

Pathological State: Cancer

Cell Line:

289
Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

Caroline Guglielmetti,Debbie Le Blon, Eva Santermans, Angelica Salas-Perdomo, Jasmijn Daans, Nathalie De Vocht, Disha Shah, Chloé Hoornaert, Jelle Praet, Jurgen Peerlings, Firat Kara, Christian Bigot, Zhenhua Mai, Herman Goossens, Niel Hens, Sven Hendrix,

GLIA (Wiley) Belgium, 29 September 2016

Neuroscience

Key words: IL-13, microglia, macrophages, severe oligodendrocyte loss and demyelination, mouse nodel

Organism: Mouse

Tissue: Brain

Pathological State: Demyelination

Cell Line:

290
Comparison of cancer cells cultured in 2D vs 3D reveals differences in AKT/mTOR/S6-kinase signaling and drug response

Angelika Riedl, Michaela Schlederer, Karoline Pudelko, Mira Stadler, Stefanie Walter, Daniela Unterleuthner, Christine Unger, Nina Kramer, Markus Hengstschläger, Lukas Kenner, Dagmar Pfeiffer, Georg Krupitza, Helmut Dolznig

Journal of Cell Science (The Company of Biologists) Austria, 23 September 2016

Oncology

Key words: Cancer cells, colon cancer, AKT/mTOR/S6-kinase, ERK phosphorylation

Organism: Human

Tissue:

Pathological State:

Cell Line: LS174T, HT29, SW620, HCT116), Caco-2 and DLD-1 (Human colon cancer cell lines)

291
Targeted multimodal nano-reporters for pre-procedural MRI and intra-operative image-guidance

Joonseok Lee, Andrew C. Gordon, Hacksung Kim, Wooram Park, Soojeong Cho, Byeongdu Lee, Andrew C. Larson, Elena A. Rozhkova, Dong-Hyun Kim

Biomaterials (Elsevier) USA, 19 September 2016

Medical imaging

Key words: Upconversion nanoparticles, Medical imaging, Cancer, Interventional radiology, Multimodal probe

Organism: Rat

Tissue: Heart, Liver, spleen, lung, kidney

Pathological State:

Cell Line:

292
Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma

Seunggu J. Han, Gerald Reis, Gary Kohanbash, Shruti Shrivastav, Stephen T. Magill, Annette M. Molinaro, Michael W. McDermott, Philip V. Theodosopoulos, Manish K. Aghi, Mitchel S. Berger, Nicholas A. Butowski, Igor Barani, Joanna J. Phillips, Arie Perry, H

Journal of Neuro-Oncology (Springer) USA, 13 September 2016

Neurology

Key words: Meningioma, PD-L1, B7-H1, Immunotherapy, Checkpoint, Lymphocyte, Macrophage

Organism: Human

Tissue: Brain

Pathological State: Cancer

Cell Line:

293
The effects of oral and topical corticosteroid in rabbit corneas

Kaoru Araki-Sasaki, Osamu Katsuta, Hidetoshi Mano, Takashi Nagano and Masatsugu Nakamura

BMC Ophthalmology (BioMed Central) Japan, 05 September 2016

Ophthalmology

Key words: Corticosteroid, Keratitis, Cornea, Wound healing, Pharmacokinetics

Organism: Rabbit

Tissue: Eye

Pathological State: Skin Wound

Cell Line:

294
Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation

Yong-Hee Rhee, Sang-Hoon Yi, Joo Yeon Kim, Mi-Yoon Chang, A-Young Jo, Jinyoung Kim, Chang-Hwan Park, Je-Yoel Cho, Young-Jin Choi, Woong Sun & Sang-Hun Lee

Scientific Reports (Nature) Korea, 24 August 2016

Neurology

Key words: Neurology, neural stem cells, Raf-Erk pathway, radial glial cells

Organism: Mouse

Tissue: Brain

Pathological State:

Cell Line:

295
Degradation of Kidney and Psoas Muscle Proteins as Indicators of Post-Mortem Interval in a Rat Model, with Use of Lateral Flow Technology

Dong-Gi Lee, Kyeong Eun Yang, Jeong Won Hwang, Hwan-Soo Kang, Seung-Yeul Lee, Seoyeon Choi, Joonchul Shin, Ik-Soon Jang, Hyun Joo An, Heesun Chung, Hyo-Il Jung , Jong-Soon Choi

PLOS ONE (PLOS) Korea, 23 August 2016

Forensic Science

Key words: Post-mortem interval (PMI) markers, kidney, muscle, GAPDH

Organism: Rat

Tissue: Kidney, Muscle

Pathological State:

Cell Line:

296
Toward the Automated Detection and Characterization of Osteoclasts in Microscopic Images

Andreas Heindl , Martin Schepelmann, Robert Nica, Rupert Ecker, Peter Pietschmann, Alexander K. Seewald, Theresia Thalhammer, Isabella Ellinger

Principles of Osteoimmunology (Springer) Austria, 19 August 2016

Automated Image Analysis

Key words: Osteoimmunology, microscopes, biological samples, automated image segmentation and analysis

Organism:

Tissue:

Pathological State:

Cell Line:

297
Dynamic Modulation of Microglia/Macrophage Polarization by miR-124 after Focal Cerebral Ischemia

Somayyeh Hamzei Taj, Widuri Kho, Markus Aswendt, Franziska M. Collmann, Claudia Green, Joanna Adamczak, Annette Tennstaedt, Mathias Hoehn

Journal of Neuroimmune Pharmacology (Springer) Germany, 18 August 2016

Neurology

Key words: Stroke, Microglia/macrophage polarization, Pro-inflammatory and anti-inflammatory phenotypes, miRNA-124, Neuroinflammation

Organism: Mouse

Tissue: Brain

Pathological State: Focal Cerebral Ischemia

Cell Line:

298
LIN28A enhances the therapeutic potential of cultured neural stem cells in a Parkinson’s disease model

Yong-Hee Rhee, Tae-Ho Kim, A-Young Jo, Mi-Yoon Chang, Chang-Hwan Park, Sang-Mi Kim, Jae-Jin Song, Sang-Min Oh, Sang-Hoon Yi, Hyeon Ho Kim, Bo-Hyun You, Jin-Wu Nam, Sang-Hun Lee

Brain: A journal of neurology (Oxford Journals) Korea, 18 August 2016

Neurology

Key words: LIN28A, neural stem cell (NSC) culture, repair capacity, Parkinson’s disease

Organism: Rat

Tissue: Brain

Pathological State: Parkinson

Cell Line:

299
The antiviral alkaloid berberine reduces chikungunya virus-induced mitogen-activated protein kinase (MAPK) signaling

Finny S. Varghese, Bastian Thaa, Siti Naqiah Amrun, Diane Simarmata, Kai Rausalu, Tuula A. Nyman, Andres Merits, Gerald M. McInerney2, Lisa F.P. Ng, Tero Ahola

Journal of Virology (ASM) Finland, 17 August 2016

Virology

Key words: Chikungunya virus, non-toxic plant alkaloid berberine, mitogen-activated protein kinase

Organism: Mouse

Tissue: Joint

Pathological State: Chikungunya Virus Infection

Cell Line:

300
Bradykinin promotes neuron-generating division of neural progenitor cells via ERK activation

Micheli M. Pillat, Claudiana Lameu, Cleber A. Trujillo, Talita Glaser, Angélica R. Cappellari, Priscilla D. Negraes, Ana M. O. Battastini, Telma T. Schwindt, Alysson Muotri, Henning Ulrich

Journal of Cell Science (The Company of Biologists) Brasil, 15 August 2016

Neurology

Key words: Bradykinin, neurogenesis, TIS21 (PC3/BTG2) expression

Organism: Mouse

Tissue: Brain

Pathological State:

Cell Line:

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