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Customer Publications (A total of 1287 papers published)

101
Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis

Helen Ashwin , Karin Seifert , Sarah Forrester , Najmeeyah Brown , Sandy MacDonald , Sally James , Dimitris Lagos , Jon Timmis , Jeremy C Mottram , Simon L. Croft , Paul M. Kaye

Wellcome Open Research (Wellcome Open Research) UK, 29 October 2018

Parasitology

Key words:Leishmania, infection, host response, transcriptomics, immunopathology

Organism: Mouse

Tissue: Spleen, Liver

Pathological State: Parasitic Infection

102
Azo-based small molecular hypoxia responsive theranostic for tumor-specific imaging and therapy

Ying Zhoua, Mrinmoy Maitib, Amit Sharmac, Miae Won, Le Yu, Lan Xi, Miao, Jinwoo Shin, Arup Podder, Kondapa Naidu Bobba, Jiyou Han, Sankarprasad Bhuniya, Jong Seung Kim

Journal of Controlled Release (Elsevier) China, India, South Korea, 28 October 2018

Oncology

Key words:molecular hypoxia, theranostic, tumor-specific imaging,

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

103
PI3K: A master regulator of brain metastasis‐promoting macrophages/microglia

Raquel Blazquez Darius Wlochowitz Alexander Wolff Stefanie Seitz Astrid Wachter Julia Perera‐Bel Annalen Bleckmann Tim Beißbarth Gabriela Salinas Markus J. Riemenschneider Martin Proescholdt Matthias Evert Kirsten Utpatel Laila Siam Bawarjan Schatlo Marko Balkenhol Christine Stadelmann Hans‐Ulrich Schildhaus Ulrike Korf Eileen Reinz Stefan Wiemann Elena Vollmer Mathias Schulz Uwe Ritter Uwe K. Hanisch Tobias Pukrop

GLIA (Wiley) Germany, 25 October 2018

Oncology

Key words:Astrocytes; BKM120; brain metastasis; macrophages; microglia; PI3K; RPPA

Organism: Mouse

Pathological State: Cancer

Cell Line: Monocyte‐derived macrophages (MDMs)

104
Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization

Wei-TaChen, Wei-Tse Hsu, Meng-Hua Yen, Chun A. Changou, Chia-Li Han, Yu-Ju Chen, Ji-Yen Cheng, Tzu-Hao Chang, Oscar Kuang-Sheng Lee, Jennifer Hui-Chun Ho

Biomaterials (Elsevier) Taiwan, 23 October 2018

Stem Cell Research

Key words:β-catenin, Cardiovascular, Laminar shear, Mesenchymal stem cells, Wnt

Organism: Human

Cell Line: Human mesenchymal stem cells (hMSCs)

105
Gene expression profiling in a mouse model of Dravet syndrom

Nicole A.Hawkins, Jeffrey D.Calhoun, Alexandra M.Huffman, Jennifer A.Kearney

Experimental Neurology (Elsevier) USA, 19 October 2018

Neuroscience

Key words:Epilepsy; Epileptic encephalopathy; Gene expression; RNA-seq; Seizure; Voltage-gated sodium channel

Organism: Mouse

Tissue: Brain

Pathological State: Dravet Syndrome

106
Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation

Janaina M. Alves, Antonio H. Martins, Claudiana Lameu, Talita Glaser, Nawal M. Boukli, Vinicius Bassaneze, Rafael Dariolli, Isis C. Nascimento, Poliana C. M. Martins, Héllio D. N. de Souza, José Eduardo Krieger, Dulce E. Casarini, Vicencia M. Sales, João B. Pesquero, Henning Ulrich

Stem cell reviews and reports (Springer) USA, Brazil, 18 October 2018

Stem Cell Research

Key words:Mouse myoblast differentiation, Muscle repair, Kinin-B2 receptor, HOE-140

Organism: Mouse

Cell Line: Myoblast cell line - C2C12 Cells

107
Transforming growth factor beta 1 mediates the low-frequency vertical vibration enhanced production of tenomodulin and type I collagen in rat Achilles tendon

Chia-Hsin Chen, Yi-Hsiung Lin, Chung-Hwan Chen, Yan-Hsiung Wang, Ming-Long Yeh, Tsung-Lin Cheng, Chau-Zen Wang

PLOS ONE (PLOS) Taiwan, 11 October 2018

Cell Biology

Key words:Tendons ,Collagens ,Gene expression ,Stiffness ,Vibration ,Mechanical properties ,Enzyme-linked immunoassays ,Polymerase chain reaction

Organism: Rat

Tissue: Tendon

108
Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

Mera vCohen, Amir Giladi, Anna-Dorothea Gorki, Dikla Gelbard Solodkin, Mor Zada, Anastasiya Hladik, Andras Miklosi, Tomer-Meir Salame, Keren Bahar Halpern, Eyal David, Shalev Itzkovitz, Tibor Harkany, Sylvia Knapp, Ido Amit

CELL (Cell Press) Israel, Austria, Sweden, 11 October 2018

Cell Biology

Key words:immune systemsingle-cell RNA sequencinglungbasophilsalveolar macrophagescellular interactiondevelopmentsignaling

Organism: Mouse

Tissue: Lung

109
Early Immunologic Response of Irreversible Electroporation versus Cryoablation in a Rodent Model of Pancreatic Cancer

Sarah B. White, MD, MS, FSIR, Zhouli Zhang, MD, PhD, Jeane Chen, PhD, Venkateswara R. Gogineni, PhD, and Andrew C. Larson, PhD

Journal of Vascular and Interventional Radiology (Elsevier) USA, 11 October 2018

Immunology

Key words:irreversible electroporation, Cryoablation, Pancreatic Cancer

Organism: Mouse

Pathological State: Cancer

Cell Line: PANC-2 (Pancreatic cancer cell line)

110
Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors

Hye Jung Baek, Sun Eui Kim, Jong Kwang Kim, Dong Hoon Shin, Tae Hyun Kim, Kwang Gi Kim, Chu-Xia Deng, Sang Soo Kim

International Journal of Biological Sciences (Ivyspring International Publisher) South Korea, China, 10 October 2018

Oncology

Key words:BRCA1, AKT, MK-2206, precision medicine

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

111
Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis

Yang WH, Heithoff DM, Aziz PV, Haslund-Gourley B, Westman JS, Narisawa S, Pinkerton AB, Millán JL, Nizet V, Mahan MJ, Marth JD

Cell Host and Microbe (Cell Press) USA, 10 October 2018

Immunology, Microbiology

Key words:glycosylation, sepsis, neuraminidase, Toll-like receptor 4, alkaline phosphatase, Ashwell-Morell receptor, lipopolysaccharide, inflammation

Organism: Mouse

Tissue: Liver

Pathological State: Sepsis

112
Age, but not short-term intensive swimming, affects chondrocyte turnover in zebrafish vertebral cartilage

Quan-Liang Jian​, Wei-Chun HuangFu​, Yen-Hua Lee, I-Hsuan Liu​

The Journal of Life and Environmental Sciences (PeerJ) Taiwan, 01 October 2018

Osteology

Key words:Aging, Cartilage, Osteoarthritis, Tissue homeostasis, Chondrocyte

Organism: Fish

Tissue: Spinal Cord

113
Extracellular domain of EpCAM enhances tumor progression through EGFR signaling in colon cancer cells

Kang-Hao Liang, Hsien-Cheng Tso, Shao-Hsi Hung, I.-I. Kuan, Jun-Kai Lai, Feng-Yi Ke, Yi-Ting Chuang, I-Ju Liu, Yi-Ping Wang, Ruey-Hwa Chen, Han-Chung Wu

Cancer Letters (Elsevier) Taiwan, 01 October 2018

Oncology

Key words:Epithelial cell adhesion molecule, Regulated intramembrane proteolysis, β-catenin, HIF1α

Organism: Human

Tissue: Colon

Pathological State: Cancer

114
Gd-EOB-DTPA DCE-MRI biomarkers in a rabbit model of liver fibrosis

Yang Ji, Chuanshan Zhang, Zhe Huang, Xia Wang, Lina Yue, Meimei Gao, Huiling Hu, Qinjun Su, Yuedong Han, Bin Liu, Ding Yang, Zhanliang Su, Zhuoli Zhang

American Journal of Translational Research (e-Century Publishing Corporation) China, USA, 30 September 2018

Hepathology

Key words:Liver fibrosis, animal, magnetic resonance imaging, pathology

Organism: Rabbit

Tissue: Liver

Pathological State: Fibrosis, Liver Cirrhosis

115
Modified Ginseng Extract Induces Apoptosis in HepG2 Cancer Cells by Blocking the CXCL8-Mediated Akt/Nuclear Factor-κB Signaling Pathway

Zhen Yang Cui, Eunbi Jo, Hyun Jin Jang, In-Hu Hwang, Kyung-Bok Lee, Hwa-Seung Yoo, Soo Jung Park, Mi-Kyung Jung, Yeon Wol Lee and Ik-Soon Jang

The American Journal of Chinese Medicine (World Scientific) South Korea, 27 September 2018

Oncology

Key words:Modified Regular Ginseng Extract; MRGX; C-X-C Motif Chemokine Ligand 8; Liver Cancer; Akt; Nuclear Factor-κB; Apoptosis

Organism: Human

Pathological State: Cancer

Cell Line: HepG2 (Liver carcinoma cell line)

116
Development of Decellularized Cornea by Organic acid Treatment for Corneal Regeneration

Mr. HungJun Lin, Dr. TsungJen Wang, Miss TingWei Li, Dr. YaoYuan Chang, Prof. Ming Thau Sheu, Prof. Yi-You Huang, Dr. Der-Zen Liu

Tissue Engineering Part A (Mary Ann Liebert Inc.) Taiwan, 22 September 2018

Tissue Engineering

Key words:cornea; decellularized scaffold; extracellular matrix; xenograft; corneal transplantation.

Organism: Rabbit

Tissue: Eye

117
The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

Bohumil Fafilek, Lukas Balek, Michaela Kunova Bosakova, Miroslav Varecha, Alexandru Nita, Tomas Gregor, Iva Gudernova, Jitka Krenova, Somadri Ghosh, Martin Piskacek, Lucie Jonatova, Nicole H. Cernohorsky, Jennifer T. Zieba, Michal Kostas, Ellen Margrethe Haugsten, Jørgen Wesche, Christophe Erneux, Lukas Trantirek, Deborah Krakow, and Pavel Krejc

Science Signaling (American Association for the Advancement of Science) Czech Republic, Belgium, USA, Norway, 18 September 2018

Cell Biology

Key words:SHIP2, ERK activation, FGF receptors, Src kinases

Organism: Rat, Human

Pathological State: Cancer

Cell Line: U2OS (Osteosarcoma cell line), RCS cells (Cultured rat chondrosarcoma cell line)

118
ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner

Jacqueline A. Brosnan-Cashman, Ming Yuan, Mindy K. Graham, Anthony J. Rizzo, Kaylar M. Myers, Christine Davis, Rebecca Zhang, David M. Esopi, Eric H. Raabe, Charles G. Eberhart, Christopher M. Heaphy, Alan K. Meeker

PLOS ONE (PLOS) USA, 18 September 2018

Oncology

Key words:Telomeres, Cloning, Glioma cells ,Glioma ,DNA cloning ,Immunoblotting ,Vector cloning ,Polymerase chain reaction

Organism: Human

Pathological State: Cancer

Cell Line: Glioma cell lines (MOG-G-UVW, SF188, U-251 and UW479)

119
Activation of estrogen receptor alpha induces beiging of adipocytes

Roberta S.Santos, Aaron P.Frank, Luciana A.Fátima, Biff F.Palmer, Deborah J.Clegg

Molecular Metabolism (Elsevier) USA, 15 September 2018

Cell Biology

Key words:Beige adipocytes, Lipolysis, Estrogen receptor alpha (ERα), Obesity, Type II diabetes mellitus (T2DM)

Organism: Mouse

Tissue: Adipose Tissue

120
Cellular-scale probes enable stable chronic subsecond monitoring of dopamine neurochemicals in a rodent model

Helen N. Schwerdt, Elizabeth Zhang, Min Jung Kim, Tomoko Yoshida, Lauren Stanwicks, Satoko Amemori, Huseyin E. Dagdeviren, Robert Langer, Michael J. Cima and Ann M. Graybiel

Communications Biology (Nature) USA,, 12 September 2018

Neuroscience

Key words:Diagnostic markers, Neurochemistry, Parkinson's disease, Sensors and probes

Organism: Rat

Tissue: Brain

121
Synthetic α5β1 integrin ligand PHSRN is proangiogenic and neuroprotective in cerebral ischemic stroke

Cheng-Chun Wu, Liang-Chao Wang, Yu-Tin Su, Wei-Yen Wie, Kuen-Jer Tsai

Biomaterials (Elsevier) Taiwan, 11 September 2018

Biological Materials

Key words:Stroke, Fibronectin, PHSRN, α5β1, Angiogensis, Neurogenesis, VEGF

Organism: Rat

Tissue: Brain

122
Phenethyl Isothiocyanate Inhibits In Vivo Growth of Xenograft Tumors of Human Glioblastoma Cells

Yu-Cheng Chou, Meng-Ya Chang, Hsu-Tung Lee, Chiung-Chyi Shen, Tomor Harnod, Yea-Jiuan Liang, Rick Sai-Chuen Wu, Kuang-Chi Lai, Fei-Ting Hsu, Jing-Gung Chung

Molecules (MDPI) Taiwan, 10 September 2018

Oncology

Key words:phenethyl isothiocyanate; apoptosis; xenograft; caspase; glioblastoma

Organism: Mouse

Tissue: Liver, Xenograft Tumor

Pathological State: Cancer

123
Factor Xa inhibition by rivaroxaban regulates fibrogenesis in human atrialfibroblasts with modulation of nitric oxide synthesis and calciumhomeostasis

Cheng-Chih Chung, Yung-Kuo Lin, Yao-Chang Chen, Yu-Hsun Kao, Yung-Hsin Yeh, Yi-Jen Chen

Journal of Molecular and Cellular Cardiology (Elsevier) Taiwan, 10 September 2018

Physiology

Key words:Fibroblasts, Fibrosis, Rivaroxaban, Protease-activated receptor, Atrial fibrillation, Stroke

Organism: Rat

Tissue: Heart

Pathological State: Fibrosis

124
Androgen receptor expression inversely correlates with immune cell infiltration in human epidermal growth factor receptor 2–positive breast cancer

Johan M. van Rooijen, Si-Qi Qiu, Hetty Timmer-Bosscha, Bert van der Vegt, James E. Boers, Carolien P. Schröder, Elisabeth G.E. de Vries

European Journal of Cancer (Elsevier) The Netherlands, China, 09 September 2018

Oncology

Key words:Androgen receptor expression, HER2-positive metastatic breast cancer, Immune cell infiltration, Trastuzumab resistance

Organism: Human

Tissue: Breast

Pathological State: Cancer

125
TLR7 agonist attenuates acetylcholine‐induced, Ca2+‐dependent ionic currents in swine tracheal submucosal gland cells

Shunichi Gamo, Tsutomu Tamada, Koji Murakami, Soshi Muramatsu, Hidemi Aritake, Masayuki Nara, Itsuro Kazama, Tatsuma Okazaki, Hisatoshi Sugiura, Masakazu Ichinose

Experimental Physiology (Wiley) Japan, 08 September 2018

Physiology

Key words:CaCC, COPD, hypersecretion, R837, submucosal glands

Organism: Pig, Human

Tissue: Lung, Spleen

126
Inhibitory control of prefrontal cortex by the claustrum

Jesse Jackson, Mahesh M. Karnani, Boris V. Zemelman, Denis Burdakov, Albert K. Lee

Neuron (Cell Press) USA, UK, Canada, 05 September 2018

Neuroscience

Key words:claustrum prefrontal NPY PV neocortex feed-forward inhibition microcircuit neurogliaform cell somatostatin interneuron VIP

Organism: Mouse

Tissue: Brain

127
Oxidized Low-Density Lipoprotein-Deteriorated Psoriasis Is Associated with the Upregulation of Lox-1 Receptor and Il-23 Expression In Vivo and In Vitro

Chun-Ming Shih, Chien-Yu Huang, Kuo-Hsien Wang, Chun-Yao Huang, Po-Li Wei, Yu-Jia Chang, Chi-Kun Hsieh, Kuan-Ting Liu, Ai-Wei Lee

International Journal of Molecular Sciences (MDPI) Taiwan, 03 September 2018

Dermatology

Key words:oxLDL; LOX-1; psoriasis

Organism: Mouse

Tissue: Skin

Pathological State: Psoriasis

128
Amentoflavone Inhibits Hepatocellular Carcinoma Progression Through Blockage of ERK/NF-ĸB Activation

Kun-Ching Lee, Wei-Ting Chen, Yu-Chang Liu, Song-Shei Lin, Fei-Ting Hsu

in vivo: international journal of experimental and clinical pathophysiology and drug research (International Institute of Anticancer Research) Taiwan, 01 September 2018

Oncology

Key words:Amentoflavone, hepatocellular carcinoma, extracellular signal-regulated kinase, nuclear factor-kappaB, bioluminescence imaging.

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

129
Enhanced Sternal Healing via Platelet-Rich Plasma and Biodegradable Gelatin Hydrogel

Masafumi Shibata, Gen Takagi, Mitsuhiro Kudo, Jiro Kurita, Yoko Kawamoto, Yasuo Miyagi, Mikimoto Kanazashi, Takashi Sakatani, Zenya Naito, Yasuhiko Tabata, Masaaki Miyamoto, and Takashi Nitta

Tissue Engineering Part A (Mary Ann Liebert Inc.) Japan, 01 September 2018

Tissue Engineering

Organism: Rabbit

Tissue: Bone

130
The tree shrew cerebellum atlas: Systematic nomenclature, neurochemical characterization and afferent projections

Rong‐Jun Ni Zhao‐Huan Huang Peng‐Hao Luo Xiao‐Hong Ma Tao Li Jiang‐Ning Zhou

Journal of Comparative Neurology (Wiley) China, 29 August 2018

Neuroscience

Key words:cerebellar nuclei, lobule fissure, inferior olive, Purkinje cell, calbindin, RRID: AB_476894

Organism: Treeshrew

Tissue: Brain

131
Focused Ultrasound-Induced Blood-Brain Barrier Opening Enhances GSK-3 Inhibitor Delivery for Amyloid-Beta Plaque Reduction

Po-Hung Hsu, Ya-Tin Lin, Yi-Hsiu Chung, Kun-Ju Lin, Liang-Yo Yang, Tzu-Chen Yen and Hao-Li Liu

Scientific Reports (Nature) Taiwan, 27 August 2018

Neuroscience

Key words:Alzheimer's diseas, eBiomedical engineering ,Blood–brain barrier, Drug delivery, Translational research, GSK-3, Amyloid-Beta Plaque

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s Disease

132
NFAT5 isoform C controls biomechanical stress responses of vascular smooth muscle cells

Maren Zappe, Anja Feldner, Caroline Arnold, Carsten Sticht, Markus Hecker and Thomas Korff

Frontiers in Physiology (Frontiers Media S.A.) Germany, 23 August 2018

Cardiology

Key words:NFAT5; TonEBP; hypertension; transcriptional regulation; vascular smooth muscle cells; wall stress

Organism: Human

Cell Line: Human arterial smooth muscle cells (HUASMCs)

133
Role of the orexin 2 receptor in palatable-food consumption-associated cardiovascular reactivity in spontaneously hypertensive rats

Shang-Cheng Huang, Tzu-Ling Li, Yen-Hsien Lee, Yu-Wen E. Dai, Yu-Chun Chen Ling-Ling Hwang

Scientific Reports (Nature) Taiwan, 23 August 2018

Cardiology

Key words:Hypertension, Hypothalamus

Organism: Rat

Tissue: Brain

134
Lack of DNA damage response at low radiation doses in adult stem cells contributes to organ dysfunction

Peter W Nagle, Nynke A Hosper, Lara Barazzuol, Anne L Jellema, Mirjam Baanstra, Marc-Jan van Goethem, Sytze Brandenburg, Ulrich Giesen, Johannes A. Langendijk, Peter van Luijk and Rob P Coppes

Clinical Cancer Research (AACR Publications) The Netherlands, 22 August 2018

Oncology

Key words:DNA Damage, Radiation, Stem Cells, Organ Dysfunction, Radiotherapy

Organism: Mouse

Tissue: Thyroid, Salivary Gland

135
Modified Methacrylate Hydrogels Improve Tissue Repair after Spinal Cord Injury

Aleš Hejčl OrcID, Jiří Růžička, Kristýna Kekulová 1OrcID, Barbora Svobodová, Vladimír Proks OrcID, Hana Macková , Kateřina Jiránková , Kristýna Kárová , Lucia Machová Urdziková, Šárka Kubinová, Jiří Cihlář , Daniel Horák and Pavla Jendelová

International Journal of Molecular Sciences (MDPI) Czech Republic, 22 August 2018

Regenerative Medicine

Key words:spinal cord injury; hydrogel; connective tissue; neurofilaments; locomotor test; plantar test

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

136
Optimization of an Anti-NMDA Receptor Autoantibody Diagnostic Bioassay

NC Chiu, YJ Lin, RF Tzang, YS Li, HJ Lin, S Das, CG Chen, CC Chen, K Hsu

Circulation (NCBI) Taiwan, Denmark, Sweden, 22 August 2018

Neuroscience

Key words:Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, autoantibody (autoAb), autoimmune encephalitis, schizophrenia, diagnostic test, fluorescein isothiocyanate (FITC), Alexa Fluor 488, antigen (Ag)

Organism: Human

Tissue: Blood

Pathological State: Encephalitis

137
Photoperiodic Flower Mimicking Metallic Nanoparticles for Image-Guided Medicine Applications

S Cho, B Lee, W Park, X Huang, DH Kim

Applied Materials and Interfaces (ACS Publications) USA, 22 August 2018

Radiotherapy

Key words:metallic nanoparticles; radiosensitizers; image-guided radiotherapy; radiation; cancer therapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

138
Striatal Microstimulation Induces Persistent and Repetitive Negative Decision-Making Predicted by Striatal Beta-Band Oscillation

Ken-ichi Amemori, Satoko Amemori,Daniel J. Gibson and Ann M. Graybie

Neuron (Cell Press) USA, 22 August 2018

Neuroscience

Key words:approach-avoidance conflict; basal ganglia; beta oscillation; caudate nucleus; cost-benefit decisions; emotion; macaque; motivation; primate; value judgment

Organism: Pig, Human

Tissue: Brain

139
Secreted products of oral bacteria and biofilms impede mineralization of apical papilla stem cells in TLR-, species-, and culture-dependent fashion

Xenos Petridis,Luc W. M. van der Sluis,1 René J. B. Dijkstra,1 Marja G. L. Brinker, Henny C. van der Mei,and Martin C. Harmsen

Scientific Reports (Nature) The Netherlands, 21 August 2018

Immunology, Microbiology

Key words:Mesenchymal stem cells, Oral diseases, biofilms

Organism: Human

Cell Line: SCAP (Stem cells from apical papilla)

140
Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature

Tej Pratap Singh,Pablo A. Vieyra-Garcia,Karin Wagner,Josef Penninger,Peter Wolf

Cell Death and Disease (Nature) Austria, 06 August 2018

Oncology

Key words:Cbl-b deficiency, UVB, skin damage, inflammation, gene signature

Organism: Mouse, Human

Tissue: Skin

141
Expression and modulation of S100A4 protein by human mast cells

Rossana Domenis, David Pilutti, Maria Orsaria, Stefania Marzinotto, Veronica Candotti, Giulia Bosisio, Michela Bulfoni, Maria Elisabetta Ruaro, Carla Di Loreto, Vincenzo Della Mea, Eleonora Toffoletti, Ambrogio P.Londero, Laura Mariuzzi, Giorgia Gri

Cellular Immunology (Elsevier) Italy, 04 August 2018

Immunology

Key words:Immunofluorescence Tryptase Metalloproteinase Mast cells biology siRNA

Organism: Human

Tissue: Bladder, Skin

Pathological State: Bladder Cyst, Crohn's Disease, Cancer

142
Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine

Chang‐Bin Liu De‐Gang Yang Xin Zhang Wen‐Hao Zhang Da‐Peng Li Chao Zhang Chuan Qin Liang‐Jie Du Jun Li Feng Gao Jie Zhang Zhen‐Tao Zuo Ming‐Liang Yang Jian‐Jun Li

CNS Neuroscience and Therapeutics (Wiley) China, 03 August 2018

Neuroscience

Key words:canine model; diffusion tensor imaging; gray matter; pathological degeneration; spinal cord injury; white matter

Organism: Dog

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

143
Crumpled Aluminum Hydroxide Nanostructures as a Microenvironment Dysregulation Agent for Cancer Treatment

MI Lerner, G Mikhaylov, AA Tsukanov, Aleksandr S. Lozhkomoev, Elazar Gutmanas, Irena Gotman, Andreja Bratovs, Vito Turk‡ Boris Turk, Sergey G. Psakhye, and Olga Vasiljeva

Nano Letters (ACS Publications) Russia, Israel, Slovenia, 02 August 2018

Nanomedicine

Key words:aluminum hydroxide; cancer treatment; Crumpled nanosheets; ion balance; molecular dynamics simulation; tumor microenvironment

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

144
Plk1 overexpression induces chromosomal instability and suppresses tumor development

Guillermo de Cárcer,corresponding author Sharavan Vishaan Venkateswaran,Lorena Salgueiro,Aicha El Bakkali, Kalman Somogyi,Konstantina Rowald,Pablo Montañés,Manuel Sanclemente,Beatriz Escobar,Alba de Martino,4 Nicholas McGranahan,5 Marcos Malumbres,corresponding author1 and Rocío Sotillo

Nature Communications (Nature) Spain, 01 August 2018

Oncology

Key words:Cancer, Cell biology, Plk1, chromosomal instability

Organism: Mouse

Tissue: Liver, Pancreas, Kidney, Small Intestine, Lung

145
Plk1 overexpression suppresses tumor development by inducing chromosomal instability

Guillermo de Cárcer, Sharavan Vishaan Venkateswaran, Lorena Salgueiro, Aicha El Bakkali, Kalman Somogyi, Konstantina Rowald, Pablo Montañés, Manuel Sanclemente, Beatriz Escobar, Alba de Martino, Nicholas McGranahan, Marcos Malumbres and Rocío Sotillo

Nature Communications (Nature) Spain, Germany, UK, 01 August 2018

Oncology

Key words:Cancer, Cell biology

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

146
SCID/NOD mice model for 5-FU induced intestinal mucositis: Safety and effects of probiotics as therapy

LawrenceHuangabJen-ShiuChiang ChiaucMei-LienChengcWai-TaoChanaChuen-BinJiangadSzu-WenChangaChun-YanYeungaeHung-ChangLee

Pediatrics and Neonatology (Elsevier) Taiwan, 26 July 2018

Gastroenterology

Key words:SCID; cytokines; fluorouracil; mucositis; probiotics

Organism: Mouse

Tissue: Small Intestine

Pathological State: Diarrhea

147
CRISPR-Cas9 Screens Reveal Genes Regulating a G0-like State in Human Neural Progenitors

Heather M Feldman, Chad M Toledo, Sonali Arora, Pia Hoellerbauer, Philip Corrin, Lucas Carter, Megan Kufeld, Hamid Bolouri, Ryan Basom, Jeffrey Delrow, Joshua Meier, Feng Zhang, José L. McFaline-Figueroa, Cole Trapnell, Steven M Pollard, Christopher L Plaisier, Patrick J Paddison

The Journal of thoracic and cardiovascular surgery (Elsevier) , 25 July 2018

148
Trehalose to cryopreserve human pluripotent stem cells

Aikaterini Ntaia , Alberto La Spadab , Pasquale De Blasioa , Ida Biunno

Stem Cell Research (Elsevier) Italy, 25 July 2018

Stem Cell Research

Key words:Cryopreservation, Trehalose, Pluripotent stem cells

Organism: Human

Cell Line: hESCs, lt-NES, hiPSCs

149
Depletion of Sirt3 leads to the impairment of adipogenic differentiation and insulin resistance via interfering mitochondrial function of adipose-derived human …

YT Wu, KT Chi, YW Lan, JC Chan, YS Ma, YH Wie

Free Radical Research (Taylor and Francis) Taiwan, 23 July 2018

Stem Cell Research

Key words:Adipogenesis, antioxidant defence, human mesenchymal stem cells, insulin resistance, mitochondrial bioenergetics, Sirt3

Organism: Human

Cell Line: adiposederived human mesenchymal stem cells

150
Succinate Accumulation Is Associated with a Shift of Mitochondrial Respiratory Control and HIF-1α Upregulation in PTEN Negative Prostate Cancer Cells

Anja Weber,Helmut Klocker,Herbert Oberacher,Erich Gnaiger,Hannes Neuwirt,Natalie Sampson and Iris E. Eder

International Journal of Molecular Sciences (MDPI) Austria, 21 July 2018

Oncology

Key words:Na+-dicarboxylate transporter; acidic tumor microenvironment; mitochondria; oxidative phosphorylation; prostate cancer; succinate

Organism: Human

Pathological State: Cancer

Cell Line: LNCaP, PC-3 (prostate cancer cell lines)

151
Prognostic and predictive values of immune infiltrate in patients with head and neck squamous cell carcinoma

Xue-MeiZhang Ling-JunSong JuanShenHao YueYa-QinHanChen LingYangShi YunLiuJia WenDengYue JiangGuo HuiFu

Human Pathology (Elsevier) China, 20 July 2018

Oncology

Key words:Head and Neck Squamous Cell Carcinoma; Immunoscore; Prognosis and Predictive; Tumor Infiltrating Lymphocytes

Organism: Human

Tissue: Head, Neck

Pathological State: Cancer

152
Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

Mario Mauthe, Idil Orhon, Cecilia Rocchi, Xingdong Zhou, Morten Luhr, Kerst-Jan Hijlkema, Robert P. Coppes, Nikolai Engedal, Muriel Mari and Fulvio Reggiori

Autophagy (Taylor and Francis) The Netherlands, 20 July 2018

Cell Biology

Key words:Autophagy; Golgi; bafilomycin A1; degradative compartments; fusion; lysosomal degradation; lysosomal inhibitors

Organism: Human

Pathological State: Cancer

Cell Line: U2OS (Osteosarcoma cell line), HeLa cells

153
Significant therapeutic effects of adult human multipotent neural cells on spinal cord injury

KH Lee, HJ Pyeon, H Nam, JS Won, JY Hwang, KA Lee, JY Yeon, SC Hong, DH Nam, K Lee, SH Lee, KM Joo

Stem Cell Research (Elsevier) South Korea, 19 July 2018

Stem Cell Research

Key words:Spinal cord injuries, Adult stem cells, Neural stem cells, Microvasculature, Chemokine1

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

154
Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition

Ján Remšík Lucia Binó Zuzana Kahounová Gvantsa Kharaishvili Šárka Šimečková Radek Fedr Tereza Kučírková Sára Lenárt Ximena Maria Muresan Eva Slabáková

Carcinogenesis (Oxford University Press) Czech Republic, 16 July 2018

Oncology

Key words:phenotype, cancer, carcinoma, epithelium, heterogeneity, antigens, cell lines, membrane glycoproteins, breast, neoplasms, prostate, transcription factor, prostate cancer, carcinogenesis, e-cadherin, tumor progression, epithelial to mesenchymal transition, molecular targeted therapy, tumor cells, malignant

Organism: Human

Tissue: Prostate, Breast

Pathological State: Cancer

155
Enhancement of chondrogenesis of adipose-derived stem cells in HA-PNIPAAm-CL hydrogel for cartilage regeneration in rabbits

Chau-Zen Wang,Rajalakshmanan Eswaramoorthy,Tzu-Hsiang Lin,Chung-Hwan Chen,Yin-Chih Fu,Chih-Kuang Wang,Shun-Cheng Wu,Gwo-Jaw Wang, Je-Ken Chang,corresponding author Mei-Ling Ho

Scientific Reports (Nature) Taiwan, 12 July 2018

Tissue Engineering

Key words:Biomaterials, Regeneration, hydrogel, cartilage

Organism: Rabbit

Cell Line: rADSCs (rabbit adipose-derived stem cells )

156
Expression of serine peptidase inhibitor Kunitz type 1 in differentiated thyroid cancer

Chien-Liang LiuPo-Sheng YangMing-Nan ChienYuan-Ching ChangChi-Hsin LinShih-Ping Cheng

Histochemistry and Cell Biology (Springer) Taiwan, 10 July 2018

Oncology

Key words:Serine protease inhibitor , Hepatocyte growth factor , Thyroid cancer Invasion

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

157
Synergistic Cross‐Talk of Hedgehog and Interleukin‐6 Signaling Drives Growth of Basal Cell Carcinoma

Christina Sternberg Wolfgang Gruber Markus Eberl Suzana Tesanovic Manuela Stadler Dominik P. Elmer Michaela Schlederer Sandra Grund Simone Roos

International Journal of Cancer (Wiley) Austria, 10 July 2018

Oncology

Key words:GLI signaling ; GLI transcription factors ; STAT transcription factors; basal cell carcinoma ; hedgehog; interleukin-6 signaling

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

158
TERT Promoter Mutations in Solitary Fibrous Tumor

Elizabeth G Demicco Khalida Wani Davis Ingram Michael Wagner Robert G. Maki Anthony Rizzo Alan Meeker Alexander J Lazar Wei‐Lien Wang

HistoPathology (Wiley) USA, 09 July 2018

Oncology

Key words:ATRX ; DAXX ; metastasis; outcome; prognosis; risk assessment; solitary fibrous tumour; telomerase reverse transcriptase

Organism: Human

Tissue: Solitary Fibrous Tumor

Pathological State: Cancer

159
Development of a Novel Orthogonal Double Gradient for High‐Throughput Screening of Mesenchymal Stem Cells–Materials Interaction

Qihui Zhou Lu Ge Carlos F. Guimarães Philipp T. Kühn Liangliang Yang Patrick van Rijn

Advanced Materials Interfaces (Wiley) The Netherlands, 04 July 2018

Biological Materials

Key words:high‐throughput screening, orthogonal double gradient, stem cell, stiffness, wettability

Organism: Human

Cell Line: Mesenchymal stem cells from human bone marrow (hBM-MSCs)

160
Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cell xenograft tumor in nude mice in vivo

Yi‐Shih Ma Jen‐Jyh Lin Chin‐Chung Lin Jin‐Cherng Lien Shu‐Fen Peng Ming‐Jen Fan Fei‐Ting Hsu Jing‐Gung Chung

Environmental Toxicology (Wiley) Taiwan, 04 July 2018

Oncology

Key words:benzyl isothiocyanate; human brain glioblastoma multiforme GBM 8401 cell; in vivo; nude mice; xenograft tumor

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

161
Antrodia cinnamomea produces anti-angiogenic effects by inhibiting the VEGFR2 signaling pathway

Tsung-TengHuang Ying-WeiLan Yun-FeiKo Chuan-MuChen Hsin-ChihLaijkDavid M.Ojcius JanMartel John D.Young Kowit-YuChong

Journal of Ethnopharmacology (Elsevier) Taiwan, 28 June 2018

Cell Biology

Key words:Antrodia cinnamomea, Anti-angiogenic activity, Endothelial cells, VEGFR2, STAT3

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

162
Dynamics of tissue ingrowth in SIKVAV-modified highly superporous PHEMA scaffolds with oriented pores after bridging a spinal cord transection

Aleš Hejčl, Jiří Růžička Vladimír Proks, Hana Macková, Šárka Kubinová Dmitry Tukmachev,Jiří Cihlář Daniel Horák Pavla Jendelová

Journal of Materials Science: Materials in Medicine (Springer) Czech Republic, 25 June 2018

Regenerative Medicine

Key words:tissue ingrowth, SIKVAV, superporous, PHEMA scaffolds, oriented pores, spinal cord injury, mesenchymal stem cells (MSCs)

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

163
Neuroplastic change of cytoskeleton in inferior colliculus after auditory deafferentation

Jae JoonHanaHo SunLeebcMin-HyunPark

Hearing Research (Elsevier) South Korea, 23 June 2018

Neuroscience

Key words:Auditory deafferentation, Deafness, SMI-32, Neurofilament heavy chain, Inferior colliculus

Organism: Rat

Tissue: Brain

Pathological State: Deafness

164
Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes

Guadalupe Navarro, Camille Allard, Jamie J. Morford, Weiwei Xu, Suhuan Liu, Adrien J.R. Molinas, Sierra M. Butcher, Nicholas H.F. Fine, Manuel Blandino-Rosano, Venkata N. Sure, Sangho Yu, Rui Zhang, Heike Münzberg, David A. Jacobson, Prasad V. Katakam,David J. Hodson, Ernesto Bernal-Mizrachi, Andrea Zsombok,and Franck Mauvais-Jarvis

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, 21 June 2018

Oncology

Key words:Beta cells; Diabetes; Endocrinology; Metabolism; Sex hormones

Organism: Mouse

Tissue: Pancreas

Pathological State: Diabetes

165
Afatinib restrains K-RAS–driven lung tumorigenesis

Herwig P. Moll, Klemens Pranz, Monica Musteanu, Beatrice Grabner, Natascha Hruschka, Julian Mohrherr

Science Translational Medicine (American Association for the Advancement of Science) Austria, 20 June 2018

Oncology

Key words:Afatinib, K-RAS, lung cancer, pan-ERBB, tyrosine kinase inhibitors

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

166
Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis

Kumud R.Poudel MinnaRoh-Johnson AllenSu ThuongHo HarithaMathsyaraja SarahAnderson William M.Grady Cecilia B.Moens MaraliceConacci-Sorrell Robert N.Eisenman

Developmental Cell (Cell Press) USA, 18 June 2018

Oncology

Key words:BAR domain; PTEN; Rac1; TIAM1; cell migration; endocytosis; endophilin; membrane remodeling; metastasis

Organism: Mouse

Tissue: Whole Organism

Pathological State: Cancer

167
Endothelial colony forming cells from human umbilical cord blood improved severe erectile dysfunction in obese type II diabetic rats

Abrar Al-Mahmood Siddiqueea , P. Ganesan Adaikana, , Lang Chu Laua , Baharudin Bin Saida , Mark Chongb , Jerry Chanc , Swee Hin Teoh

Life Science (Elsevier) Singapore, 18 June 2018

Reproductive Medicine

Key words:Severe erectile dysfunction, Human endothelial colony forming cells, Intracavernosal pressure, Zucker diabetic fatty rats

Organism: Rat

Tissue: Penis

Pathological State: Erectile dysfunction

168
Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts

Tanja Niedermair, Stephan Schirner, Raphael Seebröker, Rainer H. Straub, Susanne Grässel

Scientific Reports (Nature) Germany, 15 June 2018

Physiology

Key words:Substance P, bone remodeling, osteoblasts, osteoclasts, Bone, Mechanisms of disease

Organism: Mouse

Cell Line: Osteoclast, Osteoblast

169
Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles

Sander C Steenbeek, Thang V Pham, Joep de Ligt, Anoek Zomer, Jaco C Knol, Sander R Piersma, Tim Schelfhorst, Rick Huisjes, Raymond M Schiffelers, Edwin Cuppen, Connie R Jimenez, Jacco van Rheenen

The EMBO Journal (EMBO press) The Netherlands, 15 June 2018

Oncology

Key words:Cre‐LoxP; extracellular vesicles; intratumoral heterogeneity; intravital microscopy; signaling networks

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

170
Quantitative measurement of breast carcinoma fibrosis for the prediction in the risk of bone metastasis

Chong Sun, Bin Wang, Jianmin Li, Junjie Shangguan, Matteo Figini, Kang Zhou, Liang Pan, Quanhong Ma, Zhuoli Zhang

American Journal of Translational Research (e-Century Publishing Corporation) China, 15 June 2018

Oncology

Key words:Invasive breast carcinoma; bone metastasis; collagen deposition; early prediction

Organism: Human

Tissue: Breast

Pathological State: Cancer

171
Synergistic Antitumor Effect of Oligogalacturonides and Cisplatin on Human Lung Cancer A549 Cells

Cian-Song Huang, Ai-Chun Huang, Ping-Hsiu Huang, Diana Lo, Yuh-Tai Wang, Ming-Chang Wu

International Journal of Molecular Sciences (MDPI) Taiwan, 14 June 2018

Oncology

Key words:adjuvant therapy; cisplatin; oligogalacturonides; synergistic effect

Organism: Human

Pathological State: Cancer

Cell Line: A549 (Lung carcinoma cells)

172
Nerve Growth Factor (NGF)—Receptor Survival Axis in Head and Neck Squamous Cell Carcinoma

József Dudás, Wolfgang Dietl, Angela Romani, Susanne Reinold, Rudolf Glueckert, Anneliese Schrott-Fischer, Daniel Dejaco, Lejo Johnson Chacko, Raphaela Tuertscher, Volker Hans Schartinger, Herbert Riechelmann

International Journal of Molecular Sciences (MDPI) Austria, 14 June 2018

Oncology

Key words:TissueFaxs; cell cycle arrest; cytokeratin; necrosis

Organism: Human

Tissue: Oral Mucosa

Pathological State: Cancer

173
Breast Cancer Histological Image Classification Using Fine-Tuned Deep Network Fusion

A Mahbod, I Ellinger, R Ecker, Ö Smedby, C Wang

(Springer) , 06 June 2018

Key words:Breast cancer Histological images Classification Deep learning

174
Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke

Somayyeh Hamzei Taj, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Alessandra Quarta, Jelle Praet, Annemie Van der Linden, Peter Ponsaerts, Mathias Hoehn

Journal of Neuroinflammation (Springer) Germany, 04 June 2018

Immunology

Key words:Interleukin 13; Mesenchymal stem cells; Microglia/macrophage polarization; Neuroinflammation; Stroke

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

175
Novel Conducting and Biodegradable Copolymers with Noncytotoxic Properties toward Embryonic Stem Cells

Aruã C. da Silva, Ana Teresa S. Semeano, André H. B. Dourado, Henning Ulrich, Susana I. Cordoba de Torresi

ACS OMEGA (ACS Publications) Brazil, 31 May 2018

Stem Cell Research

Key words:Cell and Molecular biology; Conducting polymers; Environmental biology; Polyesters

Organism: Human

Cell Line: Human embryonic stem cells (hESCs)

176
Hierarchical Multiplexing Nanodroplets for Imaging-Guided Cancer Radiotherapy via DNA Damage Enhancement and Concomitant DNA Repair Prevention

Wei Jiang, Quan Li, Liang Xiao, Jiaxiang Dou, Yi Liu, Wenhao Yu, Yinchu Ma, Xiaoqiu Li, Ye-Zi You, Zhuting Tong, Hang Liu, Hui Liang, Ligong Lu, Xiaoding Xu, Yandan Yao, Guoqing Zhang, Yucai Wang, and Jun Wang

ACS NANO (ACS Publications) China, 29 May 2018

Nanomedicine

Key words:cancer radiotherapy; DNA damage and repair; hierarchical nanostructure; multimodal imaging; tumor hypoxia

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

177
Identification of galectin-3 as an autoantigen in patients with IgG4-related disease

Cory A. Perugino, DO,a,b* Sultan B. AlSalem, MBBS, MMSc,b,c* Hamid Mattoo, PhD,b Emanuel Della-Torre, MD, PhD,b,d Vinay Mahajan, Gayathri Ganesh, Hugues Allard-Chamard, Zachary Wallace, Sydney B. Montesi, Johannes Kreuzer, Wilhelm Haas, John H. Stone, Shiv Pillai

Journal of Allergy and Clinical Immunology (Elsevier) UK, USA, Italy, 29 May 2018

Immunology

Key words:IgG4-related disease, plasmablast, autoantigen, galectin-3, autoantibody

Organism: Human

Tissue: Pancreas

Pathological State: IgG4-Related Disease

178
Acellular vascular matrix grafts from human placenta chorion: Impact of ECM preservation on graft characteristics, protein composition and in vivo performance

Karl H. Schneider, Marjan Enayati, Christian Grasl, Ingrid Walter, Lubos Budinsky, Gabriel Zebic, Christoph Kaun, Anja Wagner, Klaus Kratochwill, Heinz Redl, Andreas Teuschl, Bruno K. Podesser, Helga Bergmeister

Biomaterials (Elsevier) Austria, 29 May 2018

Tissue Engineering

Key words:Decellularized matrix, Human placenta, Small diameter vascular grafts, Cell migration, Biocompatibility

Organism: Human

Tissue: Placenta

179
Allocation of Interferon Gamma mRNA Positive Cells in Caecum Hallmarks a Protective Trait Against Histomonosis

Fana Alem Kidane, Taniya Mitra, Patricia Wernsdorf, Michael Hess, Dieter Liebhart

Frontiers in Immunology (Frontiers Media S.A.) Austria, 28 May 2018

Immunology

Key words:Histomonas meleagridis; histomonosis; image analysis; immunofluorescence; in situ hybridization; interferon gamma; interleukin-13; vaccination

Organism: Turkey, Chicken

Tissue: Small Intestine, Liver, Spleen

Pathological State: Parasitic Infection

180
The overexpression of Fra1 disorders the inflammatory cytokine secretion by mTEC of myasthenia gravis thymus

Q.‐R. Li W.‐P. Ni N.‐J. Lei J.‐Y. Yang X.‐Y. Xuan P.‐P. Liu G.‐M. Gong F. Yan Y.‐S. Feng R. Zhao Y. Du

Scandinavian journal of Immunology (Blackwell Publishing Inc.) China, 28 May 2018

Neuroscience

Key words:Fos-related antigen-1; inflammatory cytokine; medulla thymic epithelial cells; myasthenia gravis

Organism: Human

Tissue: Thymus

Pathological State: Myasthenia Gravis

181
Therapeutic effects of dietary intervention on neuroinflammation and brain metabolism in a rat model of photothrombotic stroke

Ewelina Kurtys Cindy Casteels Caroline C. Real Ulrich L. M. Eisel J. Martin Verkuyl Laus M. Broersen Hans C. Klein Rudi A. J. O. Dierckx Janine Doorduin Erik F. J. de Vries

CNS Neuroscience and Therapeutics (Wiley) The Netherlands, 27 May 2018

Neuroscience

Key words:PET imaging; neuroinflammation; nutrition; photothrombotic stroke

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

182
Decreased argininosuccinate synthetase expression in Thai patients with cholangiocarcinoma and the effects of ADI-PEG20 treatment in CCA cell lines

Somphon Roeksomtawin, Panida Navasumrit, Somchamai Waraprasit, Varabhorn Parnlob, Thaniya Sricharunrat, Vajarabhongsa Bhudhisawasdi, Niramol Savaraj, Mathuros Ruchirawat

Oncology Letters (Spandidos Publications) Thailand, 24 May 2018

Oncology

Key words:Ki-67; arginine deprivation; argininosuccinate synthetase; cholangiocarcinoma; pegylated arginine deiminase

Organism: Human

Tissue: Liver

Pathological State: Cancer

Cell Line: Cholangiocarcinoma cell lines (RmCCA-1 and HuCCA), human fibroblast cell line (BJ-1)

183
Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-κB signaling pathway

Zhen Yang Cui, Soo Jung Park, Eunbi Jo, In-Hu Hwang, Kyung-Bok Lee, Sung-Woo Kim, Dae Joon Kim, Jong Chun Joo, Seok Hoon Hong, Min-Goo Lee and Ik-Soon Jang

Cell Death Discovery (Nature) South Korea, USA, 23 May 2018

Oncology

Organism: Human

Pathological State: Cancer

Cell Line: SKOV-3 cells

184
BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-β1 signaling

Yueh-Hua Chung, Ying-Hsien Huang, Tien-Huei Chu, Chun-Lin Chen, Pey-Ru Lin, Shih-Chung Huang, Deng-Chyang Wu, Chao-Cheng Huang, Tsung-Hui Hu, Ying-Hsien Kao and Ming-Hong Tai

Laboratory Investigation (Nature) Taiwan, 22 May 2018

Hepathology

Key words:BMP-2, liver fibrosis, TGF-β1 signaling

Organism: Human

Tissue: Liver

Pathological State: Hepatitis, Liver Cirrhosis

185
Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis

Henning Ulrich, Mariusz Z. Ratajczak, Gabriela Schneider, Elena Adinolfi, Elisa Orioli, Enéas G. Ferrazoli, Talita Glaser, Juliana Corrêa-Velloso, Poliana C. M. Martins, Fernanda Coutinho, Ana P. J. Santos, Micheli M. Pillat, Ulrich Sack, Claudiana Lameu

Frontiers in Pharmacology (Frontiers Media S.A.) Brazil, 18 May 2018

Oncology

Key words:bone marrow; bradykinin; metastasis; neuroblastoma; purinergic system

Organism: Human

Pathological State: Cancer

Cell Line: CHP-100 cells

186
Lactobacillus casei Variety rhamnosus Probiotic Preventively Attenuates 5-Fluorouracil/Oxaliplatin-Induced Intestinal Injury in a Syngeneic Colorectal Cancer Model

Ching-Wei Chang, Chia-Yuan Liu, Hung-Chang Lee, Yen-Hua Huang, Li-Hui Li, Jen-Shiu Chiang Chiau, Tsang-En Wang, Cheng-Hsin Chu, Shou-Chuan Shih, Tung-Hu Tsai, Yu-Jen Chen

Frontiers in Microbiology (Frontiers Media S.A.) Taiwan, 15 May 2018

Oncology

Key words:FOLFOX; Lactobacillus; apoptosis; gut microbiota; intestinal mucositis

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

187
A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment

Amelie Griveau, GiorgioS eano, Samuel J. Shelton, Robert Kupp, Arman Jahangiri, Kirsten Obernier, Shanmugarajan Krishnan, Olle R. Lindberg, Tracy J. Yuen, An-Chi Tien, Jennifer K.Sabo, Nancy Wang, Ivy Chen, Jona sKloepper, Louis Larrouquere, Mitrajit Ghosh, Itay Tirosh, Emmanuelle Huillard, Arturo Alvarez-Buylla, Michael C. Oldham, Anders I. Persson, William A. Weiss, Tracy T. Batchelor, Anat Stemmer-Rachamimov, Mario L.Suvà, Joanna J. Phillips, Manish K .Aghi, Shwetal Mehta, Rakesh K. Jain, David H. Rowitch

Cancer Cell (Cell Press) USA, 14 May 2018

Oncology

Key words:Olig2; Wnt; angiogenesis; astrocyte; blood-brain barrier; glioma; invasiveness; oligodendrocyte precursor; p53; vessel co-option

Organism: Human, Mouse

Tissue: Brain, Xenograft Tumor

Pathological State: Cancer

188
Catalpol inhibits migration and induces apoptosis in gastric cancer cells and in athymic nude mice

Zheng-HuaWangZhan-ShengHu

Biomedicine and Pharmacotherapy (Elsevier) China, 14 May 2018

Oncology

Key words:Gastric cancer, Catalpol, Migration, Apoptosis and ROS, DDP

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

189
DNA damage predicts prognosis and treatment response in colorectal liver metastases superior to immunogenic cell death and T cells

Johannes Laengle, Judith Stift, Agnes Bilecz, Brigitte Wolf, Andrea Beer, Balazs Hegedus, Stefan Stremitzer, Patrick Starlinger, Dietmar Tamandl, Dietmar Pils, Michael Bergmann

Theranostics (Ivyspring International Publisher) Austria, 10 May 2018

Oncology

Key words:DNA damage, calreticulin, immunogenic cell death, colorectal liver metastases

Organism: Human

Tissue: Colon

Pathological State: Cancer

190
Hematological findings in non-treated and gamma-irradiated mice deficient for MIC-1/GDF15.

M. HOFER, Z. HOFEROVÁ, J. REMŠÍK, M. NOVÁKOVÁ, J. PROCHÁZKOVÁ, R. FEDR, J. KOHOUTEK, L. DUŠEK, A. HAMPL, K. SOUČEK

Physiological Research (BioMed Central) Czech Republic, 10 May 2018

Hematology

Key words:GDF15 knockout mice; hematopoiesis; ionizing radiation; stress-induced cytokine

Organism: Mouse

Tissue: Spleen, Bone

191
Regorafenib inhibits tumor progression through suppression of ERK/NF-κB activation in hepatocellular carcinoma bearing mice

Mao-Chi Weng, Mei-Hui Wang, Jai-Jen Tsai, Yu-Cheng Kuo, Yu-Chang Liu, Fei-Ting Hsu, Hsin-Ell Wang

Bioscience Reports (Kluwer Academic Publishers) Taiwan, 05 May 2018

Oncology

Key words:Bioluminescence imaging; Regorafenib; apoptosis; hepatocellular carcinoma; nuclear factor kappaB

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

192
Effects of chitosan and chitosan N-acetylcysteine solutions on conjunctival epithelial cells

N Schuerer, E Stein, A Inic-Kanada, E Ghasemian, Marijana Stojanovic, Jacqueline Montanaro, Nora Bintner, Christine Hohenadl, Robert Sachsenhofer, Talin Barisani-Asenbauera

Journal of EuCornea (Elsevier) Austria, Serbia, 02 May 2018

Ophthalmology

Key words:Chitosan Chitosan-N-acetylcysteine Uptake Conjunctival epithelial cells Drug delivery

Organism: Guinea Pig

Tissue: Eye

193
Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor‐suppressing phenotype

Hong‐Tai Tzeng Ching‐Chin Su Chih‐Peng Chang Wu‐Wei Lai Wu‐Chou Su Yi‐Ching Wang

International journal of cancer (Wiley) Taiwan, 01 May 2018

Oncology

Key words:Rab37; ST2; exocytosis; macrophage; tumor microenvironment

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

194
Eupatilin inhibits the proliferation of human esophageal cancer TE1 cells by targeting the Akt‑GSK3β and MAPK/ERK signaling cascades

Xiaona Wang Yanyan Zhu Lili Zhu Xinhuan Chen Yanyan Xu Yafei Zhao Yingzhe Shao Feng Li Yanan Jiang Jing Lu Youtian Huang Xiaobin Chang Juan Zhang Xiang Li Kangdong Liu Mingyao Zhao Ziming Dong Jimin Zhao

Oncology Reports (Demetrios A. Spandidos Ed. and Pub.) China, 23 April 2018

Oncology

Key words:Eupatilin, human esophageal cancer, TE1 cells, Akt‑GSK3β, MAPK/ERK

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

195
Blimp-1 prolongs allograft survival without regimen via influencing T cell development in favor of regulatory T cells while suppressing Th1

Aline Yen LingWanga Charles Yuen YungLoh Shyi-JouChen Huang-KaiKao Cheng-HungLin Sheng-HaoChuang Chin-MingLee Huey-KangSytwu Fu-ChanWei

Molecular Immunology (Elsevier) Taiwan, 23 April 2018

Immunology

Key words:Allograft tolerance, B lymphocyte-induced maturation protein, T cells

Organism: Mouse

Tissue: Skin

Pathological State: Organ Transplantation

196
IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury

Wei-Yu Chen, Jenq-Lin Yang, Yi-Hsiu Wu, Lung-Chih Li, Ru-Fang Li, Ya-Ting Chang, Lo-Hsin Dai, Wan-Chen Wang, Ya-Jen Chang

Experimental and Molecular Medicine (Nature) Taiwan, 20 April 2018

Nephrology

Key words:IL-33/ST2 axis, hyperplasia, renal injury, unilateral ureteral obstruction (UUO)

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Injury

197
Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Samra Turajlic, Hang Xu, Kevin Litchfield, Andrew Rowan, Stuart Horswell, Tim Chambers

CELL (Cell Press) UK, 19 April 2018

Oncology

Key words:branched evolution; cancer evolution; chromosome instability; deterministic evolution; intratumor heterogeneity; linear evolution; metastasis; punctuated evolution; renal cell cancer; tumor diversity

Organism: Human

Tissue: Kidney

Pathological State: Cancer

198
Tumor-induced generation of splenic erythroblast-like Ter-cells promotes tumor progression

Han Y, Liu Q, Hou J, Gu Y, Zhang Y, Chen Z, Fan J, Zhou W, Qiu S, Zhang Y, Dong T, Li N, Jiang Z, Zhu H, Zhang Q, Ma Y, Zhang Q, Wang Q, Yu Y, Li N, Cao X

CELL (Cell Press) China, 19 April 2018

Oncology

Key words:Ter-119; Ter-cell; artemin; cancer immunotherapy; erythroblast-like; hepatocellular carcinoma; prognosis biomarker

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

199
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

Samra Turajlic, Hang Xu, Kevin Litchfield, Andrew Rowan, Tim Chambers, Jose I. Lopez, David Nicol

CELL (Cell Press) UK, 19 April 2018

Oncology

Key words:chromosome instability; cytoreductive nephrectomy; evolution of metastasis; loss of 9p; metastasectomy; metastasis; oligometastasis; renal cell cancer; solitary metastasis

Organism: Human

Tissue: Kidney

Pathological State: Cancer

200
Conditional depletion of GSK3b protects oligodendrocytes from apoptosis and lessens demyelination in the acute cuprizone model

Bin Xing Lauren E. Brink Kelly Maers Mara L. Sullivan Richard J. Bodnar Donna B. Stolz Franca Cambi

GLIA (Wiley) USA, 18 April 2018

Neuroscience

Key words:GSK3b; cell death; glia; multiple sclerosis

Organism: Mouse

Tissue: Brain

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