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Customer Publications (A total of 1287 papers published)

201
CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer

Teresa P.RaposoabMireia SuecaComescAdeyemiIdowuaBoraAgitaJamesHassallabWakkasFadhilabRobertNicadRupertEckerdTakashiYaoeMohammadIlyas

Experimental and Molecular Pathology (Elsevier) UK, 11 April 2018

Oncology

Key words:CD10, NEP, CALLA, Colorectal cancer, Epithelial-mesenchymal transition, Metastasis

Organism: Human

Tissue: Colon

Pathological State: Cancer

202
Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma

Patrick J. Cimino Youngmi Kim Hua-Jun Wu Jes Alexander, Hans-Georg Wirsching Frank Szulzewsky,1 Ken Pitter,7 Tatsuya Ozawa,1,8 Jiguang Wang,9,10,16 Julio Vazquez,11 Sonali Arora,1 Raul Rabadan Ross Levine Franziska Michor and Eric C. Holland

Genes and Development (Cold Spring Harbor Laboratory Press) USA, 09 April 2018

Oncology

Key words:glioblastoma, HoxA, homeobox RCAS, chromosome 7 gain

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

203
Photodynamic Effect of Methylene Blue and Low Level Laser Radiation in Head and Neck Squamous Cell Carcinoma Cell Lines

Barbara Kofler, Angela Romani, Christian Pritz, Teresa Bernadette Steinbichler, Volker Hans Schartinger, Herbert Riechelmann, Jozsef Dudas

International Journal of Molecular Sciences (MDPI) Austria, 07 April 2018

Oncology

Key words:TissueFaxs; head and neck carcinoma; methylene blue; photodynamic therapy

Organism: Human

Pathological State: Cancer

Cell Line: Detroit 562 cells (pharynx carcinoma)

204
The expansion in lymphoid organs of IL-4+ BATF+ T follicular helper cells is linked to IgG4 class switching in vivo

Takashi Maehara, Hamid Mattoo, Vinay S Mahajan, Samuel JH Murphy, Grace J Yuen, Noriko Ishiguro, Miho Ohta, Masafumi Moriyama, Takako Saeki, Hidetaka Yamamoto, Masaki Yamauchi, Joe Daccache, Tamotsu Kiyoshima, Seiji Nakamura, John H Stone, Shiv Pillai

Life Science Alliance () USA, Japan, 05 April 2018

Immunology

Key words:T follicular helper (TFH), BATF+ ,IgG4 class switching, Sjögren’s syndrome,secondary lymphoid organs

Organism: Human

Tissue: Salivary Gland

205
Glycyrrhetinic Acid Antagonizes Pressure-Induced Venous Remodeling in Mice

Hanna Kuk,Caroline Arnold,Andreas H. Wagner,Markus Hecker,Carsten Sticht, and Thomas Korff

Frontiers in Physiology (Frontiers Media S.A.) Germany, 04 April 2018

Physiology

Key words:endothelial cells; spider veins; venous hypertension; venous remodeling; wall stress

Organism: Human

Cell Line: HUVEC, HUVSMC (human umbilical vein endothelial and SMCs)

206
Amentoflavone enhances the therapeutic efficacy of sorafenib by inhibiting anti-apoptotic potential and potentiating apoptosis in hepatocellular carcinoma in vivo

JJ Tsai, FT Hsu, PJ Pan, CW Chen, YC Kuo

Anticancer Research (International Institute of Anticancer Research) Taiwan, 01 April 2018

Oncology

Key words:Amentoflavone sorafenib hepatocellular carcinoma ERK AKT apoptosis

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

207
Cordyceps militaris Extract Inhibits the NF-κB pathway and Induces Apoptosis through MKK7-JNK Signaling Activation in TK-10 Human Renal Cell Carcinoma

SJ Park, HJ Jang, IH Hwang, JM Kim, E Jo, MG Lee, IS Jang, J Cheon Joo

Natural Product Communications (SAGE Journals) South Korea, 01 April 2018

Oncology

Key words:Cordyceps militaris, Apoptosis, NF-κB, MKK7, JNK, TK-10

Organism: Human

Pathological State: Cancer

Cell Line: TK-10 renal cancer cell lines

208
Periostin antisense oligonucleotide suppresses bleomycin‐induced formation of a lung premetastatic niche for melanoma

Takashi Semba Eiji Sugihara Nagisa Kamoshita Sayaka Ueno Keitaro Fukuda Masafumi Yoshino Kazumasa Takao Kazunori Yoshikawa Kenji Izuhara Yoshimi Arima Makoto Suzuki Hideyuki Saya

Cancer Science (Wiley) Japan, 31 March 2018

Oncology

Key words:antisense oligonucleotide; lung fibrosis; melanoma; periostin; premetastatic niche

Organism: Mouse

Tissue: Lung

209
MRI‐guided interventional natural killer cell delivery for liver tumor treatment

Zhanliang Su, Xifu Wang, Linfeng Zheng, Tianchu Lyu, Matteo Figini, Bin Wang, Daniel Procissi, Junjie Shangguan, Chong Sun, Liang Pan, Lei Qin, Bin Zhang, Yury Velichko, Riad Salem, Vahid Yaghmai, Andrew C. Larson, Zhuoli Zhang

Cancer Medicine (Wiley) USA, 30 March 2018

Oncology

Key words:Adoptive transfer immunotherapy; hepatocellular carcinoma; interventional oncology; magnetic resonance imaging; natural killer cell

Organism: Rat

Tissue: Liver

Pathological State: Cancer

210
Collagen morphology influences macrophage shape and marker expression in vitro

Gwenda F. Vasse, Philipp T. Kühn, Qihui Zhou, Shardul A. Bhusari, Catharina Reker-Smit, Barbro N. Melgert, Patrick van Rijn

Journal of Immunology and Regenerative Medicine (Elsevier) The Netherlands, 30 March 2018

Immunology

Key words:Extracellular matrix, Collagen type I, Pulmonary fibrosis, Ym1, CD206, Migration

Organism: Human

Cell Line: Alveolar-like Makrophhages

211
Olaparib is effective in combination with, and as maintenance therapy after, first‐line endocrine therapy in prostate cancer cells

Gertrud E. Feiersinger1,Kristina Trattnig1, Peter D. Leitner, Fabian Guggenberger,Alexander Oberhuber, Sarah Peer, Martin Hermann, Ira Skvortsova, Jana Vrbkova, Jan Bouchal, Zoran Culig and Fred eric R. Santer

Molecular Oncology (Wiley) Austria, 15 March 2018

Oncology

Key words:PARP inhibition; combination therapy; endocrine therapy; maintenance therapy; olaparib; prostate cancer

Organism: Human

Pathological State: Cancer

Cell Line: LNCaP-abl (Prostate carcinoma cell lines)

212
Loss of Neuroglobin Expression Alters Cdkn1a/Cdk6-Expression Resulting in Increased Proliferation of Neural Stem Cells

Evi Luyckx, Wendy Van Leuven, Daniel Andre, Alessandra Quarta, Kristien Reekmans, Erik Fransen, Luc Moens, Thomas Hankeln, Peter Ponsaerts, and Sylvia Dewilde

Stem Cells and Development (Mary Ann Liebert Inc.) Belgium, Germany, 15 March 2018

Stem Cell Research

Key words:neuroglobin – cell cycle – transcriptomics – neural stem cells

Organism: Mouse

Cell Line: Neural stem cells

213
Effects of iota-carrageenan on ocular Chlamydia trachomatis infection in vitro and in vivo

Aleksandra Inic-Kanada, Elisabeth Stein, Marijana Stojanovic, Nadine Schuerer, Ehsan Ghasemian, Ana Filipovic, Emilija Marinkovic, Dejana Kosanovic, Talin Barisani-Asenbauer

Journal of Applied Phycology (Kluwer Academic Publishers) Austria, 13 March 2018

Microbiology

Key words:Carrageenan, Trachoma, Natural products, Chlamydia

Organism: Human

Pathological State: Bacterial Infection

Cell Line: HCjE cells (human corneal-limbal and conjunctival epithelial cell line)

214
Prostaglandin E2 Is Required for BMP4-Induced Mesoderm Differentiation of Human Embryonic Stem Cells

Bowen Zhang,1,2,3 Lijuan He,1,2,3 Yiming Liu,1,2 Jing Zhang,1,2 Quan Zeng,1,2 Sihan Wang,1,2 Zeng Fan,1,2 Fang Fang Lin Chen Yang Lv Jiafei Xi Wen Yue Yanhua Li and Xuetao Pei

Stem Cell Reports (Cell Press) China, 13 March 2018

Stem Cell Research

Key words:prostaglandin E2, cyclooxygenase-1, BMP4, mesoderm, differentiation, human embryonic stem cells, β-catenin,

Organism: Human

Cell Line: WA01 and WA09 hESCs

215
Atlas of the Striatum and Globus Pallidus in the Tree Shrew: Comparison with Rat and Mouse

Rong-Jun Ni,Zhao-Huan Huang,Yu-Mian Shu,Yu Wang Tao Li, Jiang-Ning Zhou

Neuroscience Bulletin (Springer) China, 05 March 2018

Neuroscience

Key words:Striatum, Globus pallidus, Basal ganglia, Reconstruction, Rodent, Parvalbumin

Organism: Treeshrew, Rat, Mouse

Tissue: Brain

216
Novel platforms of multiplexed immunofluorescence for study of paraffin tumor tissues

Edwin Roger Parra

Journal of Cancer Treatment and Diagnosis () USA, 01 March 2018

Cytometry

Key words:Multiplexed proteins identification Immunofluorescence Signal Amplification Spatial Cell Distribution Image Analysis

217
4:20 PM Abstract No. 350 Interferon-gamma-eluting microspheres for MRI-guided immunotherapy of liver cancer

W.ParkA.GordonS.ChoX.HuangK.HarrisZ.ZhangA.LarsonD.Kim

Journal of Vascular and Interventional Radiology (Elsevier) USA, 01 March 2018

Oncology

Organism: Rabbit

Tissue: Liver

Pathological State: Cancer

218
In vitro behavior of human mesenchymal stem cells on poly(N-isopropylacrylamide) based biointerfaces obtained by matrix assisted pulsed laser evaporation

Madalina Icriverzi, Laurentiu Rusen, Livia Elena Sima, Antoniu Moldovan, Simona Brajnicov, Anca Bonciu, Natalia Mihailescu, Maria Dinescu, Anisoara Cimpean, Anca Roseanu, Valentina Dinca

Applied Surface Science (Elsevier) Romania, 28 February 2018

Cell Biology

Key words:pNIPAM coatings, MAPLE, mesenchymal stem cells

Organism: Human

Cell Line: Human mesenchymal stem cells (hMSCs)

219
[18F]FEPPA: Improved Automated Radiosynthesis, Binding Affinity, and Preliminary in Vitro Evaluation in Colorectal Cancer

Neydher Berroterán-Infante, Theresa Balber, Petra Fürlinger, Michael Bergmann, Rupert Lanzenberger, Marcus Hacker, Markus Mitterhauser and Wolfgang Wadsak

Medicinal Chemistry Letters (ACS Publications) Austria, 21 February 2018

Radiotherapy

Key words:Affinity, autoradiography, colorectal cancer, FEPPA, radiosynthesis, TSPO

Organism: Human

Tissue: Colon

Pathological State: Cancer

220
CXCL5 facilitates melanoma cell-neutrophil interaction and lymph node metastasis

Ana Soler Cardona, Agnes Forsthuber, Katharina Lipp, Stefanie Ebersbergr, Magdalena Heinz, Klaudia Schossleitner, Elisabeth Buchberger, Mario Gröger, Peter Petzelbauer, Christoph Hoeller, Erwin Wagner, Robert Loewe

Journal of Investigative Dermatology (Elsevier) Austria, 21 February 2018

Dermatology

Key words:CXCL5, melanoma cells, chemokine mRNA expression

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

221
Hypoxia-Preconditioned Human Umbilical Vein Endothelial Cells Protect Against Neurovascular Damage After Hypoxic Ischemia in Neonatal Brain

Yi-Chao Lee, Ying-Chao Chang, Chia-Ching Wu,Chao-Ching Huang

Molecular Neurobiology (Springer) Taiwan, 19 February 2018

Neuroscience

Key words:Neonatal brain injury, neurovascular protection, hypoxia-preconditioned, human umbilical vein endothelial cells, hypoxia-inducible factor 1-alpha

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

222
Inflammatory Monocytes Drive Influenza A Virus–Mediated Lung Injury in Juvenile Mice

Bria M. Coates, Kelly L. Staricha, Clarissa M. Koch, Yuan Cheng, Dale K. Shumaker, G. R. Scott Budinger, Harris Perlman, Alexander V. Misharin and Karen M. Ridge

The Journal of Immunology (American Association of Immunologists) USA, 14 February 2018

Immunology

Key words:Influenza A virus (IAV), NLRP3 inflammasome, cytokines, monocytes

Organism: Mouse

Tissue: Lung, Heart

223
Preclinical In Vitro and In Vivo Evaluation of [18F]FE@SUPPY for Cancer PET Imaging: Limitations of a Xenograft Model for Colorectal Cancer

T. Balber, J.Singer, N. Berroterán-Infante, M. Dumanic, L. Fetty, J. Fazekas-Singer , C. Vraka, L. Nics, M. Bergmann, K. Pallitsch, H. Spreitzer, W. Wadsak , M. Hacker, E. Jensen-Jarolim, H. Viernstein, and M. Mitterhauser ,

Contrast Media and Molecular Imaging (Wiley) Austria, 13 February 2018

Oncology

Key words:[18F]FE@SUPPY, Cancer PET Imaging, Colorectal Cancer

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

224
Calcium signaling mediates five types of cell morphological changes to form neural rosettes

Hana Hříbková, Marta Grabiec, Dobromila Klemová, Iva Slaninová, Yuh-Man Sun

Journal of Cell Science (The Company of Biologists) Czech Republic, 12 February 2018

Neuroscience

Key words:Embryonic stem cells, neural stem cell niche, neural rosette formation, calcium, neurogenesis, adherens junctions, cytoskeleton proteins

Organism: Human

Cell Line: Human ESC-derived neural rosettes

225
Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers

Junko Ohtsuka, Hiroko Oshima, Issei Ezawa, Ryo Abe, Masanobu Oshima and Rieko Ohki

Scientific Reports (Nature) Japan, 02 February 2018

Oncology

Key words:Gastric cancer, p53 mutations, tumour-suppressor proteins

Organism: Mouse

Tissue: Stomach

Pathological State: Cancer

226
Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of “luminal” muscle-invasive bladder cancers

Simon C. Baker, Volker M. Arlt, Radek Indra, Madeleine Joel, Marie Stiborová, Ian Eardley, Niaz Ahmad, Wolfgang Otto, Maximilian Burger, Peter Rubenwolf, David H. Phillips, Jennifer Southgate

Molecular Carcinogenesis (Wiley) UK, 01 February 2018

Oncology

Key words:Urothelium, carcinogens, normal human urothelial (NHU) cells , EROD activity

Organism: Human

Cell Line: NHU cells (Normal human urothelial)

227
Angiogenin Attenuates Scar Formation in Burn Patients by Reducing Fibroblast Proliferation and Transforming Growth Factor β1 Secretion

SC Pan, CH Lee, CL Chen, WY Fang, LW Wu

Annals of Plastic Surgery (LWW Journals) Taiwan, 01 February 2018

Regenerative Medicine

Key words:angiogenin, fibroblast, scar, Smad2, transforming growth factor β1

Organism: Human

Tissue: Skin

Pathological State: Burn Wound

228
Grey matter OPCs are less mature and less sensitive to IFNγ than white matter OPCs: consequences for remyelination

Dennis H. Lentferink, Jacomien M. Jongsma, Inge Werkman and Wia Baron

Scientific Reports (Nature) The Netherlands, 01 February 2018

Neuroscience

Key words:Multiple sclerosis (MS), central nervous system, oligodendrocyte progenitor cells (OPCs)

Organism: Rat

Cell Line: OPS cells (Oligodendrocyte progenitor cells)

229
Assessing the selective therapeutic efficacy of superparamagnetic erlotinib nanoparticles in lung cancer by using quantitative magnetic resonance imaging and a nuclear factor kappa-B reporter gene system

Fei-Ting Hsu, Hua-Shan Liu, Ahmed Atef Ahmed Ali, Ping-Huei Tsai, Yu-Chieh Kao, Chia-Feng Lu, Hsu-Shan Huang Cheng-Yu Chen

Nanomedicine: Nanotechnology, Biology and Medicine (Elsevier) Taiwan, 31 January 2018

Nanomedicine

Key words:Erlotinib, superparamagnetic iron oxide, magnetic resonance imaging, nuclear factor-κBNon-small-cell lung cancer

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

230
Expression of cystatin C in the female reproductive tract and its effect on human sperm capacitation

Robert Kuo-Kuang Lee, Huan-Chin Tseng, Yuh-Ming Hwu, Chi-Chen Fan, Ming-Huei Lin, Jhih-Jie Yu, Ling-Yu Yeh and Sheng-Hsiang Li

Reproductive Biology and Endocrinology (Springer) Taiwan, 30 January 2018

Reproductive Medicine

Key words:Cystatin C (CST3), seminal plasma, sperm protein tyrosine phosphorylation

Organism: Human

Tissue: Cervix, Endometrium, Fallopian Tubes

231
AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling

Jian Chen, Yi-feng Yang, Yu Yang, Peng Zou, Jun Chen, Yongquan He, Sai-lan Shui, Yan-ru Cui, Ru Bai, Ya-jun Liang, Yunwen Hu, Biao Jiang, Lu Lu, Xiaoyan Zhang, Jia Liu and Jianqing Xu

Nature Microbiology (Nature) China, 29 January 2018

Microbiology

Key words:Zika virus (ZIKV), neonatal microcephaly, Guillain–Barré syndrome, AXL

Organism: Mosquito

Pathological State: Virus Infection

Cell Line: C6/36 cells

232
SPK1-transfected UCMSC has better therapeutic activity than UCMSC in the treatment of experimental autoimmune encephalomyelitis model of Multiple sclerosis

Yun-Liang Wang, Peng Xue, Chun-Yang Xu, Zhen Wang, Xin-Shan Liu, Lin-Lin Hua, Hong-Ying Bai, Zhi-Lei Zeng, Hai-Feng Duan and Jin-Feng Li

Scientific Reports (Nature) China, 29 January 2018

Neuroscience

Key words:Multiple Sclerosis (MS), central nervous system , permanent neurological damage, cytokine

Organism: Human

Cell Line: Human umbilical cord mesenchymal stem cells (HUC-MSC-SPK1)

233
Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis

J B Wechsler, A Szabo, C L Hsu, R A Krier-Burris, H A Schroeder, M Y Wang, R G Carter, T E Velez, L M Aguiniga, J B Brown, M L Miller, B K Wershil, T A Barrett and P J Bryce

Mucosal Immunology (Nature) USA, 24 January 2018

Immunology

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

234
Injectable hydroxyphenyl derivative of hyaluronic acid hydrogel modified with RGD as scaffold for spinal cord injury repair

Kristyna Zaviskova, Dmitry Tukmachev, Jana Dubisova, Irena Vackova, Ales Hejcl, Julie Bystronova, Martin Pravda, Ivana Scigalkova, Romana Sulakova, Vladimir Velebny, Lucie Wolfova, Sarka Kubinova

Journal of Biomedical Materials Research (Wiley) Czech Republic, 23 January 2018

Tissue Engineering

Key words:Hydrogel, spinal cord injury (SCI), hydroxyphenyl derivative of hyaluronic acid (HA-PH)

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

235
CCR5/CCL5 axis interaction promotes migratory and invasiveness of pancreatic cancer cells

Santosh Kumar Singh, Manoj K. Mishra, Isam-Eldin A. Eltoum, Sejong Bae, James W. Lillard Jr. and Rajesh Singh

Scientific Reports (Nature) USA, 22 January 2018

Oncology

Key words:Pancreatic cancer (PC), CCR5, CCL5, F-actin polymerization

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

236
Posterior reversible encephalopathy syndrome in stroke-prone spontaneously hypertensive rats on high-salt diet

Fanny Herisson, Iris Zhou, Jerome Mawet, E Du, Arnavaz H Barfejani, Tao Qin, Marilyn J Cipolla, Philip Z Sun, Natalia S Rost, Cenk Ayata

Journal of Cerebral Blood Flow and Metabolism (SAGE Journals) USA, 19 January 2018

Oncology

Key words:Animal models, hypertension, posterior cerebral reversible encephalopathy, cerebral blood flow, white matter

Organism: Rat

Tissue: Brain

Pathological State: Encephalopathy

237
Simvastatin induces G1 arrest by up-regulating GSK3β and down-regulating CDK4/cyclin D1 and CDK2/cyclin E1 in human primary colorectal cancer cells

Ming-Jenn Chen, An-Ching Cheng, Ming-Fen Lee, Yi-Chiang Hsu

Journal of Cellular Physiology (Wiley) Taiwan, 15 January 2018

Oncology

Key words:Simvastatin (SIM), colorectal cancer (CRC), CDK4/cyclin D1

Organism: Human

Tissue: Colon

Pathological State: Cancer

238
Canine macrophages can like human macrophages be in vitro activated toward the M2a subtype relevant in allergy

Ina Herrmanna, Jelena Gotovina, Judit Fazekas-Singera, Michael B.Fischer, Karin Hufnagl, Rodolfo Bianchini, Erika Jensen-Jarolima

Developmental and Comparative Immunology (Elsevier) Austria, 10 January 2018

Immunology

Key words:Allergy , canine, comparative, DH82M1 macrophage, M2a macrophage, polarization

Organism: Dog, Human

Pathological State: Cancer

Cell Line: U937 and DH82 cells (Makrophage like cells)

239
Formation of nanotubular TiO2 structures with varied surface characteristics for biomaterial applications

Robinson Aguirre, Mónica Echeverry-Rendón, David Quintero, Juan G. Castaño, Martin C. Harmsen, Sara Robledo, Félix Echeverría E

Journal of Biomedical Materials Research (Wiley) Colombia, 09 January 2018

Biological Materials

Key words:Anodization, titanium, nanotubular TiO2, counterion

Organism: Human

Cell Line: Adipose tissue derived stromal cells (ADSC)

240
Physical-chemical characterization and biological assessment of simple and lithium-doped biological-derived hydroxyapatite thin films for a new generation of metallic …

A.C.Popescu, P.E.Florian, G.E.Stan, G.Popescu-Pelin, I.Zgura, M.Enculescu, F.N.Oktard, R.Trusca, L.E.Sima, A.Roseanu, L.Duta

Applied Surface Science (Elsevier) Romania, Turkey, 06 January 2018

Tissue Engineering

Key words:Biological-derived hydroxyapatite, Lithium doping, Pulsed Laser Deposition, Sustainable resources, In vitro assessment

Organism: Human

Cell Line: Human mesenchymal stem cells (hMSCs)

241
Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury?

Jiri Ruzicka, Lucia Machova Urdzikova, Barbora Svobodova, Anubhav G. Amin, Kristyna Karova, Jana Dubisova, Kristyna Zaviskova, Sarka Kubinova, Meic Schmidt, Meena Jhanwar-Uniyal, and Pavla Jendelova

Neural Regeneration Research (Publishing House of Neural Regeneration Research) Czech Republic, USA, 01 January 2018

Regenerative Medicine

Key words:spinal cord injury, epigallocatechin gallate, curcumin, inflammatory response, neural regeneration

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

242
Zinc finger protein 143 expression is closely related to tumor malignancy via regulating cell motility in breast cancer

AR Paek, JY Mun, KM Hong, J Lee, DW Hong, HJ You

BMb Reports (NCBI) South Korea, 31 December 2017

Oncology

Key words:Invasive ductal carcinoma, Metastasis, Motility, ZNF143

Organism: Human

Tissue: Breast

Pathological State: Cancer

243
AKT3 drives adenoid cystic carcinoma development in salivary glands

Katalin Zboray, Julian Mohrherr, Patricia Stiedl, Klemens Pranz, Laura Wandruszka, Beatrice Grabner, Robert Eferl, Richard Moriggl, Dagmar Stoiber, Kazuhito Sakamoto, Kay-Uwe Wagner, Helmut Popper, Emilio Casanova, Herwig P. Moll

Cancer Medicine (Wiley) Austria, 28 December 2017

Oncology

Key words:AKT3, adenoid cystic carcinoma, MMTV-tTA mouse model, oncogene addiction, salivary gland cancer

Organism: Mouse

Tissue: Salivary Gland

Pathological State: Cancer

244
A benchmark for comparing precision medicine methods in thyroid cancer diagnosis using tissue microarrays

Ching-Wei Wang, Yu-Ching Lee, Evelyne Calista, Fan Zhou, Hongtu Zhu, Ryohei Suzuki, Daisuke Komura, Shumpei Ishikawa, Shih-Ping Cheng

Bioinformatics (Oxford University Press) Taiwan, USA, Japan, 23 December 2017

Biological Methods

Key words:precision medicine, cancer diagnosis, tissue microarray

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

245
Recurrent infection progressively disables host protection against intestinal inflammation

WH Yang, DM Heithoff, PV Aziz, M Sperandio, V Nizet, MJ Mahan, JD Marth

Science (American Association for the Advancement of Science) USA, Germany, 22 December 2017

Immunology

Key words:Recurrent infection, host protection, intestinal inflammation

Organism: Mouse

Tissue: Small Intestine, Colon

Pathological State: Inflammation

246
Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways

Lu Ji, Bing Zhong, Xi Jiang, Fei Mao, Gang Liu, Bin Song, Cheng-Yuan Wang, Yong Jiao, Jiang-Ping Wang, Zhi-Bin Xu, Xing Li, and Bo Zhan

Oncotarget (Impact Journals) China, 22 December 2017

Oncology

Key words:human bladder cancer, Actein (ACT), autophagy and apoptosis, ROS and JNK, AKT

Organism: Mouse, Human

Tissue: Xenograft Tumor, Liver, Lung, Kidney

Pathological State: Cancer

247
CD151, A Novel Host Factor of Nuclear Export Signaling in Influenza Virus Infection

Yongkang Qiao, Yan Ya, Kai Sen Tan, Sheryl SL. Tan, Ju Ee Seet, Thiruma Valavan Arumugam, Vincent TK. Chow, De Yun Wang

Journal of Allergy and Clinical Immunology (Elsevier) Singapore, 21 December 2017

Immunology

Key words:Influenza A virus (IAV), CD151, nuclear export, host innate immunity, inflammasome, IAV severity

Organism: Mouse

Tissue: Lung

Pathological State: Virus Infection

248
Renal allograft rejection, lymphocyte infiltration, and de novo donor-specific antibodies in a novel model of non-adherence to immunosuppressive therapy

Louisa Kühne, Bettina Jung, Helen Poth, Antonia Schuster, Simone Wurm, Petra Ruemmele, Bernhard Banas, Tobias Bergler

BMC Immunology (BioMed Central) Germany, 19 December 2017

Immunology

Key words:Donor specific antibodies, humoral rejection, renal transplantation, non-adherence, leukocyte infiltration, BAFF

Organism: Rat

Tissue: Kidney

Pathological State: Organ Transplantation

249
Magnolol inhibits venous remodeling in mice

Hanna Kuk, Caroline Arnold, Ralph Meyer, Markus Hecker and Thomas Korff

Scientific Reports (Nature) Germany, 19 December 2017

Cardiology

Key words:Magnolol, venous vasculature, endothelial cells, varicose/spider veins, peripheral vascular disease

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

250
Mitochondrial ROS activates ERK/autophagy pathway as a protected mechanism against deoxypodophyllotoxin-induced apoptosis

Sang-Hun Kim, Kwang-Youn Kim, Sul-Gi Park, Sun-Nyoung Yu, Young-Wook Kim, Hyo-Won Nam, Hyun-Hee An, Young-Woo Kim, and Soon-Cheol Ahn

Oncotarget (Impact Journals) South Korea, USA, 19 December 2017

Oncology

Key words:Deoxypodophyllotoxin, apoptosis, autophagy, mitochondrial ROS, ERK

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

251
Research report TDP-43 proteolysis is associated with astrocyte reactivity after traumatic brain injury in rodents Abbreviated title: TDP-43 proteolysis is …

CY Huang, YC Lee, PC Li, PC Liliang, K Lu, KW Wang, LC Chang, LY Shiu, MF Chen, YT Sun, HK Wang

Journal of Neuroimmunology (Elsevier) Taiwan, 15 December 2017

Neuroscience

Key words:Astrocyte, Astrogliosis, Traumatic brain injury, Transactivation response DNA-binding protein 43

Organism: Rat

Tissue: Brain

Pathological State: Traumatic Brain Injury

252
Novel Hydrogel-Advanced Modified Clay Nanocomposites as Possible Vehicles for Drug Delivery and Controlled Release

Raluca Ianchis, Claudia M. Ninciuleanu, Ioana C. Gifu, Elvira Alexandrescu, Raluca Somoghi, Augusta R. Gabor, Silviu Preda, Cristina L. Nistor, Sabina Nitu, Cristian Petcu, Madalina Icriverzi, Paula E. Florian and Anca M. Roseanu

Nanomaterials (MDPI) Romania, 13 December 2017

Nanomedicine

Key words:hydrogel; clay; nanocomposites; biocompatibility

Organism: Cow

Cell Line: HT29 and MDBK cells

253
18F-FDG PET Biomarkers Help Detect Early Metabolic Response to Irreversible Electroporation and Predict Therapeutic Outcomes in a Rat …

Xifu Wang, Zhanliang Su, Tianchu Lyu, Matteo Figini, Daniel Procissi, Junjie Shangguan, Chong Sun, Bin Wang, Na Shang, Shanzhi Gu, Quanhong Ma, Andrew C. Gordon, Kai Lin, Jian Wang, Robert J. Lewandowski, Riad Salem, Vahid Yaghmai, Andrew C. Larson, Zhuoli Zhang

Radiology (Radiological Society of North America) USA, China, 12 December 2017

Radiotherapy, Oncology

Key words:18F-FDG PET, Biomarkers, Metabolic Response, Irreversible Electroporation, Liver Tumor

Organism: Rat

Tissue: Liver

Pathological State: Cancer

254
Comparison of MOLLI, shMOLLLI, and SASHA in discrimination between health and disease and relationship with histologically derived collagen volume fraction

Nicholas Child, Gonca Suna, Darius Dabir, May-Lin Yap, Toby Rogers, Misha Kathirgamanathan, Eduardo Arroyo-Ucar, Rocio Hinojar, Islam Mahmoud, Christopher Young, Olaf Wendler, Manuel Mayr, Banher Sandhu, Geraint Morton, Marion Muhly-Reinholz, Stefanie Dimmeler, Eike Nagel, Valentina O Puntmann

European Heart Journal (Oxford University Press) UK, Germany, Spain, 11 December 2017

Cardiology

Key words:T1 mapping, MOLLI, shMOLLI, SASHA, collagen, aortic valve stenosis, myocardium, troponin, myocardial fibrosis, collagen, respiratory care units, therapeutic equivalency, transverse spin relaxation time

Organism: Human

Tissue: Heart

Pathological State: Fibrosis

255
INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis

Shin-Ai Lee, Han-Sae Lee, Shin-Kyoung Hur, Sang Won Kang, Goo Taeg Oh, Daekee Lee, and Jongbum Kwon

Oncotarget (Impact Journals) South Korea, 06 December 2017

Oncology

Key words:INO80 chromatin remodeling complex, colon cancer, APC Min mouse model, replication stress, apoptosis

Organism: Mouse

Tissue: Small Intestine, Colon

Pathological State: Cancer

256
Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer

An Ning Cheng, Chi-Chen Fan, Yu-Kang Lo, Cheng-Liang Kuo, Hui-Chun Wang, I.-Hsin Lien, Shu-Yu Lin, Chung-Hsing Chen, Shih Sheng Jiang, I.-Shou Chang, Hsueh-Fen Juan, Ping-Chiang Lyu and Alan Yueh-Luen Lee

Scientific Reports (Nature) Taiwan, 05 December 2017

Oncology

Key words:Phosphorylation, cancer therapeutic resistance, Cdc7-Dbf4 kinase, stress

Organism: Human

Tissue: Oral Mucosa

Pathological State: Cancer

257
Nocturnal resveratrol administration inhibits chemically induced breast cancer formation in rats

T. KISKOVA, V. DEMECKOVA, Z. JENDZELOVSKA, M. KIKTAVA, K. VENGLOVSKA, M. BOHMDORFER, W. JAGER, T. THALHAMMER

JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (Polish Physiological Society) Slovakia, Austria, 01 December 2017

Oncology

Key words:resveratrol, circadian rhythm, carcinogenesis, breast cancer, immunity, reactive oxygen species

Organism: Rat

Tissue: Breast

Pathological State: Cancer

258
IgE autoreactivity in bullous pemphigoid: eosinophils and mast cells as major targets of pathogenic immune reactants

P.C. Freire, C.H. Muñoz, G. Stingl

British Journal of Dermatology (Wiley) Austria, 28 November 2017

Dermatology

Key words:Bullous pemphigoid (BP), urticarial eruptions, IgG, IgE

Organism: Human

Tissue: Skin

Pathological State: Bullous Pemphigoid

259
Interaction of factor VII activating protease (FSAP) with neutrophil extracellular traps (NETs)

Simona Grasso, Ariane Neumann, Irene M.Lang, Michael Etscheid, Marenvon Köckritz-Blickwede, Sandip M.Kanse

Thrombosis Research (Elsevier) Austria, Germany, Norway, 21 November 2017

Cell Biology

Key words:NETs, FSAP, thrombosis, inflammation

Organism: Human

Tissue: Blood Vessels

260
Analysis of anti-TNF-induced skin lesions reveals strong Th1 activation with some distinct immunological characteristics

E. Stoffel, H. Maier, E. Riedl, M.-C. Brüggen, B. Reininger, M. Schaschinger, C. Bangert, E. Guenova, G. Stingl, P.M. Brunner

British Journal of Dermatology (Wiley) Austria, USA, 16 November 2017

Dermatology

Key words:Psoriasiform, eczematous eruptions, anti-TNF-α therapy, IFN-γ

Organism: Human

Tissue: Skin

Pathological State: Crohn's Disease, Colitis, Rheumatoid Arthritis, Psoriasis, Eczema

261
Chronic Stress Alters Striosome-Circuit Dynamics, Leading to Aberrant Decision-Making

Alexander Friedman, Daigo Homma, Bernard Bloem, Leif G.Gibb, Ken-ichi Amemori, Dan Hu, Sebastien Delcasso, Timothy F.Truong, Joyce Yang, Adam S.Hood, Katrina A.Mikofalvy, Dirk W.Beck, Norah Nguyen, Erik D.Nelson, Sebastian E.Toro Arana, Ruth H.Vorder Bruegge, Ki A.Goosens, Ann M.Graybiel

CELL (Cell Press) USA, 16 November 2017

Neuroscience

Key words:Striatum, basal ganglia, cost-benefit, prefrontal cortex, optogenetics, prelimbic cortex, parvalbumin-positive interneurons, fast-spiking interneuron, sexcitation-inhibition balance

Organism: Rat

Tissue: Brain

262
Controlled release of liposome-encapsulated temozolomide for brain tumour treatment by convection-enhanced delivery

Chung-Yin Lin, Rui-Jin Li, Chiung-Yin Huang, Kuo-Chen Wei

Journal of Drug Targeting (Taylor and Francis) Taiwan, 14 November 2017

Oncology

Key words:Convention-enhanced delivery, drug delivery, liposome, temozolomide, brain tumour

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

263
Phospholipase D inhibitors reduce human prostate cancer cell proliferation and colony formation

Amanda R Noble, Norman J Maitland, Daniel M Berney and Martin G Rumsby

British Journal of Cancer (Nature) UK, 14 November 2017

Oncology

Key words:Phospholipases, mTOR, PKB/Akt, prostate cancer (PCa), benign prostatic hyperplasia (BPH)

Organism: Human

Tissue: Kidney, Prostate

Pathological State: Cancer

264
Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways

Daniel L. Bourque, Taufiqur Rahman Bhuiyan, Diane P. Genereux, Rasheduzzaman Rashu, Crystal N. Ellis, Fahima Chowdhury, Ashraful I. Khan, Nur Haq Alam, Anik Paul Lazina Hossain, Leslie M. Mayo-Smith, Richelle C. Charles, Ana A. Weil, Regina C. LaRocque, Stephen B. Calderwood, Edward T. Ryan, Elinor K. Karlsson, Firdausi Qadri and Jason B. Harris

Infection and Immunity (American Society for Microbiology) USA, 13 November 2017

Immunology

Key words:Vibrio cholerae infection, cholera, Caco-2 or THP-1 cells

Organism: Human

Tissue: Small Intestine

Pathological State: Bacterial Infection

265
Digital image analysis in breast pathology—from image processing techniques to artificial intelligence

Stephanie Robertson, Hossein Azizpour, Kevin Smith, Johan Hartman

Translational Research (Elsevier) Sweden, 07 November 2017

Oncology

Key words:Breast cancer, histopathology, biomarker, artificial intelligence (AI)

Organism: Human

Tissue: Breast

Pathological State: Cancer

266
Cyclin D1 promoter -56 and -54 bp CpG un-methylation predicts invasive progression in arsenic-induced Bowen’s disease

Wei-Ting Liao, Huey-Ling You, Chee-Yin Chai, Chih-Hung Lee, Cheng-Che E. Lang, Shun-Jen Chang, Chu-Ling Yui, Hsin-Su Yu

Journal of Dermatological Science (Elsevier) Taiwan, 31 October 2017

Oncology

Key words:Arsenic-induced Bowen’s disease, cyclin D1 un-methylation, aneuploidy, predictor, invasive progression

Organism: Human

Tissue: Skin

Pathological State: Bowen’s Disease, Cancer

267
CCR7 Is Important for Mesangial Cell Physiology and Repair

Simone Wurm, Andreas Steege, Eva-Maria Rom-Jurek, Claudia R. van Roeyen, Armin Kurtz, Bernhard Banas, Miriam C. Banas

Journal of Histochemistry and Cytochemistry (SAGE Journals) Germany, 27 October 2017

Oncology

Key words:Homeostatic chemokine receptor CCR7, human mesangial cells, glomerulogenesis, mesangial biology

Organism: Mouse

Tissue: Kidney

268
HER2 challenge contest: a detailed assessment of automated HER2 scoring algorithms in whole slide images of breast cancer tissues

Talha Qaiser ,Abhik Mukherjee, Chaitanya Reddy PB, Sai D Munugoti, Vamsi Tallam, Tomi Pitkäaho, Taina Lehtimäki, Thomas Naughton, Matt Berseth, Aníbal Pedraza, Ramakrishnan Mukundan, Matthew Smith, Abhir Bhalerao, Erik Rodner, Marcel Simon, Joachim Denzler, Chao-Hui Huang, Gloria Bueno, David Snead, Ian O Ellis, Mohammad Ilyas, Nasir Rajpoot

Histopathology (Wiley) UK, 27 October 2017

Medical Image Analysis

Key words:Human epidermal growth factor receptor 2 (HER2), IHC, invasive breast cancer (BCa)

269
Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion

Juan Zhang, Yu Zhang, Wenshuang Wu, Fang Wang, Xinyu Liu, Guanghou Shui and Chunlai Nie

Cell Death and Disease (Nature) China, 26 October 2017

Oncology

Key words:Guanylate-binding protein 2 (GBP2), interferon-γ (IFN-γ), mitochondrial fission, shRNA

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

270
The Pericytic Phenotype of Adipose Tissue-derived Stromal Cells is Promoted by NOTCH2

Vincenzo Terlizzi, Matthias Kolibabka, Janette Kay Burgess, Hans Peter Hammes, Martin Conrad Harmsen

Stem Cells (Wiley) Germany, The Netherlands, 25 October 2017

Stem Cell Research

Key words:Diabetic retinopathy (DR), adipose tissue‐derived stromal cells (ASC), NOTCH2, human umbilical cord vein endothelial cells (HUVEC)

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

271
The natural compound 2,3,5,4′-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway

En-Yuan Lin, Uyanga Bayarsengee, Ching-Chiung Wang, Yung-Hsiao Chiang, Chao-Wen Cheng

Environmental Toxicology (Wiley) Taiwan, 24 October 2017

Toxicology

Key words:Tetrahydroxystilbene-2-O-β-d-glucoside (THSG), Polygoni Multiflori, adriamycin (AD), quinone oxidoreductase (NQO)-1

Organism: Mouse

Tissue: Kidney

272
Initial graft size and not the innate immune response limit survival of engrafted neural stem cells

Stefanie Vogel, Markus Aswendt, Melanie Nelles, Nadine Henn, Gabriele Schneider, Mathias Hoehn

Journal of Tissue Engineering and Regenerative Medicine (Wiley) Germany, 22 October 2017

Neuroscience

Key words:Transplantation of neural stem cells (NSCs), Luc2 and copGFP, bioluminescence imaging (BLI)

Organism: Mouse

Tissue: Brain

273
Tumor angiogenesis and bone metastasis - Correlation in invasive breast carcinoma

Chong Sun, Jianmin Li, Bin Wang, Junjie Shangguan, Matteo Figini, Na Shang, Liang Pan, Zhuoli Zhang

Journal of Immunological Methods (Elsevier) USA, 21 October 2017

Oncology

Key words:Breast carcinoma, bone metastasis,tumor angiogenesis, pathological biomarkers

Organism: Human

Tissue: Breast

Pathological State: Cancer

274
TDP-43 proteolysis is associated with astrocyte reactivity after traumatic brain injury in rodents

Chih-Yuan Huang, Yi-Che Lee, Ping-Chia Li, Po-Chou Liliang, Kang Lu, Kuo-Wei Wang, Li-Ching Chang, Li-Yen Shiu, Ming-Feng Chen, Yuan-Ting Sun, Hao-kuang Wang

Journal of Neuroimmunology (Elsevier) Taiwan, 20 October 2017

Neuroscience

Key words:Astrocyte, astrogliosis, traumatic brain injury, transactivation response DNA-binding protein 43

Organism: Rat

Tissue: Brain

Pathological State: Traumatic Brain Injury

275
The non-canonical ubiquitin activating enzyme UBA6 suppresses epithelial-mesenchymal transition of mammary epithelial cells

X Liu, L Sun, DB Gursel, C Cheng, S Huang, AW Rademaker, SA Khan, J Yin, H Kiyokawa

Oncotarget (Impact Journals) USA, 20 October 2017

Oncology

Key words:ubiquitination, breast cancer, EMT, Rho GTPase, cell cycle

Organism: Human

Cell Line: MCF-10A cells

276
Human alternative Klotho mRNA is a nonsense-mediated mRNA decay target inefficiently spliced in renal disease

Rik Mencke, Geert Harms, Jill Moser, Matijs van Meurs, Arjan Diepstra, Henri G. Leuvenink, and Jan-Luuk Hillebrands

JCI Insight (American Society for Clinical Investigation) The Netherlands, 19 October 2017

Nephrology

Key words:Aging, Nephrology, Chronic kidney disease, RNA processing

Organism: Human

Cell Line: HK-2 cells

277
Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression

In-Hu Hwang , Seung Yoon Oh , Hyun-Jin Jang, Eunbi Jo, Jong Cheon Joo, Kyung-Bok Lee, Hwa-Seung Yoo, Mi Young Lee, Soo Jung Park, Ik-Soon Jang

PLOS ONE (PLOS) South Korea, 18 October 2017

Oncology

Key words:Cellular FLICE inhibitory protein (c-FLIP), NF-κB, apoptosis, cordycepin

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

278
DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice

Eleonora Ottina, Victor Peperzak, Katia Schoeler, Emma Carrington, Roswitha Sgonc, Marc Pellegrini, Simon Preston, Marco J. Herold, Andreas Strasser and Andreas Villunger

Nature Communications (Nature) Austria, Australia, 18 October 2017

Immunology

Key words:Tet-On/Off system, BCL2 overexpression, CRISPR/Cas9, RNA interference (RNAi)

Organism: Mouse

Tissue: Spleen

279
Lactobacillus gasseri attenuates allergic airway inflammation through PPARγ activation in dendritic cells

Miao-Hsi Hsieh, Ren-Long Jan, Lawrence Shih-Hsin Wu, Pei-Chi Chen, Hui-Fang Kao,Wen-Shuo Kuo, Jiu-Yao Wang

Journal of Molecular Medicine (Springer) Taiwan, 14 October 2017

Allergy

Key words:Allergy asthma, lactic acid bacillus, peroxisome proliferator-activated receptor gamma (PPARγ), dendritic cells

Organism: Mouse

Tissue: Lung

Pathological State: Bacterial Infection

280
GD1a Overcomes Inhibition of Myelination by Fibronectin via Activation of Protein Kinase A: Implications for Multiple Sclerosis

Jing Qin, Arend H. Sikkema, Kristine van der Bij, Jenny C. de Jonge, Karin Klappe, Vera Nies, Johan W. Jonker, Jan Willem Kok, Dick Hoekstra and Wia Baron

Journal of Neuroscience (SFN) The Netherlands, 11 October 2017

Neuroscience

Key words:Fibronectin, ganglioside, multiple sclerosis, oligodendrocyte, remyelination

Organism: Mouse

Tissue: Brain

281
Therapeutic Effects of Monoclonal Antibody against Dengue Virus NS1 in a STAT1 Knockout Mouse Model of Dengue Infection

Shu-Wen Wan, Pei-Wei Chen, Chin-Yu Chen, Yen-Chung Lai, Ya-Ting Chu, Chia-Yi Hung, Han Lee, Hsuan Franziska Wu, Yung-Chun Chuang, Jessica Lin, Chih-Peng Chang, Shuying Wang, Ching-Chuan Liu, Tzong-Shiann Ho, Chiou-Feng Lin, Chien-Kuo Lee, Betty A. Wu-Hsieh, Robert Anderson, Trai-Ming Yeh and Yee-Shin Lin

The Journal of Immunology (American Association of Immunologists) Taiwan, 10 October 2017

Immunology

Key words:Dengue virus (DENV), dengue fever, DENV nonstructural protein 1 (NS1)

Organism: Mouse

Tissue: Skin

Pathological State: Virus Infection

282
Actein induces apoptosis in leukemia cells through suppressing RhoA/ROCK1 signaling pathway

Wen-Di Zhou, Xiang Wang, Xing-Zhen Sun, Jian Hu, Rong-Rong Zhang, Ze Hong

International Journal of Oncology (Spandidos Publications) China, 10 October 2017

Oncology

Key words:Actein, apoptosis,leukemia, RhoA/ROCK1 signaling pathway

Organism: Mouse

Tissue: Blood

Pathological State: Cancer

283
Linarin sensitizes tumor necrosis factor-related apoptosis (TRAIL)-induced ligand-triggered apoptosis in human glioma cells and in xenograft nude mice

Zan-feng Xu, Xiao-ke Sun, Ying Lan, Chao Han, Yong-dong Zhang, Gang Chen

Biomedicine and Pharmacotherapy (Elsevier) China, 06 October 2017

Oncology

Key words:TRAIL, glioma, linarin (LIN), apoptosis, ROS generation

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

284
PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs

Austin K. Mattox, Jina Lee, William H. Westra, Robert H. Pierce, Ronald Ghossein, William C. Faquin, Thomas J. Diefenbach, Luc G. Morris, Derrick T. Lin, Lori J. Wirth, Armida Lefranc-Torres, Eiichi Ishida, Patrick D. Chakravarty, Lauren Johnson, Yang C. Zeng, Huabiao Chen, Mark C. Poznansky, Neil M. Iyengar and Sara I. Pai

Cancer Research (AACR Publications) USA, 25 September 2017

Oncology

Key words:Oral tongue squamous cell carcinoma (OTSCC), PD-1, tumor microenvironment (TME), tumor-infiltrating lymphocytes (TIL)

Organism: Human

Tissue: Head, Neck, Lung, Blood

Pathological State: Cancer

285
Axonal components of nerves innervating the human arm

Bernhard Gesslbauer, Laura A. Hruby, Aidan D. Roche, Dario Farina, Roland Blumer, Oskar C. Aszmann

Annals of Neurology (Wiley) Austria, 20 September 2017

Neuroscience

Key words:Nerves, sensory and motir axons, spinal cord, neurofilament

Organism: Human

Tissue: Nerves

286
The microRNA ame-miR-279a regulates sucrose responsiveness of forager honey bees (Apis mellifera)

Fang Liu, Tengfei Shi, Wei Yin, Xin Su, Lei Qi, Zachary Y.Huang, Shaowu Zhang, Linsheng Yu

Insect Biochemistry and Molecular Biology (Elsevier) USA, China, 20 September 2017

Insect Molecular Biology

Key words:microRNA, honey bee, proboscis extension reflex, sucrose responsiveness, division of labour

Organism: Honey Bee

Tissue: Brain

287
Role of BDNF and neurotrophic receptors in human inner ear development

LJ Chacko, MJF Blumer, E Pechrigg, H Rask-Andersen, W Dietl, A Haim, H Fritsch, R Glueckert, J Dudas, A Schrott-Fischer

Cell and Tissue Research (Springer) Austria, Seweden, 19 September 2017

Developmental Biology

Key words:Inner ear, Human, BDNF, Neurotrophin receptors, In situ hybridization

Organism: Human

Tissue: Bone

288
Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

Rajasekharan Somasundaram, Gao Zhang, Mizuho Fukunaga-Kalabis, Michela Perego, Clemens Krepler, Xiaowei Xu, Christine Wagner, Denitsa Hristova, Jie Zhang, Tian Tian, Zhi Wei, Qin Liu, Kanika Garg, Johannes Griss, Rufus Hards, Margarita Maurer, Christine Hafner, Marius Mayerhöfer, Georgios Karanikas, Ahmad Jalili, Verena Bauer-Pohl, Felix Weihsengruber, Klemens Rappersberger, Josef Koller, Roland Lang, Courtney Hudgens, Guo Chen, Michael Tetzlaff, Lawrence Wu, Dennie Tompers Frederick, Richard A. Scolyer, Georgina V. Long, Manashree Damle, Courtney Ellingsworth, Leon Grinman, Harry Choi, Brian J. Gavin, Margaret Dunagin, Arjun Raj, Nathalie Scholler, Laura Gross, Marilda Beqiri, Keiryn Bennet

Nature Communications (Nature) USA, Austria, 19 September 2017

Oncology

Key words:Melanoma, oncogenic BRAFV600E, growth factor FGF-2,

Organism: Human

Tissue: Skin, Lymphoid Tissue

Pathological State: Cancer

289
Development of a radiolabeled caninized anti-EGFR antibody for comparative oncology trials

Judit Fazekas-Singer, Neydher Berroterán-Infante, Christina Rami-Mark, Monika Dumanic, Miroslawa Matz, Michael Willmann, Fritz Andreae, Josef Singer, Wolfgang Wadsak, Markus Mitterhauser, and Erika Jensen-Jarolim

Oncotarget (Impact Journals) Austria, 15 September 2017

Oncology

Key words:epidermal growth factor receptor, radio-immunotherapy, canine mammary carcinoma, canine antibody, comparative oncology

Organism: Dog

Tissue: Breast

Pathological State: Cancer

290
The Novel Compound Sul-121 Preserves Endothelial Function and Inhibits Progression of Kidney Damage in Type 2 Diabetes Mellitus in Mice

S. P. H. Lambooy, A. Bidadkosh, D. Nakladal, A. van Buiten, R. A. T. Girgis, A. C. van der Graaf, T. J. Wiedenmann, R. A. Koster, P. Vogelaar, H. Buikema, R. H. Henning and L. E. Deelman

Scientific Reports (Nature) The Netherlands, 11 September 2017

Nephrology

Key words:Type 2 diabetes mellitus (T2DM), diabetic nephropathy, Sul-121, glomerular fibronectin expression

Organism: Mouse

Tissue: Kidney

Pathological State: Diabetes

291
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation

W-F Chiang, T-M Cheng, C-C Chang, S-H Pan, C A Changou, T-H Chang, K-H Lee, S-Y Wu, Y-F Chen, K-H Chuang, D-B Shieh, Y-L Chen, C-C Tu, W-L Tsui and M-H Wu

Oncogene (Nature) Taiwan, 11 September 2017

Oncology

Key words:Glycosylation, CEACAM6, OSCC (oral squamous cell carcinoma), EGFR

Organism: Human

Pathological State: Cancer

Cell Line: OC-2 and OEC-M1 cells

292
A green tea polyphenol epigallocatechin-3-gallate enhances neuroregeneration after spinal cord injury by altering levels of inflammatory cytokines

Lucia Machova Urdzikova, Jiri Ruzicka, Kristyna Karova, Anna Kloudova, Barbora Svobodova, Anubhav Amin, Jana Dubisova, Meic Schmidt, Sarka Kubinova, Meena Jhanwar-Uniyal, Pavla Jendelova

Neuropharmacology (Elsevier) Czech Republic, 09 September 2017

Neuroscience

Key words:EGCG, green tea, spinal cord injury, neuroregeneration, cytokines, neuroprotection, p65NFkB

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

293
579 High-risk human papillomavirus infection in Bowen’s disease and Squamous Cell Carcinomas of the hands

S.Dorfe, S.Haas, P.Birner, R.Kirnbauer, P.Petzelbauer, S.Radakovic, H.Pehamberger, L.Harpain, A.Handisurya

Journal of Investigative Dermatology (Elsevier) Austria, 08 September 2017

Dermatology

Key words:Papillomavirus infection, Bowen’s disease, squamous cell carcinomas

Organism: Human

Tissue: Skin

Pathological State: Bowen’s Disease, Cancer

294
Exploring Metabolic Configurations of Single Cells within Complex Tissue Microenvironments

Anne Miller, Csörsz Nagy, Bernhard Knapp, Johannes Laengle, Elisabeth Ponweiser, Marion Groeger, Philipp Starkl, Michael Bergmann, Oswald Wagner, Arvand Haschemi

Cell Metabolism (Elsevier) Austria, 07 September 2017

Cell Biology

Key words:Metabolic configuration, single cell, intracellular metabolism, intercellular metabolism, enzyme histochemistry, microenvironment, immunometabolism, cancer metabolism, metabolic biomarke, metabolic imaging method

Organism: Mouse, Human

Tissue: Liver, Muscle, Colon, Breast

Pathological State: Cancer

295
4103Validation of cardiac magnetic resonance T1 mapping in cardiac amyloidosis

F. Duca, C. Zotter-Tufaro, A.A. Kammerlander, A. Panzenboeck, S. Aschauer, B. Boerries, H. Agis, R. Kain, D. Bonderman, J. Mascherbauer

European Heart Journal (Oxford University Press) Austria, 29 August 2017

Cardiology

Key words:cardiac amyloidosis, cardiac mri

Organism: Human

Tissue: Heart

Pathological State: Cardiac Amyloidosis

296
Placental Dysfunction Underlies Increased Risk of Fetal Growth Restriction and Stillbirth in Advanced Maternal Age Women

Samantha C. Lean, Alexander E. P. Heazell, Mark R. Dilworth, Tracey A. Mills and Rebecca L. Jones

Scientific Reports (Nature) UK, 29 August 2017

Reproductive Medicine

Key words:Ageing, disease model, intrauterine growth, reproductive disorders

Organism: Human

Tissue: Placenta

297
Selective targeting of a novel vasodilator to the uterine vasculature to treat impaired uteroplacental perfusion in pregnancy

Natalie Cureton, Iana Korotkova, Bernadette Baker, Susan Greenwood, Mark Wareing, Venkata R Kotamraju, Tambet Teesalu, Francesco Cellesi, Nicola Tirelli, Erkki Ruoslahti, John D Aplin, and Lynda K Harris

Theranostics (NCBI) UK, USA, Estonia, Italy, 29 August 2017

Reproductive Medicine

Key words:pregnancy, placenta, nitric oxide, endothelium, vascular biology, drug targeting

Organism: Mouse

Tissue: Placenta

298
Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment

Frank Szulzewsky, Nina Schwendinger, Dilansu Güneykaya, Patrick J Cimino, Dolores Hambardzumyan, Michael Synowitz, Eric C Holland, Helmut Kettenmann

Neuro-Oncology (Oxford University Press) USA, Germany, 26 August 2017

Oncology

Key words:glioblastoma, microglia, macrophage, osteopontin, SPP1, glioblastoma cd45 antigens macrophage-1 antigen macrophages microglia monocytes brain mice neoplasms osteopontin

Organism: Human

Pathological State: Cancer

Cell Line: Ki67 cells

299
Combination of cuprizone and experimental autoimmune encephalomyelitis to study inflammatory brain lesion formation and progression

Bernhard Josef Rüther,Miriam Scheld,Daniela Dreymueller,Tim Clarner,Eugenia Kress,Lars-Ove Brandenburg,Tine Swartenbroekx,Chloé Hoornaert,Peter Ponsaerts,Petra Fallier-Becker,Cordian Beyer,Sven Olaf Rohr,Christoph Schmitz,Uta Chrzanowski,Tanja Hochstrasser,Stella Nyamoya,Markus Kipp

GLIA (Wiley) Germany, 24 August 2017

Neuroscience

Key words:Brain-intrinsic degenerative cascades, multiple sclerosis, Cup/EAE model

Organism: Mouse

Tissue: Brain

Pathological State: Encephalomyelitis

300
Tumor-Associated Macrophages Promote Epigenetic Silencing of Gelsolin through DNA Methyltransferase 1 in Gastric Cancer Cells

Hao-Chen Wang, Chin-Wang Chen, Chia-Lung Yang, I-Min Tsai, Ya-Chin Hou, Chang-Jung Chen and Yan-Shen Shan

Cancer Immunology Research (AACR Publications) Taiwan, 23 August 2017

Oncology

Key words:Tumor suppressor gelsolin (GSN), gastric cancer, DNA methylation

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

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