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Customer Publications (A total of 1320 papers published)

01
Analysis of Telomere Lengths in p53 Signatures and Incidental Serous Tubal Intraepithelial Carcinomas Without Concurrent Ovarian Cancer

S Asaka, C Davis, SF Lin, TL Wang, CM Heaphy, IM Shih

The American journal … (journals.lww.com) USA, 01 August 2019

Oncology

Key words:ovarian cancer precursor, fallopian tube, p53 signature, serous tubal intraepithelial carcinoma, telomere

02
Increased ILC3s associated with higher levels of IL-1 aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase

Tzu‐Yi Chan, Chia‐Liang Yen, Ya‐Fang Huang, Pei‐Chi Lo, Peter A. Nigrovic, Chia‐Ying Cheng, Wei‐Zhi Wang, Szu‐Yu Wu, Chi‐Chang Shieh

European Journal of Immunology (Wiley) Taiwan, Japan, USA, 26 July 2019

Rheumatology

Key words:Innate lymphoid cells; Chronic granulomatous disease; NADPH oxidase; Reactive oxygen species; Serum-induced arthritis

Organism: Mouse

Tissue: Joint

Pathological State: Arthritis

03
Phthalate exposure alters gut microbiota composition and IgM vaccine response in human newborns

Yung-Ning Yang, Yu-Chen S.H. Yang, I-Hsuan Lin, Ying-Yu Chen, Hung-Yun Lin, Chien-Yi Wu, Yu-Tsun Su, Yao-Jong Yang, San-Nan Yang, Jau-Ling Suen

Food and Chemical Toxicology (Elsevier) Taiwan, USA, 26 July 2019

Toxicology

Key words:Di-(2-ethylhexyl) phthalate, Intravenous infusion, Microbiota, Anti-HBsAg-IgM, Newborn

04
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

Francesca Bufalieri, Paola Infante, Flavia Bernardi, Miriam Caimano, Paolo Romania, Marta Moretti, Ludovica Lospinoso Severini, Julie Talbot, Ombretta Melaiu, Mirella Tanori, Laura Di Magno, Diana Bellavia, Carlo Capalbo, Stéphanie Puget, Enrico De Smaele, Gianluca Canettieri, Daniele Guardavaccaro, Luca Busino, Angelo Peschiaroli, Simonetta Pazzaglia, Giuseppe Giannini, Gerry Melino, Franco Locatelli, Alberto Gulino, Olivier Ayrault, Doriana Fruci & Lucia Di Marcotullio

Nature Communications (Nature) Italy, France, USA, UK, 24 July 2019

Oncology

Key words:Cancer, Molecular biology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

05
Synergistic effect of NELL-1 and an ultra-low dose of BMP-2 on spinal fusion

Miss Ling Liu, Dr. Wing Moon Raymond Lam, Mrs. Mathanapriya Naidu Zheng Yang, Dr. Ming Wang, Dr. Xiafei Ren, Dr. Tao Hu, Kumarsing Amit Ramruttun, Prof. Kang Ting, Prof. James Cho-Hong Goh; Prof. Hee Kit Wong

Tissue Engineering Part A (Mary Ann Liebert Inc.) Singapore, China, 24 July 2019

Regenerative Medicine

Organism: Pig

Cell Line: BMSC

06
DIS3L2 promotes progression of hepatocellular carcinoma via hnRNP U-mediated alternative splicing

Huafeng Zhang, Songge Xing, Zhaoyong Li, Wenhao Ma, Xiaoping He, Shengqi Shen, Haoran Wei, Shi-Ting Li, Ying Shu, Linchong Sun, Xiuying Zhong, Yuhao Huangfu, Lanhong Su, Junru Feng, Xiaozhang Zhang, Ping Gao and Wei-Dong Jia

Cancer Research (AACR) China, 22 July 2019

Oncology

Key words:HCC; DIS3L2; hnRNP U; Alternative splicing; Rac1b

Organism: Human

Tissue: Liver

Pathological State: Cancer

07
Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus

I Simitsidellis, AE Zufiaurre, O Kelepouri, Elisabeth O’Flaherty, Douglas A. Gibson, Philippa T. K. Saunders

Journal of Endocrinology (bioscientifica) Ireland, 18 July 2019

Reproductive Medicine

Key words:Uterus, Endometrium, Androgen, SARM, Andarine, GTx-024, Enobosarm, 15 Ostarine, Danazol, DHT

Organism: Mouse

Tissue: Uterus

08
Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis

CY Hung, TI Hsu, JY Chuang, TP Su, WC Chang, JJ Hung

Molecular Neurobiology (Springer) Taiwan, USA, 18 July 2019

Neuroscience

Key words:Sp1, Astrocyte, Neurite outgrowth, Synaptogenesis

Organism: Mouse

Tissue: Brain

09
Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction

Thomas M. Hofbauer, Andreas Mangold, Thomas Scherz, Veronika Seidl, Adelheid Panzenböck, Anna S. Ondracek, Julian Müller, Matthias Schneider, Thomas Binder, Lena Hell, Irene M. Lang

Basic research in Cardiology (Springer) Austria, 16 July 2019

Cardiology

Key words:ST-segment elevation myocardial infarction, Neutrophil extracellular traps, Fibrocytes Thrombosis

Organism: Human

Tissue: Heart

10
Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface

Caroline M. Weight, Cristina Venturini, Sherin Pojar, Simon P. Jochems, Jesús Reiné, Elissavet Nikolaou, Carla Solórzano, Mahdad Noursadeghi, Jeremy S. Brown, Daniela M. Ferreira & Robert S. Heyderman

Nature Communications (Nature) UK, 16 July 2019

Microbiology, Immunology

Key words:Infection, Innate immunity, Pathogens, Respiratory tract diseases

Organism: Human

Pathological State: Streptococcus pneumoniae infection

Cell Line: Mucosal cells

11
Pleiotropic Effects of Epithelial Mesenchymal Crosstalk on Head and Neck Cancer: EMT and beyond

TB Steinbichler, D Savic, D Dejaco, A Romani, B Kofler, II Skvortsova, H Riechelmann, J Dudas

Cancer Microenvironment (Springer) Austria, 11 July 2019

Oncology

Key words:IL-6, EMT, JAK/STAT3/Snail signalling, radiochemotherapy, therapy resistance, conditioned medium

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

12
The Lymphoma-Associated Macrophages-To-Hodgkin-Reed-Sternberg Cells Ratio Is A Poor Prognostic Factor In Classic Hodgkin Lymphoma Patients

V Procházka, T Papajík, T Dýšková, M Dihel, S Brychtová, Z Prouzová, E Kriegová, M Lukášová, V Hanáčková

Clinical Lymphoma Myeloma and Leukemia (Elsevier) Czech Republic, 05 July 2019

Oncology

Key words:Hodgkin lymphoma, macrophage, prognosis, microenvironment

Organism: Human

Pathological State: Cancer

13
miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

Hsin-Yi Chen, Yaw-Dong Lang, Han-Nan Lin, Yun-Ru Liu, Chun-Chieh Liao, André Wendindondé Nana, Yun Yen & Ruey-Hwa Chen

Scientific reports (Nature) Taiwan, 04 July 2019

Oncology

Key words:Colon cancer, Metastasis

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

14
Entrapment of N-Hydroxyphthalimide Carbon Dots in Different Topical Gel Formulations: New Composites with Anticancer Activity

CL Savin, C Tiron, E Carasevici, CS Stan, SA Ibanescu, BC Simionescu, CA Peptu

Pharmaceutics (MDPI) Romania, 01 July 2019

Oncology

Key words:composite; N-hydroxyphthalimide; carbon dots; polymer gels; antitumoral activity

Organism: Human

Cell Line: MDA-MB-231 cells

15
Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons

Tetsuya Akiyama, Naoki Suzuki, Mitsuru Ishikawa, Koki Fujimori, Takefumi Sone, Jiro Kawada, Ryo Funayama, Fumiyoshi Fujishima, Shio Mitsuzawa, Kensuke Ikeda, Hiroya Ono, Tomomi Shijo, Shion Osana, Matsuyuki Shirota, Tadashi Nakagawa, Yasuo Kitajima, Ayumi Nishiyama, Rumiko Izumi, Satoru Morimoto, Yohei Okada, Takayuki Kamei, Mayumi Nishida, Masahiro Nogami, Shohei Kaneda, Yoshiho Ikeuchi, Hiroaki Mitsuhashi, Keiko Nakayama, Teruo Fujii, Hitoshi Warita, Hideyuki Okano, Masashi Aoki, Masashi Aoki

EBioMedicine (Elsevier) Japan, 29 June 2019

Neuroscience

Key words:Amyotrophic lateral sclerosis (ALS), Fused in sarcoma (FUS), Axon branching, Fos-B, Nerve organoid, Human-induced pluripotent stem cell (hiPSC)-derived motor neuron

Organism: Human

Tissue: Spinal Cord

Pathological State: ALS

16
Fbxw7 increases CCL2/7 in CX3CR1hi macrophages to promote intestinal inflammation

Jia He, Yinjing Song, Gaopeng Li, Peng Xiao, Yang Liu, Yue Xue, Qian Cao, Xintao Tu, Ting Pan, Zhinong Jiang, Xuetao Cao, Lihua Lai, and Qingqing Wang

The Journal of Clinical Investigation (American Society for Clinical Investigation) China, 27 June 2019

Immunology

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

17
Amelioration of Experimentally Induced Arthritis by Reducing Reactive Oxygen Species Production through the Intra-Articular Injection of Water-Soluble Fullerenol

WS Kuo, CT Weng, JH Chen, CL Wu, AL Shiau, JL Hsieh, EC So, PT Wu, SY Chen

Nanomaterials (MDPI) China, Taiwan, 23 June 2019

Nanomedicine

Key words:experimental arthritis; intra-articular injection; reactive oxygen species; rheumatoid arthritis; water-soluble fullerenol

Organism: Rat

Tissue: Joint

Pathological State: Arthritis

18
Cytotoxic T-cells and their activation status are independent prognostic markers in meningiomas

Carmen Rapp, Steffen Dettling, Fang Liu, Anna Theresa Ull, Rolf Warta, Christine Jungk, Saskia Roesch, Andreas Mock, Felix Sahm, Melissa Schmidt, Gerhard Jungwirth, Klaus Zweckberger, Katrin Lamszus, Konstaninos Gousias, Almuth F Kessler, Niels Grabe, Mario Löhr, Ralf Ketter, Steffi Urbschat, Christian Senft, Manfred Westphal, Amir Abdollahi, Jürgen Debus, Andreas von Deimling, Andreas Unterberg, Matthias Simon and Christel C Herold-Mende

Clinical Cancer Research (AACR) Germany, 21 June 2019

Immunology, Oncology

Key words:Clinically aggressive meningioma, T-cell infiltration, primary and recurrent tumors TILs, PD-1

Organism: Human

Tissue: Brain

Pathological State: Cancer

19
Differential expression of Plg-RKT and its effects on migration of proinflammatory monocyte and macrophage subsets

Barbara Thaler, Nagyung Baik, Philipp J. Hohensinner, Johanna Baumgartner, Adelheid Panzenböck, Stefan Stojkovic, Svitlana Demyanets, Ihor Huk, Gersina Rega-Kaun, Christoph Kaun, Manfred Prager, Michael B. Fischer, Kurt Huber, Walter S. Speidl, Robert J. Parmer, Lindsey A. Miles, Johann Wojta

Blood (American Society of Hematology) Austria, USA, 20 June 2019

20
Specific inhibition of the classical complement pathway prevents C3 deposition along the dermal-epidermal junction in bullous pemphigoid

Patricia Colchete Freire, Cristina Herraez Muñoz, Ulla Derhaschnig, Christian Schoergenhofer, Christa Firbas, Graham C. Parry, Sandip Panicker, James C. Gilbert, Georg Stingl, Bernd Jilma, Peter Maximilian Heil

Journal of Investigative Dermatology (Elsevier) Austria, USA, 20 June 2019

Dermatology

21
Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis

C Yang, P Sun, M Deng, P Loughran, W Li, Z Yi, S Li, XH Zhang, J Fan, TR Billar, MJ Scott

Cell Death & Disease (Nature) USA, China, 17 June 2019

Hepathology

Key words:Cell death and immune response, Innate immunity

Organism: Mouse

Tissue: Liver

Pathological State: Liver Injury

22
C/EBPβ-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice

Tobias Ackermann, Götz Hartleben, Christine Müller, Guido Mastrobuoni, Marco Groth, Britt A. Sterken, Mohamad A. Zaini, Sameh A. Youssef, Hidde R. Zuidhof, Sara R. Krauss, Gertrud Kortman, Gerald de Haan, Alain de Bruin, Zhao-Qi Wang, Matthias Platzer, Stefan Kempa & Cornelis F. Calkhoven

Communications Biology (Nature) The Netherlands, Germany, 14 June 2019

Oncology

Key words:Cancer metabolism, Cell growth

Organism: Mouse

Tissue: Bone Marrow

23
Fc glycan-mediated regulation of placental antibody transfer

Madeleine F. Jennewein, Ilona Goldfarb, Sepideh Dolatshahi, Cormac Cosgrove, Francesca J. Noelette, Marina Krykbaeva, Jishnu Das, Aniruddh Sarkar, Matthew J. Gorman, Stephanie Fischinger, Carolyn M. Boudreau, Joelle Brown, Jennifer H. Cooperrider, Jasneet Aneja, Todd J. Suscovich, Barney S. Graham, Georg M. Lauer, Tessa Goetghebuer, Arnaud Marchant, Douglas Lauffenburger, Arthur Y. Kim, Laura E. Riley, Galit Alter

Cell (Cell Press) USA, Belgium, 13 June 2019

Reproductive Medicine, Immunology

Key words:antibody functionality, antibody glycosylation, trans-placental transfer, maternal vaccination, ADCC, neonatal immunology

Organism: Human

Tissue: Placenta

24
The PPARγ Agonist Rosiglitazone Suppresses Syngeneic Mouse SCC (Squamous Cell Carcinoma) Tumor Growth through an Immune-Mediated Mechanism

RL Konger, E Derr-Yellin, N Ermatov, L Ren, RP Sahu

Molecules (MDPI) USA, 11 June 2019

Oncology, Immunology

Key words:peroxisome proliferator activated receptor gamma; rosiglitazone; T-cells; myeloid cells; anti-tumor immunity

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

25
Optimisation of multiplex immunofluorescence for a non-spectral fluorescence scanning system

CC Anyaegbu, TF Lee-Pullen, TJ Miller, TN Abel, CF Platell, MJ McCoy

Journal of Immunological Methods (Elsevier) Australia, 08 June 2019

Medical Imaging

Key words:Fluorescence microscopy, Imaging, Immunohistochemistry, T cells, Colorectal

Organism: Human

Tissue: Colon

26
Role of the PI3K‑mTOR autophagy pathway in nerve damage in rats with intermittent hypoxia‑aggravated whole brain ischemia

X Guo, Y Liu, Y Zhao, R Fan, Y Bai, X Guo, J Li, CX Chen

Molecular Medicine Reports (Spandidos Publications) China, 04 June 2019

Neuroscience

Organism: Rats

Tissue: Brain

Pathological State: Ischemia

27
Heat-killed Mycobacterium tuberculosis prime-boost vaccination induces myeloid-derived suppressor cells with spleen dendritic cell-killing capability

Eliana Ribechini, Ina Eckert, Andreas Beilhack, Nelita Du Plessis, Gerhard Walzl, Ulrike Schleicher, Uwe Ritter, and Manfred B. Lutz

The Journal of Clinical Investigation (American Society for Clinical Investigation) Germany, South Africa, 04 June 2019

Immunology

Organism: Mouse

Cell Line: BM-MDSCs and BM-DCs cell

28
Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

Yueming Zhu, Xianghui Zou, Angela E. Dean, Joseph O’ Brien, Yucheng Gao, Elizabeth L. Tran, Seong-Hoon Park, Guoxiang Liu, Matthew B. Kieffer, Haiyan Jiang, Melissa E. Stauffer, Robert Hart, Songhua Quan, Karla J. F. Satchell, Nobuo Horikoshi, Marcelo Bonini, David Gius

Nature Communications (Nature) USA, South Korea, 03 June 2019

Oncology

Key words:Breast cancer, Cancer, Enzyme mechanisms

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

29
Abnormal expression of b10 cell frequencies: possible relation to pathogenesis and disease severity of aplastic anemia

L Gu, B Fu, X Sui, H Xu

Revista da Associação Médica Brasileira (SciELO Brasil) China, 03 June 2019

Hematology

Key words:Anemia, Aplastic; B-Lymphocytes, Regulatory; Interleukin-10

Organism: Human

Cell Line: Bone marrow-derived mononuclear cells

30
Micro RNA‐133 Suppresses ZFHX 3‐dependent Atrial Remodeling and Arrhythmia

WL Cheng, YH Kao, TF Chao, YK Lin, SA Chen, YJ Chen

Acta Physiologica (Wiley) Taiwan, 01 June 2019

Cardiology

Key words:atrial ectopy, cardiac remodelling, connexin43, MicroRNA‐133, Wnt/calcium signalling, ZFHX3

Organism: Mouse

Tissue: Heart

Pathological State: Arrhythmia

31
AIF-regulated oxidative phosphorylation supports lung cancer development

Shuan Rao, Laura Mondragón, Blanka Pranjic, Toshikatsu Hanada, Gautier Stoll, Thomas Köcher, Peng Zhang, Alexander Jais, Alexander Lercher, Andreas Bergthaler, Daniel Schramek, Katharina Haigh, Valentina Sica, Marion Leduc, Nazanine Modjtahedi, Tsung-Pin Pai, Masahiro Onji, Iris Uribesalgo, Reiko Hanada, Ivona Kozieradzki, Rubina Koglgruber, Shane J. Cronin, Zhigang She, Franz Quehenberger, Helmut Popper, Lukas Kenner, Jody J. Haigh, Oliver Kepp, Malgorzata Rak, Kaican Cai, Guido Kroemer & Josef M. Penninger

Cell Research (Nature) China, Austria, France, Germany, Canada, Belgium, Sweden, 27 May 2019

Oncology

Key words:Mechanisms of disease, Non-small-cell lung cancer

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

32
Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

H Tsugawa, C Kato, H Mori, J Matsuzaki…

Cellular and molecular … (Elsevier) Japan, 27 May 2019

Oncology, Microbiology

Key words:Autophagy, CagA, Cancer Stem Cells, CD44v9, Eradication Therapy

Organism: Human

Tissue: Stomach

Pathological State: Cancer

33
LINGO-1 deficiency promotes nerve regeneration through reduction of cell apoptosis, inflammation, and glial scar after spinal cord injury in mice

LJ Huang, G Li, Y Ding, JH Sun, TT Wu, W Zhao, YS Zeng

Experimental Neurology (Elsevier) China, 25 May 2019

Neuroscience

Key words:LINGO-1 knockout, Spinal cord injury, Cell apoptosis, Inflammation, Glial scar, Nerve regeneration

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

34
Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

Matthew K.Tobin, Kianna Musaraca, Ahmed Disouky, Aashutosh Shetti, Abdullah Bheri, William G.Honer, Namhee Kim, Robert J. Dawe, David A. Bennett, Konstantinos Arfanakis, Orly Lazarov

Cell Stem Cell (Cell Press) USA, 23 May 2019

Neuroscience

Key words:human neurogenesis, adult neurogenesis, neural stem cells, neurogenesis in aging, cognitive dysfunction, aging, Alzheimer’s disease

Organism: Human

Tissue: Brain

Pathological State: Alzheimer's Disease

35
Near-Infrared Fluorescent Endoscopic Image-guided Photothermal Ablation Therapy of Colorectal Cancer using Dual-modal Gold Nanorods Targeting Tumor Infiltrating Innate Immune Cells in Transgenic TS4 CRE/APCloxΔ468 Mouse Model

Elias Gournaris, Wooram Park, Soojeong Cho, David J Bentrem, Andrew C. Larson, Dong-Hyun Kim

Applied Materials and Interfaces (ACS Publications) USA, 22 May 2019

Oncology

Key words:colon cancer, endoscopic image-guided therapy, nanomedicine, interventional oncology, photothermal therapy

Organism: Mouse

Tissue: Colon

Pathological State: Polyps

36
High Activation Of STAT5A Drives Peripheral T-Cell Lymphoma And Leukemia

Barbara Maurer, Harini Nivarthi, Bettina Wingelhofer, Ha Thi Than Pham, Michaela Schlederer, Tobias Suske, Reinhard Grausenburger, Ana-Iris Schiefer, Michaela Prchal-Murphy, Doris Chen, Susanne Winkler, Olaf Merkel, Christoph Kornauth, Maximilian Hofbauer, Birgit Hochgatterer, Gregor Hoermann, Andrea Hoelbl-Kovacic, Jana Prochazkova, Cosimo Lobello, Abbarna A. Cumaraswamy, Johanna Latzka, Melitta Kitzwögerer, Andreas Chott, Andrea Janikova, Šárka Pospíšilova, Joanna I. Loizou, Stefan Kubicek, Peter Valent, Thomas Kolbe, Florian Grebien, Lukas Kenner, Patrick T. Gunning, Robert Kralovics, Marco Herling, Mathias Müller, Thomas Rülicke, Veronika Sexl, Richard Moriggl

Haematologica (The Ferrata Sorti Foundation) Austria, Czech Republic, Germany, Canada, 21 May 2019

Oncology

Key words:Hematopoiesis, Lymphocytes, Lymphoproliferative Disorders, PTCLSTAT5

Organism: Mouse

Tissue: Lymphoid Tissue

Pathological State: Cancer

37
The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury

Barbora Svobodova, Anna Kloudova, Jiri Ruzicka, Ludmila Kajtmanova, Leos Navratil, Radek Sedlacek, Tomas Suchy, Meena Jhanwar-Uniyal, Pavla Jendelova & Lucia Machova Urdzikova

Scientific Reports (Nature) Czech Republic, USA, 21 May 2019

Regenerative Medicine

Key words:Spinal cord diseases, Spinal cord injury

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

38
Growth and cellular patterning during fetal human inner ear development studied by a correlative imaging approach

Lejo Johnson Chacko, David Wertjanz, Consolato Sergi, Jozsef Dudas, Natalie Fischer, Theresa Eberharter, Romed Hoermann, Rudolf Glueckert, Helga Fritsch, Helge Rask-Andersen, Anneliese Schrott-Fischer and Stephan Handschuh

BMC Developmental Biology (Springer) Austria, 20 May 2019

Developmental Biology

Organism: Human

Tissue: Bone

39
Nano-formulated Curcumin (LipodisqTM) modulates the local inflammatory response, reduces glial scar and preserves the white matter after spinal cord injury in rats

P Krupa, B Svobodova, J Dubisova, S Kubinova, P Jendelova, L Machova Urdzikova

Neuropharmacology (Elsevier) Czech Republic, 17 May 2019

Nanomedicine

Key words:Spinal cord injury, Nanocurcumin, Inflammatory response, Neuroregeneration, Astrogliosis, Axonal growth

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

40
Amentoflavone Effectively Blocked the Tumor Progression of Glioblastoma via Suppression of ERK/NF-B Signaling Pathway

FT Hsu, IT Chiang, YC Kuo, TC Hsia, CC Lin, YC Liu, JG Chung

The American Journal of Chinese Medicine (World Scientific) Taiwan, 17 May 2019

Oncology

Key words:Amentoflavone, Glioblastoma, Anticancer, ERK, NF-κB

Organism: Mouse

Tissue: Xenograft Tumor, Liver

Pathological State: Cancer

41
Potential Effects of CXCL9 and CCL20 on Cardiac Fibrosis in Patients with Myocardial Infarction and Isoproterenol-Treated Rats

CF Lin, CJ Su, JH Liu, ST Chen, HL Huang, SL Pan

Journal of Clinical Medicine (MDPI) Taiwan, 11 May 2019

Cardiology

Key words:myocardial infarction; cardiac fibrosis; CXCL9; CCL20; isoproterenol

Organism: Rat

Tissue: Heart

Pathological State: Cardiac Fibrosis

42
In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field

PW Nagle, MJ van Goethem, M Kempers, H Kiewit, A Knopf, JA Langendijk, S Brandenburg, P van Luijk, RP Coppes

Radiotherapy and Oncology (Elsevier) The Netherlands, 11 May 2019

Oncology

Key words:Protons, MRI, Tumor, Normal tissue, Organoids

Organism: Human

Cell Line: Human embryonic kidney cells (HEK293) and human lung adenocarcinoma cells (A549)

43
Effects of Hydroxychloroquine on the Human Placenta–Findings from In Vitro Experimental Data and a Systematic Review

RE Scott, SL Greenwood, DJL Hayes, BC Baker, RL Jones, AEP Heazell

Reproductive Toxicology (Elsevier) UK, 10 May 2019

Reproductive Medicine

Key words:Hydroxychloroquine, Placenta, TLRs, TLR 7, TLR 9, Inflammation, Toxicology, Safety, Pregnancy, SLEAPS

Organism: Human

Tissue: Placenta

44
Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

Kimberly M. Cirelli, Diane G. Carnathan, Bartek Nogal, Jacob T. Martin, Oscar L. Rodriguez, Amit A. Upadhyay, Chiamaka A. Enemuo, Etse H. Gebru, Yury Choe, Federico Viviano, Catherine Nakao, Matthias G. Pauthner, Samantha Reiss, Christopher A. Cottrell, Melissa L. Smith, Raiza Bastidas, William Gibson, Amber N. Wolabaugh, Mariane B. Melo, Benjamin Cossette, Venkatesh Kumar, Nirav B. Patel, Talar Tokatlian, Sergey Menis, Daniel W. Kulp, Dennis R. Burton, Ben Murrell, William R. Schief, Steven E. Bosinger, Andrew B. Ward, Corey T. Watson, Guido Silvestri, Darrell J. Irvine, Shane Crotty

Cell (Cell Press) USA, Sweden, 09 May 2019

Immunology

Key words:HIV vaccine, non-human primates, rhesus macaque genome, FNA, GC- TFH, memory B cells, somatic hypermutation, affinity maturation, immune complexes

Organism: Mouse

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

45
Multimodal [18F]FDG PET/CT is a direct readout for inflammatory bone repair: a longitudinal study in TNFα transgenic mice

Silvia Hayer, Markus Zeilinger, Volker Weiss , Monika Dumanic , Markus Seibt , Birgit Niederreiter ,Tetyana Shvets , Florian Pichler ,Wolfgang Wadsak , Bruno K. Podesser, Thomas H. Helbich, Marcus Hacker, Josef S. Smolen, Kurt Redlich , Markus Mitterhauser

Journal of Bone and Mineral Research (Wiley) Austria, 07 May 2019

Osteology

Key words:µPET/CT, 18F‐FDG, 18F‐NaF, bone healing, experimental arthritis, TNF blockade

Organism: Human

Tissue: Joint

46
Directional Topography Influences Adipose Mesenchymal Stromal Cell Plasticity: Prospects for Tissue Engineering and Fibrosis

GR Liguori, Q Zhou, TTA Liguori, GG Barros, PT Kühn, LF Moreira, P van Rijn, MC Harmsen

Stem Cells International (Hindawi Publishing Corporation) The Netherlands, Brazil, China, 05 May 2019

Stem Cell Research

Organism: Human

Cell Line: Adipose tissue derived stromal cells (ADSC)

47
Endoplasmic reticulum stress is involved in stress-induced hypothalamic neuronal injury in rats via the PERK-ATF4-CHOP and IRE1-ASK1-JNK pathways

S Yi, K Chen, L Zhang, W Shi, Y Zhang, S Niu, M Jia, B Cong, Y Li

Frontiers in cellular Neuroscience (Frontiers Media S.A.) China, 03 May 2019

Neuroscience

Key words:hypothalamus, stress, neuronal injury, PERK-ATF4-CHOP pathway, IRE1-ASK1-JNK pathway

Organism: Rat

Tissue: Brain

Pathological State: Stress-Induced Hypothalamic Neuronal Injury

48
Positive PD‑L1 expression is predictive for patients with advanced EGFR wild‑type non‑small cell lung cancer treated with gemcitabine and cisplatin

Y Qiu, J Jiang, M Zhang, Y Qin

Oncology Letters (Spandidos Publications) China, 02 May 2019

Oncology

Key words:programmed death ligand-1, checkpoint, immunotherapy, non-small cell lung cancer, prognosis

Organism: Human

Tissue: Lung

Pathological State: Cancer

49
Exosomal transfer of bone marrow mesenchymal stem cells-derived miR340 attenuates endometrial fibrosis

B Xiao, Y Zhu, J Huang, T Wang, F Wang, S Sun

Biology Open (The Company of Biologists) China, 01 May 2019

Stem Cell Research

Organism: Rat

Tissue: Uterus

Pathological State: Endometriosis

50
An improved method of culturing somatotropic cells from rat adenohypophysis

J Mao, Y Bao, F Mei, X Liao, F Liu, L Zhou, B Qiu, S Qi

Tissue and Cell (Elsevier) China, 30 April 2019

Biological Methods

Key words:Pericytes, Improved method, Primary culture, Somatotropic cells

Organism: Rat

Cell Line: Pericytes

51
Promyelocytic leukemia zinc finger is involved in the formation of deep layer cortical neurons

HC Lin, YH Ching, CC Huang, PC Pao, WC Chang, TJ Kao, YC Lee

Journal of Biomedical Science (Springer) Taiwan, 26 April 2019

Neuroscience

Key words:Promyelocytic leukemia zinc finger, Plzf, luxoid mice, Cortical neuron

Organism: Mouse

Tissue: Brain

52
Exercise Alleviates Osteoporosis in Rats with Mild Chronic Kidney Disease by Decreasing Sclerostin Production

HW Liao, TH Huang, YH Chang, HH Liou, YH Chou, YM Sue, PH Hung, YT Chang, PC Ho, KJ Tsai

International Journal of Molecular Sciences (MDPI) Taiwan, 25 April 2019

Osteology, Nephrology

Key words:exercise; chronic kidney disease; osteoporosis; sclerostin; chronic kidney disease–mineral bone disorder

Organism: Rat

Tissue: Bone

Pathological State: Kidney Disease

53
Th2-TRMs maintain life-long allergic memory in experimental asthma in mice

B Bosnjak, S Kazemi, LM Altenburger, G Mokrovic, MM Epstein

Frontiers in Immunology (Frontiers Media S.A.) Austria, 24 April 2019

Immunology

Organism: Mouse

Tissue: Lung

Pathological State: Asthma

54
YWHAE promotes proliferation, metastasis, and chemoresistance in breast cancer cells

YF Yang, YC Lee, YY Wang, CH Wang, MF Hou, SS Yuan

Kaohsiung journal of Medical Sciences (Wiley) Taiwan, 18 April 2019

Oncology

Key words:14‐3‐3ε, breast cancer, chemoresistance, YWHAE

Organism: Human

Tissue: Breast

Pathological State: Cancer

55
Toll‑like receptor 4 plays a tumor‑suppressive role in cutaneous squamous cell carcinoma

Erina Mikami, Mitsuhiro Kudo, Ryuji Ohashi, Kiyoko Kawahara, Yoko Kawamoto, Kiyoshi Teduka, Takenori Fujii, Taeko Kitamura, Shoko Kure, Kousuke Ishino, Takashi Sakatani, Ryuichi Wada, Hidehisa Saeki, Zenya Naito

International Journal of Oncology (Spandidos Publications) Japan, 17 April 2019

56
Functional CD3+ CD8+ PD-1-T cells accumulation and PD-L1 expression increases during tumor invasion in DCIS of the breast

S Lv, S Wang, G Qiao, X Wang, X Zhou, F Yan, Y Li, S Wang, MA Morse, A Hobeika, J Ren, HK Lyerly

Clinical Breast Cancer (Elsevier) China, USA, 16 April 2019

Oncology

Key words:DCIS, Opal technique PDl-1, PD-1, immune, microenvironment

Organism: Human

Tissue: Breast

Pathological State: Cancer

57
Low cd8+ t cell infiltration and high pd-l1 expression are associated with level of cd44+/cd133+ cancer stem cells and predict an unfavorable prognosis in pancreatic …

YC Hou, YJ Chao, MH Hsieh, HL Tung, HC Wang, YS Shan

Cancers (MDPI) Taiwan, 15 April 2019

Oncology

Key words:pancreatic cancer; T cells; cancer stem cells; CD8; PD-L1; CD44; CD133; immunotherapy

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

58
Metastatic Colorectal Cancer Rewrites Metabolic Program Through a Glut3-YAP-dependent Signaling Circuit

CC Kuo, HH Ling, MC Chiang, CH Chung, WY Lee, CY Chu, YC Wu, CH Chen, YW Lai, IL Tsai, CH Cheng, CW Lin

Theranostics (Ivyspring) Taiwan, 13 April 2019

Oncology

Key words:cancer metabolism, colorectal cancer, glucose transporter, metastasis, YAP

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

59
Interrelations of Sphingolipid and Lysophosphatidate Signaling With Immune System in Ovarian Cancer

Anastasia Meshcheryakova, Martin Svoboda, Markus Jaritz, Felicitas Mungenast, Martina Salzmann, Dietmar Pils, Dan Cacsire Castillo-Tong, Gudrun Hager, Andrea Wolf, Elena Ioana Braicu, Jalid Sehouli, Sandrina Lambrechts, Ignace Vergote, Sven Mahner, Peter Birner, Philip Zimmermann, David N. Brindley, Georg Heinze, Robert Zeillinger, Diana Mechtcheriakova

Computational and Structural Biotechnology Journal (Elsevier) Austria, Germany, Belgium, Switzerland, Canada, 10 April 2019

Oncology

Key words:Sphingolipid/lysophosphatidate system, On-site immune response, Patient-specific expression data sets, Integrative analysis algorithm, Patient stratification, From systems biology to systems medicine

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

60
Au Nanoparticles with Enzyme-Mimicking Activities Ornamented ZIF-8 for Highly Efficient Photodynamic Therapy

Y Ma, Y Zhu, XF Tang, L Hang, W Jiang, M Li, M Khan, YZ You, YC Wang

Biomaterials Science (Royal Society of Chemistry) China, 04 April 2019

Nanomedicine

Key words:AuNPs nanozyme, nano metal-organic frameworks, tumor hypoxia, photodynamic therapy

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

61
Associations between hepatitis etiology and immune cell infiltration in or around hepatocellular carcinoma

Yu-Yun Shao, Min-Shu Hsieh, Yun-Ting Tsai, Ying-Chun Shen, Zhong-Zhe Lin, Ann-Lii Cheng, Chih-Hung Hsu

Cancer Research (AACR) USA, 03 April 2019

Oncology, Virology

Organism: Human

Tissue: Liver

Pathological State: Cancer

62
Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells

Miroslav Boudny, Jana Zemanova, Prashant Khirsariya, Marek Borsky, Jan Verner, Jana Cerna, Alexandra Oltova, Vaclav Seda, Marek Mraz, Josef Jaros, Zuzana Jaskova, Michaela Spunarova, Yvona Brychtova, Karel Soucek, Stanislav Drapela, Marie Kasparkova, Jiri Mayer, Kamil Paruch, Martin Trbusek

Haematologica (Ferrata Storti Foundation) Czech Republic, 01 April 2019

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

63
The sodium–glucose co-transporter 2 inhibitor empagliflozin attenuates cardiac fibrosis and improves ventricular hemodynamics in hypertensive heart failure …

Hsiang-Chun Lee, Yi-Lin Shiou, Shih-Jie Jhuo, Chia-Yuan Chang, Po-Len Liu, Wun-Jyun Jhuang, Zen-Kong Dai, Wei-Yu Chen, Yun-Fang Chen and An-Sheng Lee

Cardiovascular Diabetology (Springer) Taiwan, 01 April 2019

Cardiology

Key words:SGLT2 inhibitor Empagliflozin Hypertensive Heart failure Cardiac fibrosis Hemodynamics High-fat PPARα ACADM

Organism: Rat

Tissue: Heart

Pathological State: Fibrosis

64
Antrodia cinnamomea induces anti-tumor activity by inhibiting the STAT3 signaling pathway in lung cancer cells

TT Huang, YW Lan, CM Chen, YF Ko, DM Ojcius, J Martel, JD Young, KY Chong

Scientific Reports (Nature) Taiwan, USA, Malaysia, 26 March 2019

Oncology

Key words:Drug development, Lung cancer

Organism: Mouse

Tissue: Lung

65
PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastoma

Yong Jae Shin, Jason K. Sa, Yeri Lee, Donggeon Kim, Nakho Chang, Hee Jin Cho, Miseol Son, Michael Y.T. Oh, Kayoung Shin, Jin-Ku Lee, Jiwon Park, Yoon Kyung Jo, Misuk Kim, Patrick J. Paddison, Vinay Tergaonkar, Jeongwu Lee , Do-Hyun Nam

Journal of Experimental Medicine (Rockefeller University Press) South Korea, China, USA, 21 March 2019

Oncology, Cell Biology

Key words:Solid Tumors, Neuroscience

Organism: Human

Tissue: Brain

Pathological State: Cancer

66
Designing pH-Triggered Drug Release Iron Oxide Nanocomposites for MRI Guided Photothermal-Chemoembolization Therapy of Liver Orthotopic Cancer

F Liu, X Li, Y Li, Y Qi, H Yuan, J He, W Li, M Zhou

Biomaterials Science (Royal Society of Chemistry) China, 19 March 2019

Nanomedicine

Key words:pH-Triggered Drug Release, Iron Oxide Nanocomposites, MRI, Photothermal-Chemoembolization Therapy, Liver Orthotopic Cancer

Organism: Rat

Tissue: Liver

Pathological State: Cancer

67
γδT cells suppress liver fibrosis via strong cytolysis and enhanced NK cell-mediated cytotoxicity against hepatic stellate cells

M Liu, Y Hu, Y Yuan, Z Tian, C Zhang

Frontiers in Immunology (Frontiers Media S.A.) China, Germany, Belgium, USA, 15 March 2019

Immunology

Key words:fibrosis, γδT cell, NKp46, cytotoxicity, γδT1, γδT17, CD137, cell crosstalk

Organism: Mouse

Tissue: Liver

Pathological State: Fibrosis

68
Traffic-related particulate matter exposure induces nephrotoxicity in vitro and in vivo

YH Hsu, HC Chuang, YH Lee, YF Lin, YJ Chen, TC Hsiao, MY Wu, HW Chiu

Free Radical Biology and Medicine (Elsevier) Taiwan, 14 March 2019

Toxicology

Key words:Nephrotoxicity, Autophagy, Apoptosis, Endoplasmic reticulum stress

Organism: Rat

Tissue: Kidney

69
ErbB3 Ligand Heregulin1 Is a Major Mitogenic Factor for Uncontrolled Lung Cancer Cell Proliferation

S Ma, S Jia, Y Ren, B Cao, X Zha, J He, C Chen

Neoplasia (Elsevier) China, 02 March 2019

Oncology

Key words:ErbB3 , Heregulin1, Lung Cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

70
Sulfasalazine could modulate the CD44v9‐xCT system and enhance cisplatin‐induced cytotoxic effects in metastatic bladder cancer

Koichiro Ogihara, Eiji Kikuchi, Shogo Okazaki, Masayuki Hagiwara,1 Toshikazu Takeda, Kazuhiro Matsumoto, Takeo Kosaka, Shuji Mikami, Hideyuki Saya, and Mototsugu Oya

Cancer Science (NCBI) Japan, 01 March 2019

Oncology

Key words:bladder cancer, CD44v9, cisplatin, metastasis, sulfasalazine

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

71
High-risk human papillomavirus oncogenes disrupt the Fanconi anemia DNA repair pathway by impairing localization and de-ubiquitination of FancD2

S Khanal, DA Galloway

PLoS Pathogens (PLOS) USA, 28 February 2019

Virology

Key words:Immunoblotting, Oncogenes, DNA repair, Phosphorylation, Human papillomavirus, HPV-16, Cell signaling, Small interfering RNAs

Organism: Human

Pathological State: Virus Infection

Cell Line: Primary human foreskin keratinocytes (HFKs)

72
Expression of the neonatal Fc-receptor in placental-fetal endothelium and in cells of the placental immune system

T Kiskova, Y Mytsko, M Schepelmann, H Helmer, R Fuchs, M Heidi, C Wadsack, I Ellinger

Placenta (Elsevier) Austria, 28 February 2019

Reproductive Medicine

Key words:Human placenta, FcRn, syncytiotrophoblast, placental-fetal endothelial cells, placental macrophages, IgG transport

Organism: Human

Tissue: Placenta

73
Ligase 3–mediated end-joining maintains genome stability of human embryonic stem cells

Aneta Kohutova, Jan Raška, Miriama Kruta, Monika Seneklova, Tomas Barta, Petr Fojtik, Tereza Jurakova, Christi A. Walter, Ales Hampl, Petr Dvorak, and Vladimir Rotrekl

The FASEB Journal (FASEB) Czech Republic, USA, 26 February 2019

Stem Cell Research

Key words:base excision repair, PARP1, 53BP1, pluripotent stem cells, alternative DNA end-joining

Organism: Human

Cell Line: Human embryonic stem cells

74
Metabolic cross-talk between human bronchial epithelial cells and internalized Staphylococcus aureus as a driver for infection

Laura M. Palma Medina, Ann-Kristin Becker, Stephan Michalik, Harita Yedavally, Elisa J.M. Raineri, Petra Hildebrandt, Manuela Gesell Salazar, Kristin Surmann, Henrike Pförtner, Solomon A. Mekonnen, Anna Salvati, Lars Kaderali, Jan Maarten van Dijl and Uwe Völker

Molecular and Cellular Proteomics (American Society for Biochemistry and Molecular Biology) Germany, The Netherlands,, 26 February 2019

Immunology

Key words:Staphylococcus aureus, in vivo proteomics, population heterogeneity, persister, bronchial epithelial cells, Apoptosis*, Autophagy Bacteria, Energy metabolism, Host-Pathogen Interaction, Infectious disease

Organism: Human

Pathological State: Bacterial Infection

Cell Line: Bronchial epithelial cells

75
Higher CXCL16 exodomain is associated with aggressive ovarian cancer and promotes the disease by CXCR6 activation and MMP modulation

H Mir, G Kaur, N Kapur, S Bae, JW Lillard, S Singh

Scientific Reports (Nature) USA, 21 February 2019

Oncology

Key words:Cancer, Ovarian cancer

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

76
State-of-the-Art of Profiling Immune Contexture in the Era of Multiplexed Staining and Digital Analysis to Study Paraffin Tumor Tissues

ER Parra, A Francisco-Cruz, II Wistuba

Cancers (MDPI) USA, 20 February 2019

Medical Image Analysis

Key words:immune profiling; cancer tissues; multiplexed methodologies; image analysis; spatial analysis

77
Long noncoding RNA AOC4P regulates tumor cell proliferation and invasion by epithelial–mesenchymal transition in gastric cancer

K Zhang, C Lu, X Huang, J Cui, J Li, Y Gao, W Liang, Y Liu, Y Sun, H Liu, B Wei, L Chen

Therapeutic Advances In Gastroenterology (SAGE Journals) China, 19 February 2019

Oncology

Key words:AOC4P, long noncoding RNAs, metastasis, prognosis, stomach neoplasm

Organism: Human

Tissue: Stomach

Pathological State: Cancer

78
B-type natriuretic peptide enhances fibrotic effects via matrix metalloproteinase-2 expression in the mouse atrium in vivo and in human atrial myofibroblasts in vitro

YT Tsai, FY Lin, CS Lin, SH Loh, CY Li, CY Lin, YW Lin, CS Tsai

Translational Research (Elsevier) Taiwan, 19 February 2019

Cardiology

Key words:B-type natriuretic peptide; atrial fibrillation; matrix metalloproteinase

Organism: Mouse

Tissue: Heart

79
SOX17 overexpression sensitizes chemoradiation response in esophageal cancer by transcriptional down-regulation of DNA repair and damage response …

I-Ying Kuo, Yu-Lin Huang, Chien-Yu Lin, Chien-Hsun Lin, Wei-Lun Chang, Wu-Wei Lai and Yi-Ching Wang

Journal of Biological Methods (Springer) Taiwan, 18 February 2019

Oncology

Key words:SOX17, Transcription regulation, Resistance, DNA repair, Concurrent chemoradiation therapy, Esophageal cancer

Organism: Human, Mouse

Tissue: Colon, Xenograft Tumor

Pathological State: Cancer

80
Ultralong circulating choline phosphate liposomal nanomedicines for cascaded chemo-radiotherapy

X Li, Y Zhao, W Jiang, S Li, M Zhan, H Liu, C Zhang, H Liang, H Liu, L Lu, Y Wang

Biomaterials Science (Royal Society of Chemistry) China, 14 February 2019

Nanomedicine

Key words:Cascaded chemo-radiotherapy, hypoxia-activated therapy, tumor hypoxia, ultralong circulating liposome

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

81
The Accumulation and Effects of Liposomal Doxorubicin in Tissues Treated by Radiofrequency Ablation and Irreversible Electroporation in Liver: In Vivo Experimental …

T Andrašina, J Jaroš, T Jůza, T Rohan, D Červinka, M Crha, V Válek, NS Goldberg

Cardiovascular and Interventional Radiology (Springer) Czech Republic, Israel, 13 February 2019

Hepathology

Key words:Liposomal doxorubicin, Radiofrequency ablation, Irreversible electroporation

Organism: Pig

Tissue: Liver

82
Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma

Jing Liu, Wenna Jiang, Kaili Zhao, Hongwei Wang, Tianxing Zhou, Weiwei Bai, Xiuchao Wang, Tiansuo Zhao, Chongbiao Huang, Song Gao, Tai Qin, Wenwen Yu, Bo Yang, Xin Li, Danqi Fu, Wei Tan, Shengyu Yang, He Ren, Jihui Hao

Journal of Experimental Medicine (Rockefeller University Press) China, USA, 07 February 2019

Oncology

Key words:EHF, anti-PD1 therapy, adenocarcinoma, pancreas

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

83
Multimodal imaging guides surgical management in a preclinical spinal implant infection model

Stephen D. Zoller, Howard Y. Park, Tove Olafsen, Charles Zamilpa, Zachary D.C. Burke, Gideon Blumstein, William L. Sheppard, Christopher D. Hamad, Kellyn R. Hori, Jen-Chieh Tseng, Julie Czupryna, Craig McMannus, Jason T. Lee, Mafalda Bispo, Francisco Romero Pastrana, Elisa J.M. Raineri, Jeffery F. Miller, Lloyd S. Miller, Jan Maarten van Dijl, Kevin P. Francis, Nicholas M. Bernthal

The Journal of Clinical Investigation (American Society of Clinical Investigation) USA, The Netherlands, 07 February 2019

Osteology

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spine implant infection

84
Fluorine-Modified Rutaecarpine Exerts Cyclooxygenase-2 Inhibition and Anti-inflammatory Effects in Lungs

CM Lee, JH Liao, SH Chen, CH Yen, YC Lee, S Huang, S Huang, C Lin, VH Chang

Frontiers in Pharmacology (Frontiers Media S.A.) Taiwan, 07 February 2019

Pulmonology

Key words:Fluorine, Rutaecarpine, Cyclooxygenase-2 , Anti-inflammatory Effects

Organism: Mouse

Tissue: Whole Organism

85
Generation of human iPSCs from fetal prostate fibroblasts HPrF

Zuzana Kahounová, Eva Slabáková, Lucia Binó, Ján Remšík, Radek Fedr, Jan Bouchal, Radek Vrtěl, Lucie Jurečková, Volodymyr Porokh, Darja Páralová, Aleš Hampl, Karel Souček

Stem Cell Research (Elsevier) Czech Republic, 07 February 2019

Stem Cell Research

Key words:induced stem cells, iPSCs, prostate fibroblasts, HPrF

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

86
Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade

Chien-Chun Steven Pai, John T. Huang, Xiaoqing Lu, Donald M. Simons, Chanhyuk Park, Anthony Chang, Whitney Tamaki, Eric Liu, Kole T. Roybal, Jane Seagal, Mingyi Chen, Katsunobu Hagihara, Xiao X. Wei, Michel DuPage, Serena S. Kwek, David Y. Oh, Adil Daud, Katy K. Tsai, Clint Wu, Li Zhang, Marcella Fasso, Ravi Sachidanandam, Anitha Jayaprakash, Ingrid Lin, Amy-Jo Casbon, Gillian A. Kinsbury, Lawrence Fong

Immunity (Cell Press) USA, 05 February 2019

Oncology

Key words:cancer immunotherapy IFN-γ activation-induced cell death anti-CTLA-4 anti-PD-1

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

87
EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke

Anne-Sophie Ernst, Laura-Inés Böhler, Anna M. Hagenston, Angelika Hoffmann, Sabine Heiland, Carsten Sticht, Martin Bendszus, Markus Hecker, Hilmar Bading, Hugo H. Marti1, Thomas Korff and Reiner Kunze

Acta Neuropathologica (Springer) Germany, 05 February 2019

Neuroscience

Key words:EphB2, Ephrin-B2, Excitotoxicity, Inflammation, Ischemic stroke, NMDA

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

88
HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis

Björn Corleis, Allison N. Bucsan, Maud Deruaz, Vladimir D. Vrbanac, Antonella C. Lisanti-Park, Samantha J. Gates, Alice H. Linder, Jeffrey M. Paer, Gregory S. Olson, Brittany A. Bowman, Abigail E.S chiff, Benjamin D. Medoff, Andrew M.Tager, Andrew D. Luster, Shabaana A. Khader, Deepak Kaushal, Douglas S. Kwon

Cell Reports (Cell Press) USA, 05 February 2019

Pulmonology

Key words:HIV-1, CD4+ T cells, cell death, tuberculosis, HIV/TB co-infection, lung, BAL

Organism: Mouse

Tissue: Lung, Spleen

Pathological State: Virus Infection

89
Hypoxic changes to the urothelium as a bystander of end-stage bladder disease

Anna Radford, Dr Jenny Hinley, Dr Alice Pilborough, Jennifer Southgate, Ramnath Subramaniam

Journal of Pediatric Urology (Elsevier) UK, 05 February 2019

Urology

Key words:Neuropathic bladder, Hypoxia, Hypoxia-inducible factor1 alpha, Obstruction, Regenerative medicine

Organism: Human

Tissue: Bladder

Pathological State: Neuropathy

90
Spatiotemporal Differences in Presentation of CD8 T Cell Epitopes during Hepatitis B Virus Infection

Atefeh Khakpoor, Yi Ni, Antony Chen, Zi Zong Ho, Vincent Oei, Ninghan Yang, Reshmi Giri, Jia Xin Chow, Anthony T. Tan, Patrick T. Kennedy, Mala Maini, Stephan Urban, Antonio Bertoletti

Journal of Virology (American Society for Microbiology) Singapore, Germany, Belgium, UK, 05 February 2019

Virology

Key words:antigen presentation, CD8 T cells, chronic hepatitis B patient, HBV DNA integration, HLA class I, liver, hepatitis B virus

Organism: Human

Tissue: Liver

Pathological State: Virus Infection

91
DSE regulates the malignant characters of hepatocellular carcinoma cells by modulating CCL5/CCR1 axis

WC Liao, HR Yen, CK Liao, TJ Tseng, CT Lan, CH Liu

American Journal of Cancer Research (NCBI) Taiwan, 01 February 2019

Oncology

Key words:Dermatan sulfate, DS epimerase, hepatocellular carcinoma, tumor infiltrated lymphocyte, CCL5

Organism: Human

Tissue: Liver

Pathological State: Cancer

92
Pathology of spontaneous and immunotherapy‐induced tumor regression in a murine model of melanoma

Kim R M Blenman, Jake Wang, Shawn Cowper, Marcus Bosenberg

Pigment Cell and Melanoma Research (Wiley) USA, 31 January 2019

Oncology

Key words:melanoma, mouse models, B cells, neutrophils, Ly6B.2, histology, tumor regression, NETs

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

93
COPD and asthma therapeutics for supportive treatment in organophosphate poisoning

J Herbert, H Thiermann, F Worek, T Wille

Clinical Toxicology (Taylor and Francis) Germany, 30 January 2019

Toxicology

Key words:Organophosphate poisoning, nerve agents, PCLS, COPD, asthma

Organism: Rat

Tissue: Lung

94
Multiple defects sensitize p53-deficient head and neck cancer cells to the WEE1 kinase inhibition

Ahmed Diab, Micheal Kao, Keffy Kehrli, Hee Yeon Kim, Julia Sidorova and Eduardo Méndez

Molecular Cancer Research (AACR Publications) USA, 24 January 2019

Oncology

Key words:Head and neck cancer, WEE1, TP53, cell cycle, mitosis, replication stress, DNA damage

Organism: Human

Cell Line: Primary fibroblast cells (HFF4), Head and neck cancer cell line UM-SCC-74a

95
Sensory Neuropeptides and their Receptors Participate in Mechano-Regulation of Murine Macrophages

Dominique Muschter , Anna-Sophie Beiderbeck , Tanja Späth, Christian Kirschneck, Agnes Schröder, Susanne Grässel

International Journal of Molecular Sciences (MDPI) Germany, 24 January 2019

Immunology

Key words:cyclic stretch; mechan-oregulation; murine macrophages; substance P; alpha-calcitonin gene-related peptide; neurokinin receptor; CGRP receptor; destabilized medial meniscus

Organism: Mouse

Pathological State: Osteoarthritis

Cell Line: Bone Marrow-derived Macrophages

96
Dynamic changes in intramedullary pressure 72 hours after spinal cord injury

Xin Zhang, Chang-Bin Liu, De-Gang Yang, Chuan Qin, Xue-Chao Dong, Da-Peng Li, Chao Zhang, Yun Guo, Liang-Jie Du, Feng Gao, Ming-Liang Yang PhD , Jian-Jun Li

Neural Regeneration research (Publishing House of Neural Regeneration Research) China, 23 January 2019

Neuroscience

Key words:anesthetized; blood-spinal barrier; conscious; edema; hemorrhage; nerve regeneration; neural regeneration; pathological mechanism; pressure measurement; rabbit; secondary spinal cord injury; telemetry

Organism: Rabbit

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

97
Safe Nanocomposite‐Mediated Efficient Delivery of MicroRNA Plasmids for Autosomal Dominant Polycystic Kidney Disease (ADPKD) Therapy

Yen‐Chang Tsai I‐Ling Teng Si‐Tse Jiang Yi‐Che Lee Yuan‐Yow Chiou Fong‐Yu Cheng

Advanced Healthcare Materials (Wiley) Taiwan, 23 January 2019

Nanomedicine

Key words:ADPKD, microRNA, MR,I nanoparticles, plasmid DNA

Organism: Mouse

Tissue: Kidney

Pathological State: Polycystic Kidney Disease

98
Chronic thromboembolic pulmonary hypertension in Austria and Japan

Stella Chausheva, Akira Naito, Aiko Ogawa, Veronika Seidl, Max-Paul Winter, Smriti Sharma, Roela Sadushi-Kolici, Ioana-Alexandra Campean, Shahroukh Taghavi, Bernhard Moser, Walter Klepetko, Keiichi Ishida, Hiromi Matsubara, Seiichiro Sakao, Irene M.Lang

The Journal of thoracic and cardiovascular surgery (Elsevier) Austria, Japan, 21 January 2019

Cardiology

Key words:Chronic thromboembolic pulmonary hypertension, pulmonary endarterectomy, balloon pulmonary angioplasty,

99
Transplantation of neural precursors generated from spinal progenitor cells reduces inflammation in spinal cord injury via NF-κB pathway inhibition

Kristyna Karova, John V. Wainwright, Lucia Machova-Urdzikova, Rishikaysh V. Pisal, Meic Schmidt, Pavla JendelovaEmail author and Meena Jhanwar-UniyalEmail author

Journal of Neuroinflammation (Springer) Czech Republic, USA, 17 January 2019

Stem Cell Research

Key words:NF-κB, p65, Spinal cord injury, Stem cells transplantation, Inflammation, TNF-α,

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

100
Probiotic Lactobacillus spp. Act Against Helicobacter pylori-induced Inflammation

Yi-Hsing Chen, Wan-Hua Tsai, Hui-Yu Wu, Chun-Ya Chen, Wen-Ling Yeh, Ya-Hui Chen, Hui-Ying Hsu, Wei-Wei Chen, Yu-Wen Chen, Wen-Wei Chang, Tzu-Lung Lin, Hsin-Chih Lai, Yu-Hsin Lin and Chih-Ho Lai

Journal of Clinical Medicine (MDPI) Taiwan, 14 January 2019

Microbiology

Key words:Helicobacter pylori; Lactobacillus; probiotic; inflammation

Organism: Mouse

Tissue: Stomach

Pathological State: Bacterial Infection

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