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Customer Publications (A total of 1355 papers published)

01
Cajaninstilbene Acid Ameliorates Cognitive Impairment Induced by Intrahippocampal Injection of Amyloid-β1-42 Oligomers

LS Wang, X Tao, XM Liu, YF Zhou, MD Zhang, YH Liao, RL Pan, Q Chang

Frontiers in Pharmacology (Frontiers Media S.A.) China, 24 September 2019

Pharmacology

Organism: Mouse

Tissue: Brain

02
A Method for Predicting the Success of Pulsinell's Four-Vessel Occlusion Rat Model by LDF Monitoring of Cerebral Blood Flow Decline

W Wang, X Liu, H Lu, L Liu, Y Wang, Y Yu, T Zhang

Journal of Neuroscience Methods (Elsevier) China, 20 September 2019

Neuroscience

Key words: Global cerebral ischemia-reperfusion injury, Laser Doppler flowmetry, Pulsinelli's four-vessel occlusion method, cerebral blood flow decline

Organism: Rat

Tissue: Brain

03
Diffusion-Weighted MR Imaging to Evaluate Immediate Response to Irreversible Electroporation in a Rabbit VX2 Liver Tumor Model

S Hu, C Sun, B Wang, K Zhou, L Pan, J Shangguan, V Yaghmai, M Figini, Z Zhang

Journal of Vascular and Interventional Radiology (Elsevier) China, 18 September 2019

Oncology

Organism: Rabbit

Tissue: Liver

Pathological State: Cancer

04
Magnesium Sulfate Mitigates the Progression of Monocrotaline Pulmonary Hypertension in Rats

CY Chang, HJ Shih, IT Huang, PS Tsai, KY Chen, CJ Huang

International Journal of Molecular Sciences (MDPI) Taiwan, 18 September 2019

Cardiology

Key words: Right heart failure, oxidation, mitochondria, inflammation, inflammasomes, apoptosis

Organism: Rat

Tissue: Lung

Pathological State: Hypertension

05
Murine iPSC-derived microglia and macrophage cell culture models recapitulate distinct phenotypical and functional properties of classical and alternative …

A Quarta, D Le Blon, T D'aes, Z Pieters, SH Taj, F Miro-Mur, E Luyckx, E Van Breedam, J Daans, H Goossens, S Dewilde, N Hens, V Pasque, AM Planas, M Hoehn, Z Berneman, P Ponsaerts

Brain, behavior, and … (Elsevier) Belgium, Germany, Spain, The Netherlands, 13 September 2019

Immunology, Neuroscience

Key words: iPSC, Microglia, Macrophages, Stroke, Neuroinflammation, Interleukin (IL) 13, Polarisation, Classical activation, Alternative activation

Organism: Mouse

Tissue: Brain

06
The Effect of Wharton Jelly-Derived Mesenchymal Stromal Cells and Their Conditioned Media in the Treatment of a Rat Spinal Cord Injury

Milada Chudickova ,Irena Vackova ,Lucia Machova Urdzikova ,Pavlina Jancova ,Kristyna Kekulova ,Monika Rehorova ,Karolina Turnovcova ,Pavla Jendelova and Sarka Kubinova

International Journal of Molecular Sciences (MDPI) Czech Republic, 12 September 2019

Neuroscience

Key words: spinal cord injury; mesenchymal stem cells; Wharton’s jelly; conditioned medium; cell secretome; cell therapy

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

07
Next-generation computational tools for interrogating cancer immunity

F Finotello, D Rieder, H Hackl, Z Trajanoski

Nature Reviews Genetics (Nature) Austria, 12 September 2019

Oncology

Key words: Antigen presentation, Cancer genetics, Cancer genomics, Cancer immunotherapy, Computational biology and bioinformatics, Tumor immunology

08
Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

X Wu, C Lei, T Xia, X Zhong, Q Yang, HB Shu

Nature communications (Nature) China, 11 September 2019

Immunology

Key words: Bacterial Infection, Innate immune cells, Pattern recognition receptors, Ubiquitylation

Organism: Mouse

Tissue: Lung

09
Region specific parasympathetic nerve remodeling in the left atrium contributes to creation of a vulnerable substrate for atrial fibrillation

Georg Gussak, Anna Pfenniger, Lisa M. Wren, Mehul Gilani, Wenwei Zhang, Shin Yoo, David A. Johnson, Amy Burrell, Brandon Benefield, Gabriel M. Knight, Bradley P. Knight, Rod Passman, Jeffrey J. Goldberger, Gary Aistrup, J. Andrew Wasserstrom, Yohannes Shiferaw, and Rishi Arora

The Journal of Clinical Investigation (Am Soc Clin Investig) USA, 10 September 2019

Cardiology

Organism: Mouse

Tissue: Heart

10
Calcium‐sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice

Cheng Z, Li A, Tu CL, Santa Maria C, Szeto N, Herberger A, Chen TH, Song F, Wang J, Liu X, Shoback DM, Chang W

Journal of Bone and Mineral Research (Wiley) USA, 09 September 2019

Osteology

Key words: chondrogenesis, osteogenesis, endochondral bone formation, cartilage, chondrocyte, osteoblast, CaSR knockout, unfixed fracture, fracture healing

11
Worm-Based Alternate Assessment of Probiotic Intervention against Gut Barrier Infection

J Kim, Y Moon

Nutrients (MDPI) South Korea, 08 September 2019

Immunology

Key words: Gut health, Probiotics, Caenorhabditis elegans, Epithelial barrier infection

Organism: Mouse

Tissue: Colon

Pathological State: Worm Infestation

12
Loss of smooth muscle CYB5R3 amplifies angiotensin-II induced hypertension by increasing sGC heme oxidation

BG Durgin, SA Hahn, HM Schmidt, MP Miller, N Hafeez, I Mathar, D Freitag, P Sandner, AC Straub

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, Germany, 05 September 2019

Cardiology

Organism: Mouse

Tissue: Heart

13
ATMIN is a tumor suppressor gene in lung adenocarcinoma

Hanna Foster, E. Josue Ruiz, Christopher Moore, Gordon W H Stamp, Emma L Nye, Ningning Li, Yihang Pan, Yulong He, Julian Downward, Axel Behrens

Cancer Research (AACR) UK, 03 September 2019

Oncology

14
Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer

TT Wei, YT Lin, SP Tang, CK Luo, CT Tsai, CT Shun, CC Chen

Oncogene (Nature) Taiwan, 02 September 2019

Oncology

Key words: Cancer therapeutic resistance, Tumor angiogenesis

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Cancer

15
Novel Semi-Replicative Retroviral Vector Mediated Double Suicide Gene Transfer Enhances Antitumor Effects in Patient-Derived Glioblastoma Models

M Lee, YS Kim, K Lee, M Kang, H Shin, JW Oh, H Koo, D Kim, Y Kim, DS Kong, DH Nam, H Won Lee

Cancers (MDPI) South Korea, 31 August 2019

Oncology

Key words: glioblastoma; patient-derived glioblastoma stem-like cells; semi- and pseudotyped-retroviral replicating vector; dual suicide gene therapy; bystander effect

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

16
The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain

E Nasyrov, KA Nolan, RH Wenger, HH Marti, R Kunze

The FASEB Journal (FASEB) Germany, Switzerland, 30 August 2019

Neuroscience

Key words: PHD, HIF, VEGF, Adrenomedullin, Cerebral angiogenesis

Organism: Mouse

Tissue: Brain

17
Insights into Early Recovery from Influenza Pneumonia by Spatial and Temporal Quantification of Putative Lung Regenerating Cells and by Lung Proteomics

JWJ Ong, KS Tan, SG Ler, J Gunaratne, H Choi, JE Seet, VTK Chow

Cells (MDPI) Singapore, 26 August 2019

Pulmonology

Key words: influenza; pneumonia; lung regeneration; stem cells; comparative quantification; P63; KRT5; proliferating alveolar type II cells; proteomics

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia

18
Macrophage HIF‐2α regulates tumor‐suppressive Spint1 in the tumor microenvironment

Rosa M. Susen, Rebekka Bauer, Catherine Olesch, Dominik C. Fuhrmann, Annika F. Fink, Nathalie Dehne, Arpit Jain, Ingo Ebersberger, Tobias Schmid, Bernhard Brüne

Molecular Carcinogenesis (Wiley) Germany, 22 August 2019

Oncology

Key words: HAI‐1, HGF, hypoxia, proliferation, tumor‐associated macrophages

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

19
Nononcogenic restoration of the intestinal barrier by E. coli–delivered human EGF

M Yu, J Kim, JH Ahn, Y Moon

The Journal of Clinical Investigation (Am Soc Clin Investig) South Korea, 22 August 2019

Microbiology

Organism: Mouse

Tissue: Small Intestine

Pathological State: Colitis

20
Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic …

Z Tang, S Cheng, Y Sun, Y Zhang, X Xiang, Z Ouyang, X Zhu, B Wang, M Hei

Experimental Neurology (Elsevier) China, 20 August 2019

Neuroscience

Key words: Hypoxia-ischemia(HI), Neuroprotection, Brain injuries, Hippocampus, Toll-like receptor 4, Rat model

Organism: Rat

Tissue: Brain

Pathological State: Hypoxic-Ischemic Brain Damage

21
Microstimulation of primate neocortex targeting striosomes induces negative decision-making

S Amemori, K Amemori, T Yoshida, GK Papageorgiou, R Xu, H Shimazu, R Desimone, AM Graybiel

European Journal of Neuroscience (Wiley) USA, 20 August 2019

Neuroscience

Key words: anterior cingulate cortex; approach-avoidance; microstimulation; orbitofrontal cortex; striatum

Organism: Monkey

Tissue: Brain

22
IL‐10 from plasmacytoid dendritic cells promotes angiogenesis in the early stage of endometriosis

JL Suen, Y Chang, YS Shiu, CY Hsu, P Sharma, CC Chiu, YJ Chen, TC Hour, EM Tsai

The Journal of Pathology (Wiley) Taiwan, 16 August 2019

Reproductive Medicine

Key words: Angiogenesis, Endometriosis, IL-10, Plasmacytoid dendritic cell, Zebrafish

Organism: Human, Mouse

Tissue: Endometrium

Pathological State: Endometriosis

23
Targeting the IL-17 receptor using liposomal spherical nucleic acids as topical therapy for psoriasis

H Liu, RS Kang, K Bagnowski, JM Yu, S Radecki, WL Daniel, BR Anderson, S Nallagatla, A Schook, R Agarwal, DA Giljohann, AS Paller

Journal of Investigative Dermatology (Elsevier) USA, 15 August 2019

Dermatology

Pathological State: Psoriasis

24
JAK‐STAT inhibition impairs K‐RAS‐driven lung adenocarcinoma progression

Julian Mohrherr, Marcel Haber, Kristina Breitenecker, Petra Aigner, Stefan Moritsch, Viktor Voronin, Robert Eferl, Richard Moriggl, Dagmar Stoiber, Balázs Győrffy, Luka Brcic, Viktória László, Balázs Döme, Judit Moldvay, Katalin Dezső, Martin Bilban, Helmut Popper, Herwig P. Moll, Emilio Casanova

International Journal of Cancer (Wiley) Austria, Hungary, 12 August 2019

Oncology

Key words: non-small cell lung cancer, lung adenocarcinoma (AC), Kirsten rat sarcoma viral proto-oncogene (K-RAS), Janus kinase (JAK),ruxolitinib, cell-line derived xenografts, genetically engineered mouse models, tumor microenvironment (TME), tumor promotinginflammation

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

25
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway

P Guan, ZM Sun, N Wang, J Zhou, LF Luo, YS Zhao, ES Ji

Life sciences (Elsevier) China, 11 August 2019

Cardiology

Key words: Resveratrol, Chronic intermittent hypoxia, Cardiac hypertrophy, mTOR

Organism: Rat

Tissue: Heart

Pathological State: Cardiac hypertrophy

26
Phosphatidylethanolamine binding protein-4 (PEBP4) is increased in IgA nephropathy and is associated with IgA-positive B-cells in affected kidneys

S Taylor, K Pieri, P Nanni, J Tica, J Barratt, A Didangelos

Journal of Autoimmunity (Elsevier) UK, 09 August 2019

Immunology

Key words: IgA nephropathy (IgAN), PEBP4, Urine, Proteomics, Biomarker, B-Cells

Organism: Human

Tissue: Kidney

Pathological State: IgA nephropathy

27
Antibiotics drive microbial imbalance and vitiligo development in mice

Emilia R. Dellacecca, Cormac Cosgrove, Zhussipbek Mukhatayev, Suhail Akhtar, Victor H. Engelhard, Alfred W. Rademaker, Katherine Knight, I. Caroline Le Poole

Journal of Investigative Dermatology (Elsevier) USA, Kazakhstan, 09 August 2019

Dermatology

Key words: Vitiligo, Microbiome, Pseudomonas, T cells

Organism: Mouse

Tissue: Small Intestine, Colon

Pathological State: Vitiligo

28
Overexpression of Histone H3 Lysine 27 Trimethylation Is Associated with Aggressiveness and Dedifferentiation of Thyroid Cancer

CC Tsai, MN Chien, YC Chang, JJ Lee, SH Dai, SP Cheng

Endocrine Pathology (Springer) Taiwan, 08 August 2019

Oncology

Key words: H3K27me3, EZH2, Thyroid cancer, Immunohistochemistry

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

29
Cancer-Derived VEGF-C Increases Chemokine Production in Lymphatic Endothelial Cells to Promote CXCR2-Dependent Cancer Invasion and MDSC Recruitment

JY Chen, YS Lai, PY Chu, SH Chan, LH Wang, WC Hung

Cancers (MDPI) Taiwan, 06 August 2019

Oncology

Key words: vascular endothelial growth factor-C; CXC chemokine receptor 2; lymphovascular niche; myeloid-derived suppressor cells

Organism: Human

Tissue: Breast

Pathological State: Cancer

30
Senescence‐associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15

Y Guo, JL Ayers, KT Carter, T Wang, SK Maden, D Edmonds, PP Newcomb, C Li, C Ulrich, M Yu, WM Grady

Aging cell (Wiley) USA, 06 August 2019

Cell Biology

Key words: Colon organoids, Colorectal cancer, GDF15, microenivronment, senescence

Organism: Human

Tissue: Colon

Pathological State: Cancer

31
Analysis of Telomere Lengths in p53 Signatures and Incidental Serous Tubal Intraepithelial Carcinomas Without Concurrent Ovarian Cancer

S Asaka, C Davis, SF Lin, TL Wang, CM Heaphy, IM Shih

The American journal … (Wolters Kluwer) USA, 01 August 2019

Oncology

Key words: ovarian cancer precursor, fallopian tube, p53 signature, serous tubal intraepithelial carcinoma, telomere

32
Increased ILC3s associated with higher levels of IL-1 aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase

Tzu‐Yi Chan, Chia‐Liang Yen, Ya‐Fang Huang, Pei‐Chi Lo, Peter A. Nigrovic, Chia‐Ying Cheng, Wei‐Zhi Wang, Szu‐Yu Wu, Chi‐Chang Shieh

European Journal of Immunology (Wiley) Taiwan, Japan, USA, 26 July 2019

Rheumatology

Key words: Innate lymphoid cells; Chronic granulomatous disease; NADPH oxidase; Reactive oxygen species; Serum-induced arthritis

Organism: Mouse

Tissue: Joint

Pathological State: Arthritis

33
Increased ILC3s associated with higher levels of IL‐1β aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase

TY Chan, CL Yen, YF Huang, PC Lo, PA Nigrovic, CY Cheng, WZ Wang, SY Wu, CC Shieh

European Journal of Immunology (Wiley) Taiwan, Japan, USA, 26 July 2019

Immunology

Key words: Innate lymphoid cells; Chronic granulomatous disease; NADPH oxidase; Reactive oxygen species; Serum-induced arthritis

Organism: Mouse

Tissue: Joint

Pathological State: Arthritis

34
Phthalate exposure alters gut microbiota composition and IgM vaccine response in human newborns

Yung-Ning Yang, Yu-Chen S.H. Yang, I-Hsuan Lin, Ying-Yu Chen, Hung-Yun Lin, Chien-Yi Wu, Yu-Tsun Su, Yao-Jong Yang, San-Nan Yang, Jau-Ling Suen

Food and Chemical Toxicology (Elsevier) Taiwan, USA, 26 July 2019

Toxicology

Key words: Di-(2-ethylhexyl) phthalate, Intravenous infusion, Microbiota, Anti-HBsAg-IgM, Newborn

35
An Amyloid-β Targeting Chemical Exchange Saturation Transfer Probe for In Vivo Detection of Alzheimer's Disease

R Wang, C Wang, Z Dai, Y Chen, Z Shen, G Xiao, Y Chen, JN Zhou, Z Zhuang, R Wu

ACS Chemical Neuroscience (ACS Publications) China, 25 July 2019

Neuroscience

Key words: Alzheimer’s disease; Amyloid-β; Magnetic resonance imaging; Chemical exchange saturation transfer; Angiopep-2

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer’s disease

36
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

Francesca Bufalieri, Paola Infante, Flavia Bernardi, Miriam Caimano, Paolo Romania, Marta Moretti, Ludovica Lospinoso Severini, Julie Talbot, Ombretta Melaiu, Mirella Tanori, Laura Di Magno, Diana Bellavia, Carlo Capalbo, Stéphanie Puget, Enrico De Smaele, Gianluca Canettieri, Daniele Guardavaccaro, Luca Busino, Angelo Peschiaroli, Simonetta Pazzaglia, Giuseppe Giannini, Gerry Melino, Franco Locatelli, Alberto Gulino, Olivier Ayrault, Doriana Fruci & Lucia Di Marcotullio

Nature Communications (Nature) Italy, France, USA, UK, 24 July 2019

Oncology

Key words: Cancer, Molecular biology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

37
Synergistic effect of NELL-1 and an ultra-low dose of BMP-2 on spinal fusion

Miss Ling Liu, Dr. Wing Moon Raymond Lam, Mrs. Mathanapriya Naidu Zheng Yang, Dr. Ming Wang, Dr. Xiafei Ren, Dr. Tao Hu, Kumarsing Amit Ramruttun, Prof. Kang Ting, Prof. James Cho-Hong Goh; Prof. Hee Kit Wong

Tissue Engineering Part A (Mary Ann Liebert Inc.) Singapore, China, 24 July 2019

Regenerative Medicine

Organism: Pig

Cell Line: BMSC

38
DIS3L2 promotes progression of hepatocellular carcinoma via hnRNP U-mediated alternative splicing

Huafeng Zhang, Songge Xing, Zhaoyong Li, Wenhao Ma, Xiaoping He, Shengqi Shen, Haoran Wei, Shi-Ting Li, Ying Shu, Linchong Sun, Xiuying Zhong, Yuhao Huangfu, Lanhong Su, Junru Feng, Xiaozhang Zhang, Ping Gao and Wei-Dong Jia

Cancer Research (AACR) China, 22 July 2019

Oncology

Key words: HCC; DIS3L2; hnRNP U; Alternative splicing; Rac1b

Organism: Human

Tissue: Liver

Pathological State: Cancer

39
Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis

CY Hung, TI Hsu, JY Chuang, TP Su, WC Chang, JJ Hung

Molecular Neurobiology (Springer) Taiwan, USA, 18 July 2019

Neuroscience

Key words: Sp1, Astrocyte, Neurite outgrowth, Synaptogenesis

Organism: Mouse

Tissue: Brain

40
Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus

I Simitsidellis, AE Zufiaurre, O Kelepouri, Elisabeth O’Flaherty, Douglas A. Gibson, Philippa T. K. Saunders

Journal of Endocrinology (bioscientifica) Ireland, 18 July 2019

Reproductive Medicine

Key words: Uterus, Endometrium, Androgen, SARM, Andarine, GTx-024, Enobosarm, 15 Ostarine, Danazol, DHT

Organism: Mouse

Tissue: Uterus

41
Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction

Thomas M. Hofbauer, Andreas Mangold, Thomas Scherz, Veronika Seidl, Adelheid Panzenböck, Anna S. Ondracek, Julian Müller, Matthias Schneider, Thomas Binder, Lena Hell, Irene M. Lang

Basic research in Cardiology (Springer) Austria, 16 July 2019

Cardiology

Key words: ST-segment elevation myocardial infarction, Neutrophil extracellular traps, Fibrocytes Thrombosis

Organism: Human

Tissue: Heart

42
Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface

Caroline M. Weight, Cristina Venturini, Sherin Pojar, Simon P. Jochems, Jesús Reiné, Elissavet Nikolaou, Carla Solórzano, Mahdad Noursadeghi, Jeremy S. Brown, Daniela M. Ferreira & Robert S. Heyderman

Nature Communications (Nature) UK, 16 July 2019

Microbiology, Immunology

Key words: Infection, Innate immunity, Pathogens, Respiratory tract diseases

Organism: Human

Pathological State: Streptococcus pneumoniae infection

Cell Line: Mucosal cells

43
B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease

Emanuel Della-Torre, Elena Rigamonti, Cory Perugino, Simona Baghai-Sain, Na Sun, Naoki Kaneko, Takashi Maehara, Lucrezia Rovati, Maurilio Ponzoni, Raffaella Milani, Marco Lanzillotta, Vinay Mahajan, Hamid Mattoo, Ivan Molineris, Vikram Deshpande, j John H. Stone, Massimo Falconi, Angelo A. Manfredi, Shiv Pillai,

Journal of Allergy and Clinical Immunology (Elsevier) Italy, USA, Japan, 15 July 2019

Allergy Research

Key words: IgG4, IgG4-related disease, B cells, plasmablasts, fibrosis, fibroblasts, rituximab, lysyl oxidase homolog 2, plateletderived growth factor

Organism: Human

Tissue: Pancreas, Lymphoid Tissue,

Pathological State: Fibrosis

44
Pleiotropic Effects of Epithelial Mesenchymal Crosstalk on Head and Neck Cancer: EMT and beyond

TB Steinbichler, D Savic, D Dejaco, A Romani, B Kofler, II Skvortsova, H Riechelmann, J Dudas

Cancer Microenvironment (Springer) Austria, 11 July 2019

Oncology

Key words: IL-6, EMT, JAK/STAT3/Snail signalling, radiochemotherapy, therapy resistance, conditioned medium

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

45
The Lymphoma-Associated Macrophages-To-Hodgkin-Reed-Sternberg Cells Ratio Is A Poor Prognostic Factor In Classic Hodgkin Lymphoma Patients

V Procházka, T Papajík, T Dýšková, M Dihel, S Brychtová, Z Prouzová, E Kriegová, M Lukášová, V Hanáčková

Clinical Lymphoma Myeloma and Leukemia (Elsevier) Czech Republic, 05 July 2019

Oncology

Key words: Hodgkin lymphoma, macrophage, prognosis, microenvironment

Organism: Human

Pathological State: Cancer

46
miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

Hsin-Yi Chen, Yaw-Dong Lang, Han-Nan Lin, Yun-Ru Liu, Chun-Chieh Liao, André Wendindondé Nana, Yun Yen & Ruey-Hwa Chen

Scientific reports (Nature) Taiwan, 04 July 2019

Oncology

Key words: Colon cancer, Metastasis

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

47
A Two-Stage U-Net Algorithm for Segmentation of Nuclei in H&E-Stained Tissues

A Mahbod, G Schaefer, I Ellinger, R Ecker…

European Congress on … (Springer) , 03 July 2019

48
Entrapment of N-Hydroxyphthalimide Carbon Dots in Different Topical Gel Formulations: New Composites with Anticancer Activity

CL Savin, C Tiron, E Carasevici, CS Stan, SA Ibanescu, BC Simionescu, CA Peptu

Pharmaceutics (MDPI) Romania, 01 July 2019

Oncology

Key words: composite; N-hydroxyphthalimide; carbon dots; polymer gels; antitumoral activity

Organism: Human

Cell Line: MDA-MB-231 cells

49
Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons

Tetsuya Akiyama, Naoki Suzuki, Mitsuru Ishikawa, Koki Fujimori, Takefumi Sone, Jiro Kawada, Ryo Funayama, Fumiyoshi Fujishima, Shio Mitsuzawa, Kensuke Ikeda, Hiroya Ono, Tomomi Shijo, Shion Osana, Matsuyuki Shirota, Tadashi Nakagawa, Yasuo Kitajima, Ayumi Nishiyama, Rumiko Izumi, Satoru Morimoto, Yohei Okada, Takayuki Kamei, Mayumi Nishida, Masahiro Nogami, Shohei Kaneda, Yoshiho Ikeuchi, Hiroaki Mitsuhashi, Keiko Nakayama, Teruo Fujii, Hitoshi Warita, Hideyuki Okano, Masashi Aoki, Masashi Aoki

EBioMedicine (Elsevier) Japan, 29 June 2019

Neuroscience

Key words: Amyotrophic lateral sclerosis (ALS), Fused in sarcoma (FUS), Axon branching, Fos-B, Nerve organoid, Human-induced pluripotent stem cell (hiPSC)-derived motor neuron

Organism: Human

Tissue: Spinal Cord

Pathological State: ALS

50
Fbxw7 increases CCL2/7 in CX3CR1hi macrophages to promote intestinal inflammation

Jia He, Yinjing Song, Gaopeng Li, Peng Xiao, Yang Liu, Yue Xue, Qian Cao, Xintao Tu, Ting Pan, Zhinong Jiang, Xuetao Cao, Lihua Lai, and Qingqing Wang

The Journal of Clinical Investigation (American Society for Clinical Investigation) China, 27 June 2019

Immunology

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

51
Amelioration of Experimentally Induced Arthritis by Reducing Reactive Oxygen Species Production through the Intra-Articular Injection of Water-Soluble Fullerenol

WS Kuo, CT Weng, JH Chen, CL Wu, AL Shiau, JL Hsieh, EC So, PT Wu, SY Chen

Nanomaterials (MDPI) China, Taiwan, 23 June 2019

Nanomedicine

Key words: experimental arthritis; intra-articular injection; reactive oxygen species; rheumatoid arthritis; water-soluble fullerenol

Organism: Rat

Tissue: Joint

Pathological State: Arthritis

52
Cytotoxic T-cells and their activation status are independent prognostic markers in meningiomas

Carmen Rapp, Steffen Dettling, Fang Liu, Anna Theresa Ull, Rolf Warta, Christine Jungk, Saskia Roesch, Andreas Mock, Felix Sahm, Melissa Schmidt, Gerhard Jungwirth, Klaus Zweckberger, Katrin Lamszus, Konstaninos Gousias, Almuth F Kessler, Niels Grabe, Mario Löhr, Ralf Ketter, Steffi Urbschat, Christian Senft, Manfred Westphal, Amir Abdollahi, Jürgen Debus, Andreas von Deimling, Andreas Unterberg, Matthias Simon and Christel C Herold-Mende

Clinical Cancer Research (AACR) Germany, 21 June 2019

Immunology, Oncology

Key words: Clinically aggressive meningioma, T-cell infiltration, primary and recurrent tumors TILs, PD-1

Organism: Human

Tissue: Brain

Pathological State: Cancer

53
Differential expression of Plg-RKT and its effects on migration of proinflammatory monocyte and macrophage subsets

Barbara Thaler, Nagyung Baik, Philipp J. Hohensinner, Johanna Baumgartner, Adelheid Panzenböck, Stefan Stojkovic, Svitlana Demyanets, Ihor Huk, Gersina Rega-Kaun, Christoph Kaun, Manfred Prager, Michael B. Fischer, Kurt Huber, Walter S. Speidl, Robert J. Parmer, Lindsey A. Miles, Johann Wojta

Blood (American Society of Hematology) Austria, USA, 20 June 2019

54
Specific inhibition of the classical complement pathway prevents C3 deposition along the dermal-epidermal junction in bullous pemphigoid

Patricia Colchete Freire, Cristina Herraez Muñoz, Ulla Derhaschnig, Christian Schoergenhofer, Christa Firbas, Graham C. Parry, Sandip Panicker, James C. Gilbert, Georg Stingl, Bernd Jilma, Peter Maximilian Heil

Journal of Investigative Dermatology (Elsevier) Austria, USA, 20 June 2019

Dermatology

55
Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis

C Yang, P Sun, M Deng, P Loughran, W Li, Z Yi, S Li, XH Zhang, J Fan, TR Billar, MJ Scott

Cell Death & Disease (Nature) USA, China, 17 June 2019

Hepathology

Key words: Cell death and immune response, Innate immunity

Organism: Mouse

Tissue: Liver

Pathological State: Liver Injury

56
C/EBPβ-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice

Tobias Ackermann, Götz Hartleben, Christine Müller, Guido Mastrobuoni, Marco Groth, Britt A. Sterken, Mohamad A. Zaini, Sameh A. Youssef, Hidde R. Zuidhof, Sara R. Krauss, Gertrud Kortman, Gerald de Haan, Alain de Bruin, Zhao-Qi Wang, Matthias Platzer, Stefan Kempa & Cornelis F. Calkhoven

Nature Communications Biology (Nature) The Netherlands, Germany, 14 June 2019

Oncology

Key words: Cancer metabolism, Cell growth

Organism: Mouse

Tissue: Bone Marrow

57
Fc glycan-mediated regulation of placental antibody transfer

Madeleine F. Jennewein, Ilona Goldfarb, Sepideh Dolatshahi, Cormac Cosgrove, Francesca J. Noelette, Marina Krykbaeva, Jishnu Das, Aniruddh Sarkar, Matthew J. Gorman, Stephanie Fischinger, Carolyn M. Boudreau, Joelle Brown, Jennifer H. Cooperrider, Jasneet Aneja, Todd J. Suscovich, Barney S. Graham, Georg M. Lauer, Tessa Goetghebuer, Arnaud Marchant, Douglas Lauffenburger, Arthur Y. Kim, Laura E. Riley, Galit Alter

Cell (Cell Press) USA, Belgium, 13 June 2019

Reproductive Medicine, Immunology

Key words: antibody functionality, antibody glycosylation, trans-placental transfer, maternal vaccination, ADCC, neonatal immunology

Organism: Human

Tissue: Placenta

58
The PPARγ Agonist Rosiglitazone Suppresses Syngeneic Mouse SCC (Squamous Cell Carcinoma) Tumor Growth through an Immune-Mediated Mechanism

RL Konger, E Derr-Yellin, N Ermatov, L Ren, RP Sahu

Molecules (MDPI) USA, 11 June 2019

Oncology, Immunology

Key words: peroxisome proliferator activated receptor gamma; rosiglitazone; T-cells; myeloid cells; anti-tumor immunity

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

59
Optimisation of multiplex immunofluorescence for a non-spectral fluorescence scanning system

CC Anyaegbu, TF Lee-Pullen, TJ Miller, TN Abel, CF Platell, MJ McCoy

Journal of Immunological Methods (Elsevier) Australia, 08 June 2019

Medical Imaging

Key words: Fluorescence microscopy, Imaging, Immunohistochemistry, T cells, Colorectal

Organism: Human

Tissue: Colon

60
Role of the PI3K‑mTOR autophagy pathway in nerve damage in rats with intermittent hypoxia‑aggravated whole brain ischemia

X Guo, Y Liu, Y Zhao, R Fan, Y Bai, X Guo, J Li, CX Chen

Molecular Medicine Reports (Spandidos Publications) China, 04 June 2019

Neuroscience

Organism: Rat

Tissue: Brain

Pathological State: Ischemia

61
Heat-killed Mycobacterium tuberculosis prime-boost vaccination induces myeloid-derived suppressor cells with spleen dendritic cell-killing capability

Eliana Ribechini, Ina Eckert, Andreas Beilhack, Nelita Du Plessis, Gerhard Walzl, Ulrike Schleicher, Uwe Ritter, and Manfred B. Lutz

The Journal of Clinical Investigation (American Society for Clinical Investigation) Germany, South Africa, 04 June 2019

Immunology

Organism: Mouse

Cell Line: BM-MDSCs and BM-DCs cell

62
Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

Yueming Zhu, Xianghui Zou, Angela E. Dean, Joseph O’ Brien, Yucheng Gao, Elizabeth L. Tran, Seong-Hoon Park, Guoxiang Liu, Matthew B. Kieffer, Haiyan Jiang, Melissa E. Stauffer, Robert Hart, Songhua Quan, Karla J. F. Satchell, Nobuo Horikoshi, Marcelo Bonini, David Gius

Nature Communications (Nature) USA, South Korea, 03 June 2019

Oncology

Key words: Breast cancer, Cancer, Enzyme mechanisms

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

63
Abnormal expression of b10 cell frequencies: possible relation to pathogenesis and disease severity of aplastic anemia

L Gu, B Fu, X Sui, H Xu

Revista da Associação Médica Brasileira (SciELO Brasil) China, 03 June 2019

Hematology

Key words: Anemia, Aplastic; B-Lymphocytes, Regulatory; Interleukin-10

Organism: Human

Cell Line: Bone marrow-derived mononuclear cells

64
Micro RNA‐133 Suppresses ZFHX 3‐dependent Atrial Remodeling and Arrhythmia

WL Cheng, YH Kao, TF Chao, YK Lin, SA Chen, YJ Chen

Acta Physiologica (Wiley) Taiwan, 01 June 2019

Cardiology

Key words: atrial ectopy, cardiac remodelling, connexin43, MicroRNA‐133, Wnt/calcium signalling, ZFHX3

Organism: Mouse

Tissue: Heart

Pathological State: Arrhythmia

65
AIF-regulated oxidative phosphorylation supports lung cancer development

Shuan Rao, Laura Mondragón, Blanka Pranjic, Toshikatsu Hanada, Gautier Stoll, Thomas Köcher, Peng Zhang, Alexander Jais, Alexander Lercher, Andreas Bergthaler, Daniel Schramek, Katharina Haigh, Valentina Sica, Marion Leduc, Nazanine Modjtahedi, Tsung-Pin Pai, Masahiro Onji, Iris Uribesalgo, Reiko Hanada, Ivona Kozieradzki, Rubina Koglgruber, Shane J. Cronin, Zhigang She, Franz Quehenberger, Helmut Popper, Lukas Kenner, Jody J. Haigh, Oliver Kepp, Malgorzata Rak, Kaican Cai, Guido Kroemer & Josef M. Penninger

Cell Research (Nature) China, Austria, France, Germany, Canada, Belgium, Sweden, 27 May 2019

Oncology

Key words: Mechanisms of disease, Non-small-cell lung cancer

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

66
Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

H Tsugawa, C Kato, H Mori, J Matsuzaki…

Cellular and molecular … (Elsevier) Japan, 27 May 2019

Oncology, Microbiology

Key words: Autophagy, CagA, Cancer Stem Cells, CD44v9, Eradication Therapy

Organism: Human

Tissue: Stomach

Pathological State: Cancer

67
LINGO-1 deficiency promotes nerve regeneration through reduction of cell apoptosis, inflammation, and glial scar after spinal cord injury in mice

LJ Huang, G Li, Y Ding, JH Sun, TT Wu, W Zhao, YS Zeng

Experimental Neurology (Elsevier) China, 25 May 2019

Neuroscience

Key words: LINGO-1 knockout, Spinal cord injury, Cell apoptosis, Inflammation, Glial scar, Nerve regeneration

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

68
Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

Matthew K.Tobin, Kianna Musaraca, Ahmed Disouky, Aashutosh Shetti, Abdullah Bheri, William G.Honer, Namhee Kim, Robert J. Dawe, David A. Bennett, Konstantinos Arfanakis, Orly Lazarov

Cell Stem Cell (Cell Press) USA, 23 May 2019

Neuroscience

Key words: human neurogenesis, adult neurogenesis, neural stem cells, neurogenesis in aging, cognitive dysfunction, aging, Alzheimer’s disease

Organism: Human

Tissue: Brain

Pathological State: Alzheimer's Disease

69
Near-Infrared Fluorescent Endoscopic Image-guided Photothermal Ablation Therapy of Colorectal Cancer using Dual-modal Gold Nanorods Targeting Tumor Infiltrating Innate Immune Cells in Transgenic TS4 CRE/APCloxΔ468 Mouse Model

Elias Gournaris, Wooram Park, Soojeong Cho, David J Bentrem, Andrew C. Larson, Dong-Hyun Kim

Applied Materials and Interfaces (ACS Publications) USA, 22 May 2019

Oncology

Key words: colon cancer, endoscopic image-guided therapy, nanomedicine, interventional oncology, photothermal therapy

Organism: Mouse

Tissue: Colon

Pathological State: Polyps

70
High Activation Of STAT5A Drives Peripheral T-Cell Lymphoma And Leukemia

Barbara Maurer, Harini Nivarthi, Bettina Wingelhofer, Ha Thi Than Pham, Michaela Schlederer, Tobias Suske, Reinhard Grausenburger, Ana-Iris Schiefer, Michaela Prchal-Murphy, Doris Chen, Susanne Winkler, Olaf Merkel, Christoph Kornauth, Maximilian Hofbauer, Birgit Hochgatterer, Gregor Hoermann, Andrea Hoelbl-Kovacic, Jana Prochazkova, Cosimo Lobello, Abbarna A. Cumaraswamy, Johanna Latzka, Melitta Kitzwögerer, Andreas Chott, Andrea Janikova, Šárka Pospíšilova, Joanna I. Loizou, Stefan Kubicek, Peter Valent, Thomas Kolbe, Florian Grebien, Lukas Kenner, Patrick T. Gunning, Robert Kralovics, Marco Herling, Mathias Müller, Thomas Rülicke, Veronika Sexl, Richard Moriggl

Haematologica (The Ferrata Sorti Foundation) Austria, Czech Republic, Germany, Canada, 21 May 2019

Oncology

Key words: Hematopoiesis, Lymphocytes, Lymphoproliferative Disorders, PTCLSTAT5

Organism: Mouse

Tissue: Lymphoid Tissue

Pathological State: Cancer

71
The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury

Barbora Svobodova, Anna Kloudova, Jiri Ruzicka, Ludmila Kajtmanova, Leos Navratil, Radek Sedlacek, Tomas Suchy, Meena Jhanwar-Uniyal, Pavla Jendelova & Lucia Machova Urdzikova

Scientific Reports (Nature) Czech Republic, USA, 21 May 2019

Regenerative Medicine

Key words: Spinal cord diseases, Spinal cord injury

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

72
Growth and cellular patterning during fetal human inner ear development studied by a correlative imaging approach

Lejo Johnson Chacko, David Wertjanz, Consolato Sergi, Jozsef Dudas, Natalie Fischer, Theresa Eberharter, Romed Hoermann, Rudolf Glueckert, Helga Fritsch, Helge Rask-Andersen, Anneliese Schrott-Fischer and Stephan Handschuh

BMC Developmental Biology (Springer) Austria, 20 May 2019

Developmental Biology

Organism: Human

Tissue: Bone

73
Nano-formulated Curcumin (LipodisqTM) modulates the local inflammatory response, reduces glial scar and preserves the white matter after spinal cord injury in rats

P Krupa, B Svobodova, J Dubisova, S Kubinova, P Jendelova, L Machova Urdzikova

Neuropharmacology (Elsevier) Czech Republic, 17 May 2019

Nanomedicine

Key words: Spinal cord injury, Nanocurcumin, Inflammatory response, Neuroregeneration, Astrogliosis, Axonal growth

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

74
Amentoflavone Effectively Blocked the Tumor Progression of Glioblastoma via Suppression of ERK/NF-B Signaling Pathway

FT Hsu, IT Chiang, YC Kuo, TC Hsia, CC Lin, YC Liu, JG Chung

The American Journal of Chinese Medicine (World Scientific) Taiwan, 17 May 2019

Oncology

Key words: Amentoflavone, Glioblastoma, Anticancer, ERK, NF-κB

Organism: Mouse

Tissue: Xenograft Tumor, Liver

Pathological State: Cancer

75
Potential Effects of CXCL9 and CCL20 on Cardiac Fibrosis in Patients with Myocardial Infarction and Isoproterenol-Treated Rats

CF Lin, CJ Su, JH Liu, ST Chen, HL Huang, SL Pan

Journal of Clinical Medicine (MDPI) Taiwan, 11 May 2019

Cardiology

Key words: myocardial infarction; cardiac fibrosis; CXCL9; CCL20; isoproterenol

Organism: Rat

Tissue: Heart

Pathological State: Cardiac Fibrosis

76
In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field

PW Nagle, MJ van Goethem, M Kempers, H Kiewit, A Knopf, JA Langendijk, S Brandenburg, P van Luijk, RP Coppes

Radiotherapy and Oncology (Elsevier) The Netherlands, 11 May 2019

Oncology

Key words: Protons, MRI, Tumor, Normal tissue, Organoids

Organism: Human

Cell Line: Human embryonic kidney cells (HEK293) and human lung adenocarcinoma cells (A549)

77
Effects of Hydroxychloroquine on the Human Placenta–Findings from In Vitro Experimental Data and a Systematic Review

RE Scott, SL Greenwood, DJL Hayes, BC Baker, RL Jones, AEP Heazell

Reproductive Toxicology (Elsevier) UK, 10 May 2019

Reproductive Medicine

Key words: Hydroxychloroquine, Placenta, TLRs, TLR 7, TLR 9, Inflammation, Toxicology, Safety, Pregnancy, SLEAPS

Organism: Human

Tissue: Placenta

78
Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

Kimberly M. Cirelli, Diane G. Carnathan, Bartek Nogal, Jacob T. Martin, Oscar L. Rodriguez, Amit A. Upadhyay, Chiamaka A. Enemuo, Etse H. Gebru, Yury Choe, Federico Viviano, Catherine Nakao, Matthias G. Pauthner, Samantha Reiss, Christopher A. Cottrell, Melissa L. Smith, Raiza Bastidas, William Gibson, Amber N. Wolabaugh, Mariane B. Melo, Benjamin Cossette, Venkatesh Kumar, Nirav B. Patel, Talar Tokatlian, Sergey Menis, Daniel W. Kulp, Dennis R. Burton, Ben Murrell, William R. Schief, Steven E. Bosinger, Andrew B. Ward, Corey T. Watson, Guido Silvestri, Darrell J. Irvine, Shane Crotty

Cell (Cell Press) USA, Sweden, 09 May 2019

Immunology

Key words: HIV vaccine, non-human primates, rhesus macaque genome, FNA, GC- TFH, memory B cells, somatic hypermutation, affinity maturation, immune complexes

Organism: Mouse

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

79
Multimodal [18F]FDG PET/CT is a direct readout for inflammatory bone repair: a longitudinal study in TNFα transgenic mice

Silvia Hayer, Markus Zeilinger, Volker Weiss , Monika Dumanic , Markus Seibt , Birgit Niederreiter ,Tetyana Shvets , Florian Pichler ,Wolfgang Wadsak , Bruno K. Podesser, Thomas H. Helbich, Marcus Hacker, Josef S. Smolen, Kurt Redlich , Markus Mitterhauser

Journal of Bone and Mineral Research (Wiley) Austria, 07 May 2019

Osteology

Key words: µPET/CT, 18F‐FDG, 18F‐NaF, bone healing, experimental arthritis, TNF blockade

Organism: Human

Tissue: Joint

80
Directional Topography Influences Adipose Mesenchymal Stromal Cell Plasticity: Prospects for Tissue Engineering and Fibrosis

GR Liguori, Q Zhou, TTA Liguori, GG Barros, PT Kühn, LF Moreira, P van Rijn, MC Harmsen

Stem Cells International (Hindawi Publishing Corporation) The Netherlands, Brazil, China, 05 May 2019

Stem Cell Research

Organism: Human

Cell Line: Adipose tissue derived stromal cells (ADSC)

81
Endoplasmic reticulum stress is involved in stress-induced hypothalamic neuronal injury in rats via the PERK-ATF4-CHOP and IRE1-ASK1-JNK pathways

S Yi, K Chen, L Zhang, W Shi, Y Zhang, S Niu, M Jia, B Cong, Y Li

Frontiers in cellular Neuroscience (Frontiers Media S.A.) China, 03 May 2019

Neuroscience

Key words: hypothalamus, stress, neuronal injury, PERK-ATF4-CHOP pathway, IRE1-ASK1-JNK pathway

Organism: Rat

Tissue: Brain

Pathological State: Stress-Induced Hypothalamic Neuronal Injury

82
Positive PD‑L1 expression is predictive for patients with advanced EGFR wild‑type non‑small cell lung cancer treated with gemcitabine and cisplatin

Y Qiu, J Jiang, M Zhang, Y Qin

Oncology Letters (Spandidos Publications) China, 02 May 2019

Oncology

Key words: programmed death ligand-1, checkpoint, immunotherapy, non-small cell lung cancer, prognosis

Organism: Human

Tissue: Lung

Pathological State: Cancer

83
Exosomal transfer of bone marrow mesenchymal stem cells-derived miR340 attenuates endometrial fibrosis

B Xiao, Y Zhu, J Huang, T Wang, F Wang, S Sun

Biology Open (The Company of Biologists) China, 01 May 2019

Stem Cell Research

Organism: Rat

Tissue: Uterus

Pathological State: Endometriosis

84
An improved method of culturing somatotropic cells from rat adenohypophysis

J Mao, Y Bao, F Mei, X Liao, F Liu, L Zhou, B Qiu, S Qi

Tissue and Cell (Elsevier) China, 30 April 2019

Biological Methods

Key words: Pericytes, Improved method, Primary culture, Somatotropic cells

Organism: Rat

Cell Line: Pericytes

85
Promyelocytic leukemia zinc finger is involved in the formation of deep layer cortical neurons

HC Lin, YH Ching, CC Huang, PC Pao, WC Chang, TJ Kao, YC Lee

Journal of Biomedical Science (Springer) Taiwan, 26 April 2019

Neuroscience

Key words: Promyelocytic leukemia zinc finger, Plzf, luxoid mice, Cortical neuron

Organism: Mouse

Tissue: Brain

86
Exercise Alleviates Osteoporosis in Rats with Mild Chronic Kidney Disease by Decreasing Sclerostin Production

HW Liao, TH Huang, YH Chang, HH Liou, YH Chou, YM Sue, PH Hung, YT Chang, PC Ho, KJ Tsai

International Journal of Molecular Sciences (MDPI) Taiwan, 25 April 2019

Osteology, Nephrology

Key words: exercise; chronic kidney disease; osteoporosis; sclerostin; chronic kidney disease–mineral bone disorder

Organism: Rat

Tissue: Bone

Pathological State: Kidney Disease

87
Wound Age Estimation by Neutrophil Migration Distance.

QQ Liu, HM Guo, L Wang, HL Lu, QX Du, RF Bai, JH Sun, YY Wang

Fa yi xue za zhi (Europe PMC) China, 25 April 2019

Immunology

88
Th2-TRMs maintain life-long allergic memory in experimental asthma in mice

B Bosnjak, S Kazemi, LM Altenburger, G Mokrovic, MM Epstein

Frontiers in Immunology (Frontiers Media S.A.) Austria, 24 April 2019

Immunology

Organism: Mouse

Tissue: Lung

Pathological State: Asthma

89
YWHAE promotes proliferation, metastasis, and chemoresistance in breast cancer cells

YF Yang, YC Lee, YY Wang, CH Wang, MF Hou, SS Yuan

Kaohsiung journal of Medical Sciences (Wiley) Taiwan, 18 April 2019

Oncology

Key words: 14‐3‐3ε, breast cancer, chemoresistance, YWHAE

Organism: Human

Tissue: Breast

Pathological State: Cancer

90
Toll‑like receptor 4 plays a tumor‑suppressive role in cutaneous squamous cell carcinoma

Erina Mikami, Mitsuhiro Kudo, Ryuji Ohashi, Kiyoko Kawahara, Yoko Kawamoto, Kiyoshi Teduka, Takenori Fujii, Taeko Kitamura, Shoko Kure, Kousuke Ishino, Takashi Sakatani, Ryuichi Wada, Hidehisa Saeki, Zenya Naito

International Journal of Oncology (Spandidos Publications) Japan, 17 April 2019

Oncology

Key words: Toll-like receptor 4, cutaneous squamous cell carcinoma, differentiation, CD44, migration, invasion, filopodia

Organism: Human

Tissue: Skin

Pathological State: Cancer

91
Functional CD3+ CD8+ PD-1-T cells accumulation and PD-L1 expression increases during tumor invasion in DCIS of the breast

S Lv, S Wang, G Qiao, X Wang, X Zhou, F Yan, Y Li, S Wang, MA Morse, A Hobeika, J Ren, HK Lyerly

Clinical Breast Cancer (Elsevier) China, USA, 16 April 2019

Oncology

Key words: DCIS, Opal technique PDl-1, PD-1, immune, microenvironment

Organism: Human

Tissue: Breast

Pathological State: Cancer

92
Low cd8+ t cell infiltration and high pd-l1 expression are associated with level of cd44+/cd133+ cancer stem cells and predict an unfavorable prognosis in pancreatic …

YC Hou, YJ Chao, MH Hsieh, HL Tung, HC Wang, YS Shan

Cancers (MDPI) Taiwan, 15 April 2019

Oncology

Key words: pancreatic cancer; T cells; cancer stem cells; CD8; PD-L1; CD44; CD133; immunotherapy

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

93
Metastatic Colorectal Cancer Rewrites Metabolic Program Through a Glut3-YAP-dependent Signaling Circuit

CC Kuo, HH Ling, MC Chiang, CH Chung, WY Lee, CY Chu, YC Wu, CH Chen, YW Lai, IL Tsai, CH Cheng, CW Lin

Theranostics (Ivyspring) Taiwan, 13 April 2019

Oncology

Key words: cancer metabolism, colorectal cancer, glucose transporter, metastasis, YAP

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

94
Interrelations of Sphingolipid and Lysophosphatidate Signaling With Immune System in Ovarian Cancer

Anastasia Meshcheryakova, Martin Svoboda, Markus Jaritz, Felicitas Mungenast, Martina Salzmann, Dietmar Pils, Dan Cacsire Castillo-Tong, Gudrun Hager, Andrea Wolf, Elena Ioana Braicu, Jalid Sehouli, Sandrina Lambrechts, Ignace Vergote, Sven Mahner, Peter Birner, Philip Zimmermann, David N. Brindley, Georg Heinze, Robert Zeillinger, Diana Mechtcheriakova

Computational and Structural Biotechnology Journal (Elsevier) Austria, Germany, Belgium, Switzerland, Canada, 10 April 2019

Oncology

Key words: Sphingolipid/lysophosphatidate system, On-site immune response, Patient-specific expression data sets, Integrative analysis algorithm, Patient stratification, From systems biology to systems medicine

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

95
Au Nanoparticles with Enzyme-Mimicking Activities Ornamented ZIF-8 for Highly Efficient Photodynamic Therapy

Y Ma, Y Zhu, XF Tang, L Hang, W Jiang, M Li, M Khan, YZ You, YC Wang

Biomaterials Science (Royal Society of Chemistry) China, 04 April 2019

Nanomedicine

Key words: AuNPs nanozyme, nano metal-organic frameworks, tumor hypoxia, photodynamic therapy

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

96
Associations between hepatitis etiology and immune cell infiltration in or around hepatocellular carcinoma

Yu-Yun Shao, Min-Shu Hsieh, Yun-Ting Tsai, Ying-Chun Shen, Zhong-Zhe Lin, Ann-Lii Cheng, Chih-Hung Hsu

Cancer Research (AACR) USA, 03 April 2019

Oncology, Virology

Organism: Human

Tissue: Liver

Pathological State: Cancer

97
The sodium–glucose co-transporter 2 inhibitor empagliflozin attenuates cardiac fibrosis and improves ventricular hemodynamics in hypertensive heart failure …

Hsiang-Chun Lee, Yi-Lin Shiou, Shih-Jie Jhuo, Chia-Yuan Chang, Po-Len Liu, Wun-Jyun Jhuang, Zen-Kong Dai, Wei-Yu Chen, Yun-Fang Chen and An-Sheng Lee

Cardiovascular Diabetology (Springer) Taiwan, 01 April 2019

Cardiology

Key words: SGLT2 inhibitor Empagliflozin Hypertensive Heart failure Cardiac fibrosis Hemodynamics High-fat PPARα ACADM

Organism: Rat

Tissue: Heart

Pathological State: Fibrosis

98
Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells

Miroslav Boudny, Jana Zemanova, Prashant Khirsariya, Marek Borsky, Jan Verner, Jana Cerna, Alexandra Oltova, Vaclav Seda, Marek Mraz, Josef Jaros, Zuzana Jaskova, Michaela Spunarova, Yvona Brychtova, Karel Soucek, Stanislav Drapela, Marie Kasparkova, Jiri Mayer, Kamil Paruch, Martin Trbusek

Haematologica (Ferrata Storti Foundation) Czech Republic, 01 April 2019

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

99
Antrodia cinnamomea induces anti-tumor activity by inhibiting the STAT3 signaling pathway in lung cancer cells

TT Huang, YW Lan, CM Chen, YF Ko, DM Ojcius, J Martel, JD Young, KY Chong

Scientific Reports (Nature) Taiwan, USA, Malaysia, 26 March 2019

Oncology

Key words: Drug development, Lung cancer

Organism: Mouse

Tissue: Lung

100
PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastoma

Yong Jae Shin, Jason K. Sa, Yeri Lee, Donggeon Kim, Nakho Chang, Hee Jin Cho, Miseol Son, Michael Y.T. Oh, Kayoung Shin, Jin-Ku Lee, Jiwon Park, Yoon Kyung Jo, Misuk Kim, Patrick J. Paddison, Vinay Tergaonkar, Jeongwu Lee , Do-Hyun Nam

Journal of Experimental Medicine (Rockefeller University Press) South Korea, China, USA, 21 March 2019

Oncology, Cell Biology

Key words: Solid Tumors, Neuroscience

Organism: Human

Tissue: Brain

Pathological State: Cancer

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