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WELCOME

TissueGnostics provides fully integrated cutting-edge tissue cytometers including a multitude of solutions from multispectral & high-throughput scanning to contextual tissue cytometry. The goal of TissueGnostics is to bring the same type of phenotypical analysis of single cells from Flow Cytometry into tissue context.

TissueGnostics has been founded by scientists from the Vienna University Hospital (AKH) in 2003. We are a globally active Austrian company and have subsidiaries in the EU, the USA and China and customers on all continents.

 

tissuefaxs confocalsystems

TISSUEFAXS Q SYSTEMS

The TissueFAXS SL Q is a highly flexible scanning platform, capable of scanning up to 120 slides at a time in brightfield, widefield fluorescence, and confocal fluorescence. 

TissueFAXS Q delivers automated whole slide confocal imaging using a confocal spinning disk, paired with a high power LED light engine and the TissueFAXS automated scanning workflow.  All TissueFAXS FL or PLUS systems, irrespective of whether they are upright or inverted, are also available in TissueFAXS Q configurations.

Upright configurations of the TissueFAXS Q can be upgraded with a 120 slide loader for high throughput whole slide confocal imaging. Multiple types of projects - whether they are to be scanned in widefield fluorescence, or confocal fluorescence - can be easily color coded in the slide manager and scanned automatically with customizable scanning templates.  

 

IHC Immune Status in situ APP: CD3+ cells in epithelial and interstitial tissues

The aim of the project was to quantify the distribution of CD3+ cells in and around the epithelial areas of prostate biopsies from a clinical study. The biopsies were provided by the Medical University of Vienna. The following images show some of the analysis steps.

  AntiCD3 TissueDetection

The first step in the APP is Tissue Detection.
AntiCD3 TissueDetection

In a second step a composite image of both brown and blue channels is created.
AntiCD3 TissueDetection

Then, a density map of the nuclei is built to determine areas with denser and larger nuclei (epithelial area candidates). 
AntiCD3 TissueDetection

Based on the density map the epithelial areas are detected and cleaned.
AntiCD3 TissueDetection

Finally, distance ranges are projected from the perimeters of the epithelial areas to provide distance measurements for CD3+ cells.
AntiCD3 TissueDetection

Detailed View

The three detailed view images below show the detection of nuclei and CD3+ staining.
AntiCD3 TissueDetection
AntiCD3 TissueDetection
AntiCD3 TissueDetection

 
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    TissueGnostics Austria
    GLOBAL HEADQUARTER

    Taborstrasse 10/2/8
    A-1020
    Vienna
    AUSTRIA

    Tel.: +43/1/216 11 90

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    TissueGnostics Asia Pacific
    BRANCH CHINA

    Room 506,
    No.6 Auto Museum East Rd,
    Fengtai District Beijing
    CHINA

    Tel.: +86/400/898 1980

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    TissueGnostics USA 
    BRANCH NORTH AMERICA

    12522 Moorpark Street
    Suite #106
    Los Angeles, CA 91604
    USA

    Tel.: +1/818/996 9787

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    TissueGnostics Romania
    BRANCH EASTERN EUROPE

    RO17719397
    Str. Sf. Andrei, nr. 15A
    700028 Iasi
    ROMANIA

    Tel.: +40/332/40 58 66

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Contact

TissueGnostics GmbH
Taborstraße 10/2/8
1020 Vienna, Austria
+43 1 216 11 90
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